[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"complicated-parapneumonic-effusion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:complicated-parapneumonic-effusion":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100637813","phase-4-flush-lyse-operate-100637813",false,"NCT07592520","Flush, Lyse, Operate","Flush, Lyse, Operate: A Pilot Trial of Step-Wise Escalation for Pleural Infection: FLO Trial","FLO","Inclusion Criteria:\n\n* Age 18+\n* Complicated Parapneumonic Effusion or Empyema Requiring Thoracostomy\n* Are able to personally or have a designated medical decision maker provide consent\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Have received any intrapleural medications prior to enrolment via current chest tube\n* Have a contraindication to tPA\u002FDNase:\n\n  * Anticoagulation\n  * Active hemorrhage\n  * Allergy to tPA\u002FDNase\n  * Pregnancy\n* Are unable to personally or do not have a designated medical decision maker provide consent","ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","The goal of this observational study is to learn if saline results in improvement for patients with infection of their plerual space. The main question it aims to answer is:\n\nWhat is the time to chest tube removal? Do these patients after need to escalate to fibrinolytics? Do these patients after need to escalate to surgery?\n\nParticipants will:\n\n* Receive receive saline into their pleural space through an existing chest tube\n* If they fail to improve, which will be determined by fluid size after treatment or signs of persistent infection, they will receive fibrynolytics through an existing chest tube\n* If they fail to improve, which will be determined by fluid size after treatment or signs of persistent infection, they will be referred to surgery.",[27,28],"Complicated Parapneumonic Effusion","Empyema, Pleural","NOT_YET_RECRUITING","2026-05-11",{"date":32,"type":33},"2026-05-18","ACTUAL",{"date":35,"type":21},"2026-04",{"date":37,"type":21},"2027-04",{"name":39,"class":40},"Dartmouth-Hitchcock Medical Center","OTHER"]