[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cognitive-side-effects-of-cancer-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cognitive-side-effects-of-cancer-therapy":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100580630","effect-of-cognitively-challenging-physical-activity-on-executive-functions-in-pediatric-cancer-patients-100580630",false,"NCT06839794","Effect of Cognitively Challenging Physical Activity on Executive Functions in Pediatric Cancer Patients","An Investigator Initiated, Non-randomized Controlled Trial on the Effect of Cognitively Challenging Physical Activity on Executive Functions in Paediatric Cancer Patients","KiKli Fit","Inclusion Criteria:\n\n* Written informed consent of parents \u002F legal guardian and participants, where applicable\n* Diagnosis of any type of cancer requiring chemo- and\u002For radiotherapy, or CNS surgery, expected to last a minimum of at least 6 weeks at the time of recruitment\n* Age: 6-17.99 years at time of recruitment\n\nExclusion Criteria:\n\n* Cognitive and physical disabilities that prevent participation in the intervention.\n* Inability to follow the procedures of the study, e.g. due to language problems.\n* Enrolment of the investigator, his\u002Fher family members, employees and other dependent persons.\n* Denied written informed consent from participants.","ALL","6 Years","17 Years",{"count":21,"type":22},70,"ESTIMATED","INTERVENTIONAL",[25],"NA","When it comes to exercise and sport for children and adolescents with cancer, there is often still the opinion that physical activity has a negative effect on the weakened body suffering from cancer. Many studies show that the opposite is the case: physical activity for children and adolescents with cancer do not jeopardise the success of treatment, but rather promote it. It has been shown that physical activity has a positive effect on motor skills, physical fitness, sleep quality, fatigue symptoms, body image and general quality of life in children and adolescents with cancer.\n\nIn addition, physical activity leads to an improved fat-to-muscle ratio, metabolic status, bone strength and reduces cardiovascular disease. Furthermore, various studies show that oncological patients with sarcopenia (loss of muscle mass) and frailty have a poorer response to their cancer therapy. This broad spectrum of effects of physical activity leads to improved and faster rehabilitation, is directly linked to the success of treatment and has led to exercise being an integral part of treatment in many paediatric oncology centres worldwide.\n\nFurthermore, more exercise that includes playful cognitive tasks is expected to lead to improved attention, memory and academic achievement. Besides, it is important to try to get children to exercise at home outside of the inpatient setting. Hybrid (on-site and digital meetings) programmes also work for children and adolescents. Additionally, the research project offers sports counselling after the end of therapy to reintegrate the patients into everyday sporting life, be it in a club or at school.\n\nThe central question of the research project is: Does cognitive challenging physical activity developed for children and adolescents undergoing acute cancer therapy improve cognitive and motor performance compared to a control group receiving standard care?",[28,29,30,31],"Childhood Cancer","Cancer-related Problem\u002FCondition","Cognitive Side Effects of Cancer Therapy","Physical Activity","RECRUITING","2025-08-11",{"date":35,"type":36},"2025-08-12","ACTUAL",{"date":38,"type":36},"2025-05-10",{"date":40,"type":22},"2028-12-01",{"name":42,"class":43},"University of Bern","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":53,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":44},"100562697","endo-brain-effects-of-endocrine-adjuvant-therapy-with-aromatase-inhibitors-on-the-cognitive-function-of-breast-cancer-patients-100562697","NCT06606535","ENDO-BRAIN: Effects of Endocrine Adjuvant Therapy with Aromatase Inhibitors on the Cognitive Function of Breast Cancer Patients","ENDO-BRAIN","Inclusion Criteria:\n\n* Breast cancer patients undergoing endocrine adjuvant therapy with AI, with or without GnRH agonists, depending on menopause status at diagnosis (cases only)\n* At least 18 years old\n* Good comprehension of oral and written Italian language\n\nExclusion Criteria:\n\n* incomplete ovarian suppression (cases)\n* previous neoplastic diseases other than the presently treated breast cancer for cases\n* known neurological or psychiatric disorders\n* use of hormonal contraception or hormonal replacement therapy (controls)",true,"FEMALE","18 Years",{"count":56,"type":22},60,"OBSERVATIONAL","The principal aim of this prospective observational study is to investigate the cognitive function of breast cancer patients that use AI, comparing it with age-matched healthy controls, utilizing cognitive assessments and functional magnetic resonance imaging (fMRI). Additionally, the project seeks to establish correlations between cognitive function and other estrogen deprivation symptoms, including vasomotor symptoms, and to evaluate a possible correlation with endothelial damage studied through Angio Optical Coherent Tomography (angio OCT).\n\nPatients will be recruited during follow up visits at the iatrogenic menopause outpatient clinic. After informed consent, the will be asked for detailed demographic data, medical, oncological and gynecological history. Hypoestrogenism symptoms will be collected through validated questionnaires. The cognitive assessment will be performed on the same day, by trained staff. The fMRI and angioOCT will be booked and performed depending on patient and clinic availability.",[30,60],"Hypoestrogenism",[62,63,64,65,66],"breast cancer","cognitive side effects","hypoestrogenism","ovarian function suppression","aromatase inhibitor","2024-09-18",{"date":69,"type":36},"2024-09-23",{"date":71,"type":36},"2024-06-13",{"date":73,"type":22},"2025-06-01",{"name":75,"class":43},"Ospedale Policlinico San Martino"]