[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"colorectal-neoplasm\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:colorectal-neoplasm":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100363145","esd-for-colorectal-lsl-using-a-selective-strategy---a-prospective-cohort-study-100363145",false,"NCT04008407","ESD for Colorectal LSL Using a Selective Strategy - a Prospective Cohort Study","Endoscopic Submucosal Dissection for Sessile Polyps and Laterally Spreading Lesions of the Colorectum Using a Selective Strategy - a Prospective Cohort Study","COVERT","Inclusion Criteria:\n\n* All patients referred for colorectal resection of large laterally spreading lesions in colon.\n* Can give informed consent to trial participation\n\nExclusion Criteria:\n\n* Previous resection or attempted resection of target adenoma lesion\n* Endoscopic appearance of invasive malignancy\n* Age less than 18 years\n* Pregnancy\n* Active Inflammatory colonic conditions (e.g. inflammatory bowel disease)\n* Use of anticoagulant or antiplatelet agents other than aspirin outside of internationally recognised guidelines\n* American Society of Anesthesiology (ASA) Grade IV-V","ALL","18 Years",{"count":20,"type":21},391,"ESTIMATED","INTERVENTIONAL",[24],"NA","Colonic Laterally spreading lesions (LSL) =\\> 20mm are at high risk to progress to cancer. Overt stigmata of submucosal invasive cancer (SMIC) has been well characterized and includes ulceration and surface pit pattern changes as per the Kudo classification of type V.\n\nIn a recent report, risk factors for LSL with SMIC and no overt stigmata (i.e. covert SMIC) were described. Resection of these lesions 'en-bloc' can allow for better histological staging and potentially reduce the need for surgical resection.",[27,28],"Colorectal Neoplasm","Endoscopic Mucosal Resection","RECRUITING","2025-03-25",{"date":32,"type":33},"2025-03-27","ACTUAL",{"date":35,"type":33},"2017-08-14",{"date":37,"type":21},"2028-02",{"name":39,"class":40},"Western Sydney Local Health District","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":4,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":66},"100376765","colo-cohort-colorectal-cancer-cohort-study-100376765","NCT04185779","COLO-COHORT (Colorectal Cancer Cohort) Study","Inclusion Criteria:\n\nGroup A\n\n* Aged ≥30 years\\* and able to give informed consent\n* Patients attending colonoscopy\n\n  * Through Bowel Cancer Screening Programme (FIT positive, Bowelscope conversion, surveillance)\n  * Through standard NHS care (most commonly due to iron deficiency anaemia, altered bowel habit, weight loss, rectal bleeding, planned polypectomy\\*\\*, those referred on basis of family history, abnormal cross-sectional imaging, polyp surveillance or post CRC surveillance)\n\n    * The age of 30 was chosen to ensure that this is a population likely to be enriched for colorectal neoplasia with neoplasia below this age uncommon \\*\\*In those attending for planned polypectomy, the results from the initial colonoscopy and the endoscopy where the polypectomy is undertaken will be summated for purposes of calculating the neoplasia profile\n\n(COLO-SPEED) Group B\n\n* Any patient attending for colonoscopy and able to give informed consent\n* ≥ 18 years old\n* Patient from the North of England\n\nExclusion Criteria:\n\nGroup A\n\n* Unable to give informed consent\n* Known polyposis syndrome\n* Previous total colectomy\n* Known colonic stricture which would limit complete colonoscopy\n* Attending for planned therapeutic procedure other than polypectomy, such as insertion of colonic stent\n* Attending for assessment of known inflammatory bowel disease (IBD) activity or for IBD surveillance\n* Patients currently recruited into an interventional CTIMP for CRC prevention\\*\n\nCOLO-SPEED (Group B) \\*\\*\n\n* Unable to give informed consent\n* Not in a centre supported by COLO-SPEED infrastructure (North of England)",{"count":49,"type":21},15000,"OBSERVATIONAL","This is a cross-sectional study aimed at identifying factors which best predicts patients at high risk of colorectal cancer or colorectal adenomas and to develop a risk prediction model.",[53,54,27,55,56],"Colorectal Cancer","Colorectal Adenoma","Predictive Cancer Model","Model","2020-10-19",{"date":59,"type":33},"2020-10-22",{"date":61,"type":33},"2019-12-13",{"date":63,"type":21},"2026-08-15",{"name":65,"class":40},"South Tyneside and Sunderland NHS Foundation Trust",3]