[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"complex-renal-calculi\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:complex-renal-calculi":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100053219","modified-mini-pcnl-versus-standard-pcnl-for-complex-kidney-stones-100053219",false,"NCT07697677","Modified Mini-PCNL Versus Standard PCNL for Complex Kidney Stones","Modified Mini Percutaneous Nephrolithotomy Versus Standard Percutaneous Nephrolithotomy for the Treatment of Complex Renal Calculi: A Multicenter Randomized Controlled Trial","MIMIC-PCNL","Inclusion Criteria:\n\n1. Adults aged ≥18 years.\n2. Serum creatinine ≤133 μmol\u002FL.\n3. American Society of Anesthesiologists (ASA) physical status classification I-III.\n4. S.T.O.N.E. score ≥8.\n5. Complex renal stones confirmed by noncontrast computed tomography, including stone surface area \\>1500 mm², multiple calyceal stones, partial or complete staghorn calculi, or complex anatomical conditions.\n6. Patients who provide written informed consent and agree to undergo either modified mini-percutaneous nephrolithotomy or standard percutaneous nephrolithotomy.\n\nExclusion Criteria:\n\n1. Solitary kidney.\n2. Morbid obesity (body mass index ≥35 kg\u002Fm²).\n3. Previous renal transplantation or urinary diversion.\n4. Congenital abnormalities of the urinary tract.\n5. Pregnancy.\n6. Uncorrected coagulopathy.\n7. Active urinary tract infection.","ALL","18 Years","70 Years",{"count":21,"type":22},1380,"ESTIMATED","INTERVENTIONAL",[25],"NA","Kidney stones that are large or complex are often treated with percutaneous nephrolithotomy, also called PCNL. Standard PCNL uses a larger access tract and is effective for removing complex kidney stones, but it may be associated with more bleeding, pain, and recovery burden. Modified mini-PCNL uses a smaller access tract and may reduce surgical trauma while maintaining a similar stone clearance rate.\n\nThis multicenter randomized trial will compare modified mini-PCNL using a 20 Fr access sheath with standard PCNL using a 24 Fr access sheath in adults with complex renal stones. About 1,380 participants from 8 urology centers will be randomly assigned to receive one of the two procedures. The main purpose of the study is to determine whether modified mini-PCNL is not worse than standard PCNL in achieving stone-free status shortly after surgery. Stone-free status will be assessed by low-dose noncontrast CT within 72 hours after surgery. The study will also compare stone-free status at 3 months, complications, operation time, length of hospital stay, need for additional procedures, and quality of life.",[28,29],"Kidney Stones","Complex Renal Calculi",[31,32,33,34,35,36,37],"Percutaneous Nephrolithotomy","Mini-PCNL","Standard PCNL","Modified Mini-PCNL","Complex Renal Stones","Stone-Free Rate","Randomized Controlled Trial","RECRUITING","2026-07-07",{"date":41,"type":42},"2026-07-13","ACTUAL",{"date":44,"type":22},"2026-07-15",{"date":46,"type":22},"2027-09-14",{"name":48,"class":49},"The First Affiliated Hospital of Guangzhou Medical University","OTHER"]