[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"collateral-circulation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:collateral-circulation":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100633463","phase-3-stratified-blood-pressure-management-after-endovascular-treatment-for-acute-ischemic-stroke-100633463",false,"NCT07527013","Stratified Blood Pressure Management After Endovascular Treatment for Acute Ischemic Stroke","Stratified Blood Pressure Management After Endovascular Treatment for Acute Ischemic Stroke (RESCUE-BP)","RESCUE-BP","Inclusion Criteria:\n\n* Age ≥ 18 years；\n* Clinical diagnosis of acute ischemic stroke caused by anterior circulation large vessel occlusion (internal carotid artery or M1\u002FM2 segment of the middle cerebral artery)；\n* Received EVT (including direct EVT and bridging therapy) within 24 hours of symptom onset；\n* Baseline ASPECTS score ≥ 3；\n* Baseline NIHSS score ≥ 6；\n* Successful recanalization achieved post-procedure (defined as expanded Thrombolysis in Cerebral Infarction \\[eTICI\\] grade ≥ 2b50);\n* Two consecutive systolic blood pressure (SBP) measurements ≥ 150 mmHg within 3 hours post-recanalization (with a measurement interval of no less than 5 minutes)；\n* Able to complete randomization within 3 hours post-recanalization；\n* Informed consent signed by the patient or their legal representative.\n\nExclusion Criteria:\n\n* Pre-stroke mRS score \\> 1；\n* Comatose state (Glasgow Coma Scale \\[GCS\\] score \\\u003C 8);\n* Symptomatic intracerebral hemorrhage occurred before randomization;\n* Within the past 3 months, occurrence of acute ST-segment elevation myocardial infarction (MI), acute decompensated heart failure, QTc \\> 500 ms, hospitalization or involuntary coronary intervention due to acute coronary syndrome, MI, or cardiac arrest; or heart failure (New York Heart Association \\[NYHA\\] class III\u002FIV or left ventricular ejection fraction \\\u003C 35%); or known history of ventricular tachycardia;\n* History of severe renal insufficiency, acute renal failure, dialysis, or estimated glomerular filtration rate (eGFR) \\\u003C 20 ml\u002Fmin\u002F1.72m²;\n* History of severe hepatic disease, or Aspartate Aminotransferase (AST) and\u002For Alanine Aminotransferase (ALT) and\u002For Gamma-Glutamyl Transferase (GGT) ≥ 3×ULN and\u002For Total Bilirubin (TBIL) ≥ 2×ULN;\n* Aortic dissection, cervical artery dissection, or cerebral artery dissection; unruptured aortic aneurysm or cerebral aneurysm; or known arteriovenous malformation;\n* Comorbidities with a life expectancy \\\u003C 6 months (e.g., malignant tumors);\n* Pregnant or lactating women;\n* Participation in another clinical trial within the past 30 days;\n* Any clinical condition judged by the research team that might limit compliance with study procedures.","ALL","18 Years",{"count":20,"type":21},544,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","The RESCUE-BP is a multi-centered, prospective, randomized, open label, blinded endpoint (PROBE) phase III trial. In patients with acute ischemic stroke who have undergone endovascular treatment and achieved successful recanalization, the evaluation will compare a stratified blood pressure management strategy based on the collateral circulation status with the guideline-recommended conventional blood pressure management strategy. Within each stratum, participants will be randomized in a 1:1 ratio to either the stratified blood pressure management strategy group or the guideline-recommended conventional blood pressure management group. The goal is to determine whether this can improve good functional outcomes at 90 days (90-day Modified Rankin Scale \\[mRS\\] score 0-2).\n\nThe study consists of four visits including the day of randomization, 24±4 hours after randomization, 7±1 days after randomization and 90±7 days after randomization. Demographic information, symptoms and signs, laboratory test, neuro-imaging assessment, neurological function rating scale will be recorded during the program.\n\nThe primary outcome is the modified Rankin Scale (mRS) score of 0 to 2 at 90±7 days after randomization. The primary safety outcome is the incidence of sICH within 24±4 hours after randomization.",[27,28,29,30,31],"Endovascular Therapy","Acute Ischaemic Stroke","Collateral Circulation","Blood Pressure Management","Prognosis","NOT_YET_RECRUITING","2026-04-17",{"date":35,"type":36},"2026-04-22","ACTUAL",{"date":38,"type":21},"2026-06-01",{"date":40,"type":21},"2028-02-29",{"name":42,"class":43},"Beijing Tiantan Hospital","OTHER"]