[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"common-mental-health-problems\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:common-mental-health-problems":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,91,129],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100575764","boosting-refugee-integration-through-psychological-intervention-100575764",false,"NCT06776523","Boosting Refugee Integration Through Psychological Intervention","BRIGHT","The inclusion criteria for participating in the study are:\n\n* refugees and asylum seekers (RAS) aged 16 or older;\n* residing in one of the participating local sites (Swiss municipalities, namely, Gemeinden, and transitional asylum centers, namely, Durchgangszentren) where PM+ is offered and which gave their consent for participation in the RCT;\n* speaking at least one of the following 12 languages: German, English, French, Arabic, Farsi, Kurdish, Tigrinya, Turkish, Ukrainian, Russian, Tamil, and Pashto;\n* obtaining a score of 20 or higher on the Kessler Psychological Distress Scale (K10; Kessler et al., 2002), a brief clinically validated screening questionnaire that assesses general psychological distress in the past 30 days. A score equal to or higher than 20 is used as an indication of moderate to high levels of psychological distress.\n\nThe exclusion criteria for participating in the study are:\n\n* significant cognitive or neurological impairment measured through specific tools developed by the WHO and integrated into the PM+ manual (impairment questionnaire);\n* acute medical conditions or severe mental disorders (e.g., psychotic or substance-abuse disorders) measured through specific tools developed by the WHO and integrated into the PM+ manual (impairment questionnaire);\n* acute risk of suicide as measured by the Suicidal Ideation Attribution Scale (SIDAS; van Spijker et al., 2014) and the Thoughts of Suicide Questionnaire (World Health Organization WHO, 2016).","ALL","16 Years",{"count":19,"type":20},1200,"ESTIMATED","INTERVENTIONAL",[23],"NA","Refugees and asylum seekers (RAS) face numerous stressors and adversities which put them at risk for developing mental health problems. However, access to adequate mental health care in host countries is limited. To address this problem, the World Health Organization (WHO) introduced Problem Management Plus (PM+), a short, low-intensity psychological intervention administered by non-professionals, aiming to alleviate common mental disorders among crisis-affected communities.\n\nThe present study aims at expanding the existing PM+ intervention by providing additional booster sessions and homework reminders while evaluating its effectiveness and implementation in the public health system.",[26,27,28,29],"Psychological Distress","PTSD","Trauma","Common Mental Health Problems",[31,26,32,33],"Problem Management Plus","Mental Health Care","Refugees","RECRUITING","2026-04-21",{"date":37,"type":38},"2026-04-27","ACTUAL",{"date":40,"type":38},"2025-01-16",{"date":42,"type":20},"2027-09",{"name":44,"class":45},"University of Zurich","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":21,"phases":59,"briefSummary":60,"conditions":61,"keywords":73,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":46},"100579744","culturally-adapted-i-cbt-for-farsidari-speaking-migrants-100579744","NCT06828276","Culturally Adapted i-CBT for Farsi\u002FDari Speaking Migrants","Culturally and Language-Adapted i-CBT for Common Mental Health Problems: A Randomized Controlled Study With Farsi\u002FDari-Speaking Migrants","i-CBT","Inclusion Criteria:\n\n* Between the ages of 15 and 29.\n* A score above the cut-off 1.75 on HSCL-25\n* Has a refugee or migrant background\n* Has a good and stable internet connection\n* Has access to a computer, tablet or smartphone\n* Is fluent in reading and writing Arabic\n* Has the ability to dedicate time to take part in the intervention for 6-10 weeks.\n\nExclusion Criteria:\n\n* Is suffering from a severe mental illness, such as psychosis or severe depression.\n* Is suffering from substance abuse\n* Is undergoing a psychological treatment\n* Has a high risk of suicide","15 Years","29 Years",{"count":58,"type":20},128,[23],"The aim of this randomized controlled trial (RCT) is to investigate the effectiveness of a culturally adapted internet-based cognitive behavioral therapy (i-CBT) intervention in reducing symptoms of common mental health issues among Farsi\u002FDari-speaking youth migrants and refugees. Investigator hypothesizes that there will be a significant decrease in psychological symptoms after participants receive the intervention compared to a control group.",[62,63,64,65,66,67,68,69,70,71,29,72],"Depressive Symptoms","Anxiety Symptoms","Grief","Psychological Trauma","Insomnia","Resilience","Stress","Psychological Well Being","Marital Relationship","Wellbeing","Rumination",[74,75,76,77,78,79,80,67,81],"Refugee","Cognitive behavioral therapy","Psychological problems","Persian speaking","Psychological well-being","Youth","Mental problems","Asylum seeker","2025-12-05",{"date":84,"type":38},"2025-12-12",{"date":86,"type":38},"2025-03-25",{"date":88,"type":20},"2026-12-31",{"name":90,"class":45},"Karolinska Institutet",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":99,"minAge":55,"maxAge":100,"enrollmentInfo":101,"targetDuration":4,"studyType":21,"phases":103,"briefSummary":104,"conditions":105,"keywords":110,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":46},"100603160","mpata-yathu-trial-for-young-women-in-zambia-100603160","NCT07132905","Mpata Yathu Trial for Young Women in Zambia","Randomized Pilot Trial of Church-Based Problem-Solving Therapy for Adolescent Girls and Young Women With a History of Gender-Based Violence in Zambia","MYT","Inclusion Criteria:\n\nTo be eligible for enrollment in the RCT, participants must meet the following criteria:\n\n1. aged 15 to 24 years;\n2. Speak Nyanja, Bemba, and\u002For English fluently;\n3. Reside in the Matero or Chawama constituency area during the time of recruitment;\n4. Report lifetime exposure to GBV, as assessed by the following sections of the WHO Multi-country Study on Women's Health and Domestic Violence Against Women instrument:\n\n   * Section 7 (Physical Violence by Intimate Partner): Reports of being slapped, pushed, hit with a fist, kicked, dragged, choked, or threatened\u002Fattacked with a weapon by a husband or partner.\n   * Section 8 (Sexual Violence by Intimate Partner): Reports of being physically forced to have sex, having sex out of fear, or being forced to engage in degrading sexual acts by a husband or partner.\n   * Section 9 (Emotional Abuse by Intimate Partner): Reports of being insulted, belittled, intimidated, or threatened by a partner.\n   * Section 10 (Physical Violence by Non-Partner): Lifetime experiences of being beaten or physically mistreated by someone other than a partner since age 15.\n   * Section 11 (Sexual Violence by Non-Partner): Forced sex or sexual acts since age 15 by a non-partner, and childhood sexual abuse before age 15.\n5. Exhibit moderate depressive symptoms indicated by a score of 10-14 on the 9-item Patient Health Questionnaire (PHQ-9), or common mental disorder (CMD) symptoms (e.g., depression, anxiety) as indicated by a score of 9 or higher on the 14-item Shona Symptom Questionnaire (SSQ-14); and\n6. Be living with HIV or demonstrate HIV risk behaviors, as defined by validated items from the World AIDS Foundation survey,25 including unprotected sex, multiple sexual partners, coerced sex, or transactional sex.\n\nExclusion Criteria:\n\nWomen will be excluded if they:\n\n1. Require emergency treatment for any crisis (mental, physical, emotional) at the time of screening\n2. Report severe symptoms of depression (score \\> 14 on PHQ-9) or no to mild depression symptoms (PHQ-9 score \\\u003C10), and\u002For severe anxiety symptoms using the Generalized Anxiety Disorder 7-item scale or GAD-7 (score \\>14 on GAD-7)\n3. Have intellectual or cognitive disabilities that limit their ability to complete the screening tools, interact with a lay counselor and\u002For provide informed consent; and\u002For\n4. Are considered in immediate danger (e.g., reoccurring physical violence) during time of the study.\n5. Are currently receiving formal mental health counseling or psychotherapy (to avoid duplication of care and potential confounding effects).","FEMALE","24 Years",{"count":102,"type":20},180,[23],"This study aims to improve mental health and HIV-related outcomes among adolescent girls and young women (AGYW) in Zambia who have experienced gender-based violence (GBV). GBV includes physical, sexual, or emotional violence from partners or others and is known to increase the risk of depression, anxiety, post-traumatic stress, and HIV infection. In Zambia, access to mental health services is limited, especially for young women in low-resource communities. This study tests a counseling program called Mpata Yathu, which means \"Our Space\" in Chinyanja, designed to provide psychological support and improve well-being for young women who have faced violence and may be living with or at risk for HIV.\n\nMpata Yathu is a culturally adapted version of the Friendship Bench, a lay counselor-delivered mental health intervention originally developed in Zimbabwe. In this adapted version, trained community lay counselors will deliver six individual problem-solving therapy (PST) sessions over a three-month period. Sessions will be delivered in private spaces within local Catholic churches in the Matero and Chawama areas of Lusaka, Zambia. Counseling sessions will also include referral options for participants who may need further support related to HIV care, GBV, or mental health concerns.\n\nThe study is a two-arm randomized controlled trial. Participants will be randomly assigned to either:\n\n1. Immediate Intervention Group - Receives the Mpata Yathu intervention between baseline and 3-month follow-up\n2. Waitlist Control Group - Receives usual care for the first 3 months and then receives the Mpata Yathu intervention between 3- and 6-month follow-up\n\nA total of 180 young women (90 per group) will participate in the trial. To be eligible, participants must be between the ages of 15 and 24, reside in the Matero or Chawama area, report lifetime GBV exposure, and show moderate depressive symptoms or symptoms of common mental disorders (CMDs). They must also be living with HIV or report behaviors that place them at risk for HIV.\n\nThe primary outcome is symptoms of CMDs, assessed using the Shona Symptom Questionnaire (SSQ-14). Secondary outcomes include depression, anxiety, and PTSD symptoms, as well as HIV-related outcomes such as clinic attendance, antiretroviral therapy (ART) adherence, and prevention behaviors such as condom use or PrEP readiness. The study will also measure feasibility, acceptability, and fidelity of the intervention.\n\nData will be collected through surveys at baseline, 3 months, and 6 months. The research team will also monitor how the intervention is implemented, how participants respond to counseling, and whether counselors follow the therapy protocol. Participants will receive a small stipend for their time and transport at each counseling session and follow-up visit.\n\nThis study is designed to test whether a trauma-informed, church-based mental health intervention can improve psychological well-being and HIV engagement among young women who are often underserved in traditional healthcare systems. If successful, this model could be expanded to other churches or schools in Zambia and similar settings. The results will inform future large-scale evaluations and could help shape new strategies for addressing GBV, mental health, and HIV among youth in sub-Saharan Africa.",[106,29,107,108,109],"HIV","PTSD - Post Traumatic Stress Disorder","Depression Disorder","Anxiety",[111,112,113,114,115,116,117,118],"Gender-based violence","Problem-solving therapy","Adolescent girls and young women","Zambia","Lay counselors","Mental health","HIV treatment engagement","HIV prevention","NOT_YET_RECRUITING","2025-08-13",{"date":122,"type":38},"2025-08-20",{"date":124,"type":20},"2025-09-22",{"date":126,"type":20},"2026-06-30",{"name":128,"class":45},"University of California, San Francisco",{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":135,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":16,"minAge":137,"maxAge":4,"enrollmentInfo":138,"targetDuration":4,"studyType":21,"phases":140,"briefSummary":141,"conditions":142,"keywords":144,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":167},"100571632","trial-of-an-online-group-psychotherapy-intervention-for-common-mental-health-disorders-100571632","NCT06722781","Trial of an Online Group Psychotherapy Intervention for Common Mental Health Disorders","UpLift-X Trial 1: A Cluster Factorial Randomised Controlled Trial of Digitally-enabled Group Psychotherapy for Common Mental Disorders","UpLift-X","Inclusion Criteria:\n\n* 17 years old and over\n* Literate and fluent in the English language, which would enable group interactions and learning via online materials\n* With access to an internet-connected device (e.g., computer, phone) and confidential space\n* Referred to NHS-TT services\n* Assessed by a qualified psychological professional and deemed to be eligible for high intensity CBT (this includes low risk of harm to self or others)\n* Currently on waiting list for high intensity CBT and not accessing any other psychological interventions. This includes patients accessing pharmacotherapy but who are additionally seeking psychological treatment\n* Presenting symptoms of one or more internalizing disorders (major depressive disorder, generalised anxiety disorder, panic disorder, agoraphobia, specific phobias, somatoform disorder, obsessive-compulsive and related disorders, body dysmorphic disorder, post-traumatic stress and related disorders)\n\nExclusion Criteria:\n\n* 16 years old and under\n* Not able to speak or read English fluently, which would require more individualised support with interpreters\n* No access to internet-connected device or confidential space to engage with digital intervention\n* Not involved with NHS-TT services\n* Assessed by a qualified psychological professional and not deemed to be eligible for high intensity CBT on the basis of mental health condition and\u002For risk assessment (e.g., acute risk of suicide at the time of assessment)\n* Already accessing a high intensity psychotherapy or other forms of psychological treatment (e.g., private therapy, counselling)\n* Presenting with symptoms of eating disorders, substance use disorders, psychotic disorders, personality disorders, bipolar disorders identified at the time of initial assessment.","17 Years",{"count":139,"type":20},660,[23],"The goal of this clinical trial is to understand how to deliver online group therapy for adults with common mental health problems in a personalised way. This study will test a new online group therapy program for various common mental health problems like anxiety and depression. The therapy is based on an approach called the Unified Protocol, which includes eight modules teaching different coping skills. The therapy will be delivered via a video call and a website, which will also have helpful videos and information about coping skills.\n\nAims:\n\n1. Does changing the order of the therapy modules affect how well treatment works or how many patients drop-out of treatment?\n2. Do some modules work better for different patients based on their individual features and if patients receive the therapy module that is most likely to be helpful for them first, does it mean they have a better chance of feeling better by the end of treatment?\n3. Does online group therapy work as well to treat common mental health problems as standard care (individual cognitive behavioural therapy \\[CBT\\])?\n\nHypotheses:\n\n1. Changing the order of therapy modules will not change how well therapy works or how many people drop-out.\n2. Patients with specific profiles (based on their individual characteristics) will benefit more from some treatment modules and will see greater improvements in their symptoms if they received their best therapy module before other modules\n3. There will be no differences in overall treatment outcome or dropout rates when comparing online group therapy vs. individual CBT\n\nResearchers will compare whether delivering the modules in different orders, with five different versions of the treatment, to see if changing the order of therapy modules affects how well it works or drop-out rates. Researchers will test how best to match patients to the most helpful parts of treatment for them. The group therapy outcomes and costs will also be compared to data from patients who have had individual CBT to see how the intervention compares to standard care.\n\nParticipants will:\n\n* Complete online symptom questionnaires before treatment starts and before each therapy session\n* Attend 12 weekly group therapy sessions delivered by a video call on a website (called Uplift-X).\n* Access online resources like videos and practice exercises to use between therapy sessions.\n* Complete the online symptom questionnaires again at the end of treatment and 6 months later.",[29,109,143],"Depression Disorders",[145,146,147,148,149,150,151,152,153,154,155,156],"Psychological interventions","Internalizing disorders","High intensity CBT","Common mental health problems","Unified Protocol","Digitally-enabled therapy","Group therapy","Digital Health Technology","NHS Talking Therapies","Personalised treatment","Pragmatic clinical trial","Transdiagnostic","2025-07-07",{"date":159,"type":38},"2025-07-10",{"date":161,"type":38},"2025-04-30",{"date":163,"type":20},"2026-09-30",{"name":165,"class":166},"Rotherham Doncaster and South Humber NHS Foundation Trust","OTHER_GOV",2]