[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"colon-adenoma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:colon-adenoma":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,45,85,112,138,156],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100470196","st-pauls-advanced-resection-center-cohort-for-colorectal-neoplasia-sparc-c-100470196",false,"NCT05402696","St. Paul's Advanced Resection Center Cohort for Colorectal Neoplasia (SPARC-C)","The St. Paul's Hospital Advanced Endoscopic Resection Centre Cohort for Colorectal Neoplasia (SPARC-C): A Prospective Observational Study","SPARC-C","Inclusion Criteria:\n\n* Patients ≥ 18 years of age referred for the management of an LNPCP\n* Able to provide informed consent.\n\nExclusion Criteria:\n\n* Unable to provide informed consent\n* Pregnant or lactating women.","ALL","18 Years",{"count":20,"type":21},3500,"ESTIMATED","10 Years","OBSERVATIONAL","The SPARC-C study is a prospective, multi-institutional observational study of patients referred for the management of large (≥ 20mm) non-pedunculated colorectal polyps (LNPCPs). Patients are managed consistent with current standards of care. Prospectively collected data includes: patient clinicodemographic details, lesion details, procedural details, and clinical outcomes.",[26,27,28],"Colon Adenoma","Colon Polyp","Colon Lesion",[30,31,32],"Colorectal neoplasia","Advanced endoscopy","Endoscopic resection","RECRUITING","2026-05-12",{"date":36,"type":37},"2026-05-15","ACTUAL",{"date":39,"type":37},"2022-06-27",{"date":41,"type":21},"2032-12-31",{"name":43,"class":44},"University of British Columbia","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":84},"100627590","liquid-biopsy-and-machine-learning-for-early-colorectal-cancer-adenomas-lynch-cancers-and-residual-disease-detection-100627590","NCT07450612","Liquid Biopsy and Machine Learning for Early Colorectal Cancer, Adenomas, Lynch Cancers, and Residual Disease Detection","BEACON","Inclusion Criteria:\n\n* All individuals included in the study need to have had a colonoscopy at the time of blood sampling.\n* Received standard diagnostic and staging (as necessary) procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment.\n* Received standard pathological and endoscopic diagnosis and assessment for cohort assignment\n\nExclusion Criteria:\n\n* Lack of informed consent\n* Inflammatory bowel disease",true,{"count":54,"type":21},1200,"This is an multicenter study that will test the diagnostic accuracy of a blood test (i.e., a liquid biopsy) for the diagnosis of colorectal cancer (CRC), advanced adenomas (AAs), as well as Lynch-syndrome associated cancers. Additionally, a pre-planned analysis will evaluate the use of this liquid biopsy as a tool for molecular residual disease monitoring purposes.",[57,58,59,26,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74],"Colorectal Cancer","Adenoma Colon","Adenoma Colon Polyp","Colo-rectal Cancer","Colon Disease","Colon Neoplasm","Lynch Syndrome","Lynch Syndrome I","Lynch Syndrome II","Lynch Syndrome I (Site-specific Colonic Cancer)","LYN Gene Mutation","Mismatch Repair Deficiency","Mismatch Repair Gene Mutation","MLH1 Gene Mutation","MSH2 Gene Mutation","MSH6 Gene Mutation","PMS2 Gene Mutation","EPCAM Gene Mutation","2026-02-27",{"date":77,"type":37},"2026-03-04",{"date":79,"type":37},"2024-01-01",{"date":81,"type":21},"2031-08-15",{"name":83,"class":44},"San Raffaele University",4,{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":52,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":92,"targetDuration":4,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":111},"100558422","training-physicians-to-differentiate-the-paris-classification-using-artificial-colon-polyp-images-100558422","NCT06550908","Training Physicians to Differentiate the Paris Classification Using Artificial Colon Polyp Images","LUTETIA2","Inclusion Criteria:\n\n* Physicians with or without experience in colonoscopy",{"count":93,"type":21},70,"INTERVENTIONAL",[96],"NA","Training in endoscopy is essential for the early detection of precursors of colorectal cancer. Up to now, this training has been carried out with image collections of findings and in practice when working on patients. The investigators want to use artificial intelligence (AI) to better train doctors to recognise these precursors. By using generative AI, the investigators were able to create realistic images that comply with data protection regulations and whose content can be predefined. Parts of the image can also be regenerated so that it is possible to create different precancerous stages in the same place in the image.\n\nIn this study the investigators want to train physicians using real images or artificial images in order to compare which version helps classify polyps better.",[99,26],"Colonic Polyp",[101],"Colonoscopy","2025-08-06",{"date":104,"type":37},"2025-08-12",{"date":106,"type":37},"2025-04-15",{"date":108,"type":21},"2025-08-31",{"name":110,"class":44},"Wuerzburg University Hospital",1,{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":94,"phases":121,"briefSummary":122,"conditions":123,"keywords":126,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":111},"100442445","cold-snare-endoscopic-mucosal-resection-emr-vs-cold-emr-with-margin-snare-tip-soft-coagulation-stsc-100442445","NCT05041478","Cold Snare Endoscopic Mucosal Resection (EMR) vs Cold EMR With Margin Snare Tip Soft Coagulation (STSC)","Cold Snare Endoscopic Mucosal Resection vs Cold Snare Endoscopic Mucosal Resection With Adjuvant Thermal Therapy to Resection Margins - A Randomised Controlled Trial","Inclusion Criteria:\n\n* Any patient undergoing colonoscopy who is older than 18 years of age, has a written consent for trial participation and has at least one laterally spreading lesion meeting the following description:\n* Localisation in the colon or rectum\n* Benign adenomatous surface features (Kudo III \u002F IV, Japan NBI Expert Team (JNET) 2a)\n* Granular or non-granular topography\n* Paris classification 0-IIa\u002FIIb +\u002F- Is\n* If present, sessile component may be no greater than 10mm in size.\n* Polyp size ranging from 15 to 40mm\n\nExclusion Criteria:\n\n* Current use of antiplatelet (excluding aspirin) or anticoagulants which have not appropriately been interrupted according to the guidelines.\n* Known bleeding disorder or coagulopathy.\n* Pregnancy\n* History of inflammatory bowel disease\n* Previously attempted or otherwise non-lifting lesions\n* Endoscopic features suggestive of submucosal invasion (Kudo Vi\u002Fn, JNET 2b \u002F 3) or concurrent colorectal cancer\n* Lesions involving the ileocaecal valve (ICV), appendiceal oriface or anorectal junction (ARJ)",{"count":120,"type":21},300,[96],"Randomised controlled trial comparing cold snare endoscopic mucosal resection (EMR) with cold snare EMR and adjuvant margin STSC in the complete resection of 15-40mm lateral-spreading adenomas",[124,26,125],"Colorectal Polyp","Colon Cancer",[101,127,128,57],"Polypectomy","Adenoma","2025-03-25",{"date":131,"type":37},"2025-03-27",{"date":133,"type":37},"2023-09-19",{"date":135,"type":21},"2028-10-01",{"name":137,"class":44},"Western Sydney Local Health District",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":145,"enrollmentInfo":146,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":148,"conditions":149,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":150,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":111},"100321968","the-australian-colonic-large-sessile-lesion-endoscopic-resection-study-100321968","NCT03471793","The Australian Colonic Large Sessile Lesion Endoscopic Resection Study","ACE","Inclusion Criteria:\n\n* Patients referred for endoscopic resection of a large sessile colonic polyp or laterally spreading tumour ≥20mm in size.\n* Able to give informed consent to involvement in the clinical study\n\nExclusion Criteria:\n\n* Unable to provide informed consent for involvement","99 Years",{"count":147,"type":21},5000,"A prospective, multicentre, observational study of all patients referred for endoscopic resection of sessile colorectal polyps sized ≥20 mm conducted with intention to treat analysis",[26,27],{"date":131,"type":37},{"date":152,"type":37},"2017-02-24",{"date":154,"type":21},"2037-02",{"name":137,"class":44},{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":160,"acronym":161,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":17,"minAge":163,"maxAge":164,"enrollmentInfo":165,"targetDuration":4,"studyType":94,"phases":167,"briefSummary":168,"conditions":169,"keywords":170,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":111},"100466563","risk-of-metachronous-findings-after-detection-of-serrated-lesions-and-high-grade-dysplasia-with-surveillance-delay-100466563","NCT05355363","Risk of Metachronous Findings After Detection of Serrated Lesions and High-grade Dysplasia With Surveillance Delay","SSL follow-up","Inclusion Criteria:\n\n* Patients 45-80 who underwent colonoscopy from 2009 to 2022 at the Montreal University Hospital Center (CHUM) with 1+ SL or HGD detected at index colonoscopy and lacking follow-up within or beyond the surveillance interval recommended by 2020 USMSTF guidelines.\n\nExclusion Criteria:\n\n* 1\\) Patients with a diagnosis of inflammatory bowel disease;\n* 2\\) Hereditary CRC syndromes;\n* 3\\) CRC at index colonoscopy;\n* 4\\) Serrated polyposis syndrome;\n* 5\\) Life expectancy too short to benefit from colonoscopy;\n* 6\\) Follow-up colonoscopy not yet due according to USMSTF guidelines. Patients with concomitant HRA and SL at index will be invited to participate if the index (or last) colonoscopy was performed more than 1 year ago. This is based on the high rates of HRA we identified in our retrospective study posing increased risks for these patients.","45 Years","80 Years",{"count":166,"type":21},730,[96],"The primary aim of this study is to determine the rate of total metachronous advanced neoplasia (TMAN) detection after index detection of serrated lesions (SL) \\[sessile serrated polyps (SSPs), traditional serrated adenomas (TSAs)\\], and metachronous high-risk adenoma (HRA) after index detection of high-grade dysplasia (HGD).\n\nWe will use the database of patients diagnosed with SL or HGD at index colonoscopy with a delay in surveillance and determine the risk of advanced lesions (especially high-risk lesion and CRC detection) of these delayed colonoscopies. The aim is to determine the effects of breach of continuity of care in these patients.",[57,26],[171,172,173,174,175,101],"sessile serrated polyps","traditional serrated adenomas","high-grade dysplasia","high-risk adenoma","cancer prevention","2025-02-07",{"date":178,"type":37},"2025-02-11",{"date":180,"type":37},"2023-02-27",{"date":182,"type":21},"2025-12-31",{"name":184,"class":44},"Centre hospitalier de l'Université de Montréal (CHUM)"]