[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"coginitive-dysfunction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:coginitive-dysfunction":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100643864","the-effects-usability-satisfaction-barriers-and-benefits-of-a-remote-multidomain-website-based-intervention-to-prevent-cognitive-decline-in-older-adults-100643864",false,"NCT07668440","The Effects, Usability, Satisfaction, Barriers, and Benefits of a Remote, Multidomain Website-based Intervention to Prevent Cognitive Decline in Older Adults","Preliminary Assessment of the Effects, Usability, Satisfaction, Barriers, and Benefits of a Remote, Multidomain Intervention Supported by a Website to Prevent Cognitive Decline in Older Adults","MeMoHealthCogR","Inclusion Criteria:\n\n* With and without cognitive complaints (i.e., they have responded 'yes' to the question: 'Do you feel that your memory or learning abilities have worsened recently?\").\n* They demonstrate independence in activities of daily living and instrumental activities of daily living. • With one or more vascular risk factors (for example, type 2 diabetes or hypertension).\n* With a score on the overall cognitive function test of≥ 24 on the Mini-Mental State Examination.\n* With a score between 0-4 on the Blessed Dementia Scale.\n* With a mobile phone or computer.\n* Have a companion, such as a child, spouse, or friend, who can support you during the assessment in case of an emergency.\n* Voluntary acceptance to participate in the study through a signed informed consent form prior to your participation.\n\nExclusion Criteria:\n\n* Depression (score \\> 15 according to the Epidemiological Studies Center Depression Scale - Revised \\[CESD-R\\]).\n* With a clinical diagnosis of any significant neurological or psychiatric disorder (for example, Parkinson's disease, schizophrenia).\n* With any heart disease.\n* Presence of a recent cancer diagnosis.\n* History of recent severe cardiovascular event (for example, myocardial infarction, stroke).\n* Significant orthopedic conditions (for example, severe osteoarthritis).\n* Uncontrolled blood pressure (very high \\> 180\u002F100 mmHg or very low \\\u003C 100\u002F60 mmHg).\n* Severe visual or hearing impairment.\n* Type 2 Diabetes Mellitus requires insulin to control hyperglycemia.","ALL","60 Years","75 Years",{"count":21,"type":22},71,"ESTIMATED","INTERVENTIONAL",[25],"NA","Mexico exhibits a high prevalence of dementia, exceeding 8%, and it is estimated that by 2050 around 3.5 million older adults will be living with this condition. In light of this scenario, it becomes a priority to intervene on the factors associated with the development of dementia through preventive strategies, particularly via multicomponent programs that integrate physical activity, cognitive training, and other components aimed at modifying lifestyles, applied early, before the appearance of clinical symptoms.\n\nIn order to expand access to this type of intervention for older adults with limited time or resources for face-to-face care, the implementation of preventive programs remotely through the use of digital media has been proposed. Web platforms constitute an accessible and cost-effective alternative for delivering complex interventions, such as the 'Mind and Movement for Cognitive Health (MeMo-Salud-Cog)' program, designed to promote lifestyles conducive to cognitive health and which has shown promising preliminary results in overall cognitive function, memory, executive function, and attention.\n\nHowever, the use of digital systems by older adults may be limited by barriers associated with ageing (cognitive, sensory, physical, and motivational), as well as social aspects (education and social isolation) or cultural factors (beliefs and perceived usefulness), which can affect the continuity of their participation. In this context, the present proposal suggests adapting the MeMo-Salud-Cog program to a remote modality, through a website and remote monitoring by healthcare professionals, with the aim of evaluating its feasibility based on usability, satisfaction, effect, and adherence, as well as analyzing perceived acceptability, emphasizng the barriers and benefits of remote intervention.\n\nThe investigators will employ a mixed design combining quantitative and qualitative methods, with a pre-post evaluation without a control group in the quantitative part and semi-structured interviews in the qualitative part (pilot study). The study population will consist of independent individuals aged 60 to 75 years affiliated with IMSS at the Family Medicine Unit 1 and 28, with or without cognitive complaints, but without impairment (MMSE ≥ 24), functional independence, at least one vascular risk factor, with a mobile phone or computer, and an informed consent letter.",[28],"Coginitive Dysfunction",[30,31,32,33,34,35],"Exercise","Cognitive Training","cognition","cognitive impairment","older adults","prevention","NOT_YET_RECRUITING","2026-06-19",{"date":39,"type":40},"2026-06-25","ACTUAL",{"date":42,"type":22},"2026-07-06",{"date":44,"type":22},"2027-10-29",{"name":46,"class":47},"Instituto Mexicano del Seguro Social","OTHER_GOV",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":48},"100573673","examining-the-effects-of-different-resistive-exercise-programs-in-individuals-with-compensated-liver-cirrhosis-100573673","NCT06749340","Examining the Effects of Different Resistive Exercise Programs in Individuals With Compensated Liver Cirrhosis","Examination of the Effects of Face-to-Face and Home-Based Resistive Exercise Program on Muscle Strength, Muscle Mass and Cognitive Functions in Individuals With Compensated Liver Cirrhosis: Randomized Controlled Single -Blind Study","Inclusion Criteria:\n\n* Being between the ages of 40 and 65;\n* Being diagnosed with liver cirrhosis;\n* Not having had a liver transplant;\n* Being cooperative;\n* Volunteering to participate in the study;\n* Having a smart device (phone\u002Ftablet\u002Fcomputer);\n* Having internet access;\n* Modified Child-Turcotte-Pugh Score to be A and B.\n\nExclusion Criteria:\n\n* Having a disease that may affect cognitive functions;\n* Having an orthopedic, neurological, psychological, cardiac, renal or pulmonary disease;\n* Having a physical or mental disability;\n* Having a communication problem;\n* Being unable to read or write;\n* Modified Child-Turcotte-Pugh Score to be C.","40 Years","65 Years",{"count":59,"type":22},20,[25],"Reasons such as sleep disorders, depression, decreased independence in daily living activities and decreased quality of life, which are seen in the majority of liver cirrhosis patients, can cause cognitive dysfunction, especially attention. It is known that physical dysfunctions are observed in patients with liver cirrhosis along with cognitive dysfunction. Sarcopenia is the most important of these dysfunctions. Sarcopenia is the progressive, widespread loss of muscle mass, function and strength. The aim of this study is to determine the effects of face-to-face and home-based progressive strengthening exercise program performed 3 times a week for 12 weeks on muscle strength, muscle mass, functionality and cognitive functions in individuals with liver cirrhosis. It is also aimed to test the feasibility and effectiveness of the home-based exercise method in individuals with liver cirrhosis. Another aim of our study is to determine the exercise dose required to improve muscle strength, muscle mass, functionality and cognitive functions in individuals with liver cirrhosis and the duration of treatment effectiveness through follow-up.",[28,63,64,65],"Compensated Liver Cirrhosis","Physical Dysfunction","Sarcopenia",[67,68,69,70,71],"cirrhosis","cognitive dysfunction","sarcopenia","strengthening","telerehabilitation","2026-02-18",{"date":74,"type":40},"2026-02-20",{"date":76,"type":22},"2026-02-19",{"date":78,"type":22},"2026-12-23",{"name":80,"class":81},"Bahçeşehir University","OTHER"]