[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"colon-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:colon-disease":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,57,83,106,127,151],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100627590","liquid-biopsy-and-machine-learning-for-early-colorectal-cancer-adenomas-lynch-cancers-and-residual-disease-detection-100627590",false,"NCT07450612","Liquid Biopsy and Machine Learning for Early Colorectal Cancer, Adenomas, Lynch Cancers, and Residual Disease Detection","BEACON","Inclusion Criteria:\n\n* All individuals included in the study need to have had a colonoscopy at the time of blood sampling.\n* Received standard diagnostic and staging (as necessary) procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment.\n* Received standard pathological and endoscopic diagnosis and assessment for cohort assignment\n\nExclusion Criteria:\n\n* Lack of informed consent\n* Inflammatory bowel disease",true,"ALL","18 Years",{"count":20,"type":21},1200,"ESTIMATED","OBSERVATIONAL","This is an multicenter study that will test the diagnostic accuracy of a blood test (i.e., a liquid biopsy) for the diagnosis of colorectal cancer (CRC), advanced adenomas (AAs), as well as Lynch-syndrome associated cancers. Additionally, a pre-planned analysis will evaluate the use of this liquid biopsy as a tool for molecular residual disease monitoring purposes.",[25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43],"Colorectal Cancer","Adenoma Colon","Adenoma Colon Polyp","Colon Adenoma","Colo-rectal Cancer","Colon Disease","Colon Neoplasm","Lynch Syndrome","Lynch Syndrome I","Lynch Syndrome II","Lynch Syndrome I (Site-specific Colonic Cancer)","LYN Gene Mutation","Mismatch Repair Deficiency","Mismatch Repair Gene Mutation","MLH1 Gene Mutation","MSH2 Gene Mutation","MSH6 Gene Mutation","PMS2 Gene Mutation","EPCAM Gene Mutation","RECRUITING","2026-02-27",{"date":47,"type":48},"2026-03-04","ACTUAL",{"date":50,"type":48},"2024-01-01",{"date":52,"type":21},"2031-08-15",{"name":54,"class":55},"San Raffaele University","OTHER",4,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":64,"targetDuration":4,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100538256","enteral-feeding-of-fibre-to-improve-microbiota-100538256","NCT06288464","Enteral Feeding of Fibre to Improve Microbiota","Does Distal Enteral Feeding of Fibre Positively Affect the Microflora in the Distal Limb of Loop Ileostomy Patients?","Inclusion Criteria:\n\n* Any individual that has been identified for distal (stoma) feeding that is able to understand verbal and written English to provide informed consent.\n* Participants must be undergoing ileostomy or colostomy reversal surgery.\n\nExclusion Criteria:\n\n* Not undergoing ileostomy or colostomy reversal.\n* Persons who might not adequately understand verbal explanations or written information given in English",{"count":65,"type":21},15,"INTERVENTIONAL",[68],"NA","Following surgical removal of diseased bowel, patients often require a temporary redirection of bowel contents to a stoma, to allow healing prior to re-joining of the remaining bowel at a later date. Some patients may experience complications, either during or after reversal surgery, and this may be due to changes in the 'friendly' bacteria that live in our bowels. Previous research shows that the distal section of bowel that is non-functioning undergoes tissue-wasting and the 'friendly' bacteria that help our digestion die. Data shows that patients that have a reduction in their microflora are more likely to experience side effects. This study investigates a method of replenishing the microflora prior to surgery.",[71,30,72],"Bowel Dysfunction","Ileum--Diseases","2025-04-04",{"date":75,"type":48},"2025-04-06",{"date":77,"type":48},"2023-01-09",{"date":79,"type":21},"2025-12-01",{"name":81,"class":55},"Lancashire Teaching Hospitals NHS Foundation Trust",1,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":101,"completionDateStruct":102,"leadSponsor":104,"locationsCount":82},"100536501","comparison-of-nom-for-acld-between-medical-and-surgical-ward-100536501","NCT06265649","Comparison of NOM for ACLD Between Medical and Surgical Ward","Acute Left Colon Diverticulitis: is it Still a Surgical Disease When Only Medical Treatment is Required? A Retrospective Study Based on Propensity Score Matching","Inclusion Criteria:\n\n* patients affected by ALCD using a contrast-enhanced CT scan at admission undergoing NOM\n\nExclusion Criteria:\n\n* immediate indication for surgery (i.e. patients with Hinchey III or IV ALCD or septic patients with Hinchey II)",{"count":91,"type":21},175,"In Europe, patients with acute left colon diverticulitis (ALCD) are usually admitted to surgical wards even when only medical treatment is required. The study compares ALCD non-operative management (NOM) between surgical and non-surgical environments regarding clinical outcomes, hospitalization length(LOS), and follow-up.",[94,30,95],"Diverticulitis","Acute Diverticulitis",[97,98],"diverticulitis","non-operative management","2025-04-02",{"date":73,"type":48},{"date":50,"type":48},{"date":103,"type":21},"2026-01",{"name":105,"class":55},"Ospedali Riuniti Trieste",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":116,"conditions":117,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":82},"100583262","safety-efficacy-and-tolerability-of-bowel-preparation-and-colonoscopy-in-patient-with-chd-ckd-and-cld-100583262","NCT06874036","Safety, Efficacy and Tolerability of Bowel Preparation and Colonoscopy in Patient With CHD, CKD and CLD","Safety, Efficacy and Tolerability of Bowel Preparation and Colonoscopy in Patient With Chronic Heart Disease, Chronic Kidney Disease and Chronic Liver Disease","Inclusion Criteria:\n\n* Adult \\>18 years\n* Diagnosed cases of chronic heart disease, chronic kidney disease or chronic liver failure planned for elective colonoscopy\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Current or past history of bowel obstruction or resection\n* Known allergies to PEG\n* Emergency colonoscopies.\n* Pregnant or lactating women\n* Paralytic ileus \u002F Bowel perforation\n* Inability to protect airway","75 Years",{"count":115,"type":21},74,"Consecutive eligible patients will be enrolled and written informed consent will be obtained from all participants. Routine blood investigations will be sent. Patients with chronic heart failure will be classified based on ejection fraction into 2 groups (EF \\\u003C\u002F\\> 40%), patients with chronic kidney disease will be classified based on KDIGO classification system into grade I-V. Patients with chronic liver disease will be classified according to the child pugh scoring system into three groups (Child A, B and C). All patients will be undergo bowel preparation under supervision. The patients will be given 10 mg of bisacodyl, the night before colonoscopy. A PEG sachet (137.15 g) containing polyethylene glycol (118 g), sodium chloride (2.93 g), potassium chloride (1.484 g), sodium bicarbonate (3.370 g), and anhydrous sodium sulfate (11.36 g) will be constituted into 2 L solution and used for bowel preparation.\n\nPatients will receive 1 L of PEG solution between 10 PM and 11 PM the day before and 1 L of PEG solution between 6 AM and 7 AM on the day of colonoscopy. Clear liquids will be allowed after the completion of the last bowel preparation until the start of the procedure. Liquid diet includes soups, fruit juices, rice kanji, or porridge in liquid consistency, and clear liquids such as coconut water and lemon juice.\n\nAfter the adequacy of bowel preparation is deemed fit, the patients will be taken for colonoscopic examination. A single blinded outcome assessment will be done by the colonoscopist\u002Fendoscopist performing the procedure (adequacy of bowel preparation) and the endoscopy nurse (tolerability and compliance).\n\nColonoscopy will be performed using standard video colonoscopes (Olympus, Tokyo, Japan) between 11:00 AM and 1:00 PM without sedation. The colonoscopist \u002F endoscopist will assess the adequacy of bowel preparation using the Boston Bowel Preparation Scale (BBPS). Excellent, good and poor bowel preparations will be defined by BBPS score of 9, 6 - 9 and \\\u003C 6, respectively. (12-14) Blood sampling will be done before bowel preparation and after colonoscopy in all patients for measurement of baseline parameters, renal function status (Serum creatinine, serum urea), serum electrolytess (serum sodium, serum potassium, serum phosphate and serum calcium) and haematocrit.\n\nAssessment of safety and tolerability will be performed using clinical examination and symptom questionnaire. Cardiovascular and gastrointestinal (GI) symptoms will be recorded. Cardiovascular symptoms such as dyspnea, palpitations, chest pain, will be recorded and scored using the NYHA classification system for symptom severity. Clinical examination will be carried out post-bowel preparation and post-procedure to assess for signs of fluid overload, i.e. auscultation for crepitations and measurement of JVP. GI symptoms such as nausea, abdominal pain, vomiting, dizziness, bloating, and headache will be recorded and scored on a 4-point scale: 1 = none, 2 = mild, 3 = moderate, and 4 = severe. The compliance of bowel preparation will be defined as \"poor\" for patients who consume less than 75% of the PEG preparation.",[30],"2025-03-11",{"date":120,"type":48},"2025-03-13",{"date":122,"type":48},"2024-08-10",{"date":124,"type":21},"2025-05-30",{"name":126,"class":55},"Asian Institute of Gastroenterology, India",{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":134,"targetDuration":4,"studyType":66,"phases":136,"briefSummary":138,"conditions":139,"keywords":140,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":149,"locationsCount":82},"100472759","phase-4-a-trial-to-compare-efficacy-and-tolerability-of-plenvu-and-picoprep-as-cleansing-agents-before-colonoscopy-100472759","NCT05436054","A Trial to Compare Efficacy and Tolerability of Plenvu® and Picoprep® as Cleansing Agents Before Colonoscopy","A Randomised Controlled Trial to Compare Efficacy and Tolerability of Plenvu® and Picoprep® as Cleansing Agents Before Colonoscopy","Inclusion Criteria:\n\n* Ambulant colonoscopy\n* Older than18\n\nExclusion Criteria:\n\n* Younger than 18\n* Known with severe heart failure\n* Known with severe renal failure (eGFR\\\u003C30)\n* Known for colonic stenosis\n* Pregnant or breastfeeding\n* Acute colonoscopy\n* Cancer screening program colonoscopy\n* Mentally retarded\n* Redo colonoscopy of patients included in this study and colonoscopy was canceled because of bad bowel preparation.\n* Patients with Phenylketonuria\n* Patients with Glucose-6-phosphate-dehydrogenase deficiency\n* Patients with colon or rectum resection",{"count":135,"type":21},400,[137],"PHASE4","The trial is about comparing the efficacy of Plenvu with Picoprep. Both are bowel cleansing agents prior to visual examination of the large bowel to exclude cancer disease.\n\n400 patients who are referred for colonoscopy to a single center in North Jutland will be randomised either to Picoprep or Plenvu. These patients will then answer a questionnaire prior to colonoscopy. The questionnaire is about the most common expected side effects and the experience of cleansing og intake of the bowel agents.\n\nThe effect of the two agents will examined using a special scoring system (Harefield) to determine the quality of bowel cleansing. Colonoscopist who evaluate the cleansing is blinded to which agent the patient has taken.",[30],[141,142],"colonoscopy","bowel cleansing","2024-11-18",{"date":145,"type":48},"2024-11-19",{"date":147,"type":48},"2022-10-01",{"date":79,"type":21},{"name":150,"class":55},"Aalborg University Hospital",{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":158,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":160,"conditions":161,"keywords":165,"overallStatus":167,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":4},"100479226","the-evaluation-of-a-preanaesthesia-assessment-clinic-100479226","NCT05520229","The Evaluation of a Preanaesthesia Assessment Clinic","The Evaluation of a Preoperative Anaesthesia Assessment Clinic on Elective Patients After Partial Excision of the Intestine","Inclusion Criteria:\n\n* Patients over 18 years old.\n* Open or laparoscopic surgery on elective patients after partial excision of the intestine.\n* Patients following the ERAS (Enhanced recovery after surgery) protocol after the year 2014.\n* Patients who attended PAC after the year 2017 and were assessed by anesthesia staff.\n\nExclusion Criteria:\n\n* Emergency patients",{"count":159,"type":21},2600,"International evidence highlights the preanaesthetic assessment clinics (PAC) as a system of benefits for both the patient and the anaesthesiologist. The system has gained global acceptance as a routine method of optimising patients' medical conditions prior to surgery and therefore minimising surgery cancellations and improving hospital efficiency. However, a systematic review found no evidence of the efficiency of (PAC) and therefore we wanted to investigate this with the use of hospitals journals.",[162,163,164,30],"Preoperative Anaesthesia Clinic","Cancellation Rate","Intraoperative Events",[166],"Anesthesia, cancellation, pre-operative, clinic, assessment","NOT_YET_RECRUITING","2022-11-01",{"date":170,"type":48},"2022-11-02",{"date":172,"type":21},"2022-12-01",{"date":174,"type":21},"2027-04-03",{"name":176,"class":55},"University of Agder"]