[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"clonidine\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:clonidine":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,91],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100636577","phase-4-adding-dexmedetomidine-or-clonidine-to-spinal-anesthesia-for-cesarean-delivery-100636577",false,"NCT07567495","Adding Dexmedetomidine or Clonidine to Spinal Anesthesia for Cesarean Delivery","Inclusion Criteria:\n\n* Pregnant women undergoing cesarean delivery with spinal anesthesia\n\nExclusion Criteria:\n\n* Significant cardiovascular, psychiatric or respiratory disease\n* using opioids or with chronic pain syndrome\n* Multiple gestation\n* BMI \\>40 kg\u002Fm2\n* Quaternary or greater cesarean\n* \\\u003C 37 weeks gestation\n* Non-English or Spanish speaking\n* planned vertical skin incision\n* planned vertical (classical) uterine incision\n* allergy to clonidine, dexmedetomidine or other study drug","FEMALE","18 Years",{"count":18,"type":19},150,"ESTIMATED","INTERVENTIONAL",[22],"PHASE4","This study will examine whether addition of dexmedetomidine or clonidine (two alpha-2 adrenergic agonists) will improve the comfort of patients during spinal anesthesia for cesarean delivery. When added to standard spinal anesthesia consisting of bupivacaine (a local anesthetic) and fentanyl and morphine (two opioids), these medications may decrease some of the pulling\u002Ftugging\u002Fpressure sensations that patients sometimes feel during cesarean delivery, may prolong the anesthetic time, and may decrease postoperative pain.",[25,26,27,28,29,30],"Cesarean Delivery","Cesarean Delivery; Neuraxial Opioids","Spinal Anesthesia for Cesarean Section","Dexmedetomidine","Clonidine","Postoperative Analgesia",[32,33,34,35,36,37],"cesarean","dexmedetomidine","clonidine","spinal","anesthesia","Adrenergic alpha-2 Receptor Agonists","NOT_YET_RECRUITING","2026-04-30",{"date":41,"type":42},"2026-05-05","ACTUAL",{"date":44,"type":19},"2026-06",{"date":46,"type":19},"2028-05",{"name":48,"class":49},"Columbia University","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":58,"minAge":16,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":20,"phases":62,"briefSummary":65,"conditions":66,"keywords":71,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":89,"locationsCount":50},"100597746","phase-2-clonidine-in-ultrasound-guided-rectus-sheath-block-for-outpatient-umbilical-hernioplasty-100597746","NCT07062497","Clonidine in Ultrasound-guided Rectus Sheath Block for Outpatient Umbilical Hernioplasty","Ultrasound-guided Rectus Abdominis Muscle Sheath Block in Outpatient Umbilical Hernioplasties: a Comparative Analysis of the Use of Clonidine as an Adjuvant - Prospective Randomized Clinical Trial","Inclusion Criteria:\n\n* Adults aged 18 to 65 years;\n* Both male and female participants;\n* ASA physical status I or II (American Society of Anesthesiologists classification);\n* Scheduled for elective ambulatory umbilical hernia repair;\n* Hernial defect size ≤ 4 cm (small to medium).\n\nExclusion Criteria:\n\n* Refusal or inability to provide written informed consent;\n* Cognitive or psychiatric disorders that impair comprehension or adherence to the study protocol;\n* Known allergy or hypersensitivity to local anesthetics, clonidine, opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), or other analgesics;\n* Participation in another clinical trial within the previous 30 days;\n* Missing data or loss to follow-up during postoperative assessments;\n* Contraindications to regional anesthesia or known coagulopathy.","ALL","65 Years",{"count":61,"type":19},62,[63,64],"PHASE2","PHASE3","This clinical trial aims to evaluate the effectiveness of an ultrasound-guided nerve block technique as the sole anesthetic method for patients undergoing outpatient umbilical hernia surgery. The procedure, called rectus sheath block (RSB), involves injecting local anesthetic near the abdominal muscles to reduce pain during and after surgery. The study will compare two groups of adult patients: one receiving the nerve block with a medication called clonidine added to the anesthetic solution, and the other receiving the same block without clonidine. Clonidine may help improve pain control and reduce the need for additional pain medications. By analyzing pain scores, recovery quality, and potential side effects, the study seeks to determine whether the use of clonidine in this context is safe, cost-effective, and beneficial for patient recovery. Participants will answer questionnaires about their pain and recovery during the first 48 hours after surgery.",[67,29,68,69,70],"Hernia, Umbilical","Pain, Postoperative","Ambulatory Surgical Procedures","Regional Anesthesia Block",[72,73,74,29,75,76,77,78,79,80,81],"Rectus Sheath Block","Ultrasound-Guided Regional Anesthesia","Umbilical Hernia Repair","Local Anesthetics","Postoperative Pain Management","Ambulatory Surgery","Quality of Recovery","Alpha-2 Adrenergic Agonists","Pain Measurement","Analgesic Adjuvants","RECRUITING","2025-07-10",{"date":85,"type":42},"2025-07-14",{"date":87,"type":42},"2025-01-07",{"date":39,"type":19},{"name":90,"class":49},"Universidade Federal do Rio de Janeiro",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":58,"minAge":16,"maxAge":59,"enrollmentInfo":97,"targetDuration":4,"studyType":20,"phases":98,"briefSummary":100,"conditions":101,"keywords":4,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":109,"leadSponsor":111,"locationsCount":50},"100555078","additive-effects-of-clonidine-used-in-propofol-sedation-in-colonoscopy-100555078","NCT06507410","Additive Effects of Clonidine Used in Propofol Sedation in Colonoscopy","Inclusion Criteria:\n\n* Age 18-65 years.\n* Both sexes.\n* American Society of Anesthesiology (ASA) physical status I-II.\n* Patients undergoing colonoscopy.\n\nExclusion Criteria:\n\n* Patients had recent history of colonoscopy.\n* Previous colonic resection.\n* Severe heart failure (ejection fraction \\\u003C 30%).\n* Known history of hypersensitivity to propofol or clonidine and any need for anesthetic drug administration other than the study protocol.",{"count":61,"type":19},[99],"NA","The objective of this study was to compare safety, satisfaction, and efficiency outcomes of propofol versus propofol with clonidine in patients undergoing colonoscopy.",[29,102,103,104],"Propofol","Sedation","Colonoscopy","2024-07-20",{"date":107,"type":42},"2024-07-23",{"date":105,"type":42},{"date":110,"type":19},"2024-09-01",{"name":112,"class":49},"Tanta University"]