[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cognitive-decline-prevention-in-robust-older-adults\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cognitive-decline-prevention-in-robust-older-adults":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":50,"leadSponsor":52,"locationsCount":5},"100640391","assessing-the-influence-of-habitual-beef-intake-on-key-molecular-markers-of-brain-health-100640391",false,"NCT07623785","Assessing the Influence of Habitual Beef Intake on Key Molecular Markers of Brain Health","Inclusion Criteria:\n\nAdults aged 65 years and older.\n\nGenerally healthy with no acute illnesses.\n\nFluent in English.\n\nWilling to consume lean beef and dairy products (cottage cheese and whey protein) daily during the intervention phases.\n\nWilling to maintain current, habitual diet, physical activity levels, and body weight throughout the study.\n\nWilling to fast for 12 hours prior to clinical visits and provide blood, urine, stool, and saliva samples.\n\nExclusion Criteria:\n\nDiagnosed with Alzheimer's disease, Parkinson's disease, or other severe cognitive disorders.\n\nHistory of gastrointestinal diseases (e.g., Crohn's disease, celiac disease) or major gastrointestinal surgery.\n\nUncontrolled diabetes, severe liver or kidney disease, or a recent cardiovascular event (within the past 6 months).\n\nAllergies or severe intolerances to beef or dairy, or adherence to a strict vegetarian or vegan diet.\n\nBody weight fluctuation of \\>5% within the past 3 months.\n\nUse of systemic antibiotics within the 2 months prior to baseline.\n\nCurrent heavy smoking or excessive alcohol consumption.",true,"ALL","65 Years",{"count":19,"type":20},20,"ESTIMATED","INTERVENTIONAL",[23],"NA","his study investigates whether eating lean beef every day can help support brain health and healthy aging in older adults. As people age, protecting memory and cognitive function becomes increasingly important. Lean beef is a rich source of essential nutrients-such as vitamin B12, iron, zinc, and creatine-that are known to support brain function. However, the direct biological effects of a beef-rich diet on brain health markers are not fully understood.\n\nIn this study, researchers will recruit 20 generally healthy older adults (aged 65 and older) to participate in a dietary feeding trial. Participants will complete two separate 2-week dietary phases. During one phase, participants will consume 5.5 ounces (156 grams) of provided lean beef daily. During the other phase, they will consume an iso-caloric, protein-matched, non-beef control food daily. A two-week \"washout\" period, where participants return to their normal diets, will separate the two phases to ensure there are no overlapping effects.\n\nResearchers will collect blood, urine, stool, and saliva samples at the beginning and end of each 2-week dietary phase. These samples will be analyzed to see if the lean beef diet improves specific biological markers in the blood related to memory, nerve protection, and overall brain aging. Ultimately, the findings from this study will help determine if incorporating lean beef into a regular diet can be a natural, food-based strategy to help preserve neurological health in older adults.",[26,27,28,29,30],"Healthy Aging","Brain Health","Cardiometabolic Health","Normal Aging","Cognitive Decline Prevention in Robust Older Adults",[32,33,34,35,36,37,38,39,40,41,42,43],"lean beef","red meat","dietary intervention","brain biomarkers","p-tau217","amyloid beta","bdnf","lipidomics","older adults","neuroprotection","nutrition","metabolomics","RECRUITING","2026-05-28",{"date":47,"type":48},"2026-06-03","ACTUAL",{"date":47,"type":20},{"date":51,"type":20},"2027-07-31",{"name":53,"class":54},"South Dakota State University","OTHER"]