[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cognitive-change\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cognitive-change":49},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,39,0,25,[9,81,118,154,181,230,268,299,332,351,374,395,424,447,473,496,520,543,570,596,617,637,664,690,713],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":57,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":80},"100454745","interventions-in-mathematics-and-cognitive-skills-100454745",false,"NCT05201534","Interventions in Mathematics and Cognitive Skills","Interventions in Math Learning Disabilities: Cognitive and Neural Correlates","Inclusion Criteria:\n\n1. Elementary school aged children starting from first grade (6-12 years old)\n2. IQ: Participants with a Full Scale IQ \\> 70 on the Wechsler Abbreviated Scle of Intelligence (WASI-II).\n3. Identification of Mathematical Learning Disabilities: Scores below the 35th percentile percentile on symbolic number processing test in Numeracy Screener and two or more Wechsler Individual Achievement Test (WIAT-IV) math subtests\n4. Identification of typically developing children: Scores at or above the 35th percentile percentile on symbolic number processing test in Numeracy Screener and all WIAT-IV math subtests\n5. Normal or corrected-to-normal vision and no hearing impairments\n6. Inclusion in MRI scan session: Right-handed\n\nExclusion Criteria:\n\n1. History of neurological or psychiatric disorder (i.e., schizophrenia, psychosis, depression, or attention deficit hyperactivity disorder.)\n2. History of trauma involving head injury\n3. Consistent psychiatric medications\n4. Exclusion from MRI scan session: No major contraindication for magnetic resonance imaging (MRI) - braces, metal implants, pacemakers, vascular stents, metallic ear tubes, consistent exposure to metal, claustrophobia)",true,"ALL","6 Years","12 Years",{"count":22,"type":23},180,"ESTIMATED","INTERVENTIONAL",[26],"NA","The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning disabilities (MLD).",[29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56],"Math Learning Disability","Child Development","Developmental Disability","Learning Disabilities","Learning Disabled","Learning Curve","Mathematics Disorder","Dyscalculia","Dyscalculia, Primary","Dyscalculia, Acquired","Specific Learning Disorder, With Impairment in Mathematics","Individuality","Behavior, Child","Behavior and Behavior Mechanisms","Behavior","Decision Making","Neuronal Plasticity","Cognition","Cognition Disorder","Cognitive Dysfunction","Cognitive Change","Cognitive Impairment, Mild","Cognitive Developmental Delay","Cognitive Orientation","Cognitive Delay, Mild","Cognitive Deficits, Mild","Cognitive Abnormality","Neuroscience",[58,59,60,61,62,63,64,65,66,67],"Numerical skills in children","Low math abilities","Mathematical Learning Disabilities","Mathematical Concepts","Mathematics","Transfer, Psychology","Generalization, Psychology","Early Intervention, Educational","Neural Pathways","Neural Networks, Computer","RECRUITING","2026-06-22",{"date":71,"type":72},"2026-06-25","ACTUAL",{"date":74,"type":72},"2023-05-05",{"date":76,"type":23},"2026-08-31",{"name":78,"class":79},"Stanford University","OTHER",1,{"id":82,"slug":83,"hasResults":12,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":12,"sex":18,"minAge":88,"maxAge":4,"enrollmentInfo":89,"targetDuration":91,"studyType":92,"phases":4,"briefSummary":93,"conditions":94,"keywords":98,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":80},"100641778","early-cognitive-changes-after-same-day-discharge-hip-and-knee-arthroplasty-100641778","NCT07598552","Early Cognitive Changes After Same-day Discharge Hip and Knee Arthroplasty","Early Cognitive Changes in Patients Aged 70 Years or Older After Same-day Discharge Hip and Knee Arthroplasty: A Prospective Cohort Study","Inclusion Criteria:\n\n* Unilateral elective primary Total Hip Arthroplasty, Total Knee Arthroplasty, or Unicompartmental Knee\n* Native Danish speaker\n* Spinal anesthesia\n\nExclusion Criteria:\n\n* Inability or unwillingness to provide informed consent\n* Inability to comply with virtual study procedures or follow-up sessions, including because of visual or hearing impairment\n* Known dementia or other diagnosed cognitive disorders or Brief Assessment of Impaired Cognition (BASIC)≤20\n* Parkinson's disease or other neurological conditions causing functional impairment\n* History of alcohol abuse (≥35 units per week)\n* Daily use of anxiolytics or hypnotics\n* Not discharged on the day of surgery","70 Years",{"count":90,"type":23},48,"7 Days","OBSERVATIONAL","The goal of this observational study is to explore early cognitive changes in patients aged 70 years or older undergoing same-day discharge after hip or knee replacement surgery. The main question it aims to answer is:\n\nDoes patients experience cognitive changes in cognitive test performance from before surgery to the first day after surgery?\n\nParticipants will:\n\n* Complete a cognitive test battery virtually about 14 days before surgery, and on the first and seventh day after their operation.\n* Record pain levels and pain medicine use during the first week after surgery",[95,49,96,97],"Postoperative Cognitive Dysfunction (POCD)","Total Knee Arthroplasty","Unicompartmental Knee Arthroplasty",[99,100,101,102,103,104,105,106,107,108,109],"Same-day discharge","Fast-track surgery","Hip arthroplasty","Knee arthroplasty","Unicompartmental knee arthroplasty","Cognitive function","SDMT","Stroop test","Verbal fluency","Older adults","recovery","2026-06-17",{"date":69,"type":72},{"date":113,"type":72},"2026-05-18",{"date":115,"type":23},"2026-11-30",{"name":117,"class":79},"Odense University Hospital",{"id":119,"slug":120,"hasResults":12,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":12,"sex":18,"minAge":125,"maxAge":126,"enrollmentInfo":127,"targetDuration":4,"studyType":24,"phases":129,"briefSummary":130,"conditions":131,"keywords":134,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":80},"100613515","suitability-of-a-26-c-indoor-environment-for-mitigating-heat-strain-in-young-adults-100613515","NCT07267598","Suitability of a 26 °C Indoor Environment for Mitigating Heat Strain in Young Adults","Evaluating the Effectiveness of a 26 °C Indoor Temperature Limit to Mitigate Physiological Strain in Young, Habitually Active Adults","Inclusion Criteria:\n\n* Non-smoking.\n* English or French speaking.\n* Ability to provide informed consent.\n* Healthy young adults without chronic disease (e.g., type 1 diabetes, hypertension)\n\nExclusion Criteria:\n\n* Endurance trained (i.e., engaged in regular physical training activities more than 3 times a week for more than 1 hour per session).\n* Undergoing passive heat exposures such as regular of saunas, warm-water immersion, other.\n* Use of or changes in medication judged by the patient or investigators to make participation in this study inadvisable.\n* Current pregnancy","18 Years","29 Years",{"count":128,"type":23},10,[26],"While an indoor upper temperature limit of 26 °C has been shown to protect heat-vulnerable older adults (DOI: 10.1289\u002FEHP11651), this guideline has not been verified in young, habitually active adults. Public health recommendations during hot weather typically emphasize staying in cool environments, avoiding strenuous activity, wearing lightweight clothing, and maintaining adequate hydration. However, young adults may be less likely to follow these guidelines. They often do not reduce their physical activity during extreme heat events and may overdress for fashion, cultural, or religious reasons. These behaviors can impose an additional thermoregulatory burden and lead to greater physiological strain during heat exposure, even though young adults generally have a higher capacity for heat dissipation than older individuals. Accordingly, it is important to evaluate whether an indoor temperature limit of 26 °C is sufficient to protect young, habitually active adults.\n\nTo address this gap, the investigators aim to assess changes in body temperature and cardiovascular strain in young, habitually active adults (18-29 years) during an 8-hour exposure to the recommended indoor upper temperature limit of 26 °C and 45% relative humidity (humidex of 29, considered comfortable). Participants will complete two conditions:\n\nA) seated rest while dressed in light clothing (T-shirt, shorts, and socks), and B) light exercise (stepping to simulate activities of daily living, 4-4.5 METs) performed once per hour (except for the lunch hour) while dressed in light clothing plus an additional insulating layer (sweatshirt and sweatpants).\n\nThis experimental design will allow investigators to determine the effects of added clothing insulation and light activity-representative of typical daily behaviors-on physiological strain in young adults, and to assess whether refinements to the recommended 26 °C indoor temperature limit are warranted for this population.",[132,133,49],"Heat Stress","Physiological Stress",[135,136,137,138,139,140,141,142,143,144],"Indoor overheating","Indoor temperatures","Heat wave","Thermoregulation","Heat strain","Heat vulnerability","Hyperthermia","Thermal comfort","Activities of daily living","Clothing insulation","2026-06-12",{"date":147,"type":72},"2026-06-16",{"date":149,"type":72},"2025-11-07",{"date":151,"type":23},"2026-12-30",{"name":153,"class":79},"University of Ottawa",{"id":155,"slug":156,"hasResults":12,"nctId":157,"briefTitle":158,"officialTitle":159,"acronym":4,"eligibilityCriteria":160,"healthyVolunteers":17,"sex":18,"minAge":125,"maxAge":161,"enrollmentInfo":162,"targetDuration":4,"studyType":24,"phases":164,"briefSummary":165,"conditions":166,"keywords":167,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":180},"100544960","effectiveness-of-cognitive-training-in-older-and-younger-adults-100544960","NCT06375681","Effectiveness of Cognitive Training in Older and Younger Adults","Examining the Effectiveness of Cognitive Training","Inclusion Criteria:\n\n* Self-reported normal or corrected-to-normal vision\n* No known neurological impairments\n* Age within inclusion range (18-30 Years for Younger Adults and 60-85 Years for Older Adults)\n\nExclusion Criteria\n\n* Physical handicap (motor or perceptual) that would impede training procedures\n* Concurrent enrollment in other cognitive training studies\n* Not being proficient enough in English that would prevent following and understanding all instructions and completing all testing sessions (typically, participants would need to have learned English before age 11; there might be some exceptions that will be decided on a case-by-case basis).\n* Unable to adhere to training schedule\n\nAdditional exclusion criteria for older adults:\n\n\\- Score \\\u003C 17 (out of 22) on the Telephone Montreal Cognitive Assessment (T-MoCA).","85 Years",{"count":163,"type":23},1600,[26],"The proposed study will enroll 1600 participants to examine the effectiveness of cognitive training. Participants will be randomized into different experimental groups and can expect to participate for up to 15 hours of research over 4 to 8 weeks.",[49],[168,169,170],"Cognitive Training","Training task","Testing context","2026-05-27",{"date":173,"type":72},"2026-05-29",{"date":175,"type":72},"2025-04-01",{"date":177,"type":23},"2027-07",{"name":179,"class":79},"University of Wisconsin, Madison",3,{"id":182,"slug":183,"hasResults":12,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":187,"eligibilityCriteria":188,"healthyVolunteers":17,"sex":18,"minAge":189,"maxAge":190,"enrollmentInfo":191,"targetDuration":4,"studyType":92,"phases":4,"briefSummary":193,"conditions":194,"keywords":201,"overallStatus":220,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":221,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":4},"100639073","meva-cognitive-wellness-platform-study-for-adults-100639073","NCT07595250","MEVA Cognitive Wellness Platform Study for Adults","Phase 1 Validation Study of the MEVA Cognitive Wellness Platform","MEVA","Inclusion Criteria:\n\n* Adults aged 55 to 75 years\n* Community-dwelling (living independently in the community)\n* English fluency sufficient for informed consent, task instructions, and questionnaires\n* Able to provide informed consent using teach-back method\n* Able to use a computer or tablet for simple tap or drag interactions\n* Functional vision sufficient for on-screen tasks with usual corrective lenses\n* Functional hearing sufficient for spoken instructions with or without hearing aids\n* Interest in cognitive wellness and personal well-being\n* Available for baseline visit and possible retest visit approximately 14 days later\n* Transportation to study site or ability to participate remotely if permitted by protocol\n* Assistive devices and accommodations are permitted\n\nExclusion Criteria:\n\n* Severe visual impairment preventing completion of digital tasks\n* Severe motor impairment preventing interaction with tablet or web application\n* Known diagnosis of moderate or severe dementia, or inability to comprehend consent and task instructions\n* Current participation in another cognitive training or technology intervention study likely to confound outcomes\n* Recent hospitalization, emergency room visit, or acute exacerbation of a medical or psychiatric condition within the past 30 days that would impede study participation\n* Current substance use disorder likely to interfere with study adherence or completion\n* Recent intensive use of a similar structured cognitive wellness or brain training application","55 Years","75 Years",{"count":192,"type":23},100,"The goal of this observational study is to evaluate the reliability, usability, and feasibility of the MEVA Cognitive Wellness Platform in community-dwelling adults aged 55 to 75.\n\nThe main questions it aims to answer are:\n\nHow consistent is the MEVA Global Cognitive Index when participants complete the MEVA activities again approximately 14 days later? How usable and acceptable is the MEVA platform for older adults in community settings? What completion rates, data quality patterns, and participant feedback are observed during use of the platform?\n\nParticipants will:\n\nComplete a baseline study visit lasting approximately 45 to 60 minutes Complete a 7-activity digital cognitive wellness battery Answer questionnaires about usability, technology acceptance, and wellness experience Complete the Saint Louis University Mental Status (SLUMS) examination as an exploratory comparison measure If selected for the retest group, return approximately 14 days later to complete the MEVA activities again\n\nMEVA is being evaluated as a cognitive wellness platform. It is not intended to diagnose, treat, prevent, screen for, or monitor any disease or medical condition.",[195,196,197,198,49,199,200],"Cognitive Wellness","Healthy Aging","Age-Related Cognitive Change","Aging","Health Behavior","Primary Care",[202,203,204,205,206,207,208,209,210,211,212,213,214,215,216,217,218,219],"Cognitive wellness","Healthy aging","Health equity","Test-retest reliability","Community-dwelling older adults","Primary care","Digital wellness","Older adult engagement","Psychometrics","Usability","Community health","Wellness tracking","Cognitive engagement","Adult development","General wellness","Montessori-informed activities","Technology acceptance","Exploratory convergent validity","NOT_YET_RECRUITING",{"date":222,"type":72},"2026-05-20",{"date":224,"type":23},"2026-05",{"date":226,"type":23},"2026-12",{"name":228,"class":229},"Mentage LLC","INDUSTRY",{"id":231,"slug":232,"hasResults":12,"nctId":233,"briefTitle":234,"officialTitle":235,"acronym":236,"eligibilityCriteria":237,"healthyVolunteers":17,"sex":18,"minAge":238,"maxAge":239,"enrollmentInfo":240,"targetDuration":4,"studyType":24,"phases":242,"briefSummary":243,"conditions":244,"keywords":250,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":80},"100620930","the-brain-health-pro-online-risk-factor-reduction-study-to-prevent-dementia-100620930","NCT07364019","The Brain Health PRO Online Risk Factor Reduction Study to Prevent Dementia","The Brain Health PRO Online Risk Factor Reduction Study for The Canadian Therapeutic Platform Trial for Multidomain Interventions to Prevent Dementia","BHPROOF","Inclusion Criteria:\n\n* Completion and documentation of the electronic Informed Consent Process (from the participant)\n* Sufficient proficiency in English or French to undergo online assessments and participate in an online educational program.\n* Technical ability to participate in an online educational program and remote assessments (i.e., regularly have access to a computer or tablet with an internet connection; have access to a desktop or laptop computer with an internet connection at least once every 6 months; ability to send and receive emails; ability to complete online assessments)\n* Sufficient vision to participate in an online educational program and complete online cognitive testing\n* Ages 50-80\n* Classified as being at increased risk of dementia based on at least one of the following:\n\n  * First-degree family history of dementia\n  * Education level at or below high school (grade 12 or less)\n  * Self-Reported: Hypertension, Hypercholesterolemia, Body Mass Index \\> 30 kg\u002Fm2 (derived from NIH Metric BMI Calculator), or Physical Inactivity (active is defined as engaging in a minimum of 20- 30 min of physical activity causing sweating and breathlessness, at least 2 times a week)\n\nExclusion Criteria:\n\n* Individuals who have a clinical diagnosis of Dementia (based on self-report)\n* Individuals who are currently participating in or have participated in a past study involving BHPro","50 Years","80 Years",{"count":241,"type":23},700,[26],"This study will recruit participants at risk for dementia to participate in an online educational program called Brain Health PRO (BHPro). The BHPro intervention is designed to address modifiable risk factors for dementia through a 6-month, fully online, educational program conveying the best available evidence for lifestyle changes that can mitigate dementia risk, and foster engagement toward one's own brain health. Achieving lifestyle changes in a diverse Canadian population through online education would be a major achievement in dementia prevention in Canada, with widespread personal and socioeconomic benefits.\n\nEligible participants will be randomly assigned to either start Brain Health PRO immediately or in 6 months (delayed-start control group). All participants will have the opportunity to have access to BHPro for 6 months during the course of the study and will have open access to all content for 12 months following the initial 6-month intervention. Participation will last from 18-24 months depending on group assignment.",[245,246,247,49,248,249],"Dementia Prevention","Subjective Cognitive Impairment","Mild Cognitive Impairment","Lifestyle Intervention","Dementia Education",[251,252,253,254,255,256,257,258],"dementia education","at risk for dementia","lifestyle intervention","dementia reduction","dementia risk factor","dementia prevention","cognitive impairment","Alzheimer risk","2026-05-14",{"date":261,"type":72},"2026-05-19",{"date":263,"type":72},"2026-05-07",{"date":265,"type":23},"2028-12-31",{"name":267,"class":79},"University of British Columbia",{"id":269,"slug":270,"hasResults":12,"nctId":271,"briefTitle":272,"officialTitle":272,"acronym":273,"eligibilityCriteria":274,"healthyVolunteers":12,"sex":18,"minAge":125,"maxAge":4,"enrollmentInfo":275,"targetDuration":4,"studyType":24,"phases":277,"briefSummary":279,"conditions":280,"keywords":286,"overallStatus":220,"whyStopped":4,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":292,"startDateStruct":293,"completionDateStruct":295,"leadSponsor":297,"locationsCount":4},"100485768","phase-1-minocycline-in-neurocognitive-outcomes---sickle-cell-disease-100485768","NCT05605366","Minocycline In Neurocognitive Outcomes - Sickle Cell Disease","MINO-SCD","Inclusion Criteria:\n\nAdults (age ≥ 18 years old) with SCD (HbSS and HbS-β0thalassemia genotypes only) who are followed at the University of Cincinnati Medical Center's SCD clinic are eligible to participate. As hydroxyurea is the standard-of-care in SCD, individuals on hydroxyurea will be included\n\nExclusion Criteria:\n\n1. adults with other SCD genotypes (HbSC or HbS- β+thalassemia),\n2. individuals with a history of overt stroke or other known neurological disorder,\n3. premature birth before 30 weeks gestation,\n4. monthly therapy with chronic blood transfusions,\n5. coexisting autoimmune condition due to an elevated risk for autoimmune-related complications with tetracyclines,\n6. tetracycline allergy.\n7. Women who are pregnant or breast-feeding",{"count":276,"type":23},30,[278],"PHASE1","Sickle cell disease (SCD) is a common, inherited blood disorder that primarily affects people of African Ancestry. It has a lot of complications including neurological complications. The neurological complications of SCD are particularly devastating and lead to cognitive decline even in the absence of overt brain injury. In such cases, it is thought that inflammation in the brain maybe partly responsible for the cognitive decline.\n\nThe main reasons for this research study are to see 1) how safe and 2) how well minocycline works to try to stop\u002Freverse cognitive decline in people with SCD. People with SCD are at risk for changes in their brain over time that can cause problems with learning, memory, and attention. Part of the reason for this is inflammation within the brain. Minocycline may be able to stop these brain changes by stopping this brain inflammation.\n\nMinocycline is a second-generation tetracycline antibiotic that has been shown to both inhibit neuroinflammation and improve cognitive function in a variety of neurodegenerative and psychiatric disorders but has not yet been studied in SCD. We are proposing here, a pilot double-blinded, randomized controlled trial to examine the tolerability and early efficacy of minocycline in adults with SCD at two dosing regimens (200 mg and 300 mg daily) versus placebo over one year. Participants will undergo a neuropsychological exam using the NIH Toolbox Cognition Battery at both study enrollment and exit (after one year) to assess for changes\u002Fstability of cognition. Participants will receive monthly phone calls\u002Ftext messages to assess for adverse events and will be seen every three months for pill counts and routine laboratory monitoring. The primary outcome will be a comparison of adverse events across the two dosing strategies versus placebo. Early evidence for cognitive benefit will also be assessed from the results of the NIH Toolbox.",[281,282,283,49,48,284,285],"Sickle Cell Disease","Cognitive Impairment","Cognitive Decline","Cognitive Deficit","Neuroinflammatory Response",[287,288,289,290],"sickle cell disease","benign hematology","cognitive dysfunction","neuroinflammation","2026-05-11",{"date":259,"type":72},{"date":294,"type":23},"2026-12-01",{"date":296,"type":23},"2028-06-15",{"name":298,"class":79},"University of Cincinnati",{"id":300,"slug":301,"hasResults":12,"nctId":302,"briefTitle":303,"officialTitle":303,"acronym":4,"eligibilityCriteria":304,"healthyVolunteers":12,"sex":305,"minAge":125,"maxAge":4,"enrollmentInfo":306,"targetDuration":4,"studyType":24,"phases":308,"briefSummary":310,"conditions":311,"keywords":317,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":323,"lastUpdatePostDateStruct":324,"startDateStruct":326,"completionDateStruct":328,"leadSponsor":330,"locationsCount":80},"100572016","phase-2-memantine-and-exercise-to-improve-cognitive-function-and-modulate-biological-pathways-of-cognitive-decline-during-chemotherapy-in-breast-cancer-100572016","NCT06727773","Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer","Inclusion Criteria:\n\nIn order to participate in the study a subject must meet all of the eligibility criteria outlined below.\n\n* Female\n* Age ≥ 18 years at the time of consent.\n* Stage I-III Breast Cancer\n* Recommended chemotherapy\n* Enroll prior to 3rd cycle of chemotherapy\n* English-speaking\n\nExclusion Criteria:\n\n* Allergy to memantine\n* Previous chemotherapy (prior to the current regimen),\n* Severe cognitive impairment, defined by Blessed Orientation Memory Concentration Test Score ≥11\n* Myocardial infarction in the last 6 months\n* Cardiovascular or orthopedic limitations to exercise\n* Severe mental illness (i.e., schizophrenia or bipolar affective disorder)\n* Current alcohol or drug abuse\n* Inability to swallow capsules \\\u003C\u002F= 5mL\u002Fmin\n* CrCl \\\u003C\u002F= 5mL\u002Fmin","FEMALE",{"count":307,"type":23},90,[309],"PHASE2","This randomized, placebo-controlled trial aims to assess the feasibility, acceptability, and preliminary efficacy of memantine and the University of Carolina (UNC)'s Get Real \\& Heel cancer exercise program (MEM+EX) in addressing cancer-related cognitive impairment (CRCI) and underlying CRCI biomarkers. Ninety stage I-III breast cancer patients during chemotherapy will be randomized into three groups: MEM+EX, memantine, or placebo. The study will evaluate recruitment, retention, adherence, acceptability, cognitive function, brain-derived neurotrophic factor (BDNF), inflammatory markers, and frailty at multiple time points.",[312,313,282,283,49,314,315,316],"Breast Cancer","Locally Advanced Breast Cancer","Breast Cancer Stage I","Breast Cancer Stage II","Breast Cancer Stage III",[318,319,320,321,322],"chemotherapy","memantine","placebo-controlled","exercise","Get Real & Heel cancer exercise program","2026-05-01",{"date":325,"type":72},"2026-05-06",{"date":327,"type":72},"2025-08-19",{"date":329,"type":23},"2029-06-15",{"name":331,"class":79},"UNC Lineberger Comprehensive Cancer Center",{"id":333,"slug":334,"hasResults":12,"nctId":335,"briefTitle":336,"officialTitle":336,"acronym":4,"eligibilityCriteria":337,"healthyVolunteers":12,"sex":305,"minAge":125,"maxAge":4,"enrollmentInfo":338,"targetDuration":4,"studyType":92,"phases":4,"briefSummary":340,"conditions":341,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":344,"startDateStruct":346,"completionDateStruct":348,"leadSponsor":350,"locationsCount":80},"100602568","cognitive-impact-of-neoadjuvant-chemotherapy-for-ovarian-cancer-100602568","NCT07125209","Cognitive Impact of Neoadjuvant Chemotherapy for Ovarian Cancer","Inclusion Criteria:\n\n* Age 18 or older\n* Pathological diagnosis of suspected epithelial ovarian cancer; of note, patients with suspected epithelial ovarian cancer who are pending a pathological diagnosis\u002Fbiopsy may be enrolled onto the study ahead of their biopsy. If the biopsy result is later inconsistent with epithelial ovarian cancer, they will be removed from the study and replaced\n* Planned to received neoadjuvant chemotherapy with carboplatin and paclitaxel; alternatives to these agents including abraxane, docetaxel, cisplatin may be used if patients have a chemotherapy reaction or otherwise cannot receive carboplatin and paclitaxel per usual standard of care\n* Patients may be receiving bevacizumab and may receive PARP inhibitors as a maintenance treatment; those receiving any other targeted therapy will be excluded\n\nExclusion Criteria:\n\n* History of diagnosed cognitive impairment, including dementia\n* History of traumatic brain injury\n* English is not their primary language\n* Known hearing or visual impairment not corrected with hearing devices and glasses\u002Fcontacts\n* Upper extremity motor impairment that would impact ability to perform the Trail Making Test\n* Baseline Mini Mental State Exam (MMSE) score less than 18",{"count":339,"type":23},18,"The purpose of this research is to assess several components of cognition in patients recently diagnosed with advanced epithelial ovarian cancer and who will be undergoing neoadjuvant chemotherapy for treatment of the cancer. 18 participants will be enrolled and can expect to be on study for approximately 10 months.",[342,49],"Ovarian Cancer","2026-04-29",{"date":345,"type":72},"2026-05-05",{"date":347,"type":72},"2026-04-28",{"date":349,"type":23},"2027-12",{"name":179,"class":79},{"id":352,"slug":353,"hasResults":12,"nctId":354,"briefTitle":355,"officialTitle":356,"acronym":4,"eligibilityCriteria":357,"healthyVolunteers":12,"sex":18,"minAge":125,"maxAge":161,"enrollmentInfo":358,"targetDuration":4,"studyType":24,"phases":359,"briefSummary":360,"conditions":361,"keywords":362,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":369,"completionDateStruct":371,"leadSponsor":373,"locationsCount":80},"100622415","heat-stress-in-individuals-with-schizophrenia-100622415","NCT07383324","Heat Stress in Individuals With Schizophrenia","Impact of Indoor Overheating on Physiological Strain in Individuals With Schizophrenia","Inclusion Criteria:\n\n* English or French speaking.\n* Ability to provide informed consent.\n* Individuals with and without schizophrenia or schizoaffective disorder.\n\nExclusion Criteria:\n\n* Endurance exercise training (greater than 3 sessions of vigorous exercise training per week for 30 minutes or more)\n* Restrictions to physical activity\n* Any history of diagnoses for other psychiatric disorders deemed to make participation in the study inadvisable.",{"count":128,"type":23},[26],"Schizophrenia is a severe mental illness affecting approximately 24 million people worldwide and is associated with more than double the all cause mortality risk of the general population. Emerging evidence demonstrates that elevated temperatures acutely worsen mental health symptoms and significantly increase the risk of heat related morbidity and mortality. For people living with schizophrenia, prolonged exposure to heat can exacerbate psychiatric symptoms, impair judgment and decision making, and reduce the ability to engage in protective behaviors such as increasing hydration, reducing clothing, improving ventilation, or seeking cooler environments. As a result, individuals with schizophrenia may experience higher rates of heat related illness. To date our understanding of heat exposure effects in individuals with schizophrenia remains incomplete, hindering the development of evidence-based strategies to protect them.\n\nThus, the primary objective of this exploratory study is to gather preliminary data on the effects of indoor overheating on physiological responses (core body temperature and cardiovascular function), cognitive performance (attention, working memory, and reaction time), and mood in adults with schizophrenia. Specifically, we will assess whether maintaining indoor conditions at the upper recommended temperature limit for older adults (26°C, 45% relative humidity \\[RH\\]; PMID: 38329752) is sufficient to mitigate physiological strain compared with exposure to a hot indoor environment (36°C, 45% RH) representative of non-air-conditioned homes during extreme heat events in individuals with schizophrenia. In both conditions, the individual will remain seated at rest while wearing light clothing (t shirt and shorts), with the exception of performing 15 minutes of stepping exercise (4-4.5 METS) each hour (excluding the lunch period) to reflect typical daily activities of daily living.",[132,133,49],[135,136,137,138,363,139,140,141,364,142,365],"Schizophrenia","Mental health","Physical activity","2026-04-20",{"date":368,"type":72},"2026-04-23",{"date":370,"type":72},"2025-11-08",{"date":372,"type":23},"2027-07-01",{"name":153,"class":79},{"id":375,"slug":376,"hasResults":12,"nctId":377,"briefTitle":378,"officialTitle":379,"acronym":4,"eligibilityCriteria":380,"healthyVolunteers":17,"sex":18,"minAge":381,"maxAge":382,"enrollmentInfo":383,"targetDuration":4,"studyType":24,"phases":384,"briefSummary":385,"conditions":386,"keywords":387,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":390,"startDateStruct":391,"completionDateStruct":392,"leadSponsor":394,"locationsCount":80},"100613024","impact-of-indoor-overheating-on-physiological-strain-in-children-100613024","NCT07261202","Impact of Indoor Overheating on Physiological Strain in Children","A Preliminary Study Assessing the Effectiveness of a 26 °C Indoor Temperature Limit on Physiological Responses in Children","Inclusion Criteria:\n\n* English or French speaking.\n* Ability to provide informed assent.\n\nExclusion Criteria:\n\n* Chronic health conditions\n* Endurance exercise training (greater than 3 sessions of vigorous exercise training per week for 30 minutes or more)\n* Restrictions to physical activity","10 Years","15 Years",{"count":128,"type":23},[26],"Communities worldwide are experiencing increasing heat extremes that challenge the limits of human thermoregulation, particularly among vulnerable populations such as children. Compared with adults, children are more susceptible to heat related illness due to less efficient thermoregulatory systems and difficulty recognizing early signs of heat stress. In addition, prolonged heat exposure can adversely affect their mental health, contributing to cognitive decline, heightened anxiety, and irritability. As children spend substantial time in hot environments at school and at home, and as these conditions intensify with climate change, actions to safeguard their health are essential. Yet our understanding of heat exposure effects in children remains incomplete, hindering the development of evidence based strategies to protect them.\n\nTo address this gap, the investigators aim to evaluate whether an indoor temperature limit of 26 °C (45 percent relative humidity), the upper threshold recommended to protect older adults, can effectively prevent dangerous increases in physiological strain and declines in cognitive function in children during a simulated daylong heatwave. The preliminary study will assess physiological and cognitive responses in children aged 10 to 15 years during a 6 hour exposure (approximating a typical school day) to two conditions: (1) the recommended indoor temperature upper limit (26 °C) and (2) a high heat condition representative of homes and schools without air conditioning during extreme heat events (36 °C). In both conditions, children will remain seated at rest while wearing light clothing (t shirt and shorts), with the exception of performing 15 minutes of stepping exercise (6-6.5 METS) each hour (excluding the lunch period) to reflect typical daily activity in a school setting. This experimental design will allow investigators to determine whether maintaining indoor temperatures at the recommended upper limit for older adults sufficiently mitigates physiological strain in children.",[132,133,49],[135,136,137,138,388,139,140,141,389,142,365],"Adolescent","Youth",{"date":368,"type":72},{"date":370,"type":72},{"date":393,"type":23},"2026-12-31",{"name":153,"class":79},{"id":396,"slug":397,"hasResults":12,"nctId":398,"briefTitle":399,"officialTitle":400,"acronym":401,"eligibilityCriteria":402,"healthyVolunteers":12,"sex":18,"minAge":125,"maxAge":403,"enrollmentInfo":404,"targetDuration":4,"studyType":24,"phases":406,"briefSummary":407,"conditions":408,"keywords":410,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":415,"lastUpdatePostDateStruct":416,"startDateStruct":418,"completionDateStruct":420,"leadSponsor":422,"locationsCount":80},"100474424","modulating-neurocognitive-processes-of-learning-to-trust-and-distrust-in-aging-100474424","NCT05457725","Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging","Characterizing and Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging II","DecidingBrain","Inclusion Criteria:\n\n* Able to provide verbal and written informed consent\n* Fluent English speaker\n* At least 8th grade education\n* On stable medication regimen\n\nExclusion Criteria:\n\n* Pregnancy\n* Magnetic resonance imaging contraindications (e.g., certain metallic objects in body, claustrophobia)\n* Current major depression defined as scores \\>14 on the Beck Depression Inventory-II\n* Impaired scores on the Telephone Interview for Cognitive Status (TICS; cut-off of \\>30)\n* Current use of medications with significant anticholinergic properties due to potential influence on memory (\"memory enhancing\"; e.g., Aricept or Namenda)\n* Current use of anticonvulsant, neuroleptic, sedatives, or other medications known to affect cognition\n* Uncorrected visual and hearing impairments\n* Neurologic conditions affecting the brain (e.g., severe stroke, epilepsy, traumatic brain injury with \\>30-minute loss of consciousness)\n* Impaired scores on a cognitive screening measure, the Montreal Cognitive Assessment (MoCA); for older adults the cutoff will be age and education corrected\n* Unstable medical illness (e.g., metastatic cancer)\n* Significant cardiovascular conditions (e.g., major heart attack)\n* Will not exclude participants who are taking anti-depressant medications. Use of antidepressants (particularly SSRI's) and anxiolytic medications will be recorded and included in post-hoc analyses","100 Years",{"count":405,"type":23},68,[26],"Much of human interaction is based on trust. Aging has been associated with deficits in trust-related decision making, likely further exacerbated in age-associated neurodegenerative disease (Alzheimer's disease\u002FAD), possibly underlying the dramatically growing public health problem of elder fraud. Optimal trust-related decision making and avoiding exploitation require the ability to learn about the trustworthiness of social partners across multiple interactions, but the role that learning plays in determining age deficits in trust decisions is currently unknown.\n\nAim: Probe the malleability of the underlying neurocircuitry of trust-learning deficits in aging. This study will utilize real-time fMRI neurofeedback to train older adults in brain activity up-regulation toward enhanced trust-related learning in aging and confirm critical mechanisms of experience-dependent social decisions in aging.\n\nGrant R01AG072658 Aim 3: Test the malleability of trust-learning neurocircuitry toward optimized trust-related decision making in aging.",[198,49,409],"Neurocognitive Disorders, Mild",[44,411,412,413,414],"Trust","Learning","Socioemotional","Vulnerability to Exploitation","2026-04-03",{"date":417,"type":72},"2026-04-06",{"date":419,"type":72},"2024-10-08",{"date":421,"type":23},"2027-04-30",{"name":423,"class":79},"University of Florida",{"id":425,"slug":426,"hasResults":12,"nctId":427,"briefTitle":428,"officialTitle":429,"acronym":4,"eligibilityCriteria":430,"healthyVolunteers":17,"sex":18,"minAge":431,"maxAge":4,"enrollmentInfo":432,"targetDuration":4,"studyType":24,"phases":434,"briefSummary":435,"conditions":436,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":438,"lastUpdatePostDateStruct":439,"startDateStruct":441,"completionDateStruct":443,"leadSponsor":445,"locationsCount":80},"100485134","phase-2-exercise-to-improve-brain-health-in-older-african-americans-100485134","NCT05597124","Exercise to Improve Brain Health in Older African Americans","Determinants of Individual Differences in the Efficacy of Aerobic Exercise to Improve Brain Health and Reduce Alzheimer's Disease Risk in Older African Americans","Inclusion Criteria:\n\n* self-identify as either African American or Black;\n* be age 60 or older;\n* able to speak, read, and understand English;\n* available over the study period; independently ambulatory (i.e., not needing a wheelchair, walker, or cane);\n* meet criteria for low levels of physical activity (less than 60 minutes per week) based on the International Physical Activity Questionnaire (IPAQ-short version);\n* scoring 28-35 (inclusive) on the Telephone Interview for Cognitive Status Modified (sensitivity \\[43%\\], specificity \\[94%\\] for lower threshold; sensitivity \\[93%\\], specificity \\[42%\\] for upper threshold)55.\n* scoring 20-26 (inclusive) on the Montreal Cognitive Assessment (MoCA) during the in-person screening\n* have clearance to participate from their primary care physician, with oversight of all our patient health under the guidance of our physician-scientist Co-I, William Hu, Chief of Cognitive Neurology at Rutgers.\n\nExclusion Criteria:\n\n* color-blindness (because some of our tasks utilize color as a cue);\n* any diagnosed neurological disorder (including headaches and peripheral neuropathy); diagnosed or self-reported non-neurological conditions that likely affect MTL outcomes, such as, major depressive disorder (or a Geriatric Depression Scale-Short Form score ≥ 5), schizophrenia, delusional disorder, schizoaffective disorder or significant psychiatric symptoms that could impair the completion of the study (e.g., psychosis), substance-related and addictive disorders (or treatment in past five years), chemotherapy or radiation treatment for cancers, planning to undergo general anesthesia during the study period;\n* exercise contraindications, such as, orthopedic complications, myocardial infarction, coronary artery bypass grafting, angioplasty or other cardiac condition in the past year, current treatment for congestive heart failure, angina, uncontrolled arrhythmia, deep vein thrombosis (DVT) or another cardiovascular event, and uncontrolled hypertension with resting systolic or diastolic blood pressures \\> 180\u002F110 mmHg.","60 Years",{"count":433,"type":23},280,[309],"The goal of this clinical trial is to test the effects of different types of exercise on brain health and Alzheimer's risk in older African Americans.\n\nSpecifically, the main question\\[s\\] it aims to answer are:\n\n* What is the effect of a Cardio-Dance Fitness (CDF) vs. a Strength, Flexibility, and Balance (SFB) intervention on a cognitive marker of Alzheimer's risk, generalization?\n* What is the effect of the CDF vs. SFB intervention on a fMRI biomarker of Alzheimer's, neural flexibility, and do improvements in neural flexibility mediate improvements in generalization?\n* Do ABCA7 genotypic variations moderate the efficacy of the CDF vs. SFB intervention for reducing Alzheimer's risk?\n\nParticipants will undergo-- at baseline and post-test-- health assessments, cognitive tests, and structural and functional magnetic resonance imaging (fMRI), and a blood-draw to assess Alzheimer's risk biomarker levels.",[198,437,196,49],"Alzheimer Disease","2026-02-18",{"date":440,"type":72},"2026-02-20",{"date":442,"type":72},"2023-04-20",{"date":444,"type":23},"2027-08-31",{"name":446,"class":79},"Rutgers, The State University of New Jersey",{"id":448,"slug":449,"hasResults":12,"nctId":450,"briefTitle":451,"officialTitle":451,"acronym":4,"eligibilityCriteria":452,"healthyVolunteers":17,"sex":18,"minAge":453,"maxAge":4,"enrollmentInfo":454,"targetDuration":4,"studyType":92,"phases":4,"briefSummary":456,"conditions":457,"keywords":459,"overallStatus":220,"whyStopped":4,"lastUpdateSubmitDate":464,"lastUpdatePostDateStruct":465,"startDateStruct":467,"completionDateStruct":469,"leadSponsor":470,"locationsCount":472},"100624826","integrating-systematic-data-of-medicine-to-explore-the-solution-for-healthy-aging-isdha-phase-4-100624826","NCT07414680","Integrating Systematic Data of Medicine to Explore the Solution for Healthy Aging (ISDHA) Phase 4","Inclusion Criteria:\n\n* Willing to sign a written participant consent form.\n* Males or females aged 40 or above who have participated in the \"Integrated Systematic Geriatric Medical Information to Explore Solutions for Healthy Aging (Pilot Project),\" the \"Integrated Systematic Geriatric Medical Information to Explore Solutions for Healthy Aging\" master planner, or the \"Integrated Systematic Medical Information to Explore Solutions for Healthy Aging\" project (not subject to exclusion criteria).\n* Males or females aged 40-59 who have participated in health checkups for employees of Chang Gung Memorial Hospital, Formosa Plastics Group, or Chang Gung University.\n* Those with a medical record of more than one year at Chang Gung Memorial Hospital.\n* Those who have resided in Taiwan for more than 180 days in the past year.\n\nExclusion Criteria:\n\n* Individuals with severe organ abnormalities, such as: heart failure (NYHA Fc ≥ III), chronic obstructive pulmonary disease (hospitalization\u002Femergency room visit or medication adjustment within the past month due to disease worsening), decompensated cirrhosis, hemodialysis, or currently undergoing cancer treatment.\n* Individuals with a history of severe autoimmune diseases.\n* Individuals with a preliminary cognitive and mental assessment score of \\\u003C26 on the Mini-Mental State Examination (MMSE) or ≥5 on the Generalized Depression Scale (GDS).\n* Individuals (who agree to undergo brain MRI) who are deemed unsuitable for MRI after evaluation (e.g., those with pacemakers, cochlear implants, or spatial phobia).\n* Individuals who have taken antibiotics within the past month.\n* Individuals whose hearing, vision, or cognitive impairments affect communication.\n* Individuals unable to stand or walk (with a walking aid) or with unsteady gait when walking.\n* Those who have undergone follow-up outpatient assessments that may affect cognitive function, including but not limited to stroke, Parkinson's syndrome, Parkinson's dementia, epilepsy, brain tumor, or a history of mental illness such as schizophrenia, severe depression, bipolar disorder, alcohol or drug abuse, or a history of loss of consciousness due to severe head trauma.\n* Those currently diagnosed with depression and undergoing treatment.\n* Those with a past medical history confirming dementia, depression, etc..\n* Those deemed unsuitable by a physician.","40 Years",{"count":455,"type":23},250,"This project aims to build up the comprehensive health database of geriatric medicine for middle-aged and elderly people in Taiwan.",[458,49,198],"Sleep Disturbance",[460,461,462,463],"dementia","depression","brain structure","system biology","2026-02-12",{"date":466,"type":72},"2026-02-17",{"date":468,"type":23},"2026-03-01",{"date":265,"type":23},{"name":471,"class":79},"Chang Gung Memorial Hospital",2,{"id":474,"slug":475,"hasResults":12,"nctId":476,"briefTitle":477,"officialTitle":478,"acronym":4,"eligibilityCriteria":479,"healthyVolunteers":12,"sex":18,"minAge":238,"maxAge":4,"enrollmentInfo":480,"targetDuration":4,"studyType":24,"phases":482,"briefSummary":483,"conditions":484,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":487,"lastUpdatePostDateStruct":488,"startDateStruct":490,"completionDateStruct":492,"leadSponsor":494,"locationsCount":80},"100492982","amplitude-titration-to-improve-ect-clinical-outcomes-100492982","NCT05699226","Amplitude Titration to Improve ECT Clinical Outcomes","Amplitude Titration to Improve ECT Clinical Outcomes Randomized Clinical Trial","Inclusion Criteria:\n\n* Diagnosis of major depressive disorder or bipolar II\n* Clinical indications for ECT with right unilateral electrode placement\n\nExclusion Criteria:\n\n* Defined neurological or neurodegenerative disorder (e.g., traumatic brain injury, epilepsy, Alzheimer's disease)\n* Other psychiatric conditions (e.g., schizophrenia, bipolar I disorder)\n* Current drug or alcohol use disorder (except for nicotine)\n* Contraindications to MRI.",{"count":481,"type":23},50,[26],"A randomized controlled trial will compare hippocampal neuroplasticity, antidepressant, and cognitive outcomes between individualized amplitude and fixed 800 mA amplitude ECT in older depressed subjects (n = 25 per group, n = 50 total). Relative to fixed 800 mA ECT:\n\nH1: Individualized amplitude arm will have improved RUL antidepressant outcome (IDS-C30 response rates and reduced BT electrode placement switch at V2).\n\nH2: Individualized amplitude arm will have improved cognitive outcomes (DKEFS-Verbal Fluency",[485,486,49],"Depression","ECT","2026-01-23",{"date":489,"type":72},"2026-01-26",{"date":491,"type":72},"2023-09-14",{"date":493,"type":23},"2028-01-01",{"name":495,"class":79},"University of New Mexico",{"id":497,"slug":498,"hasResults":12,"nctId":499,"briefTitle":500,"officialTitle":501,"acronym":502,"eligibilityCriteria":503,"healthyVolunteers":12,"sex":305,"minAge":125,"maxAge":4,"enrollmentInfo":504,"targetDuration":4,"studyType":24,"phases":505,"briefSummary":506,"conditions":507,"keywords":510,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":511,"lastUpdatePostDateStruct":512,"startDateStruct":514,"completionDateStruct":516,"leadSponsor":518,"locationsCount":80},"100418114","improving-cognitive-function-through-high-intensity-interval-training-in-breast-cancer-patients-undergoing-chemotherapy-100418114","NCT04724499","Improving Cognitive Function Through High-intensity Interval Training in Breast Cancer Patients Undergoing Chemotherapy","Improving Cognitive Function Through High-intensity Interval Training in Breast Cancer Patients Undergoing Chemotherapy (The CLARITY Trial)","CLARITY","Inclusion Criteria:\n\n* Written informed consent prior to any study-related procedures\n* Women newly diagnosed (Stage I-III) breast cancer.\n* Over the age of 18 years; children under the age of 18 will be excluded due to rarity of disease\n* The effects of exercise on the developing fetus are unknown. For this reason, women of child-bearing potential must agree to undergo a pregnancy test and to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry and for six months following duration of study participation. Should a woman become pregnant or suspect that she is pregnant while participating on the trial, she should inform her treating physician immediately.\n* Will receive (neo)adjuvant chemotherapy\n* Speak English\n* Able to provide physician clearance to participate in the exercise program\n* Able to initiate a supervised exercise program (free from any cardiovascular, respiratory or musculoskeletal disease or joint problems that preclude moderate physical activity)\n* Have not experienced a weight reduction ≥10% within the past 6 months\n* Currently participate in less than 60 minutes of structured exercise\u002Fweek\n* Does not smoke (no smoking during previous 12 months)\n* Willing to travel to DFCI for assessments (54 visits total for those who elect the exercise group with on campus training session, 6 visits for those that elect the exercise at home option, 6 visits for those assigned to the control group)\n* Ability to understand and the willingness to sign a written informed consent document.\n\nExclusion Criteria:\n\n* Patients should not have any uncontrolled illness including ongoing or active infection, uncontrolled diabetes, hypertension or thyroid disease\n* Patients with other active malignancies are ineligible for this study.\n* Patients with metastatic disease\n* Medical history of coronary heart or artery disease, chronic or acute congestive heart failure or history of systolic or diastolic insufficiencies\n* Participates in more than 60 minutes of structured exercise\u002Fweek\n* Orthopedic or other restrictions or contraindications to high-intensity (cycling) exercise\n* Have a pacemaker or any implantable device that are not MRI safe; the BWH\u002FDFCI Standard MRI screening form\n* Is unable to travel to DFCI\n* Patients who are pregnant\n* Patients with claustrophobia\n* Subjects, who in the opinion of the investigator, may not be able to comply with the safety monitoring requirements of the study.",{"count":276,"type":23},[26],"The purpose of this research is to determine whether a 16-week high intensity interval training (HIIT) exercise program will improve brain health among women undergoing chemotherapy and also improve cardiovascular (heart) function.\n\nThe names of the study interventions involved in this study are\u002Fis:\n\n* High-Intensity Interval Training (HIIT)",[312,508,509,49],"Chemotherapy Effect","Exercise Therapy",[312,508,509,49],"2026-01-20",{"date":513,"type":72},"2026-01-22",{"date":515,"type":72},"2021-07-14",{"date":517,"type":23},"2027-04-01",{"name":519,"class":79},"Dana-Farber Cancer Institute",{"id":521,"slug":522,"hasResults":12,"nctId":523,"briefTitle":524,"officialTitle":525,"acronym":526,"eligibilityCriteria":527,"healthyVolunteers":12,"sex":18,"minAge":453,"maxAge":4,"enrollmentInfo":528,"targetDuration":4,"studyType":24,"phases":530,"briefSummary":531,"conditions":532,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":534,"lastUpdatePostDateStruct":535,"startDateStruct":537,"completionDateStruct":539,"leadSponsor":541,"locationsCount":80},"100533573","cognition-after-osa-treatment-among-native-american-people-catnap-100533573","NCT06227572","Cognition After OSA Treatment Among Native American People (CATNAP)","Cognition After Obstructive Sleep Apnea (OSA) Treatment Among Native American People (CATNAP)","CATNAP","Inclusion Criteria:\n\n* Age 50 years and older\n* Self report American Indian or Alaskan Native\n* diagnosed with obstructive sleep apnea\n* prescribed PAP therapy and have a device\n* \\*Ability to understand written and spoken English; and\n* \\*Ability and willingness to follow all study protocols.\n\nExclusion Criteria:\n\n* Living in a household with someone who is enrolled in the study\n* Already using PAP device at Medicaid recommended standards\n* Cognitive decline, unable to consent on their own",{"count":529,"type":23},140,[26],"This research project will develop and implement a motivational interviewing and electronic messaging intervention to address obstructive sleep apnea (OSA), positive airway pressure (PAP) adherence, and risk of Alzheimer's disease and related dementias in American Indians. The project will work with American Indian Elders, aged 50 years and older, from three Northern Plains Reservations and surrounding communities. A total of 300 American Indian elders with a confirmed OSA diagnosis and prescribed PAP therapy will be randomized to receive usual care consisting of PAP therapy alone (control condition) or usual care plus the culturally informed CATNAP MI component (intervention condition).",[533,49],"Obstructive Sleep Apnea","2026-01-07",{"date":536,"type":72},"2026-01-09",{"date":538,"type":72},"2025-02-06",{"date":540,"type":23},"2027-12-31",{"name":542,"class":79},"Washington State University",{"id":544,"slug":545,"hasResults":12,"nctId":546,"briefTitle":547,"officialTitle":548,"acronym":549,"eligibilityCriteria":550,"healthyVolunteers":17,"sex":18,"minAge":551,"maxAge":161,"enrollmentInfo":552,"targetDuration":4,"studyType":24,"phases":554,"briefSummary":556,"conditions":557,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":561,"lastUpdatePostDateStruct":562,"startDateStruct":564,"completionDateStruct":566,"leadSponsor":568,"locationsCount":80},"100449927","early-phase-1-time-in-bed-restriction-in-older-adults-with-sleep-difficulties-with-and-without-risk-for-alzheimers-disease-100449927","NCT05138848","Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease","Slow-wave Sleep Enhancement in Those at Risk for Alzheimer's Disease: Links With Memory, Excitotoxicity, and Plasma A-beta","ALPS","Inclusion Criteria:\n\n1. Age 65-85.\n2. Self-report mean sleep efficiency (the time in bed spent asleep within the time of lights out to final awakening) \\\u003C 90% based on diary and actigraphy estimates and wake time after sleep onset \\> 20 minutes based on diary and actigraphy estimates.\n3. Self-reported normal or corrected-to-normal visual and auditory acuity.\n\nExclusion Criteria:\n\n1. Shift work involving night shift or regular work within the hours of 12am and 6am.\n2. Presence of a chronic condition that significantly affects sleep.\n3. Severe psychiatric condition including major depressive disorder, panic disorder, substance use disorders, and alcohol abuse\u002Fdependence within the past 6 months, or a lifetime history of a psychotic disorder or bipolar I disorder, based on initial online\u002Fphone self-report diagnoses, and subsequently based on a structured psychiatric interview.\n4. Current use of medications affecting sleep such as antidepressants, antipsychotic medications, anticonvulsants, and steroids.\n5. Current use of sedating drugs used at bedtime.\n6. Consumption of \\> 14 alcohol drinks per week or \\> 6 drinks at a single sitting.\n7. Consumption of \\> 3 caffeine drinks per day.\n8. Prior diagnosis of a Central nervous system (CNS) disease, such as multiple sclerosis, stroke, Parkinson's disease, Alzheimer's disease, seizure disorder, delirium or dementia, a loss of consciousness \\> 24 hours, or traumatic brain injury as identified by the Cumulative Illness Rating Scale for Geriatrics (CIRS). Participants who are diagnosed with Alzheimer's disease based on neuropsychological testing will be excluded.\n9. Sleep efficiency \\> 90% and wake time after sleep onset \\\u003C 20 minutes consistent with the rationale of the inclusion criteria described above.\n10. Apnea\u002Fhypopnea index greater than 15 as determined by one night of Apnea Link Plus screening.\n11. Metal in the body. Rationale: Due to the nature of magnetic resonance imaging (MRI), participants cannot have any metal implants in their bodies, cannot have worked in a metal shop or been exposed to metal fragments during combat. Metal dental work (e.g. fillings crowns) may be allowed if compatible with the fMRI scanner.\n12. Claustrophobia. Rationale: Could prevent the participant from completing the MRI scans.\n13. Severe obesity. BMI \\> 40. Rationale: Could prevent the participant from completing the MRI scan.\n14. Near-miss or prior automobile accident \"due to sleepiness\" within the past 12 months. Rationale: reduces the risk of sleepiness-related accidents.\n15. Employed as a commercial driver during the study (for example, bus drivers, train engineers, airplane pilots). Rationale: reduces the risk of sleepiness-related accidents.\n16. A score below 23 on the Telephone Interview for Cognitive Status. Rationale: This cut-off has been demonstrated to differentiate well between individuals with mild cognitive impairment from individuals with dementia who would have decision making impairments (Seo et al. 2011, Archives of Gerontology and Geriatrics). This ensures that decision making abilities are intact.\n17. An Epworth sleepiness score greater than 10. Rationale: ensures that sleepiness is not excessive before starting the intervention that could further increase sleepiness. (Mazzotti, Diego R., et al. \"Is the Epworth Sleepiness Scale sufficient to identify the excessively sleepy subtype of OSA?.\" Chest 161.2 (2022): 557-561; Aurora, R. Nisha, et al. \"Correlating subjective and objective sleepiness: revisiting the association using survival analysis.\" Sleep 34.12 (2011): 1707-1714.)","65 Years",{"count":553,"type":23},116,[555],"EARLY_PHASE1","Dementia caused by Alzheimer's disease affects approximately 5.6 million adults over age 65, with costs expected to rise from $307 billion to $1.5 trillion over the next 30 years. Behavioral interventions have shown promise for mitigating neurodegeneration and cognitive impairments. Sleep is a modifiable health behavior that is critical for cognition and deteriorates with advancing age and Alzheimer's disease. Thus, it is a priority to examine whether improving sleep modifies Alzheimer's disease pathophysiology and cognitive function. Extant research suggests that deeper, more consolidated sleep is positively associated with memory and executive functions and networks that underlie these processes. Preliminary studies confirm that time-in-bed restriction interventions increase sleep efficiency and non-rapid eye movement slow-wave activity (SWA) and suggest that increases in SWA are associated with improved cognitive function. SWA reflects synaptic downscaling predominantly among prefrontal connections. Downscaling of prefrontal connections with the hippocampus during sleep may help to preserve the long-range connections that support memory and cognitive function. In pre-clinical Alzheimer's disease, hyperactivation of the hippocampus is thought to be excitotoxic and is shown to leave neurons vulnerable to further amyloid deposition. Synaptic downscaling through SWA may mitigate the progression of Alzheimer's disease through these pathways. The proposed study will behaviorally increase sleep depth (SWA) through four weeks of time-in-bed restriction in older adults characterized on amyloid deposition and multiple factors associated with Alzheimer's disease risk. This study will examine whether behaviorally enhanced SWA reduces hippocampal hyperactivation, leading to improved task-related prefrontal-hippocampal connectivity, plasma amyloid levels, and cognitive function. This research addresses whether a simple, feasible, and scalable behavioral sleep intervention improves functional neuroimaging indices of excitotoxicity, Alzheimer's pathophysiology, and cognitive performance.",[558,247,559,49,560],"Alzheimer Disease, Late Onset","Sleep","Amyloid","2025-12-17",{"date":563,"type":72},"2025-12-19",{"date":565,"type":72},"2022-01-03",{"date":567,"type":23},"2026-05-31",{"name":569,"class":79},"University of Pittsburgh",{"id":571,"slug":572,"hasResults":12,"nctId":573,"briefTitle":574,"officialTitle":575,"acronym":4,"eligibilityCriteria":576,"healthyVolunteers":17,"sex":18,"minAge":20,"maxAge":577,"enrollmentInfo":578,"targetDuration":4,"studyType":24,"phases":580,"briefSummary":581,"conditions":582,"keywords":583,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":587,"lastUpdatePostDateStruct":588,"startDateStruct":590,"completionDateStruct":592,"leadSponsor":594,"locationsCount":80},"100604313","executive-function-training-for-children-and-adolescents-100604313","NCT07147894","Executive Function Training for Children and Adolescents","Understanding Mediating and Moderating Factors That Determine Transfer of Working Memory Training in Adolescents","Inclusion Criteria:\n\n* 12-17 years old.\n* Child must have a caregiver (parent\u002Fguardian) who is available to participate as a training aide.\n* Child and parent\u002Fcaregiver are able to understand\u002Fspeak adequate English or Spanish to follow and participate in study procedures\n* Both child and parent\u002Fguardian are willing to give informed consent\u002Fassent, be randomized to either intervention condition, and be willing to follow the assigned study protocol.\n* \\~50% of the participants: Meet criteria for ADHD DSM-5 diagnosis.\n\nExclusion Criteria:\n\n* Child is taking ADHD medication\u002Fstimulants.\n* Child has been formally identified as intellectually disabled.\n* Abnormal visual acuity or hearing challenges that are prohibitive to participating in the intervention\u002Fassessment.\n* History of organic mental disorders (conditions or disturbances that may be caused by injuries and\u002For neurodegenerative diseases affecting brain tissues), psychosis, history of autism spectrum disorders, intellectual disability, or active substance use or suicidal ideation (such individuals will be referred to psychiatric services).\n* Major sensory or motor impairment that would preclude valid cognitive testing.\n* Participants with color blindness, if they are unable to discriminate the task relevant stimuli.\n* Populations considered vulnerable such as wards and those with neurological or other health conditions that may prevent the ability to give informed consent.","17 Years",{"count":579,"type":23},780,[26],"The goal of this clinical trial is to evaluate how different approaches to executive function (like adding game-like features, varying the number of tasks, and providing coaching) can enhance executive function outcomes in adolescents with and without ADHD. The main questions it aims to answer are:\n\n* What components of executive function training contribute most to improving outcomes?\n* How do training components vary in their impacts on adolescents diagnosed with ADHD compared to those without a diagnosis?\n* What individual characteristics influence the effectiveness of executive function training?\n\nResearchers will test six different training setups to examine which setups are the most effective for different people. They will evaluate both how well participants follow the training schedule and whether there are changes in psychological and cognitive outcomes after training.\n\nParticipants will complete:\n\n* 40 training sessions over 4 weeks\n* A set of tests and surveys before and after the training\n* Follow-up assessments and surveys 6 months after finishing the training",[49],[584,585,586,168],"ADHD","Executive Function Training","Motivational coaching","2025-12-16",{"date":589,"type":72},"2025-12-23",{"date":591,"type":72},"2025-12-14",{"date":593,"type":23},"2028-06-30",{"name":595,"class":79},"Northeastern University",{"id":597,"slug":598,"hasResults":12,"nctId":599,"briefTitle":600,"officialTitle":600,"acronym":4,"eligibilityCriteria":601,"healthyVolunteers":17,"sex":18,"minAge":125,"maxAge":161,"enrollmentInfo":602,"targetDuration":4,"studyType":24,"phases":604,"briefSummary":605,"conditions":606,"keywords":607,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":609,"lastUpdatePostDateStruct":610,"startDateStruct":612,"completionDateStruct":614,"leadSponsor":616,"locationsCount":180},"100508020","moderators-and-mediators-of-perceptual-learning-100508020","NCT05894967","Moderators and Mediators of Perceptual Learning","Inclusion Criteria:\n\n* between18 and 30 years of age (younger cohort)\n* between 60 and 85 years of age (older cohort)\n* Corrected vision of 20\u002F40 or better (as assessed with an eye chart)\n* No reported incidence of retinal pathology or neurological disease\n\nExclusion Criteria:\n\n* Corrected vision of 20\u002F40 or worse\n* Evidence of retinal pathology or retinal disease",{"count":603,"type":23},1140,[26],"This is a research study about how training can impact performance on cognitive tasks. Participants are between 18 and 30 and 60 to 85 years of age, have normal (or corrected to normal) vision, and have no neurological conditions that would preclude their ability to complete computerized cognitive tasks. Up to 1140 participants will be on study for up to 8 weeks.",[49],[608],"Vision Training","2025-12-10",{"date":611,"type":72},"2025-12-15",{"date":613,"type":72},"2023-04-14",{"date":615,"type":23},"2027-03-31",{"name":179,"class":79},{"id":618,"slug":619,"hasResults":12,"nctId":620,"briefTitle":621,"officialTitle":621,"acronym":4,"eligibilityCriteria":622,"healthyVolunteers":17,"sex":18,"minAge":125,"maxAge":551,"enrollmentInfo":623,"targetDuration":4,"studyType":24,"phases":625,"briefSummary":626,"conditions":627,"keywords":4,"overallStatus":220,"whyStopped":4,"lastUpdateSubmitDate":628,"lastUpdatePostDateStruct":629,"startDateStruct":631,"completionDateStruct":633,"leadSponsor":635,"locationsCount":4},"100462573","study-of-low-intensity-focused-ultrasound-effects-on-cognitive-fmri-signals-100462573","NCT05303428","Study of Low-intensity Focused Ultrasound Effects on Cognitive fMRI Signals","Inclusion Criteria:\n\n* Healthy volunteers, all ethnicities, who understand and speak English.\n\nExclusion Criteria:\n\n1. Claustrophobia (scanning environment may be uncomfortable).\n2. Contraindications to MRI: including pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants.\n3. Contraindications to CT: pregnancy\n4. Active medical disorder or treatment with potential CNS effects (e.g. Alzheimer's)\n5. History of neurologic disorder. (e.g. Parkinson's, Epilepsy, or Essential Tremor)\n6. History of head injury resulting in loss of consciousness for \\>10 minutes.\n7. History of alcohol or drug dependence (through self-report).",{"count":624,"type":23},80,[26],"Study aims to examine the effects of noninvasive brain stimulation on brain signals. This insight may have potential clinical implications for addiction, pain, and mental health populations. Participants will receive MRI and CT imaging. Participants receive low-intensity focused ultrasound (LIFU) to temporarily change brain activity. Participants then receive fMRI scans to measure changes in both resting and cognitive brain signaling using structured tasks. Heart rate, blood pressure, respiratory rate, and skin moisture is monitored. Participants complete a battery of questionnaires, both behavioral and symptom monitoring. The study takes place over 4 study visits.",[49],"2025-12-08",{"date":630,"type":72},"2025-12-09",{"date":632,"type":23},"2026-10",{"date":634,"type":23},"2028-04",{"name":636,"class":79},"Virginia Polytechnic Institute and State University",{"id":638,"slug":639,"hasResults":12,"nctId":640,"briefTitle":641,"officialTitle":642,"acronym":643,"eligibilityCriteria":644,"healthyVolunteers":12,"sex":305,"minAge":453,"maxAge":4,"enrollmentInfo":645,"targetDuration":4,"studyType":92,"phases":4,"briefSummary":646,"conditions":647,"keywords":651,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":655,"lastUpdatePostDateStruct":656,"startDateStruct":658,"completionDateStruct":660,"leadSponsor":662,"locationsCount":80},"100597148","surviving-daily-life-100597148","NCT07054723","Surviving Daily Life","Daily Stress Process and Daily Cognitive Performance Among Racially Diverse Breast Cancer Survivors: A Feasibility and Validation Study","GOCE","Inclusion Criteria:\n\nIndividuals must meet all of the following inclusion criteria in order to be eligible to participate in the study:\n\n* Individuals 40 or older\n* Five or more years after breast cancer diagnosis\n* Self-identified as Asian, Black, Latina, or white\n* Able to read in English, Spanish, or Chinese\n\nExclusion Criteria:\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n* Under 40\n* Cannot provide informed consent",{"count":276,"type":23},"The primary goal of this project is to evaluate the feasibility of a 14-day mobile daily diary study among racially diverse breast cancer survivors. Further, the investigators will examine the validity and reliability of the daily stress and daily cognitive performance measures among breast cancer survivors. This pilot project will recruit 30 racially diverse breast cancer survivors (Asian, Black, Latina, and white; ages 40 and older; at least five years post-diagnosis) who are patients at the Sidney Kimmel Comprehensive Cancer Center. The daily diary survey questions will be available in English, Spanish, and Chinese to accommodate the preferred language of the target participants.",[648,49,312,649,650,48],"Stress","Breast Carcinoma","Breast Neoplasm",[652,653,654],"Mobile Survey","Daily Diary","Breast Cancer Survivors","2025-10-20",{"date":657,"type":72},"2025-10-22",{"date":659,"type":72},"2025-10-02",{"date":661,"type":23},"2026-10-31",{"name":663,"class":79},"Thomas Jefferson University",{"id":665,"slug":666,"hasResults":12,"nctId":667,"briefTitle":668,"officialTitle":669,"acronym":670,"eligibilityCriteria":671,"healthyVolunteers":12,"sex":18,"minAge":125,"maxAge":161,"enrollmentInfo":672,"targetDuration":4,"studyType":24,"phases":674,"briefSummary":675,"conditions":676,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":681,"lastUpdatePostDateStruct":682,"startDateStruct":684,"completionDateStruct":686,"leadSponsor":688,"locationsCount":80},"100581271","using-non-invasive-brain-stimulation-to-treat-word-finding-difficulty-in-chronic-traumatic-brain-injury-100581271","NCT06848140","Using Non-invasive Brain Stimulation to Treat Word Finding Difficulty in Chronic Traumatic Brain Injury","Using High Definition Transcranial Direct Current Stimulation to Treat Verbal Retrieval Deficits Secondary to Chronic Traumatic Brain Injury (STIM-CTBI)","STIM-CTBI","Inclusion Criteria:\n\n* Age between 18 and 85\n* Fluent in speaking and reading English\n* Able to provide informed consent\n* Has a TBI at least one year prior to enrollment and not related to military experience\n* Has a confirmation of verbal retrieval difficulties as measured by the Verbal Retrieval Difficulty Interview questions\n\nExclusion Criteria:\n\n* Lifetime major or active neurologic conditions (e.g., stroke, epilepsy, brain tumor, dementia, seizure occurrence less than one year ago)\n* Lifetime major or active cardiovascular conditions (e.g., cardiac arrythmia, heart failure, heart attack)\n* Current substance use disorder\n* Lifetime major psychiatric disorders (e.g., schizophrenia, bipolar disorder)\n* Severe depression at the time of enrollment (BDI-II \\>= 29) or psychiatric ER visits or hospitalization less than 6 months ago prior to enrollment\n* Current sensory (e.g., blind, deaf) or physical (e.g., severe motor weakness) impairment that interferes with testing\n* Contraindications for tDCS or MRI\n* The person cannot be left alone for 8+ hours.\n* Not verbally communicative.\n* Currently undergoing and not wishing to discontinue speech and cognitive therapy during study participation.\n* Incapable of understanding the consent or unable to consent for oneself.\n* Unable to travel to BIDMC's Berenson-Allen Center\n* Pregnancy",{"count":673,"type":23},24,[26],"The purpose of this study is to learn more about how brain stimulation affects word finding problems in people who have a traumatic brain injury (TBI). The type of brain stimulation used is called transcranial direct current stimulation (tDCS). tDCS delivers low levels of electric current to the brain and high definition tDCS (HD-tDCS) delivers the current with multiple electrodes on the scalp. This current is delivered with HD-tDCS to parts of the brain that may help with remembering things. The investigators hope that this can help to improve word finding and memory problems in people with TBI.",[677,678,679,49,680],"Traumatic Brain Injury","Word Finding Difficulty","Cognitive Symptom","Acquired Brain Injury","2025-10-19",{"date":683,"type":72},"2025-10-21",{"date":685,"type":72},"2025-10-01",{"date":687,"type":23},"2028-04-30",{"name":689,"class":79},"Beth Israel Deaconess Medical Center",{"id":691,"slug":692,"hasResults":12,"nctId":693,"briefTitle":694,"officialTitle":694,"acronym":695,"eligibilityCriteria":696,"healthyVolunteers":12,"sex":18,"minAge":697,"maxAge":431,"enrollmentInfo":698,"targetDuration":4,"studyType":92,"phases":4,"briefSummary":700,"conditions":701,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":705,"lastUpdatePostDateStruct":706,"startDateStruct":708,"completionDateStruct":710,"leadSponsor":711,"locationsCount":80},"100540139","multidimensional-evaluation-of-patients-affected-by-obstructive-apnea-syndrome-osas-before-and-after-ventilotherapy-100540139","NCT06312956","Multidimensional Evaluation of Patients' Affected by Obstructive Apnea Syndrome (OSAS) Before and After Ventilotherapy","MULTI-OSAS","Inclusion Criteria:\n\n* OSAS diagnosis (AHI \\> 5)\n* handedness: right\n\nExclusion Criteria:\n\n* previous ventilotherapy\n* neurological and\u002For neurodegenerative conditions\n* Personality disorders, autism spectrum disorders, schizophrenia, psychosis\n* sleep disorders comorbidities (eg., narcolepsy)","20 Years",{"count":699,"type":23},65,"This observational study aims to evaluate multiple dimensions of health in patients with Obstructive Sleep Apnea Syndrome (OSAS), before and after three weeks of ventilotherapy.\n\nSpecifically, the study aims to identify pre- vs post-treatment differences in the following domains:\n\n* cognitive performance\n* blood expression of biomarkers related to neurodegeneration\n* psychosocial wellbeing\n\nThus, patients will complete the following evaluations before (T0) and after (T1) ventilotherapy:\n\n* neuropsychological standard assessment\n* blood sampling\n* psychosocial self-reported questionnaires",[533,702,703,282,49,704],"Sleep Disorder","Well-Being, Psychological","Neurologic Signs","2025-09-02",{"date":707,"type":72},"2025-09-09",{"date":709,"type":72},"2024-02-29",{"date":226,"type":23},{"name":712,"class":79},"Istituto Auxologico Italiano",{"id":714,"slug":715,"hasResults":12,"nctId":716,"briefTitle":717,"officialTitle":718,"acronym":719,"eligibilityCriteria":720,"healthyVolunteers":12,"sex":18,"minAge":453,"maxAge":4,"enrollmentInfo":721,"targetDuration":4,"studyType":24,"phases":723,"briefSummary":724,"conditions":725,"keywords":728,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":730,"lastUpdatePostDateStruct":731,"startDateStruct":733,"completionDateStruct":735,"leadSponsor":737,"locationsCount":80},"100510107","oriental-intervention-for-enhanced-neurocognitive-health-orient-diet-in-patients-with-intracranial--carotid-stenosis-100510107","NCT05922137","Oriental Intervention for Enhanced Neurocognitive Health (ORIENT) Diet in Patients With Intracranial \u002F Carotid Stenosis","Oriental Intervention for Enhanced Neurocognitive Health (ORIENT) Diet in Patients With Intracranial \u002F Carotid Stenosis : a Randomized Controlled Trial","ORIENT","Inclusion Criteria:\n\n* Patients aged ≥ 40 years\n* ≥ 50% stenosis in unilateral intracranial \u002F carotid artery\n* Written informed consent available\n* Willingness to complete all assessments and participate in follow-up\n* Adequate Visual and auditory acuity to undergo neuropsychological testing\n\nExclusion Criteria:\n\n* Previous history of major head trauma and any intracranial surgery\n* Intracranial abnormalities, such as intracerebral hemorrhage, subarachnoid hemorrhage and other space occupying lesions\n* Extrapyramidal symptoms or mental illness which may affect neuropsychological measurement\n* Severe loss of vision, hearing, or communicative ability\n* Nuts, berries, olive oil, or fish allergies\n* Patients presenting a malignant disease with life expectancy \\\u003C 3 years\n* Participation in an ongoing investigational drug study\n\nExit Criteria:\n\n* Not meet the inclusion criteria\n* For any poor adherence, not comply with the requirements of the follow-up, or safety reasons determined by investigator\n* Any adverse or serious adverse events during the study period judged by Investigator",{"count":722,"type":23},120,[26],"To test the effects of 6 month additional intervention of ORIENT diet versus usual medical treatment for Intracranial \u002F Carotid Stenosis on cognitive decline, multi-mode MRI image markers and serum and fecal biomarkers in a randomized controlled trial of 120 patients with intracranial \u002F carotid stenosis, who are aged older than 40 years and without dementia.",[283,49,726,727],"Stenosis","Dementia",[729],"Cognitive decline","2025-06-11",{"date":732,"type":72},"2025-06-15",{"date":734,"type":72},"2023-05-01",{"date":736,"type":23},"2027-05-31",{"name":738,"class":79},"Second Affiliated Hospital, School of Medicine, Zhejiang University"]