[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"clinical-outcomes\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:clinical-outcomes":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,49,75,108,139,176,202],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100532920","nutritional-status-and-clinical-outcomes-in-patients-with-common-malignanciesncom-100532920",false,"NCT06219083","Nutritional Status and Clinical Outcomes in Patients With Common Malignancies(NCOM)","Study of Nutritional Status and Clinical Outcomes in Patients With Common Malignancies","NCOM","Inclusion Criteria:\n\n* Adults aged 18 years and above\n* Pathologically diagnosed with malignant tumors\n* Scheduled to undergo radiotherapy and\u002For chemotherapy\n* Clear consciousness, no communication barriers\n* Willing to undergo follow-up, not in a near-death condition\n\nExclusion Criteria:\n\n* Patients without a pathological diagnosis of malignant tumors\n* Patients with AIDS\n* Patients with mental or cognitive disorders\n* Patients who have undergone organ transplantation\n* Patients with a life expectancy less than 12 months\n* Pregnant women\n* Patients currently participating in other clinical intervention studies","ALL","18 Years",{"count":20,"type":21},1538,"ESTIMATED","5 Years","OBSERVATIONAL","This multicenter, prospective cohort study investigates the long-term impact of nutritional status on clinical outcomes in cancer patients undergoing treatment in Shaanxi Province, China. It evaluates how malnutrition, dietary patterns, and nutritional interventions affect treatment tolerance, quality of life, and survival. The study tracks dynamic changes in nutritional health and related indicators throughout various stages of chemoradiotherapy, aiming to inform evidence-based strategies for precision nutrition in oncology care.",[26,27,28,29,30],"Cancer","Chemoradiotherapy","Nutrition, Healthy","Oncology","Clinical Outcomes",[27,32,33,34,35],"Nutritional Status in Cancer Patients","Clinical Outcomes of Cancer Treatment","Cancer Patient Nutrition","Shaanxi Province Cancer Study","RECRUITING","2026-05-10",{"date":39,"type":40},"2026-05-12","ACTUAL",{"date":42,"type":40},"2020-11-12",{"date":44,"type":21},"2031-12-01",{"name":46,"class":47},"Xiaoqin Luo","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":59,"studyType":23,"phases":4,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":48},"100633639","functional-and-respiratory-predictors-of-early-postoperative-outcomes-100633639","NCT07529301","Functional and Respiratory Predictors of Early Postoperative Outcomes","The Effect of Functional Status and Respiratory Parameters on Early Postoperative Clinical Outcomes in Patients With Colorectal Cancer","Inclusion Criteria\n\nBeing between 18 and 80 years of age\n\nVoluntary agreement to participate in the study\n\nExclusion Criteria\n\nWithdrawal from the study at the participant's own request\n\nElimination Criteria\n\nPresence of a musculoskeletal condition that may prevent completion of the planned assessments\n\nPresence of a mental impairment\n\nHistory of psychiatric disorder\n\nHistory of previous major surgery","80 Years",{"count":58,"type":21},42,"12 Months","Functional status is a fundamental indicator reflecting a patient's ability to perform activities of daily living and is closely associated with early postoperative outcomes. Patients with low functional capacity are known to have an increased risk of postoperative complications, prolonged length of hospital stay, and higher mortality rates. Similarly, respiratory function plays a decisive role in the development of postoperative complications and influences early surgical outcomes. In the preoperative period, inadequate respiratory capacity and poor functional performance increase the risk of postoperative pulmonary complications and delayed recovery. Therefore, functional and respiratory assessments are regarded as integral components of the preoperative preparation process.\n\nEarly outcomes in patients undergoing colorectal cancer surgery are of critical importance in reducing mortality and morbidity. In this surgical population, advanced age, comorbidities, and diminished physical capacity may further increase the risk of postoperative complications. Accordingly, the evaluation of preoperative functional status and physiological reserve has gained increasing importance for risk stratification and perioperative management. However, studies examining the impact of functional status and respiratory parameters on early surgical outcomes in patients with colorectal cancer remain limited. Consequently, the available evidence is insufficient to establish a standardized assessment approach in clinical practice.\n\nMoreover, objective evaluation of patients' functional and respiratory capacities in the preoperative period is essential for predicting surgical risk and planning individualized perioperative care. Determining the relationships between these parameters and early clinical outcomes may facilitate the identification of high-risk patients and contribute to the development of targeted strategies aimed at preventing postoperative complications. Findings obtained in this context are expected to provide a scientific basis for clinical decision-making and multidisciplinary patient management in individuals undergoing colorectal cancer surgery, thereby guiding clinical practice.",[62,63,64,30],"Colorectal Cancer","Functional Status","Respiratory Parameters",[62,63,64,30],"2026-04-09",{"date":68,"type":40},"2026-04-14",{"date":70,"type":40},"2026-03-01",{"date":72,"type":21},"2027-02-25",{"name":74,"class":47},"Müşerref Ebru YALÇIN",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":17,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":48},"100630495","clinical-and-radiographic-outcomes-of-lesion-sterilization-and-tissue-repair-using-zinc-oxide-6-gingerol-mix-versus-triple-antibiotic-paste-in-non-vital-primary-molars-100630495","NCT07488416","Clinical and Radiographic Outcomes of Lesion Sterilization and Tissue Repair Using Zinc Oxide\u002F 6-gingerol Mix Versus Triple Antibiotic Paste in Non-vital Primary Molars","Comparative Evaluation of Clinical and Radiographic Outcomes of Lesion Sterilization and Tissue Repair Using Zinc Oxide\u002F 6-gingerol Mix Versus Triple Antibiotic Paste in Non-vital Primary Molars: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Age from 4 to 8 years.\n* Both sexes\n* Children must have at least two restorable non-vital primary molars\n* Periapical radiolucency.\n* Pain on mastication.\n* Pathological mobility.\n* Internal or external root resorption.\n* Furcation involvement should not extend to the developing tooth germ.\n\nExclusion Criteria:\n\n* Presence of systemic diseases.\n* Teeth with physiological mobility near exfoliation time.\n* Teeth with vital pulp.","4 Years","8 Years",{"count":85,"type":21},60,"INTERVENTIONAL",[88],"NA","This study aims to evaluate and compare the clinical and radiographic outcomes of Lesion sterilization and tissue repair using zinc oxide\u002F 6-gingerol mix versus triple antibiotic paste in non-vital primary molars.",[30,91,92,93,94,95,96,97,98],"Radiographic Outcomes","Lesion Sterilization","Tissue Repair","Zinc Oxide","6-gingerol","Triple Antibiotic Paste","Non-vital","Primary Molars","2026-03-18",{"date":101,"type":40},"2026-03-23",{"date":103,"type":40},"2024-10-01",{"date":105,"type":21},"2026-05-01",{"name":107,"class":47},"Al-Azhar University",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":115,"sex":116,"minAge":18,"maxAge":117,"enrollmentInfo":118,"targetDuration":4,"studyType":86,"phases":120,"briefSummary":121,"conditions":122,"keywords":128,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":48},"100617802","single--vs-double-layer-cesarean-scar-repair-and-myometrial-thickness-100617802","NCT07323355","Single- vs Double-Layer Cesarean Scar Repair and Myometrial Thickness","Effects of Single-Layer Versus Double-Layer Cesarean Scar Repair on Myometrial Thickness and Associated Clinical Outcomes","Inclusion Criteria:\n\n* Female participants aged 18-44 years.\n* Undergoing cesarean delivery at the study hospital's Obstetrics and Gynecology clinic.\n* Evaluated as clinically eligible based on history, physical examination, abdominal ultrasonography, and routine preoperative laboratory tests, including:\n\nComplete blood count (CBC), biochemical profile, prothrombin time (PT), activated partial thromboplastin time (aPTT), blood group determination. No abnormalities detected in the above assessments.\n\nExclusion Criteria:\n\n\\- Presence of chronic diseases, including: Rheumatologic diseases, renal failure, vascular malformations, hypertension, cardiac disease, diabetes mellitus, obesity, thyroid disease, congenital hematologic disorders.\n\n* Suspected or confirmed placenta previa or placenta accreta spectrum.\n* Clinical chorioamnionitis.\n* Anterior wall uterine myomas.\n* History of low transverse nonstandard uterine incision.\n* Predicted obstetric hemorrhage or other intraoperative complications.",true,"FEMALE","44 Years",{"count":119,"type":21},102,[88],"Cesarean delivery (CD) is one of the most commonly performed surgical procedures worldwide, with a rising incidence particularly in high-income countries. Although often life-saving, cesarean delivery carries both short- and long-term maternal risks. Early complications include infection, hemorrhage, and thromboembolism, while inadequate uterine healing can lead to future complications such as uterine rupture and placenta accreta spectrum disorders. Additionally, cesarean scars may result in pregnancy complications, isthmocele formation, postmenstrual bleeding, pelvic pain, and dysmenorrhea. This highlights the need for optimization of the surgical technique. Despite increasing cesarean rates, there is no consensus on the optimal uterine closure method. Techniques vary in terms of the number of layers, suture locking style, and inclusion of the endometrium, and their comparative effectiveness in reducing scar defects remains unclear. Some previous studies have reported increased uterine rupture risk with single-layer locked sutures and better healing with double-layer closure, while others found no significant difference in scar outcomes. This study aims to investigate the effects of single- versus double-layer cesarean scar closure on myometrial thickness and its clinical implications.",[123,124,125,126,127,30],"Caesarean Section","Cesarean Scar Closure","Cesarean Scar Defect (Isthmococele)","Myometrial Thickness","Postpartum Complications",[123,124,129,126],"Isthmococele","2025-12-29",{"date":132,"type":40},"2026-01-07",{"date":134,"type":40},"2025-11-11",{"date":136,"type":21},"2026-11-15",{"name":138,"class":47},"Ankara City Hospital Bilkent",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":145,"eligibilityCriteria":146,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":147,"enrollmentInfo":148,"targetDuration":4,"studyType":86,"phases":150,"briefSummary":152,"conditions":153,"keywords":160,"overallStatus":166,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":48},"100602019","phase-2-effects-of-adjunct-omega-3-long-chain-polyunsaturated-fatty-acids-in-pulmonary-tuberculosis-patient-an-early-bactericidal-activity-and-inflammatory-trial-100602019","NCT07118059","Effects of Adjunct Omega-3 Long Chain Polyunsaturated Fatty Acids in Pulmonary Tuberculosis Patient: an Early Bactericidal Activity and Inflammatory Trial","Effects of Adjunct Omega-3 Long-chain Polyunsaturated Fatty Acids in Pulmonary Tuberculosis Patients: An Early Bactericidal Activity and Inflammatory Activity Trial","TREAT 3","Inclusion Criteria:\n\n* adults aged 18-45 years\n* laboratory confirmed Pulmonary TB defined as a hard copy of a sputum result detected by WHO recommended assay or mycobacteria culture.\n* Women of childbearing potential with a negative pregnancy test on enrollment\n* All participant irrespective of HIV status who consent to have a HIV test during enrollment.\n\nExclusion Criteria:\n\n* Comorbid condition with treatment of NSAIDS is indicated\n* Institutionalized or incarcerated individuals\n* Those on Multiple drug resistance treatment for more than 4 days within the past 6 months or within 1 month to prior to TB treatment initiation\n* Pregnant or breastfeeding women or women who become pregnant in the first 4 weeks of the trial will be withdrawn\n* show lab safety values: AST or ALT \\> x3 upper limit of normal (ULN) or Total bilirubin \\> 2x the ULN, Neutrophils ≤ 700\u002Fmm³, Platelets \\\u003C 50,000\u002Fmm³, Haemoglobin \\\u003C 8 g\u002FdL, Serum creatinine \\> 2× ULN.\n* Are receiving or planning treatment with any of the following in the 3 months before or during the trial:\n\nAnticoagulants Immune-modulating therapy (e.g., cancer treatment, oral\u002Finhaled corticosteroids) Antacids or proton pump inhibitors (PPIs)\n\n* Have a known allergy or sensitivity to fish or fish oil.\n* Have a recent history (within 2 years) or current clinical evidence of:\n\nPeptic ulcer disease or GI bleeding Coagulopathy or bleeding disorders Kidney or liver disease requiring hospitalisation Cardiovascular disease or significant risk factors for it\n\n-Are HIV-positive and meet any of the following: CD4 count \\\u003C 100 cells\u002Fmm³ Viral load \\> 400 copies\u002FmL (if on ART) Not yet on ART but are expected to initiate treatment during the 8-week intervention phase\n\n* Report high-risk alcohol use (average \\>4 units\u002Fday or binge drinking patterns)\n* Have any other medical condition or situation that, in the investigator's opinion, may interfere with protocol adherence or data interpretation.\n* Plan to relocate from the study area within the next 3 months.\n* Are currently using omega-3 or omega-6 supplements and are unwilling to stop for the duration of the study.","45 Years",{"count":149,"type":21},40,[151],"PHASE2","The goal of this randomized controlled trial is to evaluate the early bactericidal activity, early inflammatory response, and safety of omega-3 long chain polyunsaturated fatty acid (n-3 PUFA) supplementation in adult patients (aged 18- 45 years) with newly diagnosed, bacteriologically confirmed drug-sensitive pulmonary tuberculosis.\n\nThe main questions it aims to answers are:\n\n* Does adjunct n-3 LCPUFA supplementation reduce the sputum culture time to positivity\n* Does it improve inflammatory markers and TB treatment outcomes compared to placebo Researchers will compare daily supplementation with \\~2g n-3 LCPUFA (EPA and DHA ) to placebo (high linoleic sunflower oil) to determine effects on bactericidal activity, inflammation, and clinical outcomes.\n\nParticipants will:\n\n* Be randomly assigned to receive either n-3 LCPUFA or Placebo daily for 8 weeks with the intensive phase of TB treatment\n* Attend clinical visit baseline, and follow up visit mostly weekly for 2 months and then monthly for 4 months of the continuous phase of TB treatment\n* Provide blood, sputum and urine samples for biomarkers and metabolomic analysis\n* Undergo assessments of iron status, body composition and muscle strength",[154,155,156,157,158,159,30],"Tuberculosis","Inflammation Biomarkers","Liver Function Tests","Iron Status","Metabolomics","Nutritional Status",[161,162,163,164,165],"Pulmonary tuberculosis","Patients","adjunct omega-3 long chain polyunsaturated fatty acid","early bactericidal","safety trial","NOT_YET_RECRUITING","2025-08-04",{"date":169,"type":40},"2025-08-12",{"date":171,"type":21},"2025-08",{"date":173,"type":21},"2026-12",{"name":175,"class":47},"North-West University, South Africa",{"id":177,"slug":178,"hasResults":11,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":4,"eligibilityCriteria":182,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":183,"targetDuration":4,"studyType":86,"phases":184,"briefSummary":185,"conditions":186,"keywords":189,"overallStatus":166,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":4},"100595612","predictors-of-outcome-after-coronary-artery-bypass-graft-surgery-using-cardiopulmonary-bypass-100595612","NCT07034716","Predictors Of Outcome After Coronary Artery Bypass Graft Surgery Using Cardiopulmonary Bypass","Effects Of Pulsatile and Non-Pulsatile Cardiopulmonary Bypass Flow On Predictors Of Outcome After Coronary Artery Bypass Graft Surgery","Inclusion Criteria:\n\ncardiac surgical patients who will undergo isolated elective CABG and fulfill these criteria:\n\n1. Aged 18 years or above.\n2. Operated with cardiopulmonary bypass.\n\nExclusion Criteria:\n\n1. Preoperative lactate level greater than 3 mmol\u002Fl.\n2. Redo surgery.\n3. If the patient will be reoperated during the study time.\n4. Preoperative hemoglobin level less than 10 mg\u002Fdl.\n5. Ejection fraction (EF) of \\\u003C30%.\n6. Renal impairment.\n7. Liver impairment.\n8. History of stroke and significant carotid artery stenosis.\n9. Chronic obstructive or restrictive lung disease.",{"count":85,"type":21},[88],"In cardiac operations, high values of blood lactate have been associated with bad outcomes if detected both during CPB and at the arrival in the intensive care unit (ICU) in adult patients. Many studies highlighted the potential role of hyperlactatemia on admission to the ICU as a marker for adverse outcome, and one study linked hyperlactatemia during CPB with postoperative morbidity and mortality. Evidence that both CENTRAL VENOUS SATURATION (ScVO2) and blood lactates during CPB are potential early predictors of morbidity and mortality in adult cardiac operations are still lacking.",[30,187,188],"Cardiac Surgery","Cardio-pulmonary Bypass",[190,191,192],"Lactate","Perfusion","Central venous saturation","2025-06-14",{"date":195,"type":40},"2025-06-24",{"date":197,"type":21},"2025-07-01",{"date":199,"type":21},"2025-12-01",{"name":201,"class":47},"Alexandria University",{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":4,"eligibilityCriteria":208,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":209,"targetDuration":4,"studyType":86,"phases":211,"briefSummary":212,"conditions":213,"keywords":4,"overallStatus":166,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":222,"leadSponsor":224,"locationsCount":48},"100184314","minimally-invasive-three-dimensional-knee-kinematic-assessment-and-surgical-guidance-using-ultrasonic-rigid-registration-100184314","NCT01674816","Minimally Invasive Three-dimensional Knee Kinematic Assessment and Surgical Guidance Using Ultrasonic Rigid Registration","(Étude de la cinématique Tridimensionnelle du Genou et Guidage Chirurgical Minimalement Effractifs Par Recalage Rigide échographique)","Inclusion Criteria:\n\n* Patients awaiting a knee surgery (total knee arthroplasty (TKA), high tibial osteotomy (HTO), anterior cruciate ligament reconstruction(ACLR))\n\nExclusion Criteria:\n\n* Active infection\n* Atypical morphology and\u002For alignment of the lower limbs\n* Knee instability (other than secondary to ACL deficiency in patients awaiting ACLR)\n* Knee flexion contracture of 10 degrees or more\n* Knee flexion of less than 120 degrees",{"count":210,"type":21},30,[88],"Problem:\n\nCurrently, no system allows precise kinematic assessment of the knee and accurate guiding of orthopedic surgical actions in a minimally invasive fashion. However, such a system would prove useful in the clinical setting to improve the quality of surgical interventions at the knee.\n\nHypothesis:\n\nA novel knee kinematic assessment and surgical guidance tool using 3D personalized imaging and minimally invasive bony fixation allows precise kinematic assessment and surgical guidance in the routine clinical setting.\n\nObjectives :\n\n* Demonstrating the capacity of the system to precisely measure 3D knee kinematics\n* Quantifying the reproducibility of the kinematic measurements\n* Measuring the impact of knee surgical procedures on knee kinematics\n* Assessing the correlations between measured articular kinematics and clinical results after knee surgery\n* Integrating the novel measuring system to the surgical flow of three knee surgical procedures\n* Quantifying the precision and reproducibility of the surgical actions guided by the system\n* Comparing the clinical results of surgeries guided by the system to those performed with the traditional technique",[214,215,216,217,30],"Knee Osteoarthritis","Knee Instability","3D Knee Kinematics","Precision of Surgical Actions","2024-02-09",{"date":220,"type":40},"2024-02-12",{"date":199,"type":21},{"date":223,"type":21},"2026-12-01",{"name":225,"class":47},"Centre hospitalier de l'Université de Montréal (CHUM)"]