[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cognitive-decline-in-older-adults\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cognitive-decline-in-older-adults":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100630237","phase-4-exercise-and-diabetes-interventions-to-improve-brain-health-in-older-adults-with-type-2-diabetes-100630237",false,"NCT07485062","Exercise and Diabetes Interventions to Improve Brain Health in Older Adults With Type 2 Diabetes","Metabolic Optimization and Training InterVentions for Aging and Type 2 Diabetes to Enhance Cognition: the MOTIVATE Study","MOTIVATE","Inclusion Criteria:\n\n1. Informed consent obtained before any trial-related activities. Trial-related activities are any procedures that are carried out as part of the trial, including activities to determine suitability for the trial.\n2. Community-dwelling\n3. Male or female\n4. Age ≥ 65 at the time of signing informed consent\n5. Glycated hemoglobin levels of ≥7% (i.e., A1c levels high enough to see intervention-related changes and increase eligibility for recruitment, but can exercise safely)\n6. Eligible for the Ontario Drug Benefit (inadequate glycemic control and on max tolerated dose of metformin or metformin contraindicated or inappropriate)\n7. Score \\>24\u002F30 on the Mini-Mental State Exam (MMSE)\n8. Score \\>6\u002F8 on the Lawton Instrumental Activities of Daily Living Scale (IADL)\n9. Have visual acuity of \\>20\u002F40 with or without corrective lenses\n10. Speak and understand English fluently\n11. Complete the Physical Activity Readiness Questionnaire (PAR-Q+) and obtain physician clearance to start a supervised exercise program\n12. Comfortable with a blood draw\n13. Not currently engaging in structured resistance exercise more than once per week\n\nExclusion Criteria:\n\n1. Have a medical condition for which semaglutide or exercise is contraindicated\n2. Use of a GLP-1 receptor agonist in the past 6 months (i.e., offers removal of Semaglutide from the system as it has a half-life of around 1 week; thus, 8-10 weeks are required for a washout.\n\n3\\) Have engaged regularly (\\>1\u002Fweek) in aerobic or RE within the past 6 months 4) Have a neurodegenerative disease (i.e., dementia) or psychiatric condition 5) Have had untreated depression in the past 6 months (6) Have experienced a recent vascular incident (i.e., stroke, myocardial infarction in the last 6 months.) (7) Have severe peripheral neuropathy, an active foot wound, or severe musculoskeletal\u002Fjoint disease (8) Active or untreated retinopathy (9) Taking psychotropic medications (excluding those for the treatment of depression)","ALL","65 Years",{"count":20,"type":21},164,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Type 2 diabetes and low levels of physical activity are associated with an increased risk of cognitive decline in older adults. Improving blood sugar control and engaging in regular exercise may help support brain health and physical function in this population.\n\nThe MOTIVATE study is a randomized clinical trial designed to examine the effects of supervised exercise and diabetes treatment with semaglutide, alone or in combination, on cognitive function, physical health, and brain-related outcomes in older adults with Type 2 diabetes. Participants will be assigned to one of four study groups involving exercise training, control exercise, semaglutide treatment, or standard diabetes care.\n\nParticipants will complete supervised exercise sessions three times per week for 32 weeks, with some participants also receiving weekly semaglutide injections for 16 weeks. Assessments will include cognitive testing, physical and functional measures, blood-based metabolic markers, and brain imaging. This study aims to improve understanding of how exercise and diabetes treatments may support brain health in older adults with Type 2 diabetes.",[27,28],"Type 2 Diabetes","Cognitive Decline in Older Adults",[30,31,32,33,34,35,27],"Exercise Training","Semaglutide","Brain Health","Cognitive Function","Older Adults","Physical Activity","NOT_YET_RECRUITING","2026-03-16",{"date":39,"type":40},"2026-03-20","ACTUAL",{"date":42,"type":21},"2026-05-01",{"date":44,"type":21},"2029-05-01",{"name":46,"class":47},"Western University, Canada","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":62,"conditions":63,"keywords":68,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":48},"100605296","tech-based-respite-care-for-caregivers-and-homebound-older-adults-100605296","NCT07160673","Tech-based Respite Care for Caregivers and Homebound Older Adults","Tech-based Respite Care for Caregivers and Homebound Older Adults: A Randomized Controlled Trial","TechRespiteRCT","Caregivers (CGs)\n\nInclusion Criteria:\n\n* Aged 18 or above\n* Provide care to at least one homebound older adult (aged 60 or above)\n* Provide no less than 6 hours of caregiving per week\n* Able to communicate in either Cantonese, Mandarin or English\n* Willing to participate for the entire duration\n* Able to tolerate VR headset for at least 5 minutes (no severe motion sickness\u002Fepilepsy)\n\nExclusion Criteria:\n\n* History of severe psychiatric disorders (e.g., schizophrenia, bipolar)\n* Severe cognitive impairment (MMSE \\\u003C10)\n* Major neurological diseases (e.g., recent stroke, severe Parkinson's)\n* Uncorrectable visual\u002Fhearing impairments affecting VR\u002Fvideo\n* Unable to tolerate VR due to motion sickness or discomfort\n* Care recipient receiving long-term care service that conflicts with study\n\nCare Recipients (CRs)\n\nInclusion Criteria:\n\n* Aged 60 or above\n* Homebound (unable to leave home without assistance)\n* Stable medical condition\n* Willing to participate for the entire duration\n* Able to tolerate VR headset for at least 5 minutes (no VR contraindications)\n* Able to understand and provide informed consent Exclusion Criteria: Same as CGs, plus MMSE \\\u003C10","18 Years",{"count":59,"type":21},180,[61],"NA","The goal of this study is to examine the effectiveness of VR-based respite in improving cognitive function, mental health, and quality of life in caregivers and homebound older adults compared to a control group using videos and a usual care group. Participants are randomly assigned to one of three groups: VR intervention, video control, or usual care.\n\nThe VR group receives immersive VR sessions using the SilVR Adventures platform. The video group receives non-immersive video sessions with similar content. The usual care group receives no additional intervention.\n\nAssessments are conducted at baseline, immediate post-intervention, and 3 months post-intervention to measure changes in depression, anxiety, loneliness, quality of life, and other outcomes. The intervention dosage will be 4 weeks (1 sessions\u002Fweek; 30 min\u002Fsession).\n\nSecondarily, the study explores differences in effectiveness between caregivers and homebound older adults, and potential moderators or mediators such as baseline health status, technological literacy, and social support.",[64,65,28,66,67],"Caregiver Stress","Social Isolation in Older Adults","Depression in Older Adults","Anxiety in Older Adults",[69,70,71,34,72,73,33,74],"Virtual Reality","Respite Care","Caregivers","Randomized Controlled Trial","Mental Health","uality of Life","2025-09-06",{"date":77,"type":40},"2025-09-12",{"date":79,"type":21},"2025-09-01",{"date":81,"type":21},"2027-02-28",{"name":83,"class":47},"Hong Kong University"]