[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"communication-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:communication-disorders":35},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,75,98,129,159,197],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":41,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":74},"100496255","cognitive-reserve-and-response-to-speech-language-intervention-in-bilingual-speakers-with-primary-progressive-aphasia-100496255",false,"NCT05741853","Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia","Cognitive Reserve and Linguistic Resilience in Bilingual Hispanics With Primary Progressive Aphasia","Inclusion Criteria:\n\n* Meets diagnostic criteria for Primary Progressive Aphasia (PPA; Gorno-Tempini et al., 2011)\n* Bilingual in Spanish and Catalan or bilingual in Spanish and English\n* Different proficiency levels across languages are expected, any prior experience in both languages is acceptable\n* Intervention study: Score of 15 or higher on the Mini-Mental State Examination\n* Note that this project will also recruit individuals to participate in assessment only, for these individuals the following inclusion criteria applies: Score of 10 or higher on the Mini-Mental State Examination\n\nExclusion Criteria:\n\n* Other central nervous system or medical diagnosis that can cause symptoms\n* Other psychiatric diagnosis that can cause symptoms\n* Significant, uncorrected visual or hearing impairment that would interfere with participation\n* Prominent initial non-speech-language impairments (cognitive, behavioral, motoric)\n* Intervention Study: Score of less than 15 on the Mini-Mental State Examination\n* Note that this project will also recruit individuals to participate in assessment only, for these individuals the following inclusion criteria applies: Score of less than 10 on the Mini-Mental State Examination",true,"ALL","40 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","Difficulties with speech and language are the first and most notable symptoms of primary progressive aphasia (PPA). While there is evidence that demonstrates positive effects of speech-language treatment for individuals with PPA who only speak one language (monolinguals), there is a significant need for investigating the effects of treatment that is optimized for bilingual speakers with PPA. This stage 2 efficacy clinical trial seeks to establish the effects of culturally and linguistically tailored speech-language interventions administered to bilingual individuals with PPA.\n\nThe overall aim of the intervention component of this study is to establish the relationships between the bilingual experience (e.g., how often each language is used, how \"strong\" each language is) and treatment response of bilinguals with PPA. Specifically, the investigators will evaluate the benefits of tailored speech-language intervention administered in both languages to bilingual individuals with PPA (60 individuals will be recruited). The investigators will conduct an assessment before treatment, after treatment and at two follow-ups (6 and 12-months post-treatment) in both languages. When possible, a structural scan of the brain (magnetic resonance image) will be collected before treatment in order to identify if brain regions implicated in bilingualism are associated with response to treatment. In addition to the intervention described herein, 30 bilingual individuals with PPA will be recruited to complete behavioral cognitive-linguistic testing and will not receive intervention. Results will provide important knowledge about the neural mechanisms of language re-learning and will address how specific characteristics of bilingualism influence cognitive reserve and linguistic resilience in PPA.",[27,28,29,30,31,32,33,34,35,36,37,38,39,40],"Primary Progressive Aphasia","Dementia","Dementia, Frontotemporal","Alzheimer Disease","Neurodegenerative Diseases","Frontotemporal Lobar Degeneration","Apraxia, Motor","Dysarthria","Communication Disorders","Language Disorders","Speech Disorders","Neurocognitive Disorders","Aphasia","Bilingual Aphasia",[42,43,44,27,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61],"Dementia, ADRD","Bilingualism","Multilingualism","Bilingual Primary Progressive Aphasia","Cognitive Reserve","Language Decline","Bilingual Language Decline","Speech-Language Therapy","Bilingual Speech-Language Therapy","Spanish speakers","Spanish-Catalan Bilinguals","Spanish-English Bilinguals","Hispanic","Catalán","Catalan","Spanish","Castellano","Speech Therapy","Latino","Cognition","RECRUITING","2026-06-08",{"date":65,"type":66},"2026-06-10","ACTUAL",{"date":68,"type":66},"2023-05-01",{"date":70,"type":21},"2027-11-30",{"name":72,"class":73},"Stephanie Grasso","OTHER",3,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":81,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":97},"100542001","adaptive-and-individualized-aac-phase-ii-100542001","NCT06337188","Adaptive and Individualized AAC Phase II","Inclusion Criteria:\n\n* Adults or Children; age greater than or equal to 6 y.o.\n* Male or female\n* Able to (a) spell, (b) follow 2-3 step directions, (c) read 40 point text\n* Have complex communication needs representing a broad spectrum of developmental and acquired severe motor impairments resulting from high spinal cord injury (SCI), chronic Guillain-Barre syndrome, brain stem stroke, cerebral palsy (CP), locked-in syndrome, among others.\n* Requires the use of an alternative access strategy to communicate and\u002For use technology that has been clinically prescribed and manually optimized following current clinical standards.\n* Sufficient control and voluntary muscle activation on either the head, hand, or foot (on the basis of clinical evaluation by clinical collaborators at University of Nebraska Medical Center) to use the proposed wearable AAC system for the purpose of this study.\n* Sufficient stamina and developmental maturity (on the basis of clinical evaluation by clinical collaborators at University of Nebraska Medical Center) to attend to the approximately 1-2 hour protocols outlined in Aims 2 and 3 without excess fatigue or distraction.\n* Availability for at least 5 testing sessions over the study period.\n* No medical or safety restrictions of active head, hand, or foot movement (as determined by clinical collaborators at University of Nebraska Medical Center).\n* Clinical evidence of preserved cognition by a score of 0 or 1 on NIHSS Consciousness and Communication item.\n* Ability to voluntarily blink eyes or raise eyebrows on command (for head selection) or contract fingers\u002Fhand grasp (for hand selection) or rotate foot (for foot selection).\n* Able to provide written, informed consent or an accompanying communication partner or parent\u002Fguardian (for individuals under 18 y.o) to provide written, informed consent\u002Fassent to participate in the study.\n* Able to speak and follow directions in English.\n\nExclusion Criteria:\n\n* Non-English speaker.\n* Inability to follow simple instructions in English.\n* Medical history of musculoskeletal conditions (arthritis, spondylosis, etc.) that causes pain on head, hand, or foot movement.\n* Restricted active or passive rotation of head and neck resulting from unstable vertebral, spinal cord, or nerve roots that places the subject at risk for execution of the protocol.\n* Medical history of cardiac or respiratory complications, or similar disorders that would severely reduce stamina and\u002For place the subject at risk for conducting the different motor activities.\n* Unable to provide informed assent\u002Fconsent in English.","6 Years",{"count":83,"type":21},20,[24],"The overall objective of this study is to develop an Augmentative and Alternative Communication (AAC) system that is effective in delivering a person-centric communication device that will provide a versatile access method that can automatically learn and adapt to the user's physical abilities by creating a personalized, comprehensive keyboard interface for communication, not otherwise available to people in need of alternative communication.",[35],"2025-09-25",{"date":89,"type":66},"2025-09-30",{"date":91,"type":66},"2024-12-03",{"date":93,"type":21},"2026-03-01",{"name":95,"class":96},"Altec Inc.","INDUSTRY",1,{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":105,"targetDuration":107,"studyType":108,"phases":4,"briefSummary":109,"conditions":110,"keywords":114,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":97},"100558107","outcomes-of-ict-assistive-technology-in-rehabilitation-pathways-100558107","NCT06546813","Outcomes of ICT Assistive Technology in RehabiliTAtIoN Pathways","ATTAIN","consecutive enrollment of subjects falling within\n\nInclusion Criteria:\n\n* patients in need of prosthetic interventions for Augmentative Alternative Communication, computer accessibility, and environmental control\n* patients who agree to participate in the study\n\nExclusion Criteria:\n\n* none",{"count":106,"type":21},50,"6 Months","OBSERVATIONAL","The study aims to improve the quality of prosthetic intervention and verify the adequacy of assistive devices, and measurement outcomes. Fifty patients in need of prosthetic interventions for Augmentative Alternative Communication, computer accessibility, and environmental control will be recruited within the DAT Unit of the Fondazione Don Carlo Gnocchi \"IRCCS S.Maria Nascente\" in Milan. At baseline (T0) a physician and a psychologist will perform a clinical evaluation and the AT outcome assessment. The participants will be contacted for the follow-up phase (T1) 3 to 6 months after having received the assistive solution. At T1 clinicians will readminister the AT outcome assessment. In order to make the assessment accessible to all participants, these tests and questionnaires will be administered on Windows PCs, using Grid3 software, or on a specifically created accessible web page.",[111,35,112,113],"Communication Aids for Disabled","Motor Disorders","Cognitive Disorder",[115,116,117,118,119],"ICT AT","AAC AT","AAL AT","Assistive Technology","Outcome Assessment","2025-08-25",{"date":122,"type":66},"2025-08-26",{"date":124,"type":66},"2023-06-01",{"date":126,"type":21},"2025-10-31",{"name":128,"class":73},"Fondazione Don Carlo Gnocchi Onlus",{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":17,"minAge":136,"maxAge":4,"enrollmentInfo":137,"targetDuration":4,"studyType":22,"phases":139,"briefSummary":140,"conditions":141,"keywords":145,"overallStatus":149,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":4},"100593373","early-speaking-valve-in-ventilator-weaning-effects-on-communication-depression-and-quality-of-life-100593373","NCT07005596","Early Speaking Valve in Ventilator Weaning: Effects on Communication, Depression, and Quality of Life","Assessing the Impact of Early Tracheostomy Speaking Valve Intervention on Communication, Depression, and Quality of Life in Long-term Ventilator-dependent Patients During the Weaning Phase","Inclusion Criteria:\n\n* Age: ≥18 years old\n* Consciousness: Glasgow Coma Scale (GCS) score 13-15 (can voluntarily open eyes or respond when called, able to follow instructions to move)\n* Tracheostomy: Performed ≥24 hours, with no bleeding, pain, subcutaneous emphysema, pneumothorax, or infection\n* Ventilator Weaning: Trained according to the hospital's Respiratory Care Center standards, able to undergo spontaneous breathing training during the day\n* Ventilator Settings: FiO2 ≤40%\n* Vital Signs: Stable:\n* Heart rate 60-100 beats\u002Fmin\n* Respiratory rate 12-20 breaths\u002Fmin\n* Systolic blood pressure \\\u003C150 mmHg, diastolic blood pressure \\\u003C90 mmHg\n* Blood oxygen saturation 95-100%, no dyspnea complaints\n* Richmond Agitation-Sedation Scale (RASS) between -1 and +1\n* Language: Able to communicate in Mandarin, Taiwanese, or Hakka\n* Consent: Willing to participate in the study\n\nExclusion Criteria:\n\n* Recent surgery, anesthesia, or sedative use affecting consciousness\n* Severe unstable vital signs or inability to breathe normally\n* Upper airway obstruction or vocal cord paralysis\n* High dependence on ventilators or high-concentration oxygen therapy\n* History of depression or currently taking antidepressant medication","18 Years",{"count":138,"type":21},70,[24],"This study evaluates the impact of early tracheostomy speaking valve intervention on communication ability, depression levels, and quality of life in ventilator-dependent patients during the weaning phase. Participants will be randomly assigned to either an experimental group using the Passy-Muir speaking valve or a control group employing standard non-verbal communication methods. Structured questionnaires will be used at multiple time points to assess changes in patient outcomes. The study aims to provide evidence supporting the use of speaking valves to enhance communication and emotional well-being in tracheostomy patients, potentially improving recovery and care strategies.",[142,35,143,144],"Respiratory Failure","Depression","Quality of Life",[146,147,148],"speaking valve","tracheostomy","communication","NOT_YET_RECRUITING","2025-06-04",{"date":152,"type":66},"2025-06-05",{"date":154,"type":21},"2025-06-15",{"date":156,"type":21},"2027-12-31",{"name":158,"class":73},"Far Eastern Memorial Hospital",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":11,"sex":17,"minAge":166,"maxAge":4,"enrollmentInfo":167,"targetDuration":4,"studyType":22,"phases":168,"briefSummary":169,"conditions":170,"keywords":176,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":194,"locationsCount":196},"100522771","paiact---an-artificial-intelligence-driven-chatbot-assisted-act-100522771","NCT06086951","Pai.ACT - An Artificial Intelligence Driven Chatbot Assisted ACT","Pai.ACT: A Deep-learning-powered, Smartphone-delivered, Acceptance and Commitment Therapy for Parents of Children With Special Needs: A Feasibility Study","Inclusion Criteria:\n\n* Primary caregivers who are Cantonese-speaking Hong Kong residents.\n* The caregiver must cohabitate with the child with special needs.\n* The child under the participant's care should be aged between 2-8 years. The child should be either diagnosed or suspected to have one of the developmental conditions such as ASD, ADHD, or DD. These conditions must be recognised by the Child Assessment Service of the Department of Health and conform to the DSM-5 criteria. The diagnosis or suspected diagnosis should be documented in the electronic medical record at the study hospital or the case profile record at the collaborating non-governmental organisations.\n\nNote: The age range of 2-8 years was selected due to the substantial impact of parenting on the developmental milestones of preschoolers and junior school-aged children.\n\nExclusion Criteria:\n\n* Parents diagnosed with severe mental illnesses are excluded.\n* Parents who are currently pregnant are excluded.\n* Parents who are less than six months postpartum are excluded.\n* Parents with a developmental disability that interferes with their ability to comprehend the program's content are excluded.\n* Parents with cognitive, language, communication, visual, or hearing impairments or disorders that could impede their understanding of the intervention content are excluded.\n* Parents currently participating in other psychosocial, psychoeducational, or parenting interventions are excluded.","19 Years",{"count":20,"type":21},[24],"Limited psychological support for parents of children with special needs in Hong Kong can profoundly impact the child rehabilitation process and the well-being of parent-child dyads. Leveraging previous evidence from our team's research, we have developed Pai.ACT, the first deep learning-based mental health advisory system for parents. Pai.ACT incorporates the counselling logic of Acceptance and Commitment Therapy (ACT) through natural language processing, enabling parents to engage in human-like voice-to-text conversations and receive assessments and stepped-care mental health interventions, including guided self-help materials and real-time, individual-based counselling based on ACT. Following the research and development phases, we aim to kick off the utilisation of Pai.ACT by (1) pilot-testing its feasibility, acceptability, and potential efficacy in improving mental health outcomes for parents of children with special needs and (2) researching to determine the most optimal service model for parents by exploring their perceptions through focus group interviews. Pai.ACT offers accessible and comprehensive mental health services to all Chinese-speaking parents, addressing their psychological burden in caring for children with special needs. Pai.ACT could bring substantial and enduring societal benefits to Chinese-speaking families by integrating mental health support services for family caregivers with current child rehabilitation services and non-governmental organisations. Furthermore, this could contribute to reducing the public stigma attached to special needs children while increasing mental health awareness.",[171,172,173,174,175,35,112],"Autism Spectrum Disorder","Attention Deficit Hyperactivity Disorder","Neurodevelopmental Disorders","Intellectual Disability","Specific Learning Disorder",[177,178,179,180,181,182,183,184,185,186],"Deep learning","Smartphone-delivered Therapy","Acceptance and Commitment Therapy","Parents","Children with Special Needs","Feasibility trial","Parental Support","Artificial Intelligence in Healthcare","Psychological Interventions","Parenting Stress","2025-01-21",{"date":189,"type":66},"2025-01-23",{"date":191,"type":66},"2023-10-01",{"date":193,"type":21},"2025-06-30",{"name":195,"class":73},"Chinese University of Hong Kong",2,{"id":198,"slug":199,"hasResults":11,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":4,"eligibilityCriteria":203,"healthyVolunteers":11,"sex":17,"minAge":204,"maxAge":4,"enrollmentInfo":205,"targetDuration":4,"studyType":22,"phases":207,"briefSummary":208,"conditions":209,"keywords":210,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":196},"100506311","fab-programme-for-parents-of-children-with-ndd-100506311","NCT05872737","FAB Programme for Parents of Children With NDD","Facilitator-guided Acceptance and Commitment Bibliotherapy for Parents of Young Children With Neurodevelopmental Disorders: A Randomised Controlled Trial","Parents of young children with NDD who fulfil the following criteria will be recruited:\n\n* Cantonese-speaking Hong Kong residents,\n* aged ≥ 21 years,\n* have a child aged between two and six years old (preschool age) with a clinically documented diagnosis\u002Fsuspected NDD diagnosis according to DSM-5 criteria (e.g., ASD, ADHD, developmental delay) and enrolled in the SWD subvented pre-school rehabilitation services offered by NGOs,\n* caregivers who adopted the responsibility of taking care of the child, living together with the child, and\n* have device(s) with internet access.\n\nParents of young children with NDD will be excluded if:\n\n* has been diagnosed with severe mental illness(es),\n* cognitive\u002Flanguage\u002Fcommunication\u002Fvisual\u002Fhearing impairment(s) or disorders that may present difficulties in comprehending the content of the intervention; and\u002For\n* are currently receiving another psychosocial, psychoeducational, or parenting intervention(s).","21 Years",{"count":206,"type":21},154,[24],"The study aims to examine the effectiveness of a psychotherapy approach called Facilitator-guided Acceptance and Commitment Bibliotherapy (FAB) in improving the psychological health of parents of young children with neurodevelopmental disorders (NDD) and reducing the emotional and behavioral symptoms of NDD children. The study will involve 154 Cantonese-speaking parents of children aged 2-6 years diagnosed with NDD in Hong Kong. The study hopes to find that FAB can improve parent-child dyads' health outcomes by enhancing psychological flexibility, parental psychological health, and mindful parenting skills.",[171,172,173,174,175,35,112],[211,212,213,214,215,216,217,218,179],"Neurodevelopmental disorders","Facilitator-guided Acceptance and Commitment Bibliotherapy","Parental psychological health","Parenting stress","Repeated-measures parallel-group design","Randomized controlled trial","Psychological flexibility","Hong Kong","2024-09-13",{"date":221,"type":66},"2024-09-19",{"date":223,"type":66},"2023-06-05",{"date":225,"type":21},"2026-09-08",{"name":195,"class":73}]