[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"colorectal-cancer-control-and-prevention\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:colorectal-cancer-control-and-prevention":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,39,72,109,140,164,185,210,236],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100640747","prediction-model-of-colorectal-adenoma-recurrence-carcinogenesis-risk-with-tcm-wm-multimodal-feature-fusion-100640747",false,"NCT07611266","Prediction Model of Colorectal Adenoma Recurrence-Carcinogenesis Risk With TCM-WM Multimodal Feature Fusion","Study on the Prediction Model of Recurrence and Carcinogenesis Risk of Colorectal Adenoma Based on the Fusion of Traditional Chinese and Western Medicine Multimodal Features","Inclusion Criteria:\n\n* Meet the diagnostic criteria for colorectal adenoma (Western medicine) and the relevant TCM syndromes.\n* Aged 18 years or older.\n* Willing to undergo regular follow-up examinations (including colonoscopy and laboratory tests) and sign the informed consent form.\n\nExclusion Criteria:\n\n* Pregnant or lactating women.\n* History of Crohn's disease, ulcerative colitis, or other malignancies.\n* Previous history of radiotherapy, chemotherapy, or gastrointestinal surgery.\n* Hereditary polyposis syndromes (e.g., familial adenomatous polyposis, MUTYH-associated polyposis, or hamartomatous polyposis syndrome).\n* Severe cognitive impairment, dementia, or mental illness.\n* Severe cardiovascular or cerebrovascular diseases, or hematological system disorders.","ALL","18 Years",{"count":19,"type":20},3000,"ESTIMATED","18 Months","OBSERVATIONAL","This project focuses on developing a risk prediction model for the recurrence and malignant transformation of colorectal adenomas by integrating multimodal features from both Traditional Chinese Medicine (TCM) and Western medicine. Led by Dr. Wei Hongtao from Beijing Friendship Hospital, Capital Medical University, the primary objective is to mine clinical characteristics from both medical systems to construct a robust predictive model. The research encompasses several key aspects: a multicenter, large-sample cohort study design with a clearly defined sample size and calculation basis; patient recruitment from multiple institutions nationwide to form training and validation sets; and strict adherence to standardized TCM and Western diagnostic criteria. Through comprehensive observation of demographic, TCM clinical (e.g., syndromes, tongue and pulse diagnosis), and Western clinical features, the study ensures data accuracy via rigorous monitoring and follow-up. Various algorithms are employed to extract and analyze these multi-source features-including endoscopic data-to build and evaluate the prediction model. Furthermore, the study aims to identify dominant subgroups to optimize TCM intervention strategies. Key performance indicators include establishing the risk model, identifying target populations, publishing high-quality papers, and training graduate students. By innovatively constructing this multimodal fusion model, the project provides a novel perspective and evidence-based foundation for the prevention and treatment of colorectal adenomas using TCM.",[25],"Colorectal Cancer Control and Prevention","RECRUITING","2026-05-20",{"date":29,"type":30},"2026-05-28","ACTUAL",{"date":32,"type":30},"2025-06-01",{"date":34,"type":20},"2028-11-30",{"name":36,"class":37},"Beijing Friendship Hospital","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":56,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":38},"100603852","life-expectancy-informed-colorectal-cancer-screening-100603852","NCT07141901","Life Expectancy-informed Colorectal Cancer Screening","Improving Colorectal Cancer Screening Decisions Through Consideration of Life Expectancy","CRC","Inclusion Criteria:\n\n* Aim 1a: Patients must meet all the inclusion criteria listed below to be included:\n\n  * \\> 75 years of age\n  * Resident of Ohio\n  * Had at least one Internal Medicine or Family Medicine visit at Cleveland Clinic Health System between January 1, 2007, and September 1, 2022.\n\nAim 1b: Clinicians must meet all the inclusion criteria listed below to be included:\n\n* Internal Medicine or Family Medicine clinician (MD, DO, or APP) practicing at Cleveland Clinic Health System in Northeast Ohio\n* Saw ≥10 study-eligible patients, defined as patients aged \\>75 years who were due or overdue for colorectal cancer screening, between 2024-2025\n* With a colonoscopy ordering rate for patients \\>75 years in either the top quarter of the distribution of all eligible clinicians or bottom quarter of all eligible clinicians\n\nAim 2: Clinics must meet all the inclusion criteria listed below to be included:\n\n• Internal Medicine or Family Medicine clinical site included in the Cleveland Clinic Health System in Northeast Ohio or Florida\n\nClinicians must meet all the inclusion criteria listed below to be included:\n\n* Currently practicing in Internal or Family Medicine as an attending clinician\n* Saw ≥10 study-eligible patients, defined as patients aged \\>75 years who were due or overdue for colorectal cancer screening, between 2024-2025\n\nPatients must meet all the inclusion criteria listed below to be included:\n\n* \\>75 years of age\n* Have not received a colonoscopy in the prior 10 years\n* Have not received a FOBT\u002FFIT in prior year\n* Had a visit in Internal Medicine or Family Medicine between January 1, 2026 and January 1, 2028\n\nExclusion Criteria:\n\n* All candidates meeting any of the exclusion criteria at baseline will be excluded from study participation.\n\nAim 1a:\n\n* Patients aged ≤75 years\n* Patients who did not have at least one subsequent Internal or Family Medicine visit in Ohio within two years from the date of their baseline visit\n* Patients being actively treated for non-skin cancer\n\nAim 1b:\n\n* Clinicians who are not in the top or bottom quarter of the distribution of colonoscopy orderers for patients aged \\>75 years\n* Trainees\u002Fresidents\n* Saw \\\u003C10 study-eligible patients between 2024-2025\n\nAim 2:\n\n* Patients aged \\\u003C75 years\n* Patients up to date with colorectal cancer screening (colonoscopy within 10 years or FOBT\u002FFIT\u002FCologuard within the past year)",true,"76 Years",{"count":50,"type":20},15000,"INTERVENTIONAL",[53],"NA","The purpose of this study is to improve life-expectancy concordant colorectal cancer screening for adults over 75 years through design and testing of a life expectancy notification to clinicians delivered via the electronic health record.\n\nThis study has three components:\n\n1. The investigators will develop a life expectancy prediction model using patient data from the Cleveland Clinic electronic health record (EHR) and test it against two existing life expectancy prediction models to determine which should be used in clinical care. This is an observational cohort study.\n2. Concurrently with the development and testing of the life expectancy prediction model, the investigators will conduct interviews with clinicians to generate knowledge regarding the optimal way to integrate life expectancy information into decision making about colorectal cancer screening in patients over 75 years. This is a qualitative study.\n3. The investigators will then conduct a cluster randomized trial of a clinical decision support-delivered life expectancy notification on life expectancy-congruent colorectal cancer screening orders by primary care clinicians.",[25],[57,58,59,60,61],"life expectancy","colorectal cancer","screening","preventative","decision support tool","NOT_YET_RECRUITING","2025-09-19",{"date":65,"type":30},"2025-09-24",{"date":67,"type":20},"2026-08-01",{"date":69,"type":20},"2029-03-01",{"name":71,"class":37},"Kathryn Martinez",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":47,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":51,"phases":82,"briefSummary":83,"conditions":84,"keywords":92,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":108},"100605106","optical-diagnosis-of-neoplasia-using-artificial-intelligence-100605106","NCT07158203","Optical Diagnosis of Neoplasia Using Artificial Intelligence","Assistance for Optical Diagnosis of Neoplasia Using Artificial Intelligence (FAIR Study)","FAIR","Endoscopists who meet the following inclusion\u002Fexclusion criteria Inclusion criteria\n\n* Endoscopists experienced with more than 100 colonoscopies. Exclusion criteria\n* Endoscopists who are involved in the development of the protocol of the present study.\n\nInclusion and exclusion criteria for the study videos. Inclusion criteria.\n\n* Videos with a duration of 15 seconds including both WL and NBI.\n* Videos with diminutive polyps with confirmed pathology. Exclusion criteria.\n* Videos with no clear image of the polyps.\n* Videos with more than one polyp on-screen.\n* Inflammatory bowel disease\n* Polyposis\n* Hereditary colorectal disease\n* Videos which CADx cannot provide sufficient number of outputs.",{"count":81,"type":20},70,[53],"Computer-aided diagnosis (CADx) for colonoscopy aims to enhance optical diagnosis but often underperforms when used alongside humans due to under-reliance on AI. Psychological interventions like cognitive forcing, such as delaying CADx suggestions, may improve human-AI interaction by fostering critical assessment. However, their impact on patient-important outcomes remains unexplored.\n\nThe investigators will conduct an ex-vivo randomized study with 70 endoscopists assessing 100 polyp videos (≤5 mm) using a CADx tool (GI Genius, Medtronic). Participants will be randomized to either:\n\n* Intervention group: CADx suggestions will be shown in the last 3 seconds of the 15 second polyp video.\n* Control group: CADx suggestions will be shown in real-time throughout the playback of the 15 second polyp video.\n\nThe primary endpoint is sensitivity for high-confidence neoplasia detection, with secondary endpoints assessing endoscopists' reliance on AI.\n\nCADx systems on the market function in various ways, such as real-time, delayed, or on-demand diagnosis. Our study aims to inform users and manufacturers whether cognitive forcing through delayed CADx suggestions enhances human-AI interaction, leading to improved clinical outcomes.",[85,86,87,25,88,89,90,91],"Polyps Colorectal","Colonoscopy","Optical Biopsy","Colorectal Cancer Screening","Behavior Change","Psychological Factors","Psychological Intervention",[93,94,95,96,97,98],"behaviour","optical biopsy","colonoscopy","CADx system","colorectal polyps","psychological intervention","2025-08-28",{"date":101,"type":30},"2025-09-05",{"date":103,"type":20},"2025-09",{"date":105,"type":20},"2025-12",{"name":107,"class":37},"Fundacin Biomedica Galicia Sur",2,{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":51,"phases":119,"briefSummary":121,"conditions":122,"keywords":126,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":4},"100580576","phase-3-prophylactic-pipac-in-patients-with-high-risk-colorectal-cancer-100580576","NCT06839092","Prophylactic PIPAC in Patients With High-risk Colorectal Cancer","Prophylactic PIPAC for Reducing the Risk of Peritoneal Carcinomatosis in Patients With Colorectal Cancer: the PROPAC Randomized Clinical Trial","PROPAC","Inclusion criteria:\n\n* Patients operated (in emergency or elective settings) for colorectal cancer (of the colon, colorectal junction or high rectum).\n* Definitive pathological stage pT4 pN0-2 cM0 pMMR and\u002For pT3-4 pN0-2 cM0 pMMR with positive cytology and\u002For pT3-4 pN0-2 M1c pMMR with limited peritoneal carcinomatosis which is limited to one abdominal quadrant and was resected during index surgery and no other distant lesion (small indeterminate pulmonary nodules to be followed are accepted)\n* Performance status 0-1.\n* Age \\> 18 years.\n* Written informed consent.\n\nExclusion criteria:\n\n* Infraperitoneal rectal cancer (middle or low rectum).\n* Age \\\u003C18 year old.\n* Age \\> 80 year old.\n* Hereditary colorectal cancer.\n* dMMR\u002FMSI colorectal cancer.\n* Inflammatory bowel disease.\n* Distant metastasis (outside limited peritoneal carcinomatosis which is limited to one abdominal quadrant and was resected during index surgery and no other distant lesion; small indeterminate pulmonary nodules to be followed are accepted)\n* Neo-adjuvant treatment.\n* Pregnancy or lactation.\n* Immunosuppression.\n* Unable to provide informed consent.\n* Previous cytoreductive surgery (CRS) (outside limited resection of peritoneal carcinomatosis during index surgery).\n* Contraindication to laparoscopy (e.g. severe adhesions, peritonitis).\n* Contraindication to and\u002For no adjuvant chemotherapy.\n* History of allergic reaction to oxaliplatin or other platinum-containing compounds.\n* Renal impairment, defined as GFR \\\u003C 50 ml\u002Fmin, (Cockcroft-Gault equation).\n* Myocardial insufficiency, defined as NYHA class \\> 2.\n* Impaired liver function defined as bilirubin ≥ 1.5 x UNL (upper normal limit).\n* Inadequate hematological function defined as ANC ≤ 1.5 x 109\u002Fl and platelets ≤ 100 x 109\u002Fl.",{"count":118,"type":20},160,[120],"PHASE3","In a multicentric randomized controlled trial, we will compare standard surgery (consisting in removal of the primary cancer) followed by 6 months of adjuvant chemotherapy associated with 3 cycles of oxaliplatin-based PIPAC (4-6 weeks apart), to standard surgery followed by 6 months of adjuvant systemic chemotherapy (routine treatment), in patients with colorectal cancer at high risk for metachronous peritoneal carcinomatosis (pT4 pN0-2 cM0 pMMR colorectal cancer of the colon, colorectal junction or high rectum and\u002For with positive cytology) in terms of 1-year and 3-year peritoneal metastasis-free survival (as measured by imaging and\u002For surgical exploration), 1-year and 3-year disease-free survival, as well as 1-year and 3-year overall survival. In terms of outcomes measurement, patients in both groups will benefit from diagnostic laparoscopy at 6 months from the index surgery, and standard surveillance consisting in clinical examination, CEA determination and thoraco-abdominal CT at 6, 12, 24, 36, 48 and 60 months after index surgery.",[25,123,124,125],"Colorectal Cancer","Colorectal Cancer Stage II","Colorectal Cancer Stage III",[127,128,129,130],"Colorectal cancer","Peritoneal carcinomatosis","PIPAC","Pressurized intraperitoneal aerosol chemotherapy","2025-07-27",{"date":133,"type":30},"2025-07-30",{"date":135,"type":20},"2026-01",{"date":137,"type":20},"2034-01",{"name":139,"class":37},"Jeremy Meyer",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":146,"targetDuration":148,"studyType":22,"phases":4,"briefSummary":149,"conditions":150,"keywords":153,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":38},"100590982","implementation-of-an-efferent-loop-stimulation-protocol-prior-to-ileostomy-closure-at-la-paz-university-hospital-100590982","NCT06974500","Implementation of an Efferent Loop Stimulation Protocol Prior to Ileostomy Closure at La Paz University Hospital","IInclusion Criteria:\n\n1. Subjects must be able to understand the purpose and risks of the study, provide informed consent, and authorise the use of confidential health information.\n2. Patients over 18 years of age who, regardless of the underlying cause, have an ileostomy and a medical indication for intestinal transit reconstruction by a general surgeon.\n3. Subjects who are able and willing to participate and to comply with follow-up for the duration of the study.\n\nExclusion Criteria:\n\n1. Subjects with an ileostomy who do not wish to undergo intestinal reconstruction.\n2. Subjects who are unable to complete at least two weeks of efferent loop stimulation prior to reconstruction surgery.\n3. Subjects who do not provide consent to participate in the study.",{"count":147,"type":20},68,"2 Years","Stoma creation is a common surgical procedure, employed in certain contexts within general surgery, particularly in colorectal and emergency surgery. Although stoma formation is a life-saving technique, the diversion of intestinal contents has pathophysiological, aesthetic, and psychological repercussions on patients' lives. Stomas may be either permanent or temporary. In temporary cases, a second intervention is required to perform ileostomy closure and restore normal intestinal transit.\n\nSeveral studies indicate that stimulation of the efferent loop prior to ileostomy closure yields benefits in patients' postoperative outcomes. Currently, there is no established protocol for this intervention at Hospital Universitario La Paz. However, implementing such a protocol-given that it is a simple, inexpensive, and accessible intervention-could offer significant cost-effectiveness. It may reduce complications and hospital stay, improve patients' quality of life, and represent a valuable contribution to the General Surgery Departmen",[151,25,152],"Postoperative Ileus","Stoma - Ileostomy",[154],"Ileostomy , Stoma, Colorectal, Posoperative","2025-05-07",{"date":157,"type":30},"2025-05-16",{"date":159,"type":30},"2025-01-01",{"date":161,"type":20},"2027-04-01",{"name":163,"class":37},"Hospital Universitario La Paz",{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":174,"conditions":175,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":108},"100575720","appropriateness-of-colonoscopy-indication-an-evaluation-of-the-clinical-and-economic-impact-100575720","NCT06775951","Appropriateness of Colonoscopy Indication: an Evaluation of the Clinical and Economic Impact.","Appropriateness of Colonoscopy Indication: an Evaluation of the Clinical and Economic Impact. Multicenter Prospective Observational Study.","PROMOTE","Inclusion Criteria:\n\n* Age \\>18 years\n* Patients undergoing outpatient and inpatient colonoscopy for any pathology, as part of the normal care process\n* Obtaining informed consent.\n\nExclusion Criteria:\n\n* Investigations performed in an emergency\u002Femergency setting",{"count":173,"type":20},1410,"The aim of the study is to evaluate the appropriateness of colonoscopy prescription and the impact of colonoscopies in diagnostic performance in order to develop and validate a predictive model for selecting patients most likely to present with significant lesions and thus lower costs and waiting lists.",[25],"2025-01-10",{"date":178,"type":30},"2025-01-15",{"date":180,"type":30},"2023-01-02",{"date":182,"type":20},"2025-10-01",{"name":184,"class":37},"IRCCS Azienda Ospedaliero-Universitaria di Bologna",{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":4,"eligibilityCriteria":191,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":192,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":194,"conditions":195,"keywords":198,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":205,"completionDateStruct":206,"leadSponsor":208,"locationsCount":38},"100564428","6-year-follow-up-data-after-the-berberine-intervention-trial-100564428","NCT06629051","6-year Follow-up Data After the Berberine Intervention Trial","A Multicenter, Placebo-controlled Clinical Study of Berberine Hydrochloride in Preventing Recurrence and Carcinogenesis After Endoscopic Removal of Colorectal Adenomas：6-year Retrospective Follow-up Data","Inclusion Criteria: participants who completed the previous berberine intervention study (NCT02226185) Exclusion Criteria: no",{"count":193,"type":20},891,"Colorectal cancer (CRC) is a common malignancy of the digestive tract, which constitutes a major public health burden. Almost 90% of CRC cases progress from precursor adenomatous polyps through adenoma-carcinoma sequence. Endoscopic detection and removal of colorectal adenoma (CRA) could reduce the incidence and mortality risk of CRC, but the recurrence rate is still high. Therefore, chemoprevention is quite important, not only solve the urgent public health problem, but also be cost-effective.\n\nIn 2020, the investigators published a multicenter, randomized, double-blind, placebo-controlled clinical study (NCT02226185) in the Lancet Gastroenterology \\& Hepatology. The result concluded that oral BBR for 2 years significantly reduced recurrence after endoscopic removal of CRA (RR 0.77, 95%CI 0.66-0.91; p=0.001). BBR also has a significant preventive effect on all polypoid lesions, including adenomas and serrated lesions (adjusted RR 0.78, 95%CI 0.66-0.91; p=0.002) . Does BBR still have a long-term protective effect on the recurrence of CRA after discontinuation? That's what the investigators concerned.\n\nThe present study is performed to observe and compare retrospectively the recurrence rate of CRAs in patients of the original BBR RCT study (NCT02226185) within 6 years after discontinuation of medication, including the overall recurrence rate of traditional adenomas within the first year, 1-3 years, 3-6 years, and the entire follow-up period of 6 years. The aim is to evaluate the long-term efficacy of BBR in preventing recurrence and carcinogenesis after endoscopic resection of CRAs.",[196,25,197],"Colorectal Adenoma","Colorectal Polyps",[199,200,58,201,97],"berberine","colorectal adenoma","long term chemoprevention","2024-10-04",{"date":204,"type":30},"2024-10-08",{"date":202,"type":20},{"date":207,"type":20},"2024-12-31",{"name":209,"class":37},"Shanghai Jiao Tong University School of Medicine",{"id":211,"slug":212,"hasResults":11,"nctId":213,"briefTitle":214,"officialTitle":215,"acronym":216,"eligibilityCriteria":217,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":218,"targetDuration":220,"studyType":22,"phases":4,"briefSummary":221,"conditions":222,"keywords":223,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":232,"leadSponsor":234,"locationsCount":38},"100564177","clinical-and-endoscopic-characterization-of-patients-with-multiple-colorectal-adenomas-a-multicenter-study-in-spain-espapolyp-study-100564177","NCT06625788","Clinical and Endoscopic Characterization of Patients With Multiple Colorectal Adenomas: A Multicenter Study in Spain (ESPAPOLYP Study)","CARACTERIZACIÓN CLÍNICA Y ENDOSCÓPICA DE PACIENTES CON MÚLTIPLES ADENOMAS COLORRECTALES: ESPAPOLIP","ESPAPOLYP","Inclusion Criteria:\n\n* 10 or more adenomas\n* \\>18 years\n\nExclusion Criteria:\n\n* Inhereted condictions\n* Inflammatory bowel disease",{"count":219,"type":20},200,"5 Years","The aim is to clinically, endoscopically, and molecularly characterize patients with multiple colorectal adenomas, establish the indication for genetic testing to rule out hereditary syndromes and identify the genes to be included, and improve endoscopic screening recommendations for these patients and their relatives.",[25],[224,225,226,227,58],"polyp","polyposis","colorectal polyposis","multiple colorectal adenoma","2024-10-01",{"date":230,"type":30},"2024-10-03",{"date":228,"type":20},{"date":233,"type":20},"2029-10-01",{"name":235,"class":37},"Asociación Española de Gastroenterología",{"id":237,"slug":238,"hasResults":11,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":4,"eligibilityCriteria":242,"healthyVolunteers":47,"sex":16,"minAge":243,"maxAge":244,"enrollmentInfo":245,"targetDuration":4,"studyType":51,"phases":247,"briefSummary":248,"conditions":249,"keywords":253,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":38},"100563398","effectiveness-of-a-pmt-intervention-to-reduce-alcohol-in-young-adults-100563398","NCT06615648","Effectiveness of a PMT Intervention to Reduce Alcohol in Young Adults","The Effectiveness of the Protection Motivation Theory in Reducing Alcohol-Related Intentions and Behaviours Among Young Adults","Inclusion Criteria:\n\n* Aged 19-25 Able to read, write and understand English\n* Current alcohol drinker\n* Access to necessary resources for a technology-based intervention (i.e., smartphone, computer, internet)\n\nExclusion Criteria:\n\n* Under the legal drinking age in Ontario of 19 at the time of signing the consent form\n* Currently actively participating in behaviour therapy treatment for alcohol or attending a rehab centre\n* Are pregnant \u002Fplan to become pregnant during the study period","19 Years","25 Years",{"count":246,"type":20},152,[53],"This study will examine the effectiveness of a 7-minute informational video using the threat and coping components of the Protection Motivation Theory (PMT) reduces alcohol intention and behaviour among young Canadian adults. Our aim is to determine whether perceived vulnerability, perceived severity, response efficacy and self-efficacy are associated with goal intentions to reduce drinking alcohol, and whether goals intentions to reduce alcohol drinking are associated with actual reductions in alcohol use among this population. Participants will be randomized to view either a specific PMT-video or a non-specific video on coffee and then complete questionnaires that relate to the PMT constructs. Intention and behaviour to drink alcohol will be compared between the two conditions over a 4-week period.",[250,251,25,252],"Behavior, Drinking","Alcohol Drinking","Healthy Volunteers",[254,255,256,257,123,258],"Protection Motivation Theory","Alcohol","Alcohol Intention","Alcohol Behaviour","Behaviour Change","2024-09-23",{"date":261,"type":30},"2024-09-26",{"date":263,"type":20},"2024-11-01",{"date":265,"type":20},"2025-03-01",{"name":267,"class":37},"Western University, Canada"]