[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"community-acquired-pneumonia-in-children\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:community-acquired-pneumonia-in-children":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,53,84],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100541087","a-trial-of-placebo-versus-macrolide-for-mycoplasma-pneumoniae-childhood-pneumonia-mythic-study-100541087",false,"NCT06325293","A Trial of Placebo Versus Macrolide for Mycoplasma Pneumoniae Childhood Pneumonia: MYTHIC Study","A Randomized Controlled Non-inferiority Trial of Placebo Versus Macrolide Antibiotics for Mycoplasma Pneumoniae Infection in Children With Community-acquired Pneumonia - the MYTHIC Study","MYTHIC","Inclusion criteria for screening phase:\n\n* Children aged 3-17 years (from 3rd up to 18th birthday) presenting to the emergency department (ED) who will be managed ambulatory or will be admitted to general ward.\n* Clinical diagnosis of CAP:\n\n  1. Diagnosis defined as the treating physician's documented diagnosis of CAP; AND\n  2. Fever ≥38.0°C (measured by any method \\[i.e., ear, axillary, rectal, or forehead site\\] in the ED or via parent report observed in the last 24h); AND\n  3. Tachypnea (defined as respiratory rate (RR) above age-specific reference value) during the assessment in ED (triage or clinical examination).\n* Written screening consent for participation in screening phase signed by parents\u002Flegal guardians and the patient if ≥14 years of age.\n\nAdditional inclusion criteria for intervention phase:\n\n* Positive Mp screening test result with the Mp IgM lateral flow assay (LFA) (grade 2 or 3).\n* Written informed consent for participation in intervention phase signed by parents or legal guardians and the patient if ≥14 years of age.\n\nExclusion criteria:\n\nExclusion criteria for screening phase:\n\n• None.\n\nExclusion criteria for intervention phase:\n\n* Contraindication to azithromycin: Documented allergy to azithromycin; cardiovascular disease, including bradycardia, arrhythmias, and\u002For QT-interval prolongation\\*; myasthenia gravis.\n\n  \\*Co-medication with arrhythmogenic or QT-interval-prolonging drug (www.qtdrugs.org) is no exclusion criteria but will be discussed with the local investigators and\u002For trial management team (TMT).\n* Underlying comorbidities: Cystic fibrosis or other chronic lung disorders (excluding asthma), primary or secondary immunodeficiency, sickle-cell anemia, or severe cerebral palsy.\n* History of recurrent pneumonia (two or more episodes) or severe pneumonia (ICU admission or complications of CAP such as lung abscess, effusion, and empyema) in lifetime.\n* Antibiotic treatment against Mp within the previous 7 days, including macrolides, tetracyclines, or fluoroquinolones.\n* Referral to ICU directly from the ED.\n* Inability to take oral medication.\n* Parents are unlikely to reliably complete follow up (FUP) visits and questionnaires (e.g., due to language barriers or living far from the study site).","ALL","3 Years","17 Years",{"count":21,"type":22},376,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to compare a placebo (a look-alike substance that contains no active drug) with a commonly used antibiotic in children with Mycoplasma pneumoniae (a specific bacterium) induced community-acquired pneumonia. The main question it aims to answer is:\n\nIs antibiotic treatment needed in Mycoplasma pneumoniae (a specific bacterium) induced pneumonia?\n\nParticipants will receive either a placebo or a antibiotic treatment and track their symptoms and vital signs until they are healthy.\n\nResearchers will then compare the length of symptoms between the placebo and the antibiotic group.",[28,29,30],"Community Acquired Pneumonia in Children","Mycoplasma Pneumoniae","Mycoplasma Pneumoniae Pneumonia",[32,33,34,35,36,37,38,39],"Mycoplasma pneumoniae","community-acquired pneumonia","randomized controlled trial","Investigator Initiated Clinical Trial (IICT)","Paediatric pneumonia","children","placebo","macrolides","RECRUITING","2026-04-29",{"date":43,"type":44},"2026-05-05","ACTUAL",{"date":46,"type":44},"2025-01-28",{"date":48,"type":22},"2028-12-31",{"name":50,"class":51},"Christoph Berger","OTHER",13,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":23,"phases":64,"briefSummary":66,"conditions":67,"keywords":68,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":83},"100554052","phase-4-short-versus-standard-of-care-antibiotic-duration-for-children-hospitalized-for-cap-100554052","NCT06494072","Short Versus Standard of Care Antibiotic Duration for Children Hospitalized for CAP","Short Versus Standard of Care Antibiotic Duration for Hospitalized Children With Uncomplicated Community-acquired Pneumonia: a Non-inferiority, Randomized Controlled Trial.","Inclusion Criteria (ALL of the following must be met):\n\n1. Children aged 3 months to \\\u003C18 years old\n2. Hospitalized in either the acute care or the pediatric intensive care units\n3. Clinically diagnosed with uncomplicated bacterial community acquired pneumonia (as determined by the treating physician)\n4. Radiological findings suggestive of pneumonia (such as consolidation, lobar or interstitial infiltrates)\n5. Achieved clinical stability within 72 hours from the first antibiotic dose (clinical stability includes being off supplemental oxygen\u002Fventilatory support and temperature remaining \\\u003C 38 Celsius).\n\nExclusion Criteria (presence of ANY of the following will exclude a potential participant):\n\n1. Hemodynamic instability at any point during hospitalization that required inotropic support\n2. Requirement of respiratory support \\> 72 hours\n3. Presence of a parapneumonic effusion \\>10 mm on decubitus x-ray or greater than ¼ of hemithorax opacified on chest imaging\n4. Need for chest tube placement\n5. Extrapulmonary involvement (ie: another infection located outside of the lungs) except for otitis media if the planned treatment is ≤ 5 days\n6. Pneumonia caused by known staphylococcus aureus identified from culture (blood, bronchoalveolar aspirate, tracheal aspirate, or pleural fluid)\n7. Antibiotic course started \\>72 hours after admission\n8. Antibiotics used for \\> 24 hours within the 2 weeks prior to admission\n9. Chronic respiratory illness other than asthma or reactive airway disease\n10. Immunocompromised patient (primary or secondary)\n11. Primary physician refusal\n12. Parent refusal\n13. Non-English speakers\n14. Pregnant or lactating female\n15. Participant will become ≥ 18 years old at or before the time of day 14 follow up\n16. Inability to adhere to follow up","3 Months","18 Years",{"count":63,"type":22},236,[65],"PHASE4","The goal of this open label, randomized, non-inferiority clinical trial is to compare the treatment success of a 5 day antibiotic course versus a standard antibiotic course (usually 7-14 days of antibiotics) in hospitalized children aged 3 months to 18 years, with uncomplicated community acquired pneumonia.\n\nThe main questions it aims to answer are:\n\n* Does a 5 day course work as well as standard (longer) courses of antibiotics for treating community acquired pneumonia in children?\n* Does a 5 day course cause less antibiotic side effects compared to a standard (longer) course of antibiotics in children with community acquired pneumonia?\n\nParticipants will\n\n* be randomly assigned to either receive 5 total days or a total duration decided by the treating physician\n* receive a brief follow up questionnaire regarding clinical symptoms, follow up care\u002Fantibiotics, and side effects via phone or email at days 5 and 14 from the start of antibiotics\n\nResearchers will compare the experimental group (receiving 5 days duration) with the control group (standard duration) to see if 5 days is as successful as a standard duration.",[28],[69,70,71,72,73],"inpatient","pediatric","hospitalized","community acquired pneumonia.","antibiotic duration","2026-02-26",{"date":76,"type":44},"2026-03-02",{"date":78,"type":44},"2024-08-22",{"date":80,"type":22},"2028-05",{"name":82,"class":51},"Medical College of Wisconsin",1,{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":61,"enrollmentInfo":91,"targetDuration":4,"studyType":93,"phases":4,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":112},"100414801","antibiotic-prescription-in-children-hospitalized-for-community-acquired-pneumonia-100414801","NCT04681339","Antibiotic Prescription in Children Hospitalized for Community-acquired Pneumonia","Antibiotic Prescription in Children Hospitalized for Community-acquired Pneumonia: a Prospective, Observational Study","Inclusion Criteria:\n\n* Hospital admission at the pediatric department of the Filderklinik or at the pediatric department of the Herdecke Community Hospital\n* Admission diagnosis pneumonia or pneumonia diagnosis within 48 hours of admission\n* Written informed consent by care giver\n* All inclusion criteria have to be fulfilled\n\nExclusion Criteria:\n\n* Insufficient knowledge of German to understand the written patient information and questionnaire",{"count":92,"type":22},200,"OBSERVATIONAL","A study to observe how often antibiotics are prescribed in children hospitalized for pneumonia and how doctors decide if a child needs antibiotics or not. Parent satisfaction will also be recorded.",[28,96],"Antibiotic Stewardship",[98,99,100,101,102],"Community acquired pneumonia","Antibiotic use","Pediatrics","Hospitalised children","Integrative medicine","2025-01-07",{"date":105,"type":44},"2025-01-08",{"date":107,"type":44},"2022-09-16",{"date":109,"type":22},"2025-12",{"name":111,"class":51},"ARCIM Institute Academic Research in Complementary and Integrative Medicine",2]