[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cognitive-function-abnormal\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cognitive-function-abnormal":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,82],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100590506","effect-of-exobdnf-lactic-acid-bacteria-supplement-on-cognitive-functions-sleep-and-psychological-100590506",false,"NCT06968299","Effect of ExoBDNF Lactic Acid Bacteria Supplement on Cognitive Functions, Sleep and Psychological","Effect of ExoBDNF Lactic Acid Bacteria Supplement on Cognitive Functions, Sleep and Psychological Outcomes: An Open-label Trial","Inclusion Criteria:\n\n1. Subjects must be volunteers who are 18 years of age or older, mentally clear and able to communicate.\n2. Subjects who agree to participate in this trial and voluntarily sign the trial consent form.\n\nExclusion Criteria:\n\n1. Subjects who are expected to be or have been confirmed to be pregnant (medical history).\n2. Subjects with gallbladder disease, gastrointestinal disease, gout, porphyria, or a history of gastric weight control surgery.\n3. Subjects with high blood pressure (≥160\u002F100 mmHg after resting for 10 minutes) or taking diuretics.\n4. Subjects with heart disease, hepatorenal insufficiency, hyperthyroidism or hypothyroidism, Cushing's syndrome, malignant tumors, or any other disease that may affect the results of the study.\n5. Subjects with severe hearing or visual impairment that makes it impossible to perform examinations and assessments.\n6. Subjects with any history of brain surgery, penetrating, neurovascular, infectious or other severe brain injury, epilepsy or other major neurological abnormalities, such as traumatic brain injury with loss of consciousness for more than 24 hours, or memory loss after head trauma for more than 7 days were excluded.\n7. Subjects with intellectual disabilities.\n8. Subjects who had consumed probiotics or were expected to consume probiotics within 2 weeks before the screening visit.\n9. Subjects who had participated in or were expected to participate in clinical trials within 4 weeks before the screening visit.",true,"ALL","18 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","This open-label, single-group, pre\u002Fpost-test clinical study was conducted to investigate whether ExoBDNF probiotic supplementation could improve cognitive ability. It is expected that 40 subjects aged 18 years and above will be recruited, with a target of 30 cases, to take ExoBDNF probiotics for a total of 8 weeks.",[27,28,29,30],"Cognitive Functions Perceptual Disturbances","Cognitive Function Abnormal","Sleep","Psychological",[32,33,34],"Probiotics","ExoBDNF","Cognitive functions","RECRUITING","2025-11-18",{"date":38,"type":39},"2025-11-24","ACTUAL",{"date":41,"type":39},"2025-05-20",{"date":43,"type":21},"2025-12-30",{"name":45,"class":46},"SunWay Biotech Co., LTD.","INDUSTRY",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":16,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":4},"100558635","brain-gym-therapy-on-quality-of-sleep-among-elderly-people-100558635","NCT06553690","Brain Gym Therapy on Quality of Sleep Among Elderly People","Impact of Brain Gym Therapy on Quality of Sleep Among Elderly People Attending Health Care Facilities","BG\u002FE","Inclusion Criteria:\n\nElderly individuals aged 60 years and above. Attending healthcare facilities and able to participate in the study. Experiencing issues with sleep quality, as determined by a score of 5 or higher on the Pittsburgh Sleep Quality Index (PSQI).\n\nWilling and able to provide informed consent. Physically capable of performing gentle physical exercises as part of Brain Gym Therapy\n\nExclusion Criteria:\n\nSevere cognitive impairment or dementia that would impede understanding or participation in the intervention.\n\nCurrent participation in another sleep intervention study. Presence of severe medical conditions that contraindicate physical activity (e.g., severe cardiovascular disease, musculoskeletal disorders).\n\nUse of sleep medications that could confound the study results. Recent history (within the past 6 months) of major psychiatric disorders, including severe depression or anxiety.\n\nAny condition that, in the opinion of the investigators, would make participation unsafe or not in the best interest of the participant.","60 Years",{"count":58,"type":21},120,[24],"This clinical trial aims to evaluate the impact of Brain Gym Therapy on the quality of sleep among elderly individuals attending healthcare facilities. The study will explore whether this non-pharmacological intervention can improve sleep quality, which is often compromised in the elderly population due to various health conditions and age-related changes. Participants will undergo Brain Gym Therapy sessions over a specified period, and their sleep quality will be assessed using validated sleep measurement tools. The findings may provide insights into alternative methods for enhancing sleep in older adults.",[62,63,28,64,65],"Sleep Disorder","Insomnia","Old Age; Debility","Brain Gym Therapy",[65,67,68,69,70],"Sleep Quality","Cognitive Exercise","Non-Pharmacological Intervention","Insomnia in Elderly","NOT_YET_RECRUITING","2024-08-11",{"date":74,"type":39},"2024-08-14",{"date":76,"type":21},"2024-08-15",{"date":78,"type":21},"2024-10-12",{"name":80,"class":81},"Cairo University","OTHER",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":16,"sex":17,"minAge":56,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":91,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":47},"100492584","a-prospective-cohort-study-on-change-of-cognitive-function-in-aged-related-hearing-loss-with-hearing-aids-100492584","NCT05694039","A Prospective Cohort Study On Change of Cognitive Function In Aged-related Hearing Loss With Hearing Aids","Inclusion Criteria:\n\nAge\\>60yrs，≤85yrs（MCI prevalence was 6.7% for ages 60-64, 8.4% for 65-69, 10.1% for 70-74, 14.8% for 75-79,and25.2% for80-84）; Sensorineural Hearing loss with pure-tone thresholds 25-70 dB HL at octave frequencies between 250 and 4000 Hz, 4 frequency PTA of ≥ 30 dB HL, and the PTA ≤ 90 dB HL; Diagnosed as Presbycusis; Score of 23 or below on Mini-Mental Status Exam (MMSE); Score of 22 or below on Montreal Cognitive Assessment (MoCA);\n\nExclusion Criteria:\n\nHearing loss exceeding the limits that can be successfully aided with hearing aids (i.e., profound hearing loss); Significant history of otologic or neurologic disorders; Hearing loss remediated with a cochlear implant (cannot wear hearing aids); Any clinically significant unstable or progressive medical condition; Any condition which, in the opinion of the investigator, places the participant at unacceptable risk if he or she were to participate in the study.","85 Years",{"count":90,"type":21},388,[24],"Background:\n\nDeafness is one of the nine potentially modifiable risk factors for dementia simulated by the Lancet dementia Prevention, intervention and Care Committee in 2017. Some studies have found that the risk factors of dementia in deafness system, with the increase of the degree of deafness, the risk of cognitive decline increases, while after long-term wear of hearing aids, the deterioration of immediate and delayed memory is less, and the possibility of cognitive decline slows down. Therefore, it is necessary for us to improve the auditory ability of patients with deafness through auditory intervention, so as to slow down its effect on dementia and reduce the incidence of dementia. At present, auditory intervention methods include hearing aid wearing and cochlear implant.\n\nHowever, there are few studies on cognitive function of presbycusis patients in China, and there is no research on how many years of auditory intervention can effectively slow down the incidence of dementia in presbycusis patients with MCI. Therefore, we intend to conduct a prospective cohort study on the changes of cognitive function of presbycusis under hearing aid intervention.",[94,95,96,28],"Age-related Hearing Loss","Hearing Loss, Sensorineural","Hearing Aid","2023-01-20",{"date":99,"type":39},"2023-01-23",{"date":101,"type":39},"2022-03-09",{"date":103,"type":21},"2028-03-09",{"name":105,"class":81},"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University"]