[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cognitive-flexibility\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cognitive-flexibility":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,50,81,131],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":37,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":4},"100623836","fascial-yoga-in-menopausal-women-100623836",false,"NCT07401810","Fascial Yoga in Menopausal Women","The Effect of Fascial Yoga on Perceived Stress, Cognitive Control, and Cognitive Flexibility in Menopausal Women","FascialYogaM","Inclusion Criteria:\n\n* Female participants aged 45-65 years\n* In the menopausal period, defined as at least 12 months since the last menstrual period\n* Able to read and understand Turkish and to complete self-report questionnaires\n\nExclusion Criteria:\n\n* Current or past diagnosis of a psychiatric disorder or ongoing psychiatric treatment\n* Regular use of antidepressant, anxiolytic, or corticosteroid medications\n* History of cancer or currently receiving active oncological treatment\n* Participation in facial yoga or similar yoga-based programs within the past 6 months\n* Any medical condition that may prevent safe participation in mild physical activity\n* Incomplete attendance to intervention sessions or incomplete outcome data during the study period",true,"FEMALE","45 Years","65 Years",{"count":22,"type":23},100,"ESTIMATED","INTERVENTIONAL",[26],"NA","Aim:\n\nThe aim of this study is to evaluate the effects of a structured fascial yoga-based behavioral intervention on perceived stress, cognitive control, and cognitive flexibility in menopausal women. The study aims to determine whether a non-pharmacological and non-invasive behavioral intervention can support psychological and cognitive functioning and reduce perceived stress in menopausal women.\n\nDesign:\n\nThis study is designed as a randomized controlled, pretest-posttest experimental study with a post-intervention follow-up assessment. Eligible participants will be randomly assigned to either the intervention group or the control group receiving usual care. Outcomes will be assessed at baseline, immediately after the intervention, and at follow-up to evaluate both the immediate and sustained effects of the intervention.\n\nMethod:\n\nA total of 100 menopausal women aged 45-65 years will be recruited from the menopause outpatient clinic and randomly assigned to either the intervention group or the control group. The intervention group will participate in a 12-week online fascial yoga program consisting of two 60-minute sessions per week.\n\nIn this study, fascial yoga is defined as a fascia-focused, non-pharmacological, and non-invasive behavioral intervention that includes myofascial release techniques, breath regulation, body awareness, and basic yoga practices to support stress regulation and cognitive functioning. The program will include myofascial release techniques, basic yoga postures suitable for all physical fitness levels, and structured breathing exercises. All sessions will be conducted online in a group format, and no audio or video recordings will be taken.\n\nThe control group will continue to receive routine outpatient care during the study period. After completion of the follow-up assessments, the fascial yoga program will be offered to participants in the control group upon request.\n\nData will be collected at three time points: at baseline before the intervention, immediately after completion of the 12-week intervention, and at the follow-up assessment 8 weeks after the intervention. Perceived stress, cognitive control, and cognitive flexibility will be assessed using validated self-report questionnaires.\n\nHypotheses:\n\nH1: Menopausal women participating in the fascial yoga intervention will show a significant reduction in perceived stress levels compared with the control group at post-intervention and follow-up assessments.\n\nH2: Menopausal women participating in the fascial yoga intervention will show a significant improvement in cognitive control and cognitive flexibility compared with the control group at post-intervention and follow-up assessments.",[29,30,31,32,33,34,35,36],"Menopause","Stress, Psychological","Cognitive Flexibility","Nonpharmacological Interventions","Randomized Controlled Trial","Cognitive Control","Perceived Stress","Yoga",[29,35,31,34,36],"NOT_YET_RECRUITING","2026-06-15",{"date":41,"type":42},"2026-06-17","ACTUAL",{"date":44,"type":23},"2026-07-01",{"date":46,"type":23},"2027-06-01",{"name":48,"class":49},"Marmara University","OTHER",{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":17,"sex":58,"minAge":59,"maxAge":20,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100629733","cognitive-evaluation-of-patients-with-eating-disorders-100629733","NCT07478510","Cognitive Evaluation of Patients With Eating Disorders","Neuro-cognitive Profiles of Patients With Nutritional and Eating Disorders","DNA_ARFID","Inclusion Criteria:\n\n* Diagnosis of a Feeding and Eating Disorder (ARFID, anorexia nervosa, or bulimia nervosa);\n* Patients of both sexes;\n* Age between 14 and 65 years;\n* Confirmed diagnosis of a Feeding and Eating Disorder;\n* Body Mass Index (BMI) \\\u003C 25;\n* Signed informed consent form for participation in the study.\n\nExclusion Criteria:\n\n* Diagnosis of Bipolar Disorder according to DSM-5-TR criteria;\n* Diagnosis of a Schizophrenia Spectrum Disorder according to DSM-5-TR criteria;\n* Intellectual disability according to DSM-5-TR criteria;\n* Presence of brain tumors;\n* History of seizure events;\n* Presence of other moderate to severe neurological disorders;\n* Lack of the patient's consent to voluntary participation in the study;\n* Lack of parental or legal guardian consent for participation of a minor in the study.","ALL","14 Years",{"count":61,"type":23},84,"OBSERVATIONAL","The goal of this cross - sectional observational study is to improve understanding of the psychological and cognitive characteristics of Feeding and Eating Disorders (FEDs), a group of conditions that represent a growing public health concern due to their significant impact on physical health, emotional well-being, and everyday functioning. Within this broader diagnostic category, particular attention is given to Avoidant\u002FRestrictive Food Intake Disorder (ARFID), a diagnosis introduced in the DSM-5 and still relatively underexplored compared to other feeding and eating disorders.\n\nDespite its clinical relevance, ARFID remains less well understood in terms of its underlying cognitive and psychological mechanisms. Individuals with ARFID often experience severe food avoidance or restriction that is not driven by weight or shape concerns, but rather by sensory sensitivities, fear of negative consequences of eating, or a lack of interest in food. For this reason, investigating ARFID can offer important insights into the diversity of mechanisms involved in feeding and eating disorders as a whole.\n\nThe study has two main objectives. The first objective is to examine the cognitive profile of individuals with ARFID, with a specific focus on autistic traits and cognitive flexibility, as previous research suggests potential overlaps between ARFID and neurodevelopmental conditions such as Autism Spectrum Disorders. Cognitive flexibility refers to the ability to adapt thoughts and behaviors in response to changing situations, and reduced flexibility may contribute to rigid eating patterns and food avoidance.\n\nThe second objective is to explore the role of body representation (how individuals perceive and mentally represent their own body) and inhibitory control (the ability to regulate or suppress automatic responses) in shaping the cognitive and behavioral features of ARFID and other feeding and eating disorders. These processes may help distinguish ARFID from other diagnoses and clarify shared and disorder-specific mechanisms across the FED spectrum.\n\nThe study involves adult participants of all genders, including individuals diagnosed with ARFID, anorexia nervosa, and bulimia nervosa, as well as healthy control participants without a history of feeding or eating disorders. This design allows meaningful comparisons between different diagnostic groups and with the general population.\n\nThe main questions the study aims to answer are:\n\nDo individuals with ARFID show a distinct cognitive profile, particularly in terms of autistic traits and cognitive flexibility, compared to individuals with other feeding and eating disorders and healthy controls?\n\nHow do body representation and inhibitory control contribute to differences in eating-related behaviors across feeding and eating disorders?\n\nAre there differences in brain activity associated with implicit, automatic attitudes toward food in individuals with feeding and eating disorders compared to healthy individuals?\n\nWhere comparison groups are included, researchers will compare participants with ARFID, anorexia nervosa, bulimia nervosa, and healthy controls to examine differences in cognitive functioning, psychological characteristics, and neural responses related to food processing.\n\nParticipants will be asked to take part in a series of non-invasive and well-established research activities, designed to be accessible and safe. These include:\n\nCompleting self-report questionnaires assessing autistic traits, body image perception, and general psychological well-being;\n\nPerforming computer-based tasks that assess cognitive flexibility and decision-making;\n\nCompleting behavioral tasks designed to measure inhibitory control and automatic associations with food-related stimuli;",[65,66,67,31,68,69],"ARFID","Anorexia Nervosa","Bulimia Nervosa","Implicit Association Test","Executive Functions","RECRUITING","2026-04-15",{"date":73,"type":42},"2026-04-16",{"date":75,"type":42},"2024-11-26",{"date":77,"type":23},"2028-03-31",{"name":79,"class":49},"Istituti Clinici Scientifici Maugeri SpA",3,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":17,"sex":18,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":24,"phases":92,"briefSummary":93,"conditions":94,"keywords":111,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":130},"100617476","evaluation-of-the-impact-of-a-nutritional-formulation-on-cognitive-performance-following-stress-exposure-100617476","NCT07319117","Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure.","A Double-blind, Placebo-controlled, Randomised, Acute, Repeated Measures Cross-over Study to Evaluate the Impact of Skoshify 'Think Tank' Nutritional Formulation on Cognitive Performance Following Stress Exposure.","Inclusion Criteria:\n\n1. Willing and able to provide written informed consent (in English)\n2. Aged 40-60\n3. Female\n4. Daily caffeine drinkers\n5. Healthy and free from significant physical and psychiatric disorders\n\nExclusion Criteria:\n\n1. Current cigarette smokers\u002Fvapers.\n2. Known food allergy or intolerance to the investigational products or control products.\n3. Not willing to consume coffee.\n4. Individuals diagnosed with psychiatric\u002Fmental health conditions.\n5. Individuals engaging in recreational drug use.\n6. Individuals with diagnosed cardiovascular conditions (e.g. heart disease, high blood pressure)\n7. Individuals taking prescribed medication except contraceptives\u002Fhormone replacement therapy\n8. Individuals suffering from Raynaud's or circulatory issues\n9. Individuals who have suffered an injury or infection in their hand\u002Farm in the last month\n10. Individuals who have suffered from chronic pain conditions or experience extreme numbness or pain in response to cold temperatures.\n11. Previous brain injury\u002Fbrain surgery\n12. Individuals who work night shifts.\n13. Currently pregnant or breastfeeding.\n14. Previous participants in a laboratory stress protocol.","40 Years","60 Years",{"count":91,"type":23},40,[26],"The proposed project will evaluate the synergistic effects of a nutritional formulation, 'Think Tank' on cognitive performance following exposure to a psychological and physical stressor. Adopting a double-blind repeated measures cross-over design, middle-aged females (40-60 years) will be recruited to take part in a two-stage research study that will examine whether the formulation enhances cognitive performance and subjective well-being following the challenge of a stressor, compared to placebo. Cognitive assessments will examine the impact of the nutritional formulation on working memory, sustained attention, cognitive flexibility and inhibitory control. The study will also assess physiological (heart rate, blood pressure and cortisol) and subjective (well-being, anxiety, positive and negative mood, stress) markers of stress reactivity. The study will also explore levels sleep quality, mental and physical fatigue, effort, productivity, and perceived impact of the intervention.",[95,96,97,98,99,31,100,101,102,103,104,105,106,107,108,109,110],"Cognitive Assessment","Working Memory","Executive Function (Cognition)","Sustained Attention","Inhibitory Control","Cortisol","Stress","Anxiety","Depression","Sleep Quality","Blood Pressure","Heart Rate","Mental Fatigue","Physical Fatigue","Productivity","Effort",[112,113,114,115,116,117,118,119,120],"Cognitive Performance","Stress Response","Creatine","Magnesium","L-Tyrosine","L-Theanine","Rhodiola","Phosphatidylserine","Citicoline","2025-12-19",{"date":123,"type":42},"2026-01-06",{"date":125,"type":23},"2025-12-15",{"date":127,"type":23},"2026-08-31",{"name":129,"class":49},"Leeds Beckett University",1,{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":58,"minAge":20,"maxAge":4,"enrollmentInfo":138,"targetDuration":4,"studyType":24,"phases":140,"briefSummary":141,"conditions":142,"keywords":146,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":158,"locationsCount":130},"100603644","the-effect-of-cognitive-behavioral-therapy-cbt-based-psychoeducation-on-cognitive-flexibility-and-rumination-in-the-elderly-100603644","NCT07139197","The Effect of Cognitive Behavioral Therapy (CBT)-Based Psychoeducation on Cognitive Flexibility and Rumination in the Elderly","The Effect of a Cognitive Behavioral Approach-Based Psychoeducation Program on Cognitive Flexibility and Rumination in Elderly Individuals Living in Nursing Homes","Inclusion Criteria:\n\n* Be 65 years of age or older,\n* Be willing to participate in the study,\n* Not have hearing or vision problems that would prevent understanding the training to be provided,\n* Have communication and comprehension skills,\n* Be literate,\n* Have a Standardized Mini Mental Test score between 25 and 30 points.\n\nExclusion Criteria:\n\n* Having any hearing or vision problems.\n* Having physical, neurological, or psychological health problems that could disrupt group harmony and integrity.\n* Having an illness or problem that could prevent them from responding to the measurement tools used in the study.\n* Having a Standardized Mini Mental Test score below 25.",{"count":139,"type":23},38,[26],"This study aimed to investigate the effect of psychoeducation on rumination and cognitive flexibility in elderly individuals residing in nursing homes. Cognitive Behavioral Therapy (CBT)-based psychoeducation has recently been applied to multiple specific groups around the world and in our country. In general, executive functioning skills and, more specifically, cognitive flexibility appear to be important for the ability to use certain CBT techniques; however, considering that these skills naturally decline with age, further research is needed. It is anticipated that the results of this study will contribute to applications in the field of psychiatric nursing.",[31,143,144,145],"Rumination","Elderly (People Aged 65 or More)","Psychoeducation",[147,148,149,150,151],"elderly","psychoeducation","cognitive flexibility","rumination","cognitive behavioral therapy","2025-08-27",{"date":154,"type":42},"2025-09-04",{"date":156,"type":23},"2025-09-01",{"date":39,"type":23},{"name":159,"class":49},"Ataturk University"]