[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"combat-related-burn-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:combat-related-burn-injury":35},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":36,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":4},"100644682","burn-asv-trial-adaptive-support-ventilation-in-severe-burn-injury-100644682",false,"NCT07674563","BURN-ASV Trial: Adaptive Support Ventilation in Severe Burn Injury","Adaptive Support Ventilation Versus Conventional Lung-Protective Ventilation in Severe Burn Injury Including Thermobaric and Drone-Related Burns: The BURN-ASV Randomized Controlled Trial","BURN-ASV","Inclusion Criteria:\n\n* Age 18 years or older.\n* Thermal burn injury involving ≥20% total body surface area (TBSA).\n* Requirement for invasive mechanical ventilation expected to exceed 24 hours.\n* Admission to a participating intensive care unit within 48 hours of injury.\n* Burn injury resulting from conventional flame burns, explosion-related burns, drone-related burns, or thermobaric blast burns.\n* Written informed consent provided by the patient or a legally authorized representative.\n\nExclusion Criteria:\n\n* Age younger than 18 years.\n* Pregnancy or breastfeeding.\n* Pre-existing chronic respiratory failure requiring home oxygen therapy or long-term mechanical ventilation.\n* Severe chronic obstructive pulmonary disease (COPD GOLD IV) or other end-stage pulmonary disease.\n* Extracorporeal membrane oxygenation (ECMO) at the time of enrollment.\n* Severe traumatic brain injury requiring controlled hyperventilation.\n* Expected death within 24 hours of ICU admission.\n* Do-not-resuscitate (DNR) order or limitations of life-sustaining treatment.\n* Previous enrollment in the current study.\n* Participation in another interventional trial that may interfere with study outcomes.","ALL","18 Years","50 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"NA","Severe burn injury frequently requires prolonged mechanical ventilation because of inhalation injury, respiratory failure, systemic inflammation, and repeated surgical procedures. Patients with extensive burns are at high risk of ventilator-associated complications, prolonged intensive care unit (ICU) stay, and death.\n\nAdaptive Support Ventilation (ASV) is an automated mode of mechanical ventilation that continuously adjusts breathing support according to the patient's respiratory needs and lung mechanics. Although ASV has shown potential benefits in general ICU populations, its effectiveness in patients with severe burn injuries has not been adequately studied.\n\nThe purpose of this randomized controlled trial is to compare Adaptive Support Ventilation with conventional lung-protective mechanical ventilation in critically ill adult burn patients, including those with inhalation injury, drone-related burns, and thermobaric blast burns. Participants will be randomly assigned to receive either ASV or conventional ventilation. The study will evaluate whether ASV improves ventilator-free days, reduces duration of mechanical ventilation, decreases ventilator-associated complications, and improves clinical outcomes.\n\nThe results of this study may help identify optimal ventilation strategies for patients with severe burn injuries and improve critical care management in both civilian and military burn centers.",[28,29,30,31,32,33,34,35],"Burn","Mechanical Ventilation","Mechanical Ventilation Complication","ICU","ICU Hospitalization","Critical Care, Intensive Care","Military Activity","Combat-Related Burn Injury",[37,35,38,39],"burn","adaptive support mechanical ventilation","mechanical ventilation","NOT_YET_RECRUITING","2026-06-24",{"date":43,"type":44},"2026-06-29","ACTUAL",{"date":46,"type":22},"2026-09-23",{"date":48,"type":22},"2026-11-23",{"name":50,"class":51},"Ukrainian Society of Regional Anesthesia and Pain Therapy","OTHER",{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":59,"enrollmentInfo":60,"targetDuration":62,"studyType":63,"phases":4,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},"100626679","ultrasound-predictors-of-persistent-burn-scar-pain-after-blast-and-drone-related-injuries-a-prospective-cohort-study-100626679","NCT07438769","Ultrasound Predictors of Persistent Burn Scar Pain After Blast and Drone-Related Injuries: A Prospective Cohort Study","US-SCAR-PAIN","Inclusion Criteria:\n\n* Age ≥18 years\n* Burn injury with clinically formed scar\n* Enrollment 2-12 weeks after injury\n* Scar located on extremities, chest wall, or neck\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Severe cognitive impairment preventing valid questionnaires\n* Hemodynamic instability or inability to complete baseline evaluation\n* Active systemic infection (enrollment deferred until stable)\n* Pre-existing chronic pain condition unrelated to burn scar that would confound outcomes (investigator judgment)","60 Years",{"count":61,"type":22},150,"6 Months","OBSERVATIONAL","Persistent burn scar pain is common after blast and drone-related injuries and may be driven by scar fibrosis, vascular activity, and peripheral nerve involvement within scar tissue. This prospective cohort study aims to determine whether early ultrasound features of scars and nerves predict persistent clinically significant scar pain at 3 and 6 months. Ultrasound measures include scar thickness, echogenicity, Power Doppler vascularity, dynamic adhesion (gliding) assessment, and ultrasound signs of nerve involvement (\"US-nerve positive\"). Clinical outcomes include pain intensity (NRS), neuropathic pain screening (DN4), and functional interference.",[66,67,35,68],"Burn Scar Pain","Neuropathic Pain","Scar-Related Pain",[70,71,72,73,74,75,76],"Burn scar pain","ultrasound","nerve entrapment","blast injury","drone injury","neuropathic pain","chronic pain prediction","2026-02-22",{"date":79,"type":44},"2026-02-27",{"date":81,"type":22},"2026-03-24",{"date":83,"type":22},"2026-05-23",{"name":50,"class":51},1]