[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cognitive-aging\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cognitive-aging":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,96],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":24,"studyType":25,"phases":4,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100571927","physical-and-cognitive-aging-study-in-older-adults-100571927",false,"NCT06726616","Physical and Cognitive Aging Study in Older Adults","PASOS: Physical and Cognitive Aging Study in Older Adults","PASOS","Inclusion Criteria:\n\n• Hispanic and non-Hispanic adults age 55-85 years, at least 8th grade education, community dwelling.\n\nAdditional Inclusion for Hispanic Americans\n\n* Self-identify as Hispanic American\n* Report Spanish as primary language • No evidence of dementia or mild cognitive impairment based on cognitive screening \\[i.e., Montreal Cognitive Assessment (MoCA) administered during Visit 1; ≥26 among non-Hispanic White, ≥25 among Hispanics, ≥24 among non-Hispanic Blacks (Milani et al., 2018)\\]\n\nExclusion Criteria:\n\n* Inability to provide informed consent\n* Artificial joint or severe disability that would make it impossible or contraindicated performing the isokinetic test\n* Sensory loss (vision, hearing) or motor deficits that would preclude participation in the experimental tasks or neuropsychological assessment\n* Previous major strokes or other known significant brain abnormalities or diseases affecting the brain and\u002For cognition (e.g., Parkinson disease, multiple sclerosis, seizure disorder, brain surgery, moderate TBI, REM Behavior Sleep Disorder, untreated sleep apnea, etc.)\n* Unstable and uncontrolled medical conditions (metastatic cancer, HIV, moderate-severe kidney disease, uncontrolled diabetes, uncontrolled hypertension, severe cardiac disease, etc.). No current cancer diagnosis.\n* Current or past history of major psychiatric disturbance including schizophrenia, or active psychosis, bipolar disorder, current major depressive episode, current alcohol or substance abuse or history thereof within the past six months\n* Use of antipsychotics, sedatives, or other medications with significant anticholinergic properties (due to potential influence on memory)\n* Use of prescribed 'memory enhancing' medications, such as Aricept or Namenda\n* Previous participation in a cognitive or physical activity training study within the last 6 months or current involvement in another study involving cognitive, physical or other intervention at the time of enrollment",true,"ALL","55 Years","85 Years",{"count":22,"type":23},100,"ESTIMATED","12 Months","OBSERVATIONAL","Hispanic Americans are the fastest growing older adult group in the United States, disproportionally increasing the risk of an Alzheimer's disease and related dementias diagnosis. Efforts to reduce this risk and mitigate the related cognitive\u002Fphysical declines are critical. The aim of this study is to assess the feasibility of enrolling older adults into an aging trajectory cohort, while generating preliminary data on associations of physical and cognitive aging trajectories. Our secondary objective is to generate preliminary data on the association of standard measures of physical activity and physical function with cognitive status. This study fits within our longitudinal research goal to reduce dementia incidence by understanding the mechanisms that drive the cognitive-physical aging trajectory.",[28,29,30,31,32],"Older Adults (65 Years and Older)","Hispanic Americans","Cognitive Aging","Aging, Healthy","Exercise","RECRUITING","2026-06-03",{"date":36,"type":37},"2026-06-04","ACTUAL",{"date":39,"type":37},"2025-03-19",{"date":41,"type":23},"2027-09-20",{"name":43,"class":44},"University of Florida","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":54,"enrollmentInfo":55,"targetDuration":24,"studyType":25,"phases":4,"briefSummary":57,"conditions":58,"keywords":73,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":45},"100464026","biobank-and-brain-health-in-bordeaux-100464026","NCT05322343","Biobank and Brain Health in Bordeaux.","Biobank and Brain Health in Bordeaux. A Population-based Cohort to Study the Biology of Brain and Cognitive Aging in Young Seniors","B-cube","Inclusion Criteria:\n\nFor the main study:\n\n1. live in Bordeaux metropolitan area,\n2. be between 55 and 80 years old (included),\n3. selected in terms of socioeconomic level, according to a sampling strategy by age groups and income categories representative of the general population between 55 and 80 years of age\n4. be affiliated with the social security system,\n5. agree to take a blood sample for the biobank.\n\nFor the MRI sub-study: be between 55 and 75 years old (included). Inclusion criteria for the immune response substudy: be 70 years of age or older or participate in the MRI study; agree to take a supplemental blood sample for this substudy.\n\nExclusion Criteria:\n\nFor the main study: persons under guardianship (or more generally under protection), unable to give consent to participate.\n\nFor the MRI sub-study: have a contraindication to MRI examination (pacemaker, a valve prosthesis or any other internal electrical\u002Fmagnetic device; history of neurosurgery or aneurysm; claustrophobia; presence of metal fragments in the eyes, brain or spinal cord).","80 Years",{"count":56,"type":23},2050,"B cube is a new generation cohort to study the determinants and natural history of brain aging, using molecular epidemiology, in a representative sample (N=2000) of the general population from the age of 55 (the approximate age of onset of the first cognitive disorders and a target population particularly receptive to prevention messages). Special interest will be given to nutrition, a promising environmental exposure for prevention.",[59,60,30,61,62,63,64,65,66,67,68,69,70,71,72],"Brain","Aging","Immunosenescence","Mental Processes","Mental Disorders","Neurocognitive Disorders","Cognition","Brain Diseases","Dementia","Alzheimer Disease","Mental Health","Behavioral Symptoms","Depression","Anxiety",[74,75,76,77,78,79,80,81,82,83,84,85,86],"Epidemiologic Methods","Risk factors","Public Health","Environmental Exposure","Exposome","Dietary Exposure","Diet","Food and Nutrition","Nutritional Status","Metabolomics","Systems biology","Environmental Biomarkers","Inflammation Mediators","2025-08-08",{"date":89,"type":37},"2025-08-11",{"date":91,"type":37},"2022-03-22",{"date":93,"type":23},"2030-03-22",{"name":95,"class":44},"University Hospital, Bordeaux",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":17,"sex":18,"minAge":104,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":25,"phases":4,"briefSummary":108,"conditions":109,"keywords":113,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":45},"100596630","neuropsychological-evaluation-in-intellectual-disability-endi-100596630","NCT07047963","Neuropsychological Evaluation in Intellectual Disability (ENDI)","Neuropsychological Evaluation in Intellectual Disability","ENDI","Inclusion Criteria:\n\nPreliminary phase:\n\n1. The inclusion criteria for the group of people with intellectual disabilities are as follows:\n\n   * Participant who has received full information on the organization of the research and has not objected to his or her participation and to the use of his or her data.\n   * Legal guardian of the participant, if applicable, who has received full information on the organization of the research and has not objected to participation and use of his\u002Fher data.\n   * Age at inclusion: ≥ 25 and ≤ 65 years\n   * Notion of intellectual disability in medical records\n   * Access to the oral language of the participant with an intellectual disability: the subject's speech must be comprehensible to the evaluator and the subject must be able to understand simple statements. It is not possible to use an oral comprehension test (e.g. Token test by Renzi \\& Vignolo, 1962), as the norms achieved in healthy subjects would exclude almost all patients with intellectual disabilities, who have more limited language skills.\n   * Enrolled in or benefiting from a social security scheme.\n2. The inclusion criteria for the normotypic group are as follows:\n\n   * Participant having received full information on the organization of the research and not having objected to his or her participation and to the use of his or her data.\n   * Age at inclusion: ≥ 25 and ≤ 65 years\n   * Affiliation with a social security scheme or beneficiary of such a scheme\n\nMain phase:\n\nInclusion criteria are as follows:\n\n* Participant with T21 who has received full information on the organization of the research and has not objected to participation and use of his\u002Fher data\n* Legal guardian of the participant with T21, where applicable, who has received full information on the organization of the research and has not objected to his or her participation and the use of his or her data.\n* Person with trisomy 21\n* Age at inclusion: ≥ 25 and ≤ 65 years\n* Access to the oral language of the participant with T21: the subject's speech must be comprehensible to the evaluator and the subject must be able to understand simple statements. It is not possible to use an oral comprehension test (e.g. Token test by Renzi \\& Vignolo, 1962), as the norms achieved in healthy subjects would exclude almost all patients with intellectual disabilities, who have more limited language skills.\n* Membership of a social security scheme or beneficiary of such a scheme\n\nExclusion Criteria for both phases of the study are as follows:\n\n* Disabling motor and\u002For sensory impairments preventing completion of the tests\n* Insufficient command of the French language to complete the tests\n* Severe general medical condition or alcoholism (habitual consumption of 3 drinks\u002Fday or history of alcohol withdrawal)\n* History of stroke, severe head trauma, or cancer\n* Change in long-term medication within 8 weeks prior to evaluation\n* Refusal to participate by the subject and\u002For legal representative\n* Individuals referred to in Articles L.1121-5 to L.1121-7 of the French Public Health Code:\n\n  * Pregnant women, women in labor, or breastfeeding mothers\n  * Individuals deprived of liberty by judicial or administrative decision\n  * Individuals undergoing psychiatric treatment under Article L.3213-1 of the French Public Health Code","25 Years","65 Years",{"count":107,"type":23},40,"The goal of this observational study is to evaluate the acceptability ofpatients with trisomy 21 (T21) to perform the full battery of ENDI neurospychological tests and each of the subsets.\n\nIn this study, three types of population will be recruted : normotypic volunteers, patients with Intellectual Disability and patients T21carriers.\n\nThis study is separated into 2 phases :\n\n* A the preliminary phase : this phase will be used to evaluate subtest design, ergonomics and understanding of instructions, and to identify any malfunctions. The observations gathered will enable the principal investigator to refine the digital design of the battery in collaboration with the publishing company. In this phase, normotypical volunteers and patients with intellectual disabilities will be recruted to perform ENDI test battery.\n* A main phase : this phase will enable to answer to the main objective. in this phase, patients with Trisomy 21 aged between 25 and 65 will be recruted to perform ENDI test battery.",[110,111,30,68,112],"Down Syndrome (Trisomy 21)","Neuropsychology","Alzheimer Disease, Early Onset",[110,102,114,115,116],"Trisomy 21","neuropsychology","ENDI tests battery","NOT_YET_RECRUITING","2025-06-24",{"date":120,"type":37},"2025-07-02",{"date":122,"type":23},"2025-07-01",{"date":124,"type":23},"2026-11-01",{"name":126,"class":44},"Central Hospital, Nancy, France"]