[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"complicated-grief\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:complicated-grief":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100605836","sleep-difficulties-after-loss-exploring-the-beneficial-effect-of-brief-behavioral-therapy-for-insomnia-in-a-sample-of-bereaved-individuals-100605836",false,"NCT07167706","Sleep Difficulties After Loss: Exploring the Beneficial Effect of Brief Behavioral Therapy for Insomnia in a Sample of Bereaved Individuals","Sleep Difficulties After Loss (SLEEPLOSS): Exploring the Beneficial Effect of Brief Behavioral Therapy for Insomnia in a Sample of Bereaved Individuals","SLEEPLOSS","Inclusion Criteria:\n\n* Age ≥18 years\n* Bereaved (experienced the death of a perceived loved one) ≥6 months ago\n* Insomnia: a score of \\>10 on the Insomnia Severity index (ISI) and\u002For meet the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria for Insomnia Disorder\n\nExclusion Criteria:\n\n* Other sleep disor-ders (sleep apnea, parasomnia, narcolepsy)\n* Use of drugs impacting sleep\n* Severe psychological or physical disorders that may confound sleep (symptoms of CGR allowed)\n* Neurodegenerative disorders\n* Shift work\n* Insufficient Danish proficiency\n* Previous experience with BBTI or cognitive behavioral therapy for insomnia (CBT-I)","ALL","18 Years",{"count":20,"type":21},58,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of the study is to investigate whether a brief behavioral therapy for insomnia (BBTI) improves sleep in bereaved patients screened for insomnia compared to an active control group (sleep hygiene education). The study will also explore if BBTI improves symptoms of complicated grief. The investigators will recruit approximately 58 bereaved participants with insomnia.",[27,28,29],"Insomnia","Insomnia Chronic","Complicated Grief",[27,28,31,32,33,34,29,35,36,37],"Brief Behavioral Therapy for Insomnia","BBTI","Sleep","Sleep Quality","Grief","Bereavement","Complicated Grief Reactions","NOT_YET_RECRUITING","2025-11-14",{"date":41,"type":42},"2025-11-17","ACTUAL",{"date":44,"type":21},"2025-12-30",{"date":46,"type":21},"2027-05-31",{"name":48,"class":49},"University of Aarhus","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":50},"100589375","transcranial-magnetic-stimulation-to-treat-prolonged-grief-disorder-100589375","NCT06953596","Transcranial Magnetic Stimulation to Treat Prolonged Grief Disorder","Transcranial Magnetic Stimulation to Treat Prolonged Grief Disorder: A Single-centre, Single-arm, Open-label Phase I\u002FII Proof-of-concept and Feasibility Clinical Trial","Inclusion Criteria:\n\n1. Bereaved individuals \\>\u002F= 18 years of age\n2. Score \\>25 on the Inventory of Complicated Grief\n3. Must have a primary care physician\n4. Ability to understand and communicate in English\n5. Ability to provide first-person informed consent\n\nExclusion Criteria:\n\n1. Current or previously diagnosed seizure disorder\n2. Documented brain lesions\n3. Contraindications to TMS (i.e., metallic skull plates, clips, stimulators, pacemakers)\n4. Current substance abuse disorder (e.g., schizophrenia)\n5. Pregnancy or lactation, or trying to conceive\n6. Advanced, incurable illness with an expected prognosis of \\\u003C3 months - bereaved family members are known to be at elevated risk of death from medical illness, but if death is expected in the near future, it would be difficult to justify using an entire week of their limited time for an unproven therapy.",{"count":59,"type":21},15,[24],"Grief is a normal response after the death of a loved one. With time, the grief response decreases and people learn to cope with their loss. However, for some, the response becomes more intense and distressing. This is called prolonged grief disorder (PGD). People with PGD experience emotional pain and a deep longing for their loved one. PGD normally occurs \\\u003C10% of people after a loss, but it has become more common since the COVID-19 pandemic (\\~30%). If left untreated, PGD leads to poor quality of life and increased risk of death. Treatment options such as medication and therapy are available; however, they can cause negative side effects and take a long time to work. To help individuals with PGD, we need treatments that work well and quickly.\n\nRepetitive transcranial magnetic stimulation (rTMS) is a safe, non-invasive treatment that delivers magnetic pulses to brain areas responsible for mood. rTMS has been approved in Canada to treat mood disorders. There is research to show that rTMS is safe and well-tolerated, and that works well in treating Post-Traumatic Stress Disorder (PTSD), a condition with similar symptoms to PGD. To determine whether rTMS is effective for treating PGD, we first need to determine if rTMS as a treatment for PGD is safe and feasible among grieving individuals.",[63,29],"Prolonged Grief Disorder",[65,66,36,67,68,69],"Neuromodulation","Repetitive Transcranial Magnetic Stimulation","Proof-of-Concept","Feasibility","Intermittent Theta Burst Stimulation (iTBS)","2025-04-29",{"date":72,"type":42},"2025-05-01",{"date":74,"type":21},"2025-07-01",{"date":76,"type":21},"2026-04-30",{"name":78,"class":49},"Bruyère Health Research Institute."]