[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"colorectal-anastomosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:colorectal-anastomosis":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,56,83,116,145,167],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":38,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100619934","post-market-study-of-the-signia-circular-stapler-with-tri-staple-technology-in-left-sided-colon-sigmoid-and-rectal-resections-100619934",false,"NCT07351071","Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal Resections","A Prospective, Multicenter, Single-arm, Post Market Study to Evaluate the Safety and Performance of the Signia™ Circular Stapler With Tri-Staple™ Technology in Elective Open or Minimally Invasive Left-sided Colon, Sigmoid, and Rectal Resections (SECURE)","SECURE","Preoperative Inclusion Criteria:\n\n1. Subject is competent and willing to provide documented informed consent to participate in this clinical study\n2. Subject is intended to undergo an elective left sided colon\u002Fcolorectal procedure where a creation of an anastomosis will be completed with the Signia™ circular stapler\n3. Subject is ≥ 18 years of age at time of consent\n\nPreoperative Exclusion Criteria:\n\n1. Subject is unable or unwilling to comply with the study requirements or follow-up schedule\n2. Subject with ASA classification ≥ IV\n3. Subject is pregnant (as determined by standard site practices)\n4. The procedure is an emergency procedure\n5. The procedure is a revision\u002Freoperation for the same indication\n6. The subject has a documented confounding medical condition which in the opinion of the investigator, will not be appropriate for the study, or the subject has an estimated life expectancy of less than 6 months\n7. Subject has participated or plans to participate in an investigational drug or device research study that would interfere with the results of this study\n8. Subject will undergo multiple synchronous colon resections\n9. Subject with a bleeding disorder or is undergoing anticoagulant treatment that has not been reversed (anticoagulant prophylaxis prescribed as part of the surgical protocol is allowed)\n10. Subject has undergone chemotherapy or received biologics within 6 weeks prior to the day of the procedure\n11. Subject has history of chronic corticosteroid use (used greater than 3 months within a year prior to the index procedure)\n12. Subject has chronic immunosuppression therapy (used greater than 3 months within a year prior to the index procedure)\n13. Any subject undergoing an ileal-anal pouch anastomosis surgery\n\nIntraoperative Exclusion Criteria\n\n1. Anastomosis not attempted with the Signia™ circular stapler\n2. Any subject for which the device is intended to be used outside the instructions for use (IFU)","ALL","18 Years",{"count":20,"type":21},137,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this study is to evaluate the safety and performance of the Signia™ power handle, Signia™ circular adapter, and Signia™ Tri-Staple™ 2.0 circular reloads (hereafter referred to as Signia™ circular stapler) in patients undergoing left sided colon, sigmoid, or rectal resections in a post market setting.",[27,28,29,30,31,32,33,34,35,36,37],"Colorectal Anastomosis","Left-sided Colon Resection","Anastomotic Leak","Anastomotic Complication","Digestive System Diseases","Gastrointestinal Diseases","Colonic Diseases","Intestinal Diseases","Rectal Diseases","Postoperative Complications","Anastomotic Leaks",[27,28,39,29,40,41,42],"Circular stapler","Rectal cancer","Low anterior resection","Powered stapler","RECRUITING","2026-06-11",{"date":46,"type":47},"2026-06-12","ACTUAL",{"date":49,"type":47},"2025-12-30",{"date":51,"type":21},"2027-02-28",{"name":53,"class":54},"Medtronic - MITG","INDUSTRY",9,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":22,"phases":65,"briefSummary":66,"conditions":67,"keywords":68,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":82},"100630464","the-impact-of-early-regular-diet-vs-conventional-clear-fluids-regimen-on-colorectal-anastomosis-100630464","NCT07488013","The Impact of Early Regular Diet vs Conventional Clear Fluids Regimen on Colorectal Anastomosis","Inclusion Criteria:\n\n* Patients with a single, primary large bowel anastomosis\n\nExclusion Criteria:\n\n* Patients with large bowel anastomosis and proximal diversion.\n* Patients with severe systemic illnesses or comorbidities that may impact surgical outcomes or dietary tolerance (e.g., severe heart failure, renal failure, liver failure).\n* Patients who require post-operative intensive care unit (ICU) admission or mechanical ventilation\n* Patients with pre-existing conditions that may affect gastrointestinal function or nutrient absorption (e.g., Crohn's disease, malabsorption syndromes).","60 Years",{"count":64,"type":21},80,[24],"The goal of this clinical trial is to compare the effect of early regular feeding protocol vs conventional clear fluids regimen as per ERAS protocols in patients undergoing colorectal anastomosis. The main questions it aims to answer are:\n\n1. Food tolerance and return of normal bowel Habbits.\n2. Rate of Anastomotic leakage\n3. Length of hospital stay",[27],[69,70,71],"colorectal anastomosis","ERAS protocol","Early feeding","2026-03-17",{"date":74,"type":47},"2026-03-23",{"date":76,"type":47},"2025-07-01",{"date":78,"type":21},"2026-10",{"name":80,"class":81},"Ayman Alayat","OTHER",1,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":93,"phases":4,"briefSummary":94,"conditions":95,"keywords":99,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":115},"100625032","single-stapled-technique-for-colorectal-anastomosis-100625032","NCT07417358","Single-Stapled Technique for Colorectal Anastomosis","Single-Stapled Technique for Colorectal Anastomosis After Left-Sided Colectomy, Sigmoid Resection or Partial Mesorectal Excision: A Multicentre Prospective Observational Cohort Study","SST","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Planned (elective) left-sided colorectal resection with creation of a colorectal anastomosis, including: Left hemicolectomy, and\u002For Sigmoid resection, and\u002For Partial mesorectal excision (PME).\n* Benign or malignant indication.\n* Prospective cohort: Ability to provide written informed consent.\n* Retrospective cohort: Eligible patients operated during 2023-2025 at participating centers, identified through medical record review, meeting the same surgical inclusion criteria.\n\nExclusion Criteria:\n\n* Total mesorectal excision (TME) (e.g., low rectal cancer surgery requiring TME).\n* Non-left-sided colorectal resections (e.g., right-sided colectomy) or procedures outside the study-defined operations.\n* Surgery not involving a colorectal anastomosis (e.g., end colostomy\u002FHartmann's procedure without anastomosis).\n* Emergency\u002Furgent colorectal resection (non-elective surgery).\n* Prospective cohort: Inability to provide informed consent.",{"count":92,"type":21},500,"OBSERVATIONAL","The goal of this observational multicenter study is to evaluate the safety and feasibility of a single-stapled technique (SST) for colorectal anastomosis and to explore whether this technique is associated with a reduced rate of anastomotic leakage compared with the conventional double-stapled technique (DST).\n\nThe study includes adult patients undergoing planned left-sided colorectal resection with colorectal anastomosis, including sigmoid resection, left hemicolectomy, or partial mesorectal excision (PME), for benign or malignant disease.\n\nThe main questions it aims to answer are:\n\nWhat is the rate of anastomotic leakage within 90 days after surgery in patients operated with the single-stapled technique?\n\nIs the single-stapled technique feasible and safe across different surgical approaches (open, laparoscopic, and robot-assisted surgery) in a multicenter setting?\n\nFurthermore, outcomes after single-stapled anastomosis will be compared with a retrospective cohort of patients operated with the conventional double-stapled technique to explore potential differences in anastomotic leakage rates and postoperative complications.\n\nParticipants will receive standard surgical care as determined by the treating surgical team. Patients included in the prospective part of the study will undergo colorectal anastomosis using the single-stapled technique as part of routine clinical practice. Data on perioperative variables, postoperative complications (including anastomotic leakage graded according to international consensus definitions), and follow-up outcomes will be collected prospectively using an electronic case report form (eCRF). A retrospective cohort from the same participating centers will be identified through medical record review using identical inclusion criteria.\n\nThe results of this study are intended to provide robust multicenter data on the safety and clinical outcomes of the single-stapled technique and to serve as the basis for planning a future randomized controlled multicenter trial.",[96,27,97,98],"Colorectal Cancer","Anastomotic Leakage","Diverticular Disease of Left Side of Colon",[100,101,102,103,104,105],"Single-stapled anastomosis","Colorectal anastomosis","Anastomotic leakage","Colorectal surgery","Left-sided colon resection","Partial mesorectal excision","2026-02-10",{"date":108,"type":47},"2026-02-18",{"date":110,"type":47},"2026-01-07",{"date":112,"type":21},"2029-06-30",{"name":114,"class":81},"Umeå University",5,{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":120,"acronym":121,"eligibilityCriteria":122,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":123,"targetDuration":4,"studyType":22,"phases":125,"briefSummary":126,"conditions":127,"keywords":4,"overallStatus":135,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":82},"100583820","impact-of-prior-identification-and-education-of-patients-requiring-a-digestive-stoma-for-fecal-diversion-100583820","NCT06881303","Impact of Prior Identification and Education of Patients Requiring a Digestive Stoma for Fecal Diversion","RESTODIG","Inclusion Criteria:\n\n* Men or women aged 18 and over\n* for whom a fecal diversion stoma is planned on a scheduled or emergency basis\n* affiliated with the French social security system\n\nExclusion Criteria:\n\n* Patient in a period of exclusion from another research protocol at the time of signing the no-objection form,\n* Subjects covered by articles L1121-5 to 1121-8 of the French Public Health Code (minors, adults under guardianship or trusteeship, patients deprived of their liberty, pregnant or breast-feeding women),\n* No digestive stoma or fecal diversion planned\n* Person who does not understand French",{"count":124,"type":21},100,[24],"There are many indications for performing a fecal diversion stoma. In both scheduled and emergency situations, and whatever the context (indication or type of fecal diversion stoma), stomal complications can occur early (10-60%) or late (25%), and may require repeat surgery. The most frequent complications are necrosis, retraction, bleeding, evisceration, occlusion, abscess, hyperflow with hydroelectrolytic consequences, skin lesions, prolapse or eventration. What's more, a temporary stoma can become permanent.\n\nThe positioning and fabrication of the digestive stoma for fecal diversion must therefore comply with well-defined criteria to reduce the risk of stomal complications and the difficulties of fitting the stoma, and thus improve the autonomy and therefore the quality of life of the ostomate patient. The guide to good stoma therapy practice recommends that the site of the future stoma should be marked out preoperatively. What's more, the psychological impact of a stoma is such that preoperative and regular postoperative education is essential. This identification and initiation of education is carried out by stoma nurses and\u002For surgeons.\n\nThe impact of preoperative stoma identification and education on stoma complications, quality of life and patient autonomy has been reported in a few comparative series. The impact of preoperative education on quality of life has also been reported.\n\nHowever, despite this \"Evidence Based Medicine\", and the guide to good stoma therapy practice, the identification and education of the future fecal diversion stoma are not always carried out preoperatively. Reasons for this may include lack of time, lack of human resources, in the general context of a shrinking public hospital, or in the current context of distancing and dehumanization of the profession, or lack of conviction on the part of practitioners.\n\nTo this end, the investigators would like to propose a prospective observational study aimed at evaluating the impact of identification and education prior to the performance of a fecal diversion stoma in a programmed situation on the one hand, and an emergency situation on the other.\n\nThe main objective will be to compare quality of life specifically related to the stoma at 30 days postoperatively with the StomaQOL score, between 2 groups of patients:\n\n* unexposed group: no preoperative stoma identification and education\n* exposed group: preoperative stoma identification and education. This comparison will be stratified according to whether surgery is scheduled or emergency surgery.\n\nTotal 100 patients :\n\n* In scheduled surgery: 30 exposed and 30 unexposed patients\n* In emergency surgery: 10 exposed and 30 unexposed patients\n\nTimeline:\n\nInclusion period: 12 months Follow-up period: 12 months Total duration: 24 months",[27,128,129,130,131,132,133,134],"Endometrial","Anastomotic Leak Rectum","Ulcerative Colitis (Disorder)","Adenomatous Polyposis Coli, Familial","Crohn Disease","Digestive Cancers","Protectomy","NOT_YET_RECRUITING","2025-11-17",{"date":138,"type":47},"2025-11-18",{"date":140,"type":21},"2026-03-01",{"date":142,"type":21},"2028-03-01",{"name":144,"class":81},"Assistance Publique Hopitaux De Marseille",{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":22,"phases":154,"briefSummary":155,"conditions":156,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":166},"100560509","colorectal-anastomosis-outcomes-using-the-novel-powered-circular-stapler-compared-with-manual-circular-staplers-100560509","NCT06578065","Colorectal Anastomosis Outcomes Using the Novel Powered Circular Stapler Compared With Manual Circular Staplers.","Colorectal Anastomosis Outcomes Using the Novel Powered Circular Stapler Compared With Manual Circular Staplers. A Randomized Multicentre Controlled Trial.","Inclusion Criteria:\n\n* Patient or its legal representative informed consent.\n* Age ≥ 18 years.\n* Patients who will undergo a colorectal anastomosis after left colectomy, sigmoidectomy or anterior rectal resection, for benign or malignant pathology (NOTE: Hartmann reversal cases also included).\n\nExclusion Criteria:\n\n* Diverting stoma.\n* Emergency surgery.\n* American Society of Anaesthesiologists (ASA) score ≥ IV.\n* Transanal total mesorectal excision approach.",{"count":153,"type":21},540,[24],"Patients whom meet all eligibility criteria will be assigned random 1:1 to one of the following arms:\n\n* ECPS group: Echelon Circular™ Powered Stapler (n=270)\n* MCS Group: manual circular staplers (n=270) Patients will be followed during 30 days in order to evaluate the primary endpoint.",[27],"2024-08-30",{"date":159,"type":47},"2024-09-04",{"date":161,"type":47},"2024-06-27",{"date":163,"type":21},"2026-09-01",{"name":165,"class":81},"Fundación para la Investigación del Hospital Clínico de Valencia",4,{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":174,"targetDuration":4,"studyType":22,"phases":176,"briefSummary":177,"conditions":178,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":82},"100558058","end-to-end-anastomosis-with-omega-suture-versus-end-to-anterior-rectal-wall-in-colorectal-anastomosis-in-sigmoid-and-upper-rectal-cancer-100558058","NCT06546176","End to End Anastomosis With Omega Suture Versus End to Anterior Rectal Wall In Colorectal Anastomosis in Sigmoid and Upper Rectal Cancer","Comparative Study Between End to End Anastomosis With Omega Suture Versus End to Anterior Rectal Wall In Colorectal Anastomosis in Sigmoid and Upper Rectal Cancer","Inclusion Criteria:\n\n* Patients aged \\>18 years.\n* Both sexes.\n* Recto sigmoidal carcinoma.\n* Upper rectal cancer.\n\nExclusion Criteria:\n\n* Patients younger than 18 years\n* Recurrent or non-resectable cancer\n* Complicated cancer (e.g., obstructed or perforated)\n* Previous left-sided colorectal surgery or anorectal surgeries\n* Lower rectal cancer",{"count":175,"type":21},40,[24],"The aim of this study is to compare end to end anastomosis with omega suture versus end to anterior rectal wall in colorectal anastomosis as regard post operative anastomotic leakage, bowel function, operative time and intra operative blood loss.",[179,27,180,181,182],"End to End Anastomosis","End to Anterior Rectal Wall","Sigmoid Cancer","Upper Rectal Cancer","2024-08-07",{"date":185,"type":47},"2024-08-09",{"date":187,"type":47},"2023-09-01",{"date":189,"type":21},"2024-09-01",{"name":191,"class":81},"Ain Shams University"]