[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cognitive-complaint\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cognitive-complaint":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100632711","tavns--cct-for-neurocognitive-rehab-100632711",false,"NCT07517237","taVNS + CCT for Neurocognitive Rehab","Combining At-Home Transcutaneous Auricular Vagus Nerve Stimulation and Computerized Cognitive Training for Neurocognitive Rehabilitation","NeuroHUB","Inclusion Criteria:\n\ni. Ages 45-80 (inclusive) ii. Adequate sensorimotor function (including motor function of dominant hand to complete CCT) and verbal expressive abilities to complete all assessments.\n\niii. Access to reliable Wi-Fi and a Bluetooth-enabled mobile phone or tablet with internet connection capable of supporting study procedures.\n\niv. Self-reported change in cognitive functioning (e.g., memory, attention, thinking abilities) compared to prior functioning, persisting ≥ 6 months and associated with concern and\u002For impact on daily functioning.\n\nv. Is on fixed pharmacotherapy (i.e. stable dose of medication\u002Fs) for ≥ 4 weeks before enrollment, and expected to remain stable throughout study participation. This includes, but is not limited to, cholinesterase inhibitors, NMDA receptor antagonists, and antidepressants.\n\nExclusion Criteria:\n\ni. Prior diagnosis of Mild Cognitive Impairment or Dementia (NIA-AA) or Mild or Major Neurocognitive Disorder (DSM-5).\n\nii. taVNS contraindications (e.g., history of seizures, history of trauma or damage to ear, reduced\u002Fimpaired sensation in the ear).\n\niii. MRI contraindications (e.g., ferromagnetic implants, claustrophobia). iv. Presence of a neurological, medical, or psychiatric condition that is acute, unstable, or severe, and that, in the judgment of the study investigators, would significantly interfere with safe participation, valid assessment of cognition or mood, or interpretation of study outcomes.\n\nv. Enrolled in a clinical trial or has received an investigational medication or device in the last 30 days that may impact cognition or mood.\n\nvi. For female participants, a positive pregnancy test if still menstruating within the past 12 months.","ALL","45 Years","80 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this study is to investigate whether combining transcutaneous auricular vagus nerve stimulation (taVNS) with computerized cognitive training might help improve thinking abilities and mood. Participants will self-administer these treatment in their homes and undergo pre- and post-treatment assessments of thinking abilities and mood and brain MRIs.",[28,29,30,31],"Psychosocial Well-being","Neurocognitive Function","Cognitive Complaint","Cognitive Dysfunction",[33,31,34,35,36],"Transcutaneous Auricular Vagus Nerve Stimulation","Psychosocial Function","cognitive training","mindfulness meditation","RECRUITING","2026-04-03",{"date":40,"type":41},"2026-04-08","ACTUAL",{"date":43,"type":41},"2026-03-12",{"date":45,"type":22},"2026-09-15",{"name":47,"class":48},"Medical University of South Carolina","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":49},"100598217","neurophysiological-and-behavioral-study-of-the-cognitive-deficits-associated-with-cerebral-small-vessel-disease-in-the-shiva-cohort-shiva-cogneurophys-100598217","NCT07068620","Neurophysiological and Behavioral Study of the Cognitive Deficits Associated With Cerebral Small Vessel Disease in the SHIVA Cohort. SHIVA-CogNeurophys","Neurophysiological and Behavioral Study of the Cognitive Deficits Associated With Cerebral Small Vessel Disease in the SHIVA Cohort - SHIVA-CogNeurophys","SHIVA-CogNeuro","Inclusion Criteria:\n\n* Patients included or previously included in the SHIVA cohort\n* Basic computer skills (ability to open a browser, use a mouse and keyboard)\n* Access to a personal computer with an internet connection\n* Independent in Activities of Daily Living (ADL) with a score ≥ 5\u002F6, and in Instrumental Activities of Daily Living (IADL) with a score ≥ 4\u002F8\n* Informed and written consent signed by the participant and the investigating physician for this study\n\nExclusion Criteria:\n\n* Motor impairments preventing the use of a keyboard and mouse (e.g., motor issues related to severe hand osteoarthritis)\n* Depressive symptoms indicated by a score of 2 to 4 on the mini Geriatric Depression Scale (mini GDS), which includes 4 items\n* Age-related macular degeneration (AMD)\n* Untreated glaucoma\n* Untreated psychiatric conditions that interfere with cognitive assessments\n* Diagnosed attention deficit disorder with or without hyperactivity or patients who could not complete all cognitive tests required in the SHIVA cohort\n* Systemic diseases that cause cognitive changes, such as obesity and metabolic disorders\n* History of epilepsy or seizures\n* Scalp sensitivity or skin lesions (dermatitis, wounds, etc.)\n\nContraindications for the use of electrical stimulation:\n\n* Surgical clips, metal sutures, staples, stents\n* Osteosynthesis material in the head or neck\n* Pacemaker\n* Implanted hearing aid\n* Ocular foreign bodies, shrapnel, bullets\n* Metalworker\n* Pacemaker or neurostimulator\n* Heart valve or endovascular material\n* Ventricular shunt valve\n\n  * Recent exposure (\\\u003C 6 months) to brain stimulation (tDCS, TMS, etc.)\n  * Ongoing participation in a clinical trial or cognitive training program","18 Years",{"count":60,"type":22},80,[25],"Cerebral small vessel disease (cSVD) is characterized by an alteration of the structure and function of small penetrating brain arteries. Highly prevalent in older individuals from the general population, it represents a leading cause of stroke and a major contributor to cognitive decline and risk of dementia.\n\nBetter detection and management of covert cSVD would have a major impact on preventing disability and costs related to stroke, cognitive impairment and dementia. The aim of the present study is to identify novel electroencephalographic (EEG) biomarkers of the cognitive deficits associated with cSVD, and how these biomarkers and cognitive performance are affected by personalized cognitive training or transcranial alternating current stimulation (tACS), a non-invasvie brain stimulation technique.",[64,65,30],"Cerebral Small Vessel Disease","Stroke",[67,68,69,70,71,72,73,74,35,75],"Cognitive decline","dementia","stroke","small vessel disease","healthy brain aging","electroencephalography","neuromodulation","transcranial alternating current stimulation","cognitive rehabilitation","2026-01-30",{"date":78,"type":41},"2026-02-02",{"date":80,"type":41},"2025-08-07",{"date":82,"type":22},"2028-03-07",{"name":84,"class":48},"University Hospital, Bordeaux"]