[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cognitive-training\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cognitive-training":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,45,75,105,130,162],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100614721","effect-of-functional-core-stability-training-or-cognitive-training-on-balance-and-postural-control-in-chronic-ankle-instability-100614721",false,"NCT07283276","Effect of Functional Core Stability Training or Cognitive Training on Balance and Postural Control in Chronic Ankle Instability","Effect of Adding Functional Core Stability Training or Cognitive Training on Balance and Postural Control in Rehabilitation of Chronic Ankle Instability","Inclusion Criteria:\n\nInclusion criteria will be based on the standard criteria outlined by the International Ankle Consortium\n\n1. History of chronic lateral ankle sprain and\u002For recurrent sprain and\u002For \"feelings of instability or giving way\" for 6 months or more before the study, with at least 2 episodes.\n2. Patients are between 18 and 30 years old. 3- Body mass index less than 30\n\n4\\. The patient has a history of at least one significant ankle sprain with associated inflammatory symptoms and at least one day of interrupted physical activity.\n\n5\\. Patients who have unilateral chronic ankle instability. 6. Self-reported ankle instability should be confirmed using a validated ankle instability questionnaire (greater than 24).\n\nExclusion Criteria:\n\nThose with a history of spine, pelvis, and lower extremity injury, fracture, or surgery 2- Those with low back pain that require medical or surgical intervention. 3- Having a history of an acute lower extremity injury or lower extremity surgery or fracture in the 3 months before the Study 4. Participation in formal ankle rehabilitation in the 3 months before the study.\n\n5\\. Being diagnosed with neurologic dysfunction, such as multiple sclerosis, Parkinson's disease, or head injury","ALL","18 Years","30 Years",{"count":20,"type":21},45,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of the study is to investigate dynamic core stability training versus cognitive training on balance, functional performance, postural control, ankle instability scores, ankle dorsiflexion range of motion, and mental workload in chronic ankle instability",[27,28,29,30,31],"Cognitive Training","Functional Core Stability Training","Balance; Distorted","Postural Control","Chronic Ankle Instability","RECRUITING","2025-12-02",{"date":35,"type":36},"2025-12-15","ACTUAL",{"date":38,"type":36},"2025-08-15",{"date":40,"type":21},"2026-03-01",{"name":42,"class":43},"Cairo University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100562343","phase-2-cognitive-training-and-neuroplasticity-in-mild-cognitive-impairment-cogit-2-trial-100562343","NCT06601933","Cognitive Training and Neuroplasticity in Mild Cognitive Impairment: COGIT-2 Trial","COGIT-2","Inclusion Criteria:\n\n1. Access to a home desktop or laptop computer or tablet at acceptable internet speed for the study duration.\n2. Participants need to be 55 to 89 years of age (inclusive) at the time of informed consent.\n3. Females need to be post-menopausal (last period more than 12 months earlier by history).\n4. Subjective cognitive complaints, i.e., memory or other cognitive complaints, e.g., naming\u002Flanguage.\n5. Meets criteria for cognitive impairment (CI), including either EMCI (early MCI) or LMCI (late MCI), defined as memory impairment documented by scoring below the education adjusted cutoff on the Logical Memory II subscale (Story A, Delayed Paragraph Recall) from the Wechsler Memory Scale - III (WMS-III) (the maximum score is 25). The criteria for MCI (includes EMCI and LMCI) and used in COGIT-2 are as follows: EMCI is defined by a WMS-III Logical memory delayed recall score of 3-6 with 0-7 years of education, score of 5-9 with 8-15 years of education, and score of 9-11 with 16 or more years of education. LMCI is defined by a WMS-III Logical Memory delayed recall score ≤ 2 with 0-7 years of education, score ≤ 4 with 8-15 years of education, and score ≤ 8 with ≥ 16 years of education.\n6. Montreal Cognitive Assessment (MoCA) score ≥ 20\u002F30.\n7. An informant (relative, friend, other caregiver) who contacts the participant at least weekly is required to provide information about the participant's functioning. This can be a telephone informant in the case of participants who do not have a live-in informant or close significant other. If the informant drops out, an alternate informant can be designated by the participant but the new informant will need to sign the informant information sheet in person.\n8. Must be English-speaking: Wide Range Achievement Test (WRAT3) score must indicate at least a 6th grade reading level with a score of ≥ 37.\n\nExclusion Criteria:\n\n1. Diagnosis of dementia of any type.\n2. Current clinical diagnosis of schizophrenia, schizoaffective disorder, psychosis, or bipolar I disorder (Diagnostic and Statistical Manual of Mental Disorders (DSM-5 TR) criteria).\n3. Current unstable or untreated major depression, or active suicidality based on a Suicide Severity Rating Scale (C-SSRS Screen version: positive answer to question 1 or 2 followed by item 6 positive answer leads to exclusion. Negative answer to questions 1 and 2: interview ends and the participant is not excluded for active suicidality).\n4. Current or recent (past 6 months) alcohol or substance use disorder (DSM-5 TR criteria).\n5. Clinical stroke with residual neurological deficits. While we will not exclude participants with cerebrovascular disease or transient ischemic attacks (TIAs), we do not wish to include participants with a frank clinical stroke because it is not clear that this type of participant is similar to the MCI participant generally, and clear-cut neurological impairment, e.g., hemiplegia\u002Fhemiparesis or speech impairment, may compromise the ability to do the procedures and to complete the neuropsychological test battery.\n6. Use of medications known to have a negative impact on cognition: benzodiazepines in lorazepam equivalents greater than or equal to 1 mg daily, narcotics, anticholinergics (ACB Calculator level 3 medication leads to exclusion), large number of sedating medications in combination. Medications with anticholinergic\u002Fantihistaminergic properties will be reviewed, e.g., low dose quetiapine (≤ 25 mg daily) will be permitted, but daily use of diphenhydramine or equivalent will be reviewed. Current use of lecanemab or donanemab will be exclusionary.\n7. Presence of any of the following disorders: a) Central Nervous System Infections, with cerebrospinal fluid evidence of meningitis, encephalitis, or other infectious process; b) dementia of any type; c) Huntington's disease; d) Multiple sclerosis; e) Parkinson's disease; f) Other neurologic disorders with focal signs, e.g., amyotrophic lateral sclerosis.\n8. Acute, severe unstable medical illness in the judgment of the clinician. For cancer, acutely ill participants (including those with metastases) are excluded, but history of successfully treated cancer does not result in exclusion.\n9. Contraindication to MRI scan: MRI incompatible pacemakers and metal implants, any other contraindication to MRI. For participants with possible claustrophobia, they must be willing to do the MRI with adjunct lorazepam 0.5 mg to reduce anxiety. For participants who are recruited and are eligible for MRI but are unable to complete the baseline MRI, a repeat MRI for the same time-point can be attempted if the subject is willing. Baseline MRI is required for study inclusion.\n10. Regular use of crosswords or formal computerized cognitive training platforms averaging once per week or more than once per week in the past year. Eligible participants who join the trial are instructed not to do these procedures on their own during the trial, i.e., independent of the study.\n11. Participation concurrently in another therapeutic clinical trial of a cognitive enhancing drug or device or procedure.\n12. Geriatric Depression Scale (Short Form) score of ≥ 6.","55 Years","89 Years",{"count":55,"type":21},240,[57],"PHASE2","Effective, clinically meaningful treatments are lacking for patients with mild cognitive impairment (MCI), which is associated with increased risk of transition to dementia. Cognitive training represents an important therapeutic strategy. In a previous study, crossword puzzles were found to be superior to computerized cognitive training on the primary cognitive outcome and function with decreased brain atrophy. Building on these findings, this study will evaluate and compare the impact of high dose crosswords (4 puzzles per week) to low dose crosswords (1 puzzle per week) and a health education control group on the cognition and function of participants.",[60,27],"Mild Cognitive Impairment (MCI)",[62,27,63,64],"Mild Cognitive Impairment","Crossword Puzzles","Health Education","2025-10-30",{"date":67,"type":36},"2025-10-31",{"date":69,"type":36},"2024-12-17",{"date":71,"type":21},"2029-02-28",{"name":73,"class":43},"Columbia University",4,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":16,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":22,"phases":88,"briefSummary":89,"conditions":90,"keywords":91,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":4},"100475535","promoting-inclusive-education-through-executive-functions-100475535","NCT05472194","Promoting Inclusive Education Through Executive Functions","Promoting Inclusive Education Through Executive Functions - Study Protocol of a Randomized Control Trial","EduFun","Inclusion Criteria:\n\n* Typically developed children of 5, 6, and 7 years old attending the regular curriculum at public educational services -kindergarten and elementary school.\n\nExclusion Criteria:\n\n* Presence or history of cognitive deficits, neurological or psychiatric condition.",true,"5 Years","7 Years",{"count":87,"type":21},470,[24],"Background: Recently governments worldwide have been doing enormous efforts to ensuring egalitarian educational opportunities for all children. However, the number of children that remain out of the school or lack proficiency in academic performance is still very worrying. One of the factors that seems to contribute to such inequalities is socioeconomic status (SES). SES strongly impacts the developmental trajectory of both the brain and cognitive abilities as off early childhood, further affecting learning and academic success.\n\nDespite the great interest in building inclusive societies and the promising results of executive functions' training programs for leveling the SES-achievement disparities, only a few studies have actually included schools from low-SES settings and lack a comprehensive, evidence-based background underlying the intervention protocols. Thus, with a preventive emphasis, the current project aims to implementing and evaluating a cost-effective game-based training protocol to promote and boost the development of executive functions in preschool and elementary school-aged children from disadvantaged contexts, ultimately contributing to prevent school dropout and reduce academic inequalities.",[27],[92,93,94],"Inclusive Education","Executive Functions","Cognitive Tools","NOT_YET_RECRUITING","2024-12-04",{"date":98,"type":36},"2024-12-06",{"date":100,"type":21},"2025-09",{"date":102,"type":21},"2027-12-09",{"name":104,"class":43},"University of Minho",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":113,"minAge":114,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":22,"phases":118,"briefSummary":119,"conditions":120,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":44},"100555870","brain-research-and-integrative-neuroscience-network-for-covid-19-100555870","NCT06517706","Brain Research and Integrative Neuroscience Network for COVID-19","Brain Research and Integrative Neuroscience Network for COVID-19 (BRAINN)","BRAINN","Inclusion Criteria:\n\n* Reported cognitive difficulties due to COVID-19 infection\n* WHO Long COVID criteria will be used\n\nExclusion Criteria:\n\n* Significant history of neuropsychiatric conditions prior to contracting COVID-19; history of neurological conditions such as TBI, CVA, MS prior to contracting COVID-19.","FEMALE","25 Years","60 Years",{"count":117,"type":21},70,[24],"The aim of the experimental study is to investigate two interventions for the management of cognitive symptoms resulting from long COVID. Participants will be randomly assigned into two interventions. 1. Categorization Program (CP) training with active tDCS or 2. Categorization Program training with sham tDCS.",[27,121],"Transcranial Direct Current Stimulation","2024-12-03",{"date":98,"type":36},{"date":125,"type":36},"2024-11-15",{"date":127,"type":21},"2025-12-31",{"name":129,"class":43},"University of Cyprus",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":83,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":137,"targetDuration":4,"studyType":22,"phases":139,"briefSummary":140,"conditions":141,"keywords":147,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":4},"100570699","effects-of-cognitive-training-on-chemotherapy-induced-cognitive-impairment-in-colon-cancer-patients-undergoing-treatmentchemobrain-in-oncology-patients-with-colon-cancer-undergoing-active-treatment-100570699","NCT06710639","Effects of Cognitive Training on Chemotherapy-Induced Cognitive Impairment in Colon Cancer Patients Undergoing Treatment(Chemobrain) in Oncology Patients With Colon Cancer Undergoing Active Treatment","Effects of a Cognitive Training Program on Chemotherapy-induced Cognitive Impairment (Chemobrain) in Oncology Patients With Colon Cancer Undergoing Active Treatment: A Randomized Controlled Trial","Inclusion Criteria:\n\nBeing an adult (18 years or older). Having a recent pathological diagnosis of newly diagnosed colon cancer and starting oncological treatment.\n\nBeing fully capable of performing daily functions. Willingness to voluntarily participate in the study and signing the informed consent.\n\nExclusion Criteria:\n\nLack of literacy skills or significant language comprehension deficits. Having a diagnosis of a Central Nervous System tumor or participating in another cognitive stimulation program.\n\nHaving a clinical diagnosis of a neurocognitive disorder as defined in the DSM-V.\n\nWithdrawal Criteria:\n\nDropping out of the program or not completing the final evaluation.",{"count":138,"type":21},50,[24],"Introduction: With the increasing survival rate in colon cancer, as a result of technological and biomedical advancements, it is essential to thoroughly study the secondary symptoms related to the oncological disease process. One of the most common and underestimated symptoms is cancer-related cognitive impairment (CRCI).\n\nObjective: To evaluate the efficacy of a cognitive training program in controlling CRCI in individuals with colon cancer undergoing active treatment.\n\nMethodology: A randomized controlled clinical trial with two parallel groups: an intervention group (IG) and a control group (CG). The study population will include individuals newly diagnosed with colon cancer. A sample size of 50 participants has been estimated, with 25 in each group, to detect a difference of 2.95 points or more in the MoCA cognitive impairment questionnaire. All participants will receive an educational leaflet based on the new WHO guidelines, which recommend specific measures to reduce the risk of cognitive impairment. In addition to receiving this informational leaflet, the IG will participate in a cognitive training program (CT) focused on everyday cognition (EC) individually. Each participant will receive a dossier with 80 intervention sessions divided into four training periods (P1-P4), each containing 20 activities. Each period will last for one month. Baseline and 4-month post-intervention evaluations will be conducted for both groups, measuring sociodemographic and clinical variables, as well as study-related cognitive impairment variables: Cognitive function (MoCA test), Everyday Cognition (PECC), Anxiety (Hamilton), Functionality (LB), Sleep Quality (PSQI), Quality of Life (ECOG), and Subjective Memory Complaints (FACT-COG).\n\nImpact: The results of this study could lead to the design of specific cognitive interventions and the establishment of protocols for colon cancer patients undergoing active treatment, helping them manage one of the most underestimated symptoms in this patient population-CRCI-whose incidence is increasing due to the improved survival rates in this disease.",[142,143,27,144,145,146],"Oncology","Cancer-related Cognitive Impairment","Everyday Cognition","Clinical Trials","Colon Cancer",[142,148,149,150,151,152],"Cancer-related cognitive impairment","Cognitive training","Everyday cognition","Clinical trials","Colon cancer","2024-11-26",{"date":155,"type":36},"2024-11-29",{"date":157,"type":21},"2025-03-01",{"date":159,"type":21},"2026-01-31",{"name":161,"class":43},"University of Salamanca",{"id":163,"slug":164,"hasResults":11,"nctId":165,"briefTitle":166,"officialTitle":167,"acronym":168,"eligibilityCriteria":169,"healthyVolunteers":83,"sex":16,"minAge":17,"maxAge":170,"enrollmentInfo":171,"targetDuration":4,"studyType":22,"phases":173,"briefSummary":174,"conditions":175,"keywords":179,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":4},"100551447","neurofeedback-removal-of-emotional-information-from-mind-100551447","NCT06460207","Neurofeedback Removal of Emotional Information From Mind","A 4-day Study of Neurofeedback Training of Cognitive Control in Healthy Adults","remtrain","Inclusion Criteria:\n\n* Right-handed\n* Speak English fluently\n* Minimum 8th grade education\n* Good hearing\n* Good vision or minimal correction with contacts or eyeglasses\n\nExclusion Criteria:\n\n* History of significant illnesses (including cardiovascular disease, cancer, immunodeficiency disorders (including HIV infection)\n* Diabetes\n* Unstable endocrine disorders\n* Neurological disorders\n* Neuromuscular disorders\n* Blood dyscrasias\n* History of major psychiatric disorders (including schizophrenia, bipolar disorder, and dementia)\n* Substance dependence\n* History of head trauma with loss of consciousness\n* Cerebrovascular accident\n* Seizures\n* Neurosurgical intervention\n* Metal implants in the body (including pacemakers, neurostimulators, or other metal objects)\n* Metal piercings that cannot be removed for the scan\n* Women who are pregnant or who think they may be pregnant","40 Years",{"count":172,"type":21},40,[24],"This project will examine whether individuals can be trained, using real-time feedback about brain function during neuroimaging, to effectively remove thoughts from mind by providing them with a sense of what it feels like to successfully remove a thought.",[176,27,177,178],"Neurofeedback","Memory, Short-Term","Functional Magnetic Resonance Imaging (fMRI)",[180,181,182,183],"Suppression","Maintenance","Cognitive Control","Working Memory","2024-06-10",{"date":186,"type":36},"2024-06-14",{"date":188,"type":21},"2024-09",{"date":190,"type":21},"2025-12",{"name":192,"class":43},"University of Texas at Austin"]