[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cognitive-assessment\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cognitive-assessment":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,100,129],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100619729","phase-1-snacks-and-brain-health-100619729",false,"NCT07348406","Snacks and Brain Health","Effects of Pecans on Brain Health in Older Americans With Mild Cognitive Impairment: Gut-brain Axis","Inclusion Criteria:\n\n* men and women \\> 50 years-old\n* self-reported IQCODE (informant questionnaire on cognitive decline in the elderly) average score \\\u003C 4.5\n* self-reported significant functional impairment (related to cognitive impairment) in basic or advanced activities of daily living as evidenced by the Activities of Daily Living (ADLs) questionnaire. If answers to at least one endorsement in the \"NO, dependence due to memory concerns\".\n* Stable medications (≥ 12-week unchanged dose before baseline) with no planned changes during trial.\n* habitually consume less than two servings (2 ozs = 1\u002F4 cup) of nuts or nut spreads per week\n* willing to accept randomization\n\nExclusion Criteria:\n\n* reported nut allergy or intolerance\n* self-reported untreated hypothyroidism, severe liver disease, or end-stage chronic kidney disease\n* heavy alcohol drinker: in the past 3 months: men ≥14 drinks\u002Fweek or women ≥7 drinks\u002Fweek\n* recent (\\\u003C1 month) appearance of diarrhea or hematochezia before study intervention begins. Rationale: A one-month waiting period after diarrhea or hematochezia (blood in stool) is recommended for a gut microbiome test to ensure the results accurately reflect the state and microbial composition, since diarrhea and hematochezia can significantly alter the gut environment and skew test results.\n* recent (\\\u003C1 month) exposure to antibiotics before study intervention begins. Rationale: A one-month waiting period after antibiotics is recommended for a gut microbiome test because it allows the microbial community time to recover and reach a more stable state, ensuring a more accurate and representative snapshot of the gut microbiome composition, since antibiotic usage can significantly reduce microbial diversity.\n* Self-reported unstable GI disorder\n* likeliness of moving during the trial, lack of transportation, or unavailability at sample collection times","ALL","50 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23,24],"PHASE1","PHASE2","This project will investigate whether daily snack consumption can improve memory, mood, and overall brain function in people with cognitive impairment. Sixty participants, aged 50 and older, with cognitive impairment, will be randomly assigned to eat snacks, either pecans or pretzels, for three months. Researchers will also study how snacks (pecans and pretzels) may influence the body, including changes in gut bacteria, blood markers of inflammation, and signals that connect the gut and the brain.",[27,28,29],"Cognitive Assessment","Psychological Function","GI Health",[31,32,33],"neuroinflammation","gut microbiome","fMRI","NOT_YET_RECRUITING","2026-03-30",{"date":37,"type":38},"2026-04-01","ACTUAL",{"date":40,"type":20},"2026-05-15",{"date":42,"type":20},"2028-09-30",{"name":44,"class":45},"Texas Tech University Health Sciences Center","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":60,"briefSummary":62,"conditions":63,"keywords":80,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":46},"100617476","evaluation-of-the-impact-of-a-nutritional-formulation-on-cognitive-performance-following-stress-exposure-100617476","NCT07319117","Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure.","A Double-blind, Placebo-controlled, Randomised, Acute, Repeated Measures Cross-over Study to Evaluate the Impact of Skoshify 'Think Tank' Nutritional Formulation on Cognitive Performance Following Stress Exposure.","Inclusion Criteria:\n\n1. Willing and able to provide written informed consent (in English)\n2. Aged 40-60\n3. Female\n4. Daily caffeine drinkers\n5. Healthy and free from significant physical and psychiatric disorders\n\nExclusion Criteria:\n\n1. Current cigarette smokers\u002Fvapers.\n2. Known food allergy or intolerance to the investigational products or control products.\n3. Not willing to consume coffee.\n4. Individuals diagnosed with psychiatric\u002Fmental health conditions.\n5. Individuals engaging in recreational drug use.\n6. Individuals with diagnosed cardiovascular conditions (e.g. heart disease, high blood pressure)\n7. Individuals taking prescribed medication except contraceptives\u002Fhormone replacement therapy\n8. Individuals suffering from Raynaud's or circulatory issues\n9. Individuals who have suffered an injury or infection in their hand\u002Farm in the last month\n10. Individuals who have suffered from chronic pain conditions or experience extreme numbness or pain in response to cold temperatures.\n11. Previous brain injury\u002Fbrain surgery\n12. Individuals who work night shifts.\n13. Currently pregnant or breastfeeding.\n14. Previous participants in a laboratory stress protocol.",true,"FEMALE","40 Years","60 Years",{"count":59,"type":20},40,[61],"NA","The proposed project will evaluate the synergistic effects of a nutritional formulation, 'Think Tank' on cognitive performance following exposure to a psychological and physical stressor. Adopting a double-blind repeated measures cross-over design, middle-aged females (40-60 years) will be recruited to take part in a two-stage research study that will examine whether the formulation enhances cognitive performance and subjective well-being following the challenge of a stressor, compared to placebo. Cognitive assessments will examine the impact of the nutritional formulation on working memory, sustained attention, cognitive flexibility and inhibitory control. The study will also assess physiological (heart rate, blood pressure and cortisol) and subjective (well-being, anxiety, positive and negative mood, stress) markers of stress reactivity. The study will also explore levels sleep quality, mental and physical fatigue, effort, productivity, and perceived impact of the intervention.",[27,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79],"Working Memory","Executive Function (Cognition)","Sustained Attention","Inhibitory Control","Cognitive Flexibility","Cortisol","Stress","Anxiety","Depression","Sleep Quality","Blood Pressure","Heart Rate","Mental Fatigue","Physical Fatigue","Productivity","Effort",[81,82,83,84,85,86,87,88,89],"Cognitive Performance","Stress Response","Creatine","Magnesium","L-Tyrosine","L-Theanine","Rhodiola","Phosphatidylserine","Citicoline","RECRUITING","2025-12-19",{"date":93,"type":38},"2026-01-06",{"date":95,"type":20},"2025-12-15",{"date":97,"type":20},"2026-08-31",{"name":99,"class":45},"Leeds Beckett University",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":54,"sex":16,"minAge":107,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":21,"phases":110,"briefSummary":111,"conditions":112,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":4},"100612630","effects-of-transcutaneous-auricular-vagus-nerve-stimulation-on-cognitive-performance-and-sex-differences-100612630","NCT07256080","Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Cognitive Performance and Sex Differences","A Sham-Controlled Cross-Over Study Examining the Effects of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Cognitive Performance and Gender Differences in Healthy Adults","Inclusion Criteria:\n\n* Healthy young adults aged 18-30 years\n* Ability to provide informed consent\n* Right-handed participants (to reduce variability in cognitive performance)\n* Normal or corrected-to-normal vision and hearing\n* Female participants tested during the follicular phase of the menstrual cycle (days 5-10) to minimize hormonal effects on cognition and vagal tone\n\nExclusion Criteria:\n\n* History of neurological or psychiatric disorders\n* Cardiovascular disease\n* Use of psychoactive medications\n* Substance dependence, including alcohol, illicit drugs, or nicotine\n* Pregnancy or breastfeeding\n* Skin conditions or ear anomalies that interfere with electrode placement\n* Metal implants in the head or neck region\n* History of epilepsy or migraine","18 Years","30 Years",{"count":19,"type":20},[61],"This study investigates the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on cognitive performance in healthy adults. The study uses a sham-controlled, cross-over design in which each participant receives both active taVNS and sham stimulation in separate sessions. Each participant completes both conditions (active and sham) in a randomized order using a crossover design. Cognitive performance will be assessed before and after each session using standardized tests. The study also explores whether males and females respond differently to taVNS, in order to identify potential sex-related differences in cognitive outcomes.",[27,113,114,115,116,117,118,119],"Cognition","taVNS","Vagus Nerve Stimulation","Executive Functions","Healthy Participants","Neuromodulation","Sex Differences","2025-11-27",{"date":122,"type":38},"2025-12-01",{"date":124,"type":20},"2025-12",{"date":126,"type":20},"2026-05",{"name":128,"class":45},"Bahçeşehir University",{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":133,"acronym":134,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":16,"minAge":136,"maxAge":107,"enrollmentInfo":137,"targetDuration":139,"studyType":140,"phases":4,"briefSummary":133,"conditions":141,"keywords":144,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":46},"100605256","cannabis-abstinence-and-neurocognitive-assessment-in-adolescence-100605256","NCT07160153","Cannabis Abstinence and Neurocognitive Assessment in Adolescence","CANAA","Inclusion Criteria:\n\n* Adolescents aged 15-18 years with a diagnosis of cannabis dependence or harmful cannabis use.\n\nExclusion Criteria:\n\n* psychiatric comorbidity - Dual diagnosis, including psychotic disorders, mood disorders, severe organic brain damage, or autism spectrum disorder, with the exception of compensated and stabilized anxiety disorder. Psychopharmacological treatment is permitted, except for antipsychotics prescribed for psychosis.\n* somatic comorbidity - Severe endocrine disorders such as diabetes mellitus, thyroid dysfunction, or severe cardiovascular disease.\n* Violation of abstinence between the first and second neuropsychological assessments, as well as severe decompensation of mental state requiring modification of established psychopharmacological treatment.","15 Years",{"count":138,"type":20},29,"2 Months","OBSERVATIONAL",[142,143,27],"Cannabis Dependence","Harmful Use",[142,145,146,147,148],"Cannabis Use Disorder","Abstinence","Cognitive Function","Disorder; Abstinence; Cognitive Function; Neuropsychological","2025-09-15",{"date":151,"type":38},"2025-09-19",{"date":153,"type":38},"2024-12-03",{"date":155,"type":20},"2029-08-31",{"name":157,"class":45},"University Hospital Pilsen"]