[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cognitive-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cognitive-disorder":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,46,76,105,129,159,184],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100562009","virtual-reality-training-for-inhibitory-control-in-neurocognitive-disorders-100562009",false,"NCT06597591","Virtual Reality Training for Inhibitory Control in Neurocognitive Disorders","Acceptability of a VR-based Training for Inhibitory Control in Subjects With Neurocognitive Disorders","VR4IC","Inclusion Criteria:\n\n1. consulting the Nice hospital Memory Center\n2. diagnosis of Mild Neurocognitve Disorder or slight major neurocognitive disorder (DSM V)\n3. 60 years old or more\n4. presence of deficits in inhibitory control as assessed by the Frontal Assessment Battery\n5. fluent in French\n6. able to understand the informed consent form and voluntarily consents to participate\n\nExclusion Criteria:\n\n1. presence of significant vision or motor problems which would impact ability to perform the task\n2. significant self-reported motion sickness\n3. vulnerable persons as defined in articles L1121-5 to 8 of the French Public Health Code","ALL","60 Years",{"count":20,"type":21},48,"ESTIMATED","INTERVENTIONAL",[24],"NA","Executive function disorders, such as inhibitory control (IC) difficulties, are very common in older adults with neurocognitive disorders (NCD). Management of these disorders is possible using traditional tools and tools based on new technologies, such as serious games and virtual reality (VR). However, today, few immersive tools exist that are specifically focused on IC training. The present study aims to evaluate the acceptability of an immersive application focused on IC in 48 patients with neurocognitive disorders. Participants that will test either an immersive (VR-headset) or a non-immersive (tablet) version of the application for 4 weeks, twice a week, and fill-in acceptability related questionnaires before, during and after the end of the intervention.",[27],"Cognitive Disorder",[29,30,31,32],"inhibitory control","serious game","virtual reality","cognitive disorder","RECRUITING","2026-06-16",{"date":36,"type":37},"2026-06-18","ACTUAL",{"date":39,"type":37},"2024-11-18",{"date":41,"type":21},"2027-11-18",{"name":43,"class":44},"Centre Hospitalier Universitaire de Nice","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":45},"100485428","characterization-of-dysmorphology-in-subjects-with-creatine-transporter-deficiency-100485428","NCT05600946","Characterization of Dysmorphology in Subjects With Creatine Transporter Deficiency","* INCLUSION CRITERIA:\n\n  1. Patient is male and between 2-40 years of age, inclusive.\n  2. Patient has genomic confirmation of a pathologic mutation in the SLC6A8 gene.\n  3. Patient is able to complete study-related procedures within limitations imposed by condition under study.\n  4. Patients parents\u002Fguardians\u002Fcaregivers must provide written consent (informed consent) to study-related procedures, and if appropriate, the patient will provide an assent.\n\nEXCLUSION CRITERIA:\n\n1. Patient has had status epilepticus within 3 months of screening.\n2. Patients has had a seizure that lasts 5 minutes or longer, and a second seizure without recovering consciousness from the first one, or if a person has repeated seizures for 30 minutes or longer.\n3. Patient is unable to comply with the study procedures or has a clinical disease or laboratory abnormality that in the opinion of the investigator would potentially increase the risk of participation.","MALE","2 Years","40 Years",{"count":56,"type":21},19,"OBSERVATIONAL","Background:\n\nCreatine transporter deficiency (CTD) is a genetic disorder that mainly affects the brain in males. CTD causes intellectual disability that can be mild to severe. People with CTD may have seizures and behavioral issues. They may have slow growth and tire easily. CTD may sometimes be confused with autism or other disorders. Better diagnostics are needed. The study team in an NIH study noted that the faces of children with CTD can look similar. For this natural history study, an expert will examine photos of children with CTD. Any shared traits found might help to diagnose CTD.\n\nObjective:\n\nTo look for shared facial features of children with CTD.\n\nEligibility: Males aged 2 to 40 years old with CTD who were in study 17-CH-0020.\n\nDesign:\n\nSome participants in study 17-CH-0020 had pictures taken of their faces. The NIH study team wants to share these photos with a colleague in Canada. This person is an expert at evaluating how genetic disorders affect people s bodies.\n\nParticipant data collected during the study may also be sent to this expert. This data may include diagnostic images and results from lab tests.\n\nSome children did not have their pictures taken during study 17-CH-0020. Parents are asked to take pictures of these children and send them to the study team. These photos can be sent to a secure portal. The photos can also be taken in-person during a clinic visit.\n\nThe photos may be printed in clinical study journals. But this is not required. Parents will be asked to sign a separate consent before the photos are published....",[27,60,61],"Metabolic Disease","Autism Spectrum Disorder",[63,61,64,65],"Developmental Delay","Children","Natural History","2026-06-03",{"date":68,"type":37},"2026-06-04",{"date":70,"type":37},"2022-10-24",{"date":72,"type":21},"2026-09-01",{"name":74,"class":75},"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","NIH",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":45},"100611585","additional-effects-of-immersive-vr-360-degree-videos-with-aerobic-exercises-on-cognitive-functions-in-elderly-with-mild-cognitive-impairment-100611585","NCT07242495","Additional Effects of Immersive vr 360 Degree Videos With Aerobic Exercises on Cognitive Functions in Elderly With Mild Cognitive Impairment","Inclusion Criteria:\n\n* Older population aged from 60years and above\n* Normal\u002F normal to corrected vision\n* MoCA Score of 18-25 for screening \u002F MCI patients\n* Can do Independent ADLS\n\nExclusion Criteria:\n\n* Individuals with preexisting conditions such as severe motion sickness that could be exacerbated by VR usage.\n* Communication impairments\n* Participants with other neurological disorders.\n* Sensory deficits (such as uncontrolled hearing or visual issues)",true,{"count":84,"type":21},34,[24],"One of the key challenges faced by individuals with Mild Cognitive Impairment (MCI) is the decline in cognitive abilities, particularly global cognition, attention, and executive function, which are essential for maintaining independence and performing daily activities. Impaired cognition can significantly reduce quality of life in older adults, leading to difficulties in managing routine tasks, reduced social engagement, and increased dependency on caregivers. Common signs and symptoms include forgetfulness, difficulty concentrating, slower problem-solving, and challenges in planning or organizing daily activities. This study aims to explore and compare the effectiveness of two interventions-immersive Virtual Reality (VR) 360-degree videos combined with aerobic exercises, and aerobic exercises alone-in improving cognitive functions in older adults with MCI. Key outcome measures, including the Montreal Cognitive Assessment (MoCA) and Trail Making Test (TMT), will evaluate the effectiveness of the interventions on global cognition, attention, and executive function. We will include older adults aged 60 years and above with MoCA scores between 18-25 (MCI patients), who are able to perform independent ADLs. The participants will be assessed at the start of the intervention through the MoCA scale for MCI screening and baseline TMT testing for inclusion.",[88,27,89],"Cognitive Dysfunctions","Cognitive Decline",[91,92,93,94,95],"Cognitive rehabilitation","Virtual Reality","Mild cognitive Impairment","Elderly","Aerobic exercise","2025-11-17",{"date":98,"type":37},"2025-11-21",{"date":100,"type":37},"2024-09-14",{"date":102,"type":21},"2026-01-10",{"name":104,"class":44},"Foundation University Islamabad",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":82,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":22,"phases":112,"briefSummary":113,"conditions":114,"keywords":116,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":128,"locationsCount":45},"100606964","effects-of-video-games-and-ball-tossing-on-eye-hand-coordination-in-elderly-with-mild-cognitive-impairment-100606964","NCT07182396","Effects of Video Games and Ball Tossing on Eye Hand Coordination in Elderly With Mild Cognitive Impairment.","Inclusion Criteria:\n\n* Older population aged from 60years and above\n* Normal\u002F normal to corrected vision\n* MoCA Score of 18-25 for screening \u002F MCI patients\n* Can do Independent ADLS\n* Beery VMI Score: 80 and above score\n\nExclusion Criteria:\n\n* History of head trauma, loss of consciousness, stroke, rapid cognitive decline\n* Diagnosis of mental illness\u002Fneurocognitive disorders\n* Diagnosed Vestibular disorders\n* Hearing, vision and communication impairments",{"count":84,"type":21},[24],"One of the key challenges faced by individuals with mild cognitive impairment (MCI) is the decline in cognitive and motor abilities, particularly eye-hand coordination (EHC), which is essential for performing daily activities and maintaining independence. Impaired EHC can severely affect the quality of life in older adults, leading to difficulties in performing routine tasks like dressing, eating, and bathing, and increasing dependency on caregivers.\n\nSigns and symptoms include difficulty with precise movements like buttoning clothes, spilling drinks while pouring, struggling to catch a ball, messy handwriting. This study aims to explore and compare the effectiveness of two interventions-video games and ball tossing exercises-in improving Eye-hand coordination (EHC) in older adults with Mild Cognitive Impairment (MCI).\n\nKey outcome measures, including the Beery-Buktenica Developmental Test of Visual-Motor Integration (Beery VMI) and its supplemental test visual perception test and motor coordination test, will evaluate the effectiveness of the interventions on eye hand coordination.\n\nWe will include older adults with 60 and above age with MoCA score of 18-25(MCI patients), who can do independent ADLs and beery vmi score of 80 and above.\n\nThe participants would be assessed at the start of intervention through MoCA scale for MCI screening and Beery VMI testing method for Eye Hand Coordination for inclusion score.",[115,27,89],"Cognitive Dysfunction",[117,118,119,120,121],"Eye hand coordination","mild cognitive impairment","video games intervention","MoCA","Beery VMI( Beery Buktenica developmental test)","2025-09-12",{"date":124,"type":37},"2025-09-19",{"date":126,"type":37},"2024-09-13",{"date":102,"type":21},{"name":104,"class":44},{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":133,"acronym":134,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":136,"targetDuration":138,"studyType":57,"phases":4,"briefSummary":139,"conditions":140,"keywords":144,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":45},"100558107","outcomes-of-ict-assistive-technology-in-rehabilitation-pathways-100558107","NCT06546813","Outcomes of ICT Assistive Technology in RehabiliTAtIoN Pathways","ATTAIN","consecutive enrollment of subjects falling within\n\nInclusion Criteria:\n\n* patients in need of prosthetic interventions for Augmentative Alternative Communication, computer accessibility, and environmental control\n* patients who agree to participate in the study\n\nExclusion Criteria:\n\n* none",{"count":137,"type":21},50,"6 Months","The study aims to improve the quality of prosthetic intervention and verify the adequacy of assistive devices, and measurement outcomes. Fifty patients in need of prosthetic interventions for Augmentative Alternative Communication, computer accessibility, and environmental control will be recruited within the DAT Unit of the Fondazione Don Carlo Gnocchi \"IRCCS S.Maria Nascente\" in Milan. At baseline (T0) a physician and a psychologist will perform a clinical evaluation and the AT outcome assessment. The participants will be contacted for the follow-up phase (T1) 3 to 6 months after having received the assistive solution. At T1 clinicians will readminister the AT outcome assessment. In order to make the assessment accessible to all participants, these tests and questionnaires will be administered on Windows PCs, using Grid3 software, or on a specifically created accessible web page.",[141,142,143,27],"Communication Aids for Disabled","Communication Disorders","Motor Disorders",[145,146,147,148,149],"ICT AT","AAC AT","AAL AT","Assistive Technology","Outcome Assessment","2025-08-25",{"date":152,"type":37},"2025-08-26",{"date":154,"type":37},"2023-06-01",{"date":156,"type":21},"2025-10-31",{"name":158,"class":44},"Fondazione Don Carlo Gnocchi Onlus",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":165,"eligibilityCriteria":166,"healthyVolunteers":11,"sex":17,"minAge":167,"maxAge":4,"enrollmentInfo":168,"targetDuration":4,"studyType":22,"phases":170,"briefSummary":171,"conditions":172,"keywords":174,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":45},"100522925","early-detection-of-deafness-in-a-memory-center-100522925","NCT06088953","EARLY DETECTION OF DEAFNESS IN A MEMORY CENTER","DEAFNESS SCREENING IN A MEMORY CENTER IN SUBJECTS WITH COGNITIVE DISORDERS","CogAudio","Inclusion Criteria:\n\n* Patient with mild to moderate cognitive impairment, with an MMSE score ≥15\u002F30\n* Patient mastering the French language\n* Patient who has given written consent to participate in the trial\n* Socially insured patient\n* Patient willing to comply with all study procedures and duration\n* Patient accompanied by a study partner\n\nExclusion Criteria:\n\n* Medical history of diagnosed deafness, fitted or not\n* History of progressive otological pathology or presence of tympanic obstruction (\\>1\u002F3 of the surface of the eardrum)\n* History of unstabilized psychiatric pathology\n* Major visual impairment (Age-Related Macular Degeneration AMD...)\n* Established diagnosis of major language disorders (Primary Progressive Aphasia APP...)\n* Major under legal protection measure","50 Years",{"count":169,"type":21},200,[24],"Age-related hearing loss (ARHL), like neurodegenerative diseases, appears insidiously with age. As major public health issues, they are nonetheless under-diagnosed because the presence of one can hinder the objectification of the other.\n\nThe CogAudio project aims to detect early and in an ambulatory mode in a memory centre a speech perception disorder in noise thanks to the VRB test in patients weakened by cognitive disorders.",[27,173],"Deafness",[27,173],"2025-08-19",{"date":177,"type":37},"2025-08-20",{"date":179,"type":37},"2025-05-27",{"date":181,"type":21},"2027-08-27",{"name":183,"class":44},"University Hospital, Lille",{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":190,"eligibilityCriteria":191,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":192,"targetDuration":4,"studyType":22,"phases":194,"briefSummary":195,"conditions":196,"keywords":197,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":45},"100577659","a-mixed-intervention-to-improve-resilience-for-patient-with-neurocognitive-disorders-100577659","NCT06801171","A Mixed Intervention to Improve Resilience for Patient With Neurocognitive Disorders","Randomized Clinical Trial Testing a Mixed Intervention to Improve Resilience in People Aged Over 60 Years With Neurocognitive Disorders.","RESILIENCE","Inclusion Criteria:\n\n1. Man or Woman aged \\> 60 years\n2. Have a minor neurocognitive disorder according to the criteria of the DSM 5\n3. Score of 145 or less on the Wagnild and Young Resilience Scale (RS) (Wagnild, 2009).\n4. Subject able to read and write French;\n5. Subject beneficiaries of a social security scheme;\n6. Ability to understand and sign free and informed consent.\n\nExclusion Criteria:\n\n1. Subject already practicing meditation and\u002For yoga and\u002For Tai Chi\n2. Subject currently undergoing psychological therapy (whatever the approach)\n3. Subject with a major hearing, visual or motor disability likely to interfere with the proposed interventions or the performance of assessments;\n4. Presence and\u002For recent history (within the last 5 years prior to inclusion in the study) of major psychiatric disorders (e.g., schizophrenia, severe depression, addiction, bipolar disorders, psychotic disorders, risk of dissociation, panic attack, generalized anxiety disorder, etc.)\n5. If taking psychotropic treatment, the dose must have been stable for 4 weeks\n6. Vulnerable persons are defined in Articles L1121-5 to -8",{"count":193,"type":21},90,[24],"The study aims to test a program combining cognitive behavioral therapy techniques, positive psychology techniques, mindfulness meditation and yoga, in order to improve resilience in patient with minor cognitive disorder.\n\nThis intervention will be compared to a control group, but also with a group testing another intervention (an intervention that does not improve resilience in the elderly, namely a \"cognitive stimulation\" intervention) in order to ensure that the effect potentially obtained is not due to the simple management of the participant.\n\nThe duration of the intervention will be 3 months, with an evaluation directly before and after the intervention.\n\nIn addition, in order to best evaluate the effectiveness of the interventions over time, two follow-up measurements will be proposed: a measurement one month after the intervention, then a final one three months after the intervention.",[27],[198,199,200],"neurocognitive disorder","resilience","mixed intervention","2025-05-02",{"date":203,"type":37},"2025-05-04",{"date":205,"type":37},"2025-04-30",{"date":207,"type":21},"2027-12-01",{"name":43,"class":44}]