[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cognitive-ability-general\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cognitive-ability-general":64},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,46,79,109,141,182,206,236,283],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100604708","older-adults-methadone-and-cognitive-function-100604708",false,"NCT07153029","Older Adults, Methadone, and Cognitive Function","Cognitive Functioning Among Older Adults in Methadone Treatment for Opioid Use Disorder","Inclusion Criteria:\n\n* age 55 and older\n* currently in outpatient methadone treatment for opioid use disorder\n* participant is alert\u002Fable to communicate\u002Fable to give acceptable answers on the \"Evaluation to Sign Consent form\n* participant has normal or correct to normal vision\n\nExclusion Criteria:\n\n* age 54 or younger\n* not in methadone treatment for opioid use disorder","ALL","55 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"NA","The increasing prevalence of opioid use disorder (OUD) among older adults, coupled with high overdose rates and cognitive impairments associated with opioid use, highlights a critical gap in addiction treatment. Cognitive impairments can persist despite treatment and negatively impact recovery outcomes, yet cognitive screening and interventions are rarely integrated into OUD care. This study aims to evaluate the feasibility of remotely delivered, smartphone-based cognitive assessments (administered through NeuroUX web-based software) for older adults (55+) in methadone treatment. The tasks have been \"gamified\" to make them engaging and brief, which could be appealing to patients. They will complete the tasks for 15 days using the phone provided or their own phone. During days 6-15 of testing, tasks will become incrementally more difficult based on participant performance to assess the feasibility of cognitive training. Cognitive training uses engaging games or tasks to strengthen thinking skills like memory and focus, much like physical exercise strengthens the body. Adherence, acceptability, and usability of the tasks will be assessed. Secondary analyses will explore relationships between task performance and participant characteristics (e.g., baseline cognitive functioning, methadone dose, timing of methadone dose). Findings from this pilot study will provide foundational data for a future grant application to develop and test digital cognitive assessment and training interventions tailored to older adults in addiction treatment. By addressing a critical yet understudied aspect of OUD care this research has the potential to enhance treatment engagement, improve clinical outcomes, and support long-term recovery in the growing older population.",[26,27],"Opioid Use Disorder","Cognitive Ability General",[29,30,31,32],"older adults","cognition","feasibility","ecological momentary assessment","RECRUITING","2026-06-01",{"date":36,"type":37},"2026-06-03","ACTUAL",{"date":39,"type":37},"2024-12-03",{"date":41,"type":20},"2026-07-01",{"name":43,"class":44},"University of Maryland, Baltimore","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":16,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":59,"conditions":60,"keywords":65,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":45},"100569180","investigating-the-effects-of-beef-consumption-on-cognitive-and-brain-health-100569180","NCT06690892","Investigating the Effects of Beef Consumption on Cognitive and Brain Health","Understanding the Cognitive and Brain Health Effects of Increasing Beef Consumption in Young Adults","Inclusion Criteria:\n\n* Provision of signed and dated informed consent form\n* Stated willingness to comply with all study procedures and lifestyle considerations and availability for the duration of the study\n* Males and females; Age 19-24\n* Willingness to adhere to the ready-to-eat beef intervention regimen\n* Lives within 75 miles of Lincoln, NE\n* BMI between 18.5 and 39.9\n* Not pregnant or nursing\n* No history of cognitive or metabolic diseases indicated by diagnosis, including neurodegenerative disease, stroke, Type 1 and 2 diabetes, metabolic syndrome, cardiovascular disease, liver disease, kidney disease, and cancer\n* No history of eating or anxiety disorders\n* Willing to discontinue dietary supplement use throughout the duration of the study, if they are consuming supplement at the time of the registration\n* No known contraindication to MRI scans as determined by the MRI screening survey questions\n\nExclusion Criteria:\n\n* Current use of medications that may affect their responses to dietary intervention, such as amphetamines, antidepressants, anti-diabetic medications, laxatives, antibiotics, statins and diuretics.\n* Known intolerance or allergy to beef\n* Current use of nicotine products, including vaping\n* Previous use of nicotine products, including vaping, within the recent 6 months at the time of pre-screening",true,"19 Years","24 Years",{"count":57,"type":20},240,[23],"The goal of this clinical trial is to learn if eating more beef will lead to better cognition and a healthier brain in younger adults. The main questions it aims to answer are:\n\n* Does eating more beef lead to higher scores on cognitive tests and better quality of life?\n* Does eating more beef lead to better brain function?\n\nResearchers will compare participants in the experimental group (participants who will eat 25 ounces of beef every week during the dietary intervention) to control participants (participants who will eat 5 ounces of beef every week during the dietary intervention).\n\nParticipants will:\n\n* Be instructed to prepare and consume ready-to-eat beef meals along with their regular diet and not eat any more beef other than what they are given\n* Visit the study facilities once every week to pick up ready-to-eat beef meals; and complete a brief survey every week to track their consumption of the provided beef meals, and a dietary survey every 4 weeks\n* Visit the study facilities before and after the 12-week of intervention period for researchers to study them",[61,62,63,64],"Dietary Intervention","Dietary Proteins","Dietary Assessment","Cognitive Ability, General",[66,67,68,69],"beef consumption","beef dietary intervention","brain health","cognitive health","2026-05-28",{"date":72,"type":37},"2026-05-29",{"date":74,"type":37},"2025-09-22",{"date":76,"type":20},"2026-09",{"name":78,"class":44},"University of Nebraska Lincoln",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":53,"sex":85,"minAge":86,"maxAge":4,"enrollmentInfo":87,"targetDuration":89,"studyType":90,"phases":4,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":45},"100639606","automated-iadl-sensing-to-refine-measurement-of-older-adult-daily-activity-100639606","NCT07585864","Automated IADL Sensing to Refine Measurement of Older Adult Daily Activity","Inclusion Criteria:\n\n1. Participant in University of Pittsburgh Pepper Center research registry\n2. Age 75+\n3. Female\n4. Residing in community\n5. Meets criteria for normal cognition or mild cognitive impairment on telephone screening (Memory Impairment Screen \\>= 5)\n6. Daily, independent performance of cooking and light cleaning tasks\n\nExclusion Criteria:\n\n1. Inability to provide informed consent\n2. Meets criteria for possible dementia (Memory Impairment Screen \\\u003C= 4)\n3. Reports difficulty with activities of daily living (dressing, feeding oneself, using toilet, bathing)\n4. Uses mobility assistance device for indoor ambulation\n5. Medical conditions that may interfere with participation (e.g., severe untreated psychiatric disorders, unstable cardiovascular conditions, Parkinson's disease)\n6. Current participation in other interventional studies or clinical trials.","FEMALE","75 Years",{"count":88,"type":20},20,"1 Day","OBSERVATIONAL","The instrumental activities of daily living (IADL) refer to complex daily activities required for adult independence, such as preparing a meal or taking medications. This study will assess the efficacy of sensing technologies (smartwatch, computer vision, eye tracking) for recognizing IADL activities in naturalistic settings and score performance relative to ratings from occupational therapists. If successful in assessing the efficiency of IADL, the sensing technologies will be a valuable addition to geriatric assessment.",[27,93],"Functional Abilities",[95,96,97,98],"Occupational therapy","machine learning","accelerometry","computer vision","NOT_YET_RECRUITING","2026-05-13",{"date":102,"type":37},"2026-05-15",{"date":104,"type":20},"2026-06",{"date":106,"type":20},"2027-06",{"name":108,"class":44},"University of Pittsburgh",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":16,"minAge":116,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":21,"phases":119,"briefSummary":120,"conditions":121,"keywords":128,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":45},"100562918","the-effect-of-nature-and-game-based-activities-on-older-people-100562918","NCT06609408","The Effect of Nature and Game Based Activities on Older People","The Effect of Nature and Game Based Activities on Happiness, Spiritual Well-Being, Frailty and Cognitive Status of Older People in Nursing Home","Inclusion Criteria:\n\n* Older people who have been in a nursing home for at least 6 months,\n* Older people aged 65 years and over,\n* Older people with a Mini Mental State score of 24 and above,\n* Older people who are open to communication and co-operation will be included in the study.\n\nExclusion Criteria:\n\n* Older people with physical problems that may prevent them from participating in nature and game based activities (such as stroke, Parkinson\\'s),\n* Older people with visual and hearing loss that may pose an obstacle to nature and game based activities,\n* Older people with mental problems (such as dementia) that would prevent participation in nature and game based activities were excluded from the study.","65 Years",{"count":118,"type":20},52,[23],"The purpose of this study is determine the effect of nature and game based activities on happiness, spiritual well-being, frailty and cognitive status of older people in nursing home.\n\nHypotheses of the Research H0: Nature and game-based activities don't affect the happiness, spiritual well-being, cognitive function and frailty of older people in nursing home.\n\nH1a: Happiness levels of older people in nursing home will be an increase after nature and game-based activities.\n\nH1b: Spiritual well-being levels of older people in nursing home will be an increase after nature and game-based activities.\n\nH1c: Cognitive function levels of older people in nursing home will be an increase after nature and game-based activities.\n\nH1d: Frailty status of older people in nursing home will be a decrease after nature and game-based activities.",[122,123,124,125,126,127,64],"Nature, Human","Older People","Nursing Home","Happiness","Spiritual Well-being","Frailty",[129,123,124,125,130,127,131],"Nature","Spiritual Well-Being","Cognition","2025-06-11",{"date":134,"type":37},"2025-06-12",{"date":136,"type":20},"2025-07-01",{"date":138,"type":20},"2026-05-01",{"name":140,"class":44},"Ondokuz Mayıs University",{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":145,"acronym":146,"eligibilityCriteria":147,"healthyVolunteers":53,"sex":16,"minAge":148,"maxAge":4,"enrollmentInfo":149,"targetDuration":4,"studyType":21,"phases":151,"briefSummary":152,"conditions":153,"keywords":158,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":181},"100501810","red-blood-cell-transfusion-in-ecmo---a-feasibility-trial-100501810","NCT05814094","Red Blood Cell Transfusion in ECMO - A Feasibility Trial","ROSETTA","Inclusion Criteria:\n\n* Patients receiving ECMO\n* Age: 18 years or older\n\nExclusion Criteria:\n\n* Contraindication to RBC transfusion (including known patient preference)\n* Limitations of care put in place either through patient wishes or the treating medical teams\n* ECMO treatment for more than 12 hours. The start of ECMO is defined as the time of initiation of extracorporeal blood flow unless ECMO was initiated during a surgical intervention in which case the start is defined as the arrival time into the initial ICU.\n* The treating physician anticipates that ECMO treatment will cease before the end of tomorrow\n* Where the treating physician deems the study is not in the patient's best interest\n* Where the treating physician has concern regarding patient ability to tolerate restrictive or liberal transfusion trigger thresholds\n* Patients actively listed for a solid organ transplant\n* Patients who are suspected or confirmed to be pregnant\n* Previous ECMO treatment during the same hospital admission","18 Years",{"count":150,"type":20},120,[23],"Extracorporeal Membrane Oxygenation (ECMO) is an invasive and resource intense treatment used to support critically ill patients who have suffered severe cardiac arrest, cardiac failure or respiratory failure (including severe cases of COVID-19). ECMO acts as a mechanical circulatory support temporarily replacing the function of the heart or lungs by oxygenating blood and removing carbon dioxide, allowing time for these organs to recover. Many critically ill patients, including those on ECMO, have an increased risk of bleeding and reduced production\u002Fincreased destruction of red blood cells (RBCs). This can lead to anaemia (haemoglobin levels \\\u003C120 g\u002Fl), a condition where the body lacks enough healthy RBCs to carry enough oxygen to the body's tissues. Therefore, patients on ECMO frequently require RBC transfusion, with clinicians having to decide if administering an RBC transfusion (with its associated risks) is higher than tolerating complications of anaemia.\n\nROSETTA is a feasibility study that aims to determine the safety and feasibility of randomizing patients on ECMO to a restrictive RBC transfusion strategy (maintain Hb concentration above 70g\u002FL) or to a more liberal transfusion strategy (maintain Hb concentration above 90g\u002FL). Feasibility is defined as the ability to achieve a mean separation of at least 10g\u002FL between the average lowest daily haemoglobin values in the two study groups.",[154,155,156,64,157],"Blood Loss Anemia","Extracorporeal Membrane Oxygenation Complication","Disability Physical","Functional Status",[159,160,161,31,162,163,164,165,166,167,168,169,170,171],"Hb","RBC transfusion","ECMO","safety","blood transfusion","Australia","blood products","ICU","critical care","intensive care","bleeding","transfusion","Hb values","2025-05-27",{"date":174,"type":37},"2025-05-31",{"date":176,"type":37},"2023-09-20",{"date":178,"type":20},"2025-12-30",{"name":180,"class":44},"Australian and New Zealand Intensive Care Research Centre",2,{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":4,"eligibilityCriteria":188,"healthyVolunteers":11,"sex":16,"minAge":189,"maxAge":4,"enrollmentInfo":190,"targetDuration":4,"studyType":21,"phases":192,"briefSummary":194,"conditions":195,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":45},"100592151","phase-3-cilostazol-ginkgo-for-cognitive-function-in-elderly-diabetes-100592151","NCT06989697","Cilostazol-Ginkgo for Cognitive Function in Elderly Diabetes","Impact of Cilostazol and Ginkgo Leaf Extract on Cognitive Function in Elderly Patients With Type 2 Diabetes","Inclusion Criteria:\n\n* Patients diagnosed with type 2 diabetes mellitus\n* Adults aged 60 years or older\n* Patients with a Mini-Mental State Examination (MMSE) score between 24 and 28 within the past 3 months\n\nExclusion Criteria:\n\n* Patients with type 1 diabetes mellitus, diabetic ketoacidosis, or diabetic coma or precoma\n* Patients with poorly controlled blood glucose (HbA1c \\> 10.0%)\n* Patients with an MMSE score below 24\n* Patients diagnosed with dementia (e.g., Alzheimer's disease)\n* Patients with suspected cognitive impairment due to other causes\n* Patients requiring antiplatelet or anticoagulant therapy other than the investigational product\n* Patients with thyroid dysfunction requiring treatment (i.e., abnormal TSH levels)\n* Patients with severe depression\n* Patients with severe infections, recent surgery (perioperative status), or major trauma\n* Patients with pituitary or adrenal insufficiency\n* Patients with other medical conditions requiring hospitalization\n* Patients with a history of alcohol or drug abuse within 1 year prior to screening\n* Patients with a history of taking medications that may affect cognitive function within 3 months prior to screening\n* Patients deemed by the investigator to be otherwise unsuitable for study participation","60 Years",{"count":191,"type":20},80,[193],"PHASE3","This exploratory pilot study aims to evaluate the cognitive improvement effects of combination therapy with cilostazol (200 mg) and ginkgo biloba extract (160 mg) in elderly patients with type 2 diabetes mellitus. Both agents have demonstrated potential cognitive benefits through mechanisms such as enhanced cerebral blood flow, anti-inflammatory activity, and neuroprotection. Given the increased risk of cognitive decline and dementia in patients with type 2 diabetes, and the need for preventive strategies, this study will investigate whether the combination therapy can prevent or mitigate cognitive deterioration. Findings from this study may provide foundational data for the future development of therapeutic interventions targeting cognitive impairment in patients with diabetes.",[196,64],"Type 2 Diabets Mellitus","2025-05-22",{"date":199,"type":37},"2025-05-25",{"date":201,"type":37},"2025-01-01",{"date":203,"type":20},"2027-06-30",{"name":205,"class":44},"Seoul National University Bundang Hospital",{"id":207,"slug":208,"hasResults":11,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":4,"eligibilityCriteria":212,"healthyVolunteers":53,"sex":16,"minAge":213,"maxAge":214,"enrollmentInfo":215,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":216,"conditions":217,"keywords":222,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":234,"locationsCount":45},"100575657","associations-between-dietary-intake-and-cardiometabolic-and-gut-microbiota-outcomes-100575657","NCT06775132","Associations Between Dietary Intake and Cardiometabolic and Gut Microbiota Outcomes","Associations Between Dietary Intake and Cardiometabolic and Gut Microbiota Outcomes in Singapore Adults","Inclusion Criteria:\n\n1. Able to give informed consent\n2. Adults 21-80 years old\n3. English-literate\n4. Have venous access sufficient to allow for blood sampling as per the protocol\n5. No drastic change of diet for the past 1 year\n6. If taking medication, has been consistently taking antihypertensive\u002Fcholesterol-lowering\u002Ftype-2 diabetic medication for more than 5 years prior to starting the study.\n\nExclusion Criteria:\n\n1. Taking dietary supplements and fermented foods, which may impact the gut microbiota (e.g. antibiotics, prebiotics, probiotics, yogurt, kimchi) 2 months before starting the 1st study visit only.\n2. Taking dietary supplements or medications, which may impact sleep outcomes (e.g. Nutritional Shakes (e.g. Ensure), tryptophan, 5-hydroxytryptophan or melatonin supplementations) 1 month before starting the study.\n3. Taking dietary supplements which may impact the eye outcomes (e.g. Vitamin A, vitamin A-containing multivitamin) 2 months before starting the study.","21 Years","80 Years",{"count":57,"type":20},"This cross-sectional study aims to investigate the associations between dietary intake, cardiometabolic health markers, and gut microbiota composition in Singapore adults.",[218,219,220,64,221],"Cardiometabolic Risk Factors","Gut -Microbiota","Skin Condition","Sleep Quality",[223,224,225,226,227],"Endothelial progenitor cells","Gut microbiota","Cardiovascular diseases risk factors","MoCA","Advanced glycation end products","2025-05-19",{"date":230,"type":37},"2025-05-21",{"date":232,"type":37},"2025-02-03",{"date":178,"type":20},{"name":235,"class":44},"National University of Singapore",{"id":237,"slug":238,"hasResults":11,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":242,"eligibilityCriteria":243,"healthyVolunteers":11,"sex":16,"minAge":189,"maxAge":4,"enrollmentInfo":244,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":246,"conditions":247,"keywords":263,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":4},"100590537","project-icope-brazil-assessment-of-intrinsic-capacity-in-brazilian-older-adults-100590537","NCT06968702","Project ICOPE Brazil: Assessment of Intrinsic Capacity in Brazilian Older Adults","Project ICOPE Brazil: Assessment of Intrinsic Capacity in Older Adults as a Basis for Implementation of the WHO ICOPE Strategy in the Unified Health System.","ICOPE-BR","Inclusion Criteria:\n\n* People aged ≥ 60 years, with no age limit;\n* Being registered (with available contact information) in the participating health care units;\n* Being available to go in person to the data collection sites for the assessments.\n\nExclusion criteria\n\n* Inability to access the data collection site;\n* Severe neurologic and\u002For cognitive impairments that preclude interaction with the evaluators to complete the proposed tests and data collections;\n* Advanced serious illness or under palliative care:\n\nClinical Frailty Scale (CFS)20 score of 8 (severely frail) or 9 (terminally ill).",{"count":245,"type":20},3838,"The ICOPE Brazil study aims to understand aging trajectories in Brazil, especially healthy aging trends based on intrinsic capacity, a collective of mental and physical capacities one may have to maintain their functional ability to execute daily life activities. Tests and questionnaires will be applied to collect data on mobility capacity, cognitive capacity, nutritional status, vision, and hearing (sensorial) capacities, and mental health. These assessments are in consonance with what the World Health Organization proposed in the Integrated Care for Older People Program (ICOPE). Participants will be followed up for three years, and the primary outcomes of interest are loss of intrinsic capacity, mobility impairment, cognitive impairment, incident depressive symptoms, loss of functional ability, incident frailty, incident sarcopenia, incident falls, hospitalization, multimorbidity, and mortality.",[248,127,249,250,251,252,64,253,254,255,256,257,258,259,260,261,262],"Intrinsic Capacity","Aging","Healthy Aging","Functional Ability","Mobility and Independence","Cognitive Impairment","Sensory Hearing Loss","Sensory Deficits","Visual Acuity","Visual Impairment","Mood Disorders","Depressive Symptoms","Vitality","Nutritional Risk","Nutrition Assessment",[264,251,265,266,267,127,253,268,269,260,270,271,272,273],"Instrinsic Capacity","ICOPE","Aging trends","Older Adults","Mobility","Sensory","Psychological","Cohort","healthy aging","public health","2025-05-05",{"date":276,"type":37},"2025-05-13",{"date":278,"type":20},"2025-05-15",{"date":280,"type":20},"2029-11",{"name":282,"class":44},"University of Sao Paulo",{"id":284,"slug":285,"hasResults":11,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":289,"eligibilityCriteria":290,"healthyVolunteers":53,"sex":16,"minAge":291,"maxAge":116,"enrollmentInfo":292,"targetDuration":4,"studyType":21,"phases":294,"briefSummary":295,"conditions":296,"keywords":299,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":309,"lastUpdatePostDateStruct":310,"startDateStruct":312,"completionDateStruct":314,"leadSponsor":316,"locationsCount":4},"100583289","investigating-the-combined-effects-of-intermittent-hypoxia-and-exercise-on-cognitive-and-cerebral-function-in-middle-aged-adults-100583289","NCT06874387","Investigating the Combined Effects of Intermittent Hypoxia and Exercise on Cognitive and Cerebral Function in Middle-Aged Adults","Towards a Better Understanding of the Combination of Intermittent Hypoxia and Physical Exercise: Comparison of Effects on Cognitive and Cerebral Capacities in Middle-Aged Adults","HYPOX-AGE","* Inclusion Criteria:\n\n  * Adults aged 50 to 65 years (male and female)\n  * Montreal Cognitive Assessment (MoCA) score ≥ 24\n  * No participation in any structured exercise intervention in the last 6 months\n  * No exposure to altitudes above 1,500 m in the preceding 3 months\n  * No chronic kidney, cardiovascular, metabolic, neurological, or orthopedic -disease\n  * No history of significant respiratory conditions (e.g., asthma, exercise-induced -bronchospasm, dyspnea on exertion)\n  * No current immunosuppressive treatment (e.g., corticosteroids, antidepressants)\n  * No history of cancer or arthritis treatments\n  * No recent blood donation (within the last 2 months)\n  * Must be covered by a Social Security system or equivalent\n  * Signed informed consent after receiving clear and transparent study information\n  * Eligibility confirmed by a medical doctor during the inclusion process\n* Exclusion Criteria:\n\n  * Active smoking\n  * Major cardiovascular complications within the last 3 months (e.g., myocardial i-infarction, unstable angina, severe arrhythmias)\n  * Severe hypertension (≥180 mmHg systolic or ≥110 mmHg diastolic)\n  * Chronic respiratory insufficiency (e.g., COPD, sleep apnea)\n  * Diabetes mellitus\n  * Need for continuous or intermittent oxygen therapy\n  * Participation in another clinical study at the same time\n  * Use of corticosteroids or other systemic immunosuppressants\n  * Any condition compromising safety or study compliance, as determined by the medical team\n  * Pregnancy or breastfeeding\n  * Legal or administrative protections (e.g., individuals under guardianship, persons deprived of liberty)\n  * High baseline physical activity levels (PASE score \\>90 indicating moderate-to-intense physical activity)","50 Years",{"count":293,"type":20},176,[23],"This study investigates whether intermittent hypoxia (IH) and physical activity (PA), either alone or in combination (simultaneously or sequentially), can improve cognitive function and brain health in middle-aged adults (50-65 years old). The hypothesis is that (1) each intervention alone (IHT or PA) provides cognitive benefits and (2) combining IHT with PA may yield additive or synergistic effects, particularly when administered simultaneously rather than sequentially. By comparing these distinct interventions, the study aims to determine which approach best preserves or enhances cognitive performance in middle-aged adults. Findings from this research may inform non-pharmacological strategies to promote healthy aging and reduce the risk of age-related cognitive decline.",[64,297,298],"Brain Health","Cerebral Oxygenation",[300,301,302,303,304,297,305,306,250,307,308],"intermittent Hypoxia Training","Hypoxic Conditioning","Physical Activity","Exercise Intervention","Cognitive Function","Non-Pharmacological Interventions","Middle-Aged Adults","Cognitive Decline Prevention","Neuroplasticity","2025-03-07",{"date":311,"type":37},"2025-03-13",{"date":313,"type":20},"2025-04-01",{"date":315,"type":20},"2026-12-30",{"name":317,"class":44},"Ayoub Boulares"]