[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"colon-polyps\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:colon-polyps":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,58,83,112,139],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":33,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":57},"100617125","recurrence-after-gastric-and-intestinal-polyp-resection-100617125",false,"NCT07314554","Recurrence After Gastric and Intestinal Polyp Resection","Recurrence Rate and Risk Factors After Endoscopic Resection of Gastric and Intestinal Polyps: A Retrospective and Prospective Cohort Study","RAGIP","Inclusion Criteria:\n\n* Age 18 years or older\n* First-time endoscopic examination (gastroscopy or colonoscopy) at the study center\n* Pathologically confirmed polyp of any type (adenomatous, hyperplastic, inflammatory, fundic gland polyp, hamartomatous, serrated lesion)\n* Complete endoscopic resection performed (including EMR, ESD, snare polypectomy, hot biopsy forceps, or argon plasma coagulation)\n* Negative resection margins or complete resection assessed by pathology\n* At least one follow-up endoscopic examination completed (for retrospective cohort) or willingness to complete follow-up (for prospective cohort)\n* Complete baseline clinical data available\n\nExclusion Criteria:\n\n* Hereditary polyposis syndromes (familial adenomatous polyposis, Lynch syndrome, Peutz-Jeghers syndrome, juvenile polyposis syndrome)\n* Inflammatory bowel disease (ulcerative colitis or Crohn's disease)\n* Previous history of gastric or colorectal cancer\n* Cancer detected at initial resection (stage T1b or higher)\n* Non-polyp pathology (e.g., submucosal tumors, normal mucosa)\n* Incomplete resection with positive margins that were not re-treated\n* Lost to follow-up with no available surveillance data (for retrospective cohort)\n* Pregnancy at time of enrollment\n* Inability or unwillingness to provide informed consent (for prospective cohort)","ALL","18 Years",{"count":20,"type":21},2000,"ESTIMATED","3 Years","OBSERVATIONAL","This is a retrospective and prospective cohort study designed to evaluate the recurrence rate and identify risk factors after endoscopic resection of gastric and intestinal polyps.\n\nBACKGROUND: Gastric and intestinal polyps are common digestive diseases with potential for malignant transformation. Although endoscopic resection is the standard treatment, recurrence rates range from 10-50%, and the mechanisms and risk factors remain unclear.\n\nOBJECTIVES:\n\nPrimary: To assess short-term (1-year) and long-term (3-year) recurrence rates after endoscopic polyp resection Secondary: To identify independent risk factors and develop a recurrence risk prediction model\n\nDESIGN: Mixed retrospective-prospective cohort study\n\n* Retrospective cohort: Patients who underwent polyp resection from 2021-2022, with follow-up data through 2024\n* Prospective cohort: Patients enrolled from 2024-2025, with standardized follow-up through 2028\n\nSETTING: Single tertiary referral center with \\>10,000 endoscopic polyp resections performed since 2021\n\nPARTICIPANTS: Approximately 1,600-1,800 adult patients (≥18 years) who underwent complete endoscopic resection of gastric or intestinal polyps\n\nFOLLOW-UP:\n\n* Short-term: 1 year post-resection (±2 months)\n* Long-term: 3 years post-resection (±3 months)\n\nMAIN OUTCOME: Recurrence rate defined as new polyp detection at original or different sites during endoscopic surveillance\n\nPOTENTIAL RISK FACTORS: Patient demographics, polyp characteristics (size, number, location, pathology), resection method, Helicobacter pylori status, lifestyle factors, and medication use\n\nEXPECTED IMPACT: Results will inform personalized surveillance strategies and optimize resource allocation for post-polypectomy follow-up.",[26,27,28,29,30,31,32],"Gastric Polyps","Intestinal Polyps","Colon Polyps","Colorectal Polyps","Adenomatous Polyps","Gastric Adenoma and Early Gastric Cancer","Colorectal Adenoma",[34,35,36,37,38,39,40,41,42,43,44],"Polyp recurrence","Endoscopic resection","Polypectomy","Endoscopic mucosal resection","Endoscopic submucosal dissection","Risk factors","Surveillance","Follow-up","Adenoma","Gastric polyp","Colorectal polyp","NOT_YET_RECRUITING","2026-06-07",{"date":48,"type":49},"2026-06-09","ACTUAL",{"date":51,"type":21},"2026-07-26",{"date":53,"type":21},"2029-02-25",{"name":55,"class":56},"LanZhou University","OTHER",1,{"id":59,"slug":4,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":17,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":4,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":4,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":4},"100621039","NCT07365436","Imaging the Colon Using a Colonoscope Compatible Imaging Probe","Study for Imaging the Lower Gastrointestinal Tract Using a Colonoscopy-Compatible OCT Probe","Inclusion Criteria:\n\n* 45 years of age or older\n* Capable of giving informed consent\n* Capable of following bowel prep instructions\n\nExclusion Criteria:\n\n* 75 years of age or older\n* Any contraindication to bowel prep or colonoscopy\n* Current diagnosis of any bleeding disorders\n* Currently using drugs that interfere with coagulation (excluding low-dose aspirin)\n* Pregnancy","45 Years","75 Years",{"count":67,"type":21},250,"INTERVENTIONAL",[70],"NA","The goal of this study is to use a colonoscope compatible device capable of taking images of the lower gastrointestinal tract. The main question it aims to answer is:\n\nIs the colonoscope compatible optical coherence tomography probe (CC-OCT probe) an effective device to use to take images of the gut?\n\nDuring the participant's standard of care colonoscopy, the CC-OCT probe will be inserted into the colonoscope. The CC-OCT probe will then collect images of the participant's gastrointestinal tract in real time.",[28,73],"Colonoscopy","2026-01-22",{"date":76,"type":49},"2026-01-26",{"date":78,"type":21},"2026-03",{"date":80,"type":21},"2029-12",{"name":82,"class":56},"Massachusetts General Hospital",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":90,"sex":17,"minAge":91,"maxAge":65,"enrollmentInfo":92,"targetDuration":4,"studyType":68,"phases":94,"briefSummary":95,"conditions":96,"keywords":99,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":57},"100616679","impact-of-computer-aided-detection-system-on-the-proximal-adenoma-miss-rate-100616679","NCT07308743","Impact of Computer-aided Detection System on the Proximal Adenoma Miss Rate","Impact of Computer-aided Detection System on the Proximal Adenoma Miss Rate: a Multicenter Tandem Rondomized Controlled Trial","Inclusion Criteria:\n\n1. Patients age 40-75 years old, regardless of gender\n2. Patients presenting for physical examination, colorectal cancer screening or diagnosis\n3. Patients voluntarily signs an informed consent form\n\nExclusion Criteria:\n\n1. Unable to cooperate ot tolerate colonoscopy\n2. History of inflammatory bowel disease\n3. History of colorectal cancer\n4. Previous colorectal surgery\n5. History of recurrent constipation\n6. Taking anticoagulant and antiplatelet drugs berfore procedure\n7. High risk conditions such as severe cardiovascular and cerebrovascular diseases, severe anemia, or uncorrected infections\n8. Pregnant or lactating women Researchers concluded that patient was not suitable to participate in this trial.",true,"40 Years",{"count":93,"type":21},686,[70],"This is a prospective, multicenter randomized controlled trial designed to determine whether the use of computer-aided detection system could reduce the miss rates of adenomas, SSLs, and polyps in the proximal colon during tandem colonoscopy.",[97,28,98],"Colon Adenomas","Sessile Serrated Lesion",[100,101,102],"computer-aided detection","proximal adenoma miss rate","Randomized Tandem Colonoscopy Study","2025-12-17",{"date":105,"type":49},"2025-12-30",{"date":107,"type":21},"2025-12",{"date":109,"type":21},"2027-07",{"name":111,"class":56},"Nanfang Hospital, Southern Medical University",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":68,"phases":121,"briefSummary":122,"conditions":123,"keywords":125,"overallStatus":129,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":57},"100568108","impact-of-artificial-intelligence-on-trainee-polyp-miss-rates-100568108","NCT06676930","Impact of Artificial Intelligence on Trainee Polyp Miss Rates","Impact of Computer Aided Detection on Trainee Polyp Miss Rates Using a Tandem Colonoscopy Design","Inclusion Criteria:\n\n* Adult patients referred for screening or surveillance colonoscopy\n\nExclusion Criteria:\n\n* Patients referred for polypectomy or diagnostic colonoscopy\n* Patients with prior right colon surgery\n* Prolonged insertion time (\\>20 minutes)\n* Poor bowel preparation (Boston Bowel Preparation Score less than or equal to 6)",{"count":120,"type":21},180,[70],"Based on prior studies, trainee and practicing gastroenterologists miss pre-cancerous polyps (adenomas and serrated polyps) during colonoscopy. The use of computer-aided detection (CADe) systems, a form of artificial intelligence (AI) has been shown to help identify colorectal lesions for practicing gastroenterologists. However, less is known how AI impacts polyp detection for trainees.\n\nThe investigators are conducting a tandem colonoscopy study wherein a portion of the colon is examined first by the trainee and then the attending physician. For each procedure, randomization will occur which will determine whether or not the trainee will utilize AI for their examination of the colon. At the end of the study, the investigators will determine whether AI helps trainees miss fewer polyps during colonoscopy. The investigators will also conduct interviews with trainees to understand how AI impacts colonoscopy training.",[28,73,124],"Artificial Intelligence (AI)",[126,127,128],"tandem colonoscopy","randomized controlled trial","adenoma miss rate","RECRUITING","2024-11-04",{"date":132,"type":49},"2024-11-06",{"date":134,"type":49},"2024-09-10",{"date":136,"type":21},"2026-09",{"name":138,"class":56},"Northwestern University",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":145,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":147,"conditions":148,"keywords":149,"overallStatus":129,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":57},"100234665","prospective-study-of-colon-serrated-polyps-100234665","NCT02332785","Prospective Study of Colon Serrated Polyps","Inclusion Criteria:\n\n1\\. All Patients with a serrated polyp (Hyperplastic polyps above sigmoid colon, sessile serrated adenoma, traditional serrated adenoma)\n\nExclusion Criteria:\n\nN\u002FA",{"count":146,"type":21},10000,"With this study, the investigators plan to review the clinical, epidemiology, pathology, and endoscopic features of colon serrated lesions as well as outcome of endoscopic resection of these lesions. The findings will help us define the natural history of colon serrated lesions, develop techniques for endoscopic management of patients with serrated lesions, and identity areas for improvement. The data will be used for continuing quality improvement and presenting our outcomes at academic meetings and publishing our results in peer reviewed journals.",[28],[150,151,152,153,154,73,155,156,157],"Colon Serrated Polyps","Serrated polyp","Hyperplastic polyps above sigmoid colon","Sessile serrated adenoma","Traditional serrated adenoma","Endoscopy","Data collection","Data review","2019-05-13",{"date":160,"type":49},"2019-05-14",{"date":162,"type":49},"2014-11",{"date":164,"type":21},"2027-11",{"name":166,"class":56},"M.D. Anderson Cancer Center"]