[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"coma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:coma":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,51,86,112,143,178,210,239,261,283,307],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100563531","combined-whole-brain-structural-and-functional-mri-for-the-prediction-of-neurological-recovery-after-cardiac-arrest-100563531",false,"NCT06617377","Combined Whole-brain Structural and Functional MRI for the Prediction of Neurological Recovery After Cardiac Arrest","Use of Brain Structural and Functional Connectomes for the Prediction of Neurological Recovery in Coma Patients After Cardiac Arrest","ARISE","Inclusion Criteria:\n\n* Adult patients (male or female ≥ 18 years).\n* Coma, as indicated by a Glasgow Coma Scale (GCS) ≤ 8 (motor score ≤ 2) immediately after CA resuscitation and before sedation onset.\n* Persisting unconsciousness, defined as the inability to obey verbal commands, after at least 72 hours from complete withdrawal of sedation in normothermia conditions.\n* Written informed consent from patient's legal representative.\n* Affiliation or beneficiary to the French social security system.\n\nExclusion Criteria:\n\n* Brain death.\n* Coma explained by other cause than CA.\n* Likely poor neurological outcome based on early predictors, following ERC-ESCIM 2021 recommendations. In a comatose patient with GCS motor score ≤ 3 at ≥ 72 h from ROSC, in the absence of confounders, the identification of at least two of the following: bilaterally absent pupillary light and corneal reflexes at ≥ 72h, bilaterally absent N20 SSEP ≥ 24h; neuron-specific enolase (NSE) \\> 60 μg\u002Fl at 48h and\u002For 72h, status myoclonus ≤72h.\n* Decision of WLST previous to patient recruitment, based on early predictors of poor neurological outcome, age, co-morbidity, general organ function and patient's preferences.\n* Life expectancy shorter than 6 months based on pre-morbid conditions.\n* Former neurological functional disability (mRS \\> 2 before CA).\n* MRI contraindication: medical material not MRI compatible, claustrophobia\n* Known hypersensitivity to gadoteric acid, meglumin or any drug containing gadolinium\n* Severe kidney failure defined as a KDIGO score \\> 3 (glomerular filtration rate \\\u003C 30 ml\u002Fmin\u002F1.73 m2 or renal replacement therapy).\n* Hemodynamic shock or severe respiratory failure precluding patient's transport and MRI scanning.\n* Pregnancy or nursing woman.\n* Patient under juridical protection.","ALL","18 Years",{"count":20,"type":21},263,"ESTIMATED","INTERVENTIONAL",[24],"NA","To assess the performance of a predictive model resulting from the analysis of sMRI\u002FfMRI\u002Fcontrast-enhanced MRI-derived personalized connectomic data, as compared with standard predictors (clinical examination, electrophysiology, serum biomarker, standard neuroimaging) collected ≥ 72h from sedation withdrawal and in normothermia condition, to predict anoxoischemic coma neurological outcome at 6 months.",[27,28,29,30],"Coma","Cardiac Arrest","Disorder of Consciousness","Neurologic Disorder",[32,33,34,35,36,37],"prognosis","coma","cardiac arrest","Structural MRI","resting-state","cognitive motor dissociation","RECRUITING","2026-06-24",{"date":41,"type":42},"2026-06-29","ACTUAL",{"date":44,"type":42},"2026-03-16",{"date":46,"type":21},"2029-09",{"name":48,"class":49},"University Hospital, Toulouse","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":70,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":50},"100630260","fnirs-for-disorders-of-consciousness-100630260","NCT07485361","fNIRS for Disorders of Consciousness","Functional Near-infrared Spectroscopy in Disorders of Consciousness: Protocol Testing and Pilot in Neuro-ICU Setting","Inclusion Criteria:\n\nHealthy Control Participants:\n\n* Age 18 years or older\n* Proficient in English language\n* Intact cognition\n* Montreal Cognitive Assessment (MoCA) score \\> 26\n\nDoC Patients:\n\n* Age 18 years or older\n* Proficient in English language\n* Surrogate decision maker available\n* Admission to the intensive care unit within 28 days\n* Documented Glasgow Coma Scale (GCS) score\n* Auditory Function subscale score ≥1 on the Coma Recovery Scale-Revised (CRS-R)\n\nExclusion Criteria:\n\nHealthy Control Participants:\n\n* Known baseline hearing impairment without available hearing aids\n* Neurological or psychiatric history\n\nDoC Patients:\n\n* Known baseline hearing impairment without available hearing aids\n* Inability to obtain informed consent\n* Extensive bilateral frontal injury on available imaging (CT\u002FMRI)\n* Patients who have undergone craniectomy surgery\n* IV sedation in the past 24 hours\n* Absent auditory startle response (\\\u003C1 from Auditory Function subscale score of CRS-R)",true,{"count":60,"type":21},55,"OBSERVATIONAL","The goal of this observational study is to learn whether functional near-infrared spectroscopy (fNIRS) can measure brain activity in healthy adults and in people with disorders of consciousness (DoC) in the neuro-intensive care unit (Neuro-ICU). DoC include conditions such as coma and minimally conscious state that occur after severe brain injury. These conditions make it difficult to assess a person's level of awareness because many clinical tests rely on observable behaviors such as speaking or moving, which are commonly impaired after brain injury.\n\nThe main questions the study aims to answer are:\n\n* Can fNIRS detect changes in brain activity in healthy adults when they receive sensory stimulation or perform mental tasks?\n* Can the same fNIRS protocol be used in patients with disorders of consciousness in the Neuro-ICU to measure brain responses and determine whether the method is feasible in this clinical setting?\n\nThe investigators will first study healthy adult volunteers to establish baseline brain responses and determine which tasks produce the most reliable signals. The protocol will then be applied to patients with disorders of consciousness admitted to the Neuro-ICU.\n\nParticipants will take part in a single research session lasting about 30 to 45 minutes while wearing the lightweight fNIRS headband that measures brain oxygen levels using near-infrared light. During the session, participants will:\n\n* Wear a non-invasive fNIRS headband placed on the forehead\n* Receive gentle sensory stimulation (for example, compression devices on the legs or hands)\n* Listen to sounds or spoken sentences\n* Perform guided mental tasks such as imagining walking through their home or imagining moving a limb\n\nThe study does not test a treatment and will not change medical care. The goal is to determine whether fNIRS can safely and reliably measure brain activity at the bedside and provide preliminary information that may help guide future research on improving the assessment of consciousness after brain injury.",[64,65,27,66,67,68,69],"Disorders of Consciousness Due to Severe Brain Injury","Disorders of Consciousness","Minimally Conscious State","Unresponsive Wakefulness Syndrome","Brain Injury","TBI Traumatic Brain Injury",[71,72,73,74,75,76],"Functional Near-Infrared Spectroscopy","Neurocritical Care","Functional Neuroimaging","Neuro Intensive Care Unit","Neurovascular Coupling","Consciousness Assessment","2026-06-04",{"date":79,"type":42},"2026-06-08",{"date":81,"type":42},"2026-05-01",{"date":83,"type":21},"2026-12",{"name":85,"class":49},"University of California, Los Angeles",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":95,"conditions":96,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":50},"100639950","recovery-trajectory-for-coma-and-disorders-of-consciousness-100639950","NCT07614074","Recovery Trajectory for Coma and Disorders of Consciousness","Coma Cohort","Inclusion Criteria:\n\n* Age greater than or equal to 18 years on the day of hospital admission\n* Coma duration of at least 24 hours from presentation to the receiving hospital, or died prior to the 24 hour timepoint without return of consciousness. Coma defined as: GCS score of less than or equal to 10 AND GCS score of less than 6 on the motor component of the GCS(not following commands) AND GCS score less than 3 on the verbal component AND alteration of consciousness not explained by sedation only\n* Coma due to a neurological process (Including but not limited to: trauma, stroke, hypoxic- ischemic brain injury (HIBI), CNS infection, seizure, other processes at the discretion of the investigator)\n* Admission to the intensive care unit, or deceased prior to admission.\n\nExclusion Criteria:\n\n* Pre-existing score of 5 or less on the motor component of the Glasgow Coma Scale prior to hospital admission.\n* Transfer from another acute care hospital in which the motor component of the Glasgow Coma Scale on the day after initial hospital arrival is not known or cannot be reconstructed from medical records or history.\n* Coma due to sepsis, systemic metabolic processes (ex: organ failure or sedation).\n* GCS score of greater than 2 for eye opening with lack of command following due to a focal brain lesion causing receptive aphasia.\n* Prisoner",{"count":94,"type":21},2000,"This study aims to better understand recovery after coma caused by serious neurologic illness or injury. Patients who are unconscious (in a coma or disorder of consciousness) due to conditions such as stroke, cardiac arrest, traumatic brain injury, seizures, brain infection, or other neurologic emergencies may be enrolled during their hospitalization.\n\nThe purpose of this observational research study is to learn which medical, neurologic, psychological, and social factors are associated with recovery over time. Researchers will collect information from the medical record during hospitalization, including details about the patient's illness, treatments received, brain imaging, and neurologic examinations.\n\nFor patients who survive hospitalization, the study team will contact participants or their caregivers after discharge to assess recovery at scheduled time points using questionnaires and structured interviews about physical function, quality of life, emotional well-being, and daily activities.\n\nThis study does not assign participants to any experimental treatment. Participation will not change the medical care patients receive. Information learned from this study may help improve future care for patients with coma and disorders of consciousness.",[27,65,97,98,99,100,101,102],"Cardiac Arrest (CA)","Traumatic Brain Injuries","Ischemic Stroke","Hemorrhagic Stroke, Intracerebral","Meningitis\u002FEncephalitis","Status Epilepticus","2026-05-28",{"date":105,"type":42},"2026-06-02",{"date":107,"type":42},"2023-09-26",{"date":109,"type":21},"2033-09",{"name":111,"class":49},"University of California, San Francisco",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":122,"conditions":123,"keywords":127,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":50},"100611983","evaluation-and-optimization-of-telephone-triage-using-artificial-intelligence-ai-models-for-the-detection-of-demands-for-time-dependent-pathology-at-the-emergency-and-urgent-care-coordination-center-ccue-100611983","NCT07247669","Evaluation and Optimization of Telephone Triage Using Artificial Intelligence (AI) Models for the Detection of Demands for Time-dependent Pathology at the Emergency and Urgent Care Coordination Center (CCUE).","Proyecto \"trIAje\": evaluación y optimización Del Triaje telefónico Mediante Modelos de Inteligencia Artificial (IA) Para la detección de Demandas Por patología Tiempo-dependiente en el Centro Coordinador de Urgencias y Emergencias (CCUE).","TrIAje Project","Inclusion Criteria:\n\nTelephone calls recorded with codes A36 + A58 (unconsciousness\u002Fcardiorespiratory arrest), A16 (respiratory distress), A23 (non-traumatic chest pain) and A54 (stroke).\n\nExclusion Criteria:\n\n* Demands with relevant information about the patient or the event incomplete or absent.",{"count":121,"type":21},5000000,"Improving Telephone Triage in Emergency Calls with AI The Coordinating Centre for Urgencies and Emergencies in Andalusia (CCUE) handles thousands of calls every day. Each call needs to be assessed based on the information given over the phone to determine how serious the case is. The reasons for calling range from minor health issues to life-threatening emergencies like cardiac arrest (CPA).\n\nThis project focuses on improving telephone triage for four key emergency situations that often indicate severe or life-threatening conditions:\n\nUnconsciousness \u002F Cardiac arrest Difficulty breathing Chest pain (non-traumatic, possible heart-related issues) Stroke symptoms Our goal is to make telephone triage more accurate and efficient by using advanced Artificial Intelligence (AI) techniques, including Machine Learning (ML) and Natural Language Processing (NLP). These tools will help CCUE operators make better and faster decisions, ensuring that patients receive the right care as quickly as possible.\n\nHow it will be done:\n\nThe investigators will analyze anonymized historical call data from the emergency coordination system (CCR) and digital clinical records (HCDM). This includes:\n\nStructured data: Predefined fields, such as answers to standard triage questions.\n\nUnstructured data: Free-text notes and other information recorded during the call.\n\nA hybrid AI approach will be used, combining:\n\nTraditional AI methods (supervised learning and deep learning) to classify cases.\n\nGenerative AI techniques (advanced language models) to extract useful insights from free-text data.\n\nBuilding the Best Prediction Model\n\nTo find the most effective AI model, we will test different machine learning techniques, including:\n\nDecision Trees Random Forests Support Vector Machines (SVM) XGBoost Ensemble methods Neural Networks We will also analyze which questions and variables are the most important in predicting the severity of a case. Based on this, we will suggest improvements to the current triage questions to enhance accuracy.\n\nMeasuring Success\n\nWe will evaluate the AI model using key performance metrics, including:\n\nAccuracy (overall correctness) Sensitivity (ability to detect real emergencies) Specificity (ability to avoid false alarms) False Positive \\& False Negative Rates (how often the system makes mistakes) Likelihood Ratios (how well the system distinguishes between urgent and non-urgent cases) F1-Score \\& ROC Curve (overall performance indicators) Why This Matters This project will assess how effective the current telephone triage system is and develop a new AI-powered model to improve it. The goal is to help emergency operators quickly identify the most serious cases, reducing response times and improving patient outcomes. In the future, the investigators aim to integrate this improved AI model into the CCUE system to enhance emergency response across Andalusia.",[124,125,126,97,27],"Chest Pain","Stroke Acute","Respiratory Failure",[128,129,130,131,132,133],"Emergency Medical Communication Center","Triage Telephone","Emergency Medical Services","Priority","Machine Learning","Artificial Intelligence","2026-05-12",{"date":136,"type":42},"2026-05-13",{"date":138,"type":42},"2025-03-01",{"date":140,"type":21},"2027-12-31",{"name":142,"class":49},"Centro de Emergencias Sanitarias 061 Andalucía",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":151,"targetDuration":4,"studyType":22,"phases":153,"briefSummary":154,"conditions":155,"keywords":160,"overallStatus":167,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":177},"100618415","the-coma-family-program-coma-f-a-resilience-program-for-caregivers-of-patients-with-severe-acute-brain-injury-100618415","NCT07331324","The Coma Family Program (COMA-F): A Resilience Program for Caregivers of Patients With Severe Acute Brain Injury","The Coma Family Program (COMA-F): A Multi-site Clinical Trial of a Resilience Program for Caregivers of Patients With Severe Acute Brain Injury","COMA-F","Inclusion Criteria:\n\n1. 18 years or older - study population\n2. English fluency and literacy - measures and intervention are in English\n3. Screens positive for emotional distress on either depression or anxiety subscales (\\>7) of the Hospital Anxiety and Depression scale - study population (caregivers must be at-risk for chronic distress via heightened acute distress)\n4. Confirmed by the clinical team as the primary caregiver of a patient who has been admitted to an intensive care unit (ICU) with a severe acute brain injury with the following characteristics:\n\n   1. 18 years or older - study population\n   2. Admitted with ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, traumatic brain injury, or hypoxic-ischemic encephalopathy - study population\n   3. Glasgow Coma Scale score below 9 (in judgement of the clinical team) while not intubated or an inability to follow meaningful commands while intubated at any point during the hospitalization for \\> 24 consecutive hours due to the brain injury itself and not a confounding factor (e.g., sedation or seizures) - study population\n   4. Still alive in ICU at the time the clinical team approaches the caregiver about possible recruitment - excludes caregivers of those that passed away as would require a different intervention (e.g., grieving intervention)\n   5. Has been committed to or has already received long-term life-sustaining treatments including tracheostomy and\u002For percutaneous endoscopic or surgical gastrostomy tube placement (trach or PEG) - study population; at time of enrollment patients can be in various early stages of cognitive\u002Ffunctional recovery from initial coma, but all were severe enough to require trach and\u002For PEG\n   6. Has a prognosis for survival of greater than 3 months and does not have a concurrent diagnosis of a terminal illness or injury as judged by the clinical team - as in \"d\"; such caregivers would require different intervention\n   7. Is still in ICU or has been transferred to a lower level of care (e.g., stepdown) for \\\u003C7 days at the time of consent - study population; we aim to begin the intervention when caregivers are acutely distressed in the context of the patient's ICU stay or shortly after the ICU stay (i.e., within 7 days of leaving)\n\nExclusion Criteria:\n\n* 1\\. Serious mental illness, substance misuse, or active suicidal intent or plan - requires higher level of care",{"count":152,"type":21},150,[24],"The purpose of this research study is to determine whether COMA-F is more efficacious at reducing emotional distress in caregivers of patients with severe acute brain injuries, compared to health education control.",[156,157,158,159,27,68],"Caregiver Distress","Emotional Distress","Caregivers","Resilience",[161,162,163,164,33,165,166],"caregivers","emotional distress","caregiver burden","resilience","severe acute brain injury","mindfulness","NOT_YET_RECRUITING","2026-02-18",{"date":170,"type":42},"2026-02-20",{"date":172,"type":21},"2026-05",{"date":174,"type":21},"2030-12",{"name":176,"class":49},"Massachusetts General Hospital",3,{"id":179,"slug":180,"hasResults":11,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":184,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":186,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":188,"conditions":189,"keywords":192,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":209},"100463958","predictive-outcome-in-comatose-patients-100463958","NCT05321459","Predictive Outcome in Comatose Patients","New Predictive Tool of Awakening in Comatose Patients in the Intensive Care Unit","PRECOM","Inclusion Criteria:\n\n* Age above18 years old\n* Patient affiliated to a French Heath Care Insurance\n* Admitted in the intensive care unit (ICU) for coma post extra- or intra-hospital cardiac arrest (CA) with shockable or non-shockable rhythm\n* Persistent coma on day 3 after post CA, defined by the inability to respond to a verbal command in an appropriate manner (motor Glasgow components ≤ 3) and at the time of neurophysiological recordings (D3-D7 ± week -end).\n\nExclusion Criteria:\n\n* Decision to limit resuscitation therapies taken by the resuscitation team\n* Inability to perform the auditory evoked potentials (AEP) (deafness, skin lesion or any condition preventing to record AEP).\n* Opposition by the trusted person or by the patient once he\u002Fshe wakes up",{"count":187,"type":21},100,"Evaluating the prognosis of comatose patients after cardiac arrest (CA) in the intensive care unit (ICU) remains challenging. It requires a multimodal approach combining standardized clinical examination, serum biomarkers, imaging and classically electrophysiological examinations, (among them auditive evoked potentials or AEP) but none has a sufficient sensitivity\u002Fspecificity. In a preliminary study, the investigators developed an algorithm from the signal collected with AEP, and generated a probability map to visually classify the participants after the algorithm processing. Participants could be classified either with a good neurological prognosis or with bad neurological prognosis or death.\n\nThe investigators hypothesize that the \"PRECOM\" tool, applied blindly to a large prospective multicenter cohort of patients admitted to intensive care for coma in the aftermath of CA will predict neurological prognosis at 3 months with high sensitivity and specificity.",[27,190,191],"Heart Arrest","Cardiopulmonary Resuscitation",[193,194,195,196,197,198,199],"Post cardiac arrest for comatose patients","Electroencephalography","Somatosensory evoked potentials","Auditory evoked potentials","Prognosis","Algorithms","Classification","2025-12-16",{"date":202,"type":42},"2025-12-23",{"date":204,"type":42},"2023-11-15",{"date":206,"type":21},"2028-05-29",{"name":208,"class":49},"Assistance Publique - Hôpitaux de Paris",7,{"id":211,"slug":212,"hasResults":11,"nctId":213,"briefTitle":214,"officialTitle":215,"acronym":216,"eligibilityCriteria":217,"healthyVolunteers":58,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":218,"targetDuration":4,"studyType":22,"phases":220,"briefSummary":221,"conditions":222,"keywords":225,"overallStatus":167,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":50},"100606607","assessment-of-structural-brain-changes-related-to-anoxic-coma-using-high-field-and-very-low-field-mobile-mri-100606607","NCT07177755","Assessment of Structural Brain Changes Related to Anoxic Coma Using High-field and Very Low Field Mobile MRI","Assessment of Structural Brain Changes Related to Anoxic Coma Using High-field (3T) and Very Low-field (0.064T) Mobile MRI - CUBE","CUBE","Inclusion criteria :\n\nCOMA PATIENTS\n\n* Adult patients (male or female ≥ 18 years).\n* Coma, as indicated by a Glasgow Coma Scale (GCS) ≤ 8 (motor score ≤ 2) immediately after CA resuscitation and before sedation onset.\n* Written informed consent from patient's legal representative.\n* Affiliation to the French social security system\n\nHEALTHY VOLUNTEERS\n\n* Adult patients (male or female ≥ 18 years).\n* Written informed consent.\n* Affiliation to the French social security system\n\nExclusion criteria :\n\nCOMA PATIENTS\n\n* Brain death.\n* Coma explained by other cause than CA.\n* Pregnancy.\n* MRI contraindication: medical material not MRI compatible.\n* Hemodynamic instability or respiratory failure precluding patient's transport and MRI scanning.\n\nHEALTHY VOLUNTEERS\n\n* Pregnancy.\n* MRI contraindication: medical material not MRI compatible.\n* Volunteers who do not wish to be informed of an abnormality detected on MRI a posteriori",{"count":219,"type":21},60,[24],"Standard predictors of outcome after cardiac arrest (CA) have substantial limitations in terms of reliability and generalizability. By providing brain structural connectivity maps, or connectomes, advanced MRI techniques, operating through high-strength magnetic field (HF; 1.5 to 3-T), have precisely revealed white and grey brain matter damages induced by CA, and have demonstrated the high sensitivity and specificity of these indicators for predicting neurological outcome after CA. However, HF MRI requires rigid safety precautions, highly trained technicians and patient transport to dedicated hospital imaging suites, hindering the implementation of these promising neuroimaging techniques in the setting of critical illness.\n\nInterestingly, a recent report demonstrates the capability of a proof-of-concept very low-field (VLF; 0.064-T) mobile MRI to obtain neuroimaging at the bedside in critically ill patients. Nevertheless, the spatial resolution of VLF-MRI seems low and there is no available evidence about the use of VLF-MRI to extract highly needed new predictors of neurological recovery based on critical brain structural connectomes.\n\nThe CUBE project holds the promise of providing a radical paradigm shift in the field of neuroprognostication of anoxic coma patients. The current proposal is a \"proof-of concept\" study which aims to compare for the first time, HF, VLF and enhanced VLF (recon-VLF) structural connectomes from anoxic coma patients and healthy subjects across the time (3 paired HF and VLF brain scan across the first two weeks after CA). To obtain recon-VLF data, the Investigators will use an ensemble of ground-breaking methods to increase the native spatial resolution of VLF-MRI data. The whole brain imaging dataset will be used to prepare future neuroprognostication studies based on fully bedside assessment of brain structural integrity after CA.",[223,97,224,27],"Anoxic Coma","Anoxia-Ischemia, Brain",[223,226,227,228,229,230],"Cardiac arrest","VLF MRI","HF MRI","structural brain","connectomes","2025-09-10",{"date":233,"type":42},"2025-09-17",{"date":235,"type":21},"2025-09-15",{"date":237,"type":21},"2029-03",{"name":48,"class":49},{"id":240,"slug":241,"hasResults":11,"nctId":242,"briefTitle":243,"officialTitle":244,"acronym":245,"eligibilityCriteria":246,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":247,"targetDuration":4,"studyType":22,"phases":248,"briefSummary":249,"conditions":250,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":258,"locationsCount":260},"100558308","treatment-of-electroencephalographic-status-epilepticus-after-cardiopulmonary-resuscitation-2-telstar-2-100558308","NCT06549426","Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation-2 (TELSTAR-2)","Treatment of ELectrographic STatus Epilepticus After Cardiopulmonary Resuscitation-2: Multicenter Randomised Clinical Trial and Health Economic Evaluation of Anti-seizure Treatment in Comatose Cardiac Arrest Patients With SE on Continuous EEG","TELSTAR-2","Inclusion Criteria:\n\n1. Coma (Glasgow Coma Scale score ≤ 8) after out of hospital cardiac arrest and resuscitation\n2. Age ≥ 18 years\n3. Continuous EEG with at least eight electrodes started \\\u003C 24h after return of spontaneous circulation (ROSC)\n4. ESE or possible ESE according to the Salzburg and ACNS criteria\n5. Possibility to start treatment within three hours after detection of ESE\n\nExclusion Criteria:\n\n1. Known history of another medical condition with limited life expectancy (\\\u003C six months)\n2. Any progressive brain illness, such as a brain tumor or neurodegenerative disease\n3. Pre-admission Glasgow Outcome Scale score of 3 or lower\n4. Reason other than the neurological condition to withdraw treatment\n5. EEG background activity prior to the emergence of ESE indicative of extensive irreversible anoxic brain injury\n6. Follow-up impossible due to logistic reasons, for example not living in the Netherlands or Belgium",{"count":152,"type":21},[24],"The goal of this comparative effectiveness trial is to study electrographic status epilepticus (ESE) treatment in comatose patients after cardiac arrest. The main questions the trial aims to answer are:\n\n* Does ESE treatment improve outcome?\n* What is the impact of ESE treatment on healthcare costs?\n\nParticipants in the the intervention group will receive standard care completed with anti-seizure treatment. The control group will receive standard care without anti-seizure treatment.",[27,251],"Electrographic Status Epilepticus","2025-05-13",{"date":254,"type":42},"2025-05-16",{"date":256,"type":42},"2025-04-10",{"date":174,"type":21},{"name":259,"class":49},"University of Twente",20,{"id":262,"slug":263,"hasResults":11,"nctId":264,"briefTitle":265,"officialTitle":266,"acronym":4,"eligibilityCriteria":267,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":268,"targetDuration":4,"studyType":22,"phases":270,"briefSummary":271,"conditions":272,"keywords":4,"overallStatus":167,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":50},"100569626","the-safety-and-efficacy-of-median-nerve-electrical-stimulation-for-improving-neurological-function-prognosis-in-patients-with-cardiac-arrest-100569626","NCT06696690","The Safety and Efficacy of Median Nerve Electrical Stimulation for Improving Neurological Function Prognosis in Patients With Cardiac Arrest","The Safety and Efficacy of Median Nerve Electrical Stimulation for Improving Neurological Function Prognosis in Patients With Cardiac Arrest: A Multicenter, Prospective, Randomized Controlled Study","Inclusion Criteria:\n\n1. Age ≥ 18 years old.\n2. Hemodynamics remains continuously stable for ≥ 7 days.\n3. There is still a lack of purposeful movements after the return of spontaneous circulation following cardiopulmonary resuscitation.\n4. Advanced life support is provided within 6 hours after the return of spontaneous circulation (ROSC).\n\nExclusion Criteria:\n\n1. Patients with hemodynamic instability.\n2. Pregnant patients.\n3. Those who have abnormal anatomical structures on the median nerve conduction pathway and are unable to receive electrical stimulation.\n4. Patients with a confirmed history of epilepsy before admission or during hospitalization.\n5. Patients with severe arrhythmia or those who have pacemakers implanted.\n6. Patients whose family members do not agree to their enrollment in the study.",{"count":269,"type":21},400,[24],"Median nerve stimulation (MNS), a non-invasive brain stimulation technique, has been widely adopted in clinical arousal therapies and multiple clinical investigations have attested to the efficacy of this technique; nevertheless, evidence concerning the application of MNS in improving the neurological prognosis of patients with return of spontaneous circulation (ROSC) following cardiac arrest (CA) remains scarce. The current study endeavors to assess the safety and efficacy of MNS treatment in enhancing the neurological prognosis of CA patients after ROSC and it is designed as a multicenter, prospective, randomized controlled trial with an estimated sample size of 400 patients. Eligible patients will be randomly allocated in a 1:1 ratio to either receive MNS treatment or sham stimulation treatment for 8 hours per day for 14 consecutive days and the primary outcome measure is the proportion of patients in each group with a Cerebral Performance Category (CPC) score ranging from 1 to 2, 6 months after randomization, which will help to determine the effectiveness of MNS in providing neuroprotection for patients with ROSC after CA.",[273,27,274],"Median Nerve","Post Cardiac Arrest Brain Injury",{"date":276,"type":42},"2025-04-11",{"date":278,"type":21},"2025-05-01",{"date":280,"type":21},"2027-12-01",{"name":282,"class":49},"Tang Ziren",{"id":284,"slug":285,"hasResults":11,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":289,"eligibilityCriteria":290,"healthyVolunteers":11,"sex":17,"minAge":291,"maxAge":18,"enrollmentInfo":292,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":293,"conditions":294,"keywords":295,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":50},"100559479","rapid-response-eeg-in-children-with-suspected-status-epilepticus-100559479","NCT06564662","Rapid-Response EEG in Children With Suspected Status Epilepticus","Observational Single-Center Study: Improving Timely Detection of Electrographic Seizures by Use of Rapid-Response EEG in Children With Suspected Status Epilepticus Admitted to the Pediatric ICU","RECS","Inclusion Criteria:\n\n* all patients with suspected status epilepticus as determined by the treating team in the pediatric ER or ICU\n\nExclusion Criteria:\n\n* none","2 Years",{"count":219,"type":21},"Seizures are common in children (\\~350 per 100,000 patients per year) and require immediate medical attention. If the seizure is prolonged (\\> 5 minutes) it is called status epilepticus and delayed treatment leads to higher risk in drug resistance and brain injury. The current standard of care for children admitted to the ICU with established or suspected status epilepticus is to start a conventional continuous EEG study that helps diagnosing seizures by typical electro graphic patterns. It takes on average 4 hours to start and another two hours to obtain a reading by epileptologists. This is far beyond the time window of starting an EEG study (60 minutes) as recommended by the neurocritical care society. In adult ICUs, point of care \"Rapid Response EEG\" are becoming a new standard of care and our ICU adopted this practice in 2020. It can be easily placed by the ICU staff rather than a specifically trained EEG technician but has a lower resolution due to fewer leads (10 vs. 20). The purpose of this study is to determine wether and by how much time RR-EEG yields faster preliminary EEG reports that the previously available conventional EEG (cEEG) and wether the detection of electro graphic seizures is comparable. This is a retrospective cohort study following patients who are admitted to the PICU and are placed on either cEEG or RR-EEG for status epilepticus.",[102,27],[194,296,297],"Child","Intensive Care Units, Pediatric","2024-08-19",{"date":300,"type":42},"2024-08-21",{"date":302,"type":42},"2021-12-09",{"date":304,"type":21},"2026-12-08",{"name":306,"class":49},"Children's Hospital at Montefiore",{"id":308,"slug":309,"hasResults":11,"nctId":310,"briefTitle":311,"officialTitle":312,"acronym":313,"eligibilityCriteria":314,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":315,"enrollmentInfo":316,"targetDuration":4,"studyType":22,"phases":318,"briefSummary":319,"conditions":320,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":323,"startDateStruct":325,"completionDateStruct":327,"leadSponsor":329,"locationsCount":50},"100510146","short-term-cervical-spinal-cord-stimulation-in-patients-with-disorders-of-consciousness-after-intracerebral-hemorrhage-100510146","NCT05922644","Short-term Cervical Spinal Cord Stimulation in Patients With Disorders of Consciousness After Intracerebral Hemorrhage","The Safety and Efficacy of Short-term Cervical Spinal Cord Stimulation in Patients With Disorders of Consciousness After Intracerebral Hemorrhage: a Multicenter, Prospective, Randomized, Outcome-blind Interventional Study","SCS-ICH","Inclusion Criteria:\n\n* Age between 18 and 65 years old\n* Patients with postoperative consciousness disorders after cerebral hemorrhage for more than 28 days\n* CRS-R score meets the MCS diagnosis\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Secondary brain injury caused by arteriovenous malformation, cerebral aneurysm, cavernous hemangioma, brain tumor and carbon monoxide poisoning\n* History of previous epileptic seizures\n* Critical condition, unstable intracranial condition, risk of rebleeding\n* Unstable vital signs requiring mechanical ventilation\n* Contraindications for spinal cord surgery\n* Severe sympathetic overactivity syndrome.","65 Years",{"count":317,"type":21},344,[24],"Disorders of consciousness (DOC) refers to the persistent loss of consciousness after 28 days in patients with brain injury caused by trauma, stroke, or hypoxia. It includes coma, vegetative state, and minimally conscious state. At present, there is no effective treatment for DOC. Only one RCT study of amantadine has proved that it may be effective for the treatment of DOC. In recent years, more evidence has shown that neuromodulation technology is beneficial to the recovery of DOC. Cervical spinal cord stimulation surgery is a new treatment method for patients with DOC. Electrodes are implanted in the high cervical spinal cord C2-C5. By adjusting different electrical stimulation parameters, it has a wake-promoting effect. In this study, patients were selected into the spinal cord stimulation group and the conventional treatment group according to the wishes of their families. The patients in the spinal cord stimulation group were given 21 days of cervical spinal cord stimulation treatment on the basis of conventional brain rehabilitation. Patients were followed up routinely and completed designated examinations at 12 months to determine the safety and efficacy of cervical spinal cord stimulation therapy.",[27,321],"Stroke","2023-06-28",{"date":324,"type":42},"2023-07-03",{"date":326,"type":21},"2023-07-01",{"date":328,"type":21},"2030-09-01",{"name":330,"class":49},"Beijing Tiantan Hospital"]