[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"complications\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:complications":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,44,65,86,119,150,179,207],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100582883","chlorhexidine-gluconate-versus-saline-for-flushing-the-surgical-area-during-colorectal-cancer-surgery-100582883",false,"NCT06869096","Chlorhexidine Gluconate Versus Saline for Flushing the Surgical Area During Colorectal Cancer Surgery","A Comparative Study of Chlorhexidine Versus Saline Irrigation of the Surgical Area During Colorectal Cancer Surgery: a Multicenter, Stratified Randomized Controlled Trial.","Inclusion Criteria:\n\n1. Patients aged 18-85 years,\n2. Patients with surgically resectable colorectal tumors confirmed by CT\u002FMRI before surgery\n3. All patients had a performance status score of 0 or 1 in the Eastern Tumor Cooperative group\n4. American Society of Anesthesiology grade I-III\n\nExclusion Criteria:\n\n1. The tumor may have distant metastasis\n2. History of previous abdominal surgery\n3. The patient has a history of other malignant tumors diagnosed in the past 5 years and has received radiotherapy and chemotherapy in the past\n4. There are obvious contraindications to surgery (obvious abnormal liver and kidney function, pregnancy)\n5. Participated in other clinical trials within the past 6 months","ALL","18 Years","85 Years",{"count":20,"type":21},532,"ESTIMATED","INTERVENTIONAL",[24],"NA","The aim of this study was to compare the effectiveness of chlorhexidine versus saline in flushing the surgical area during colorectal cancer surgery. The primary outcomes included surgical site infection, postoperative complication rates, et al.",[27,28,29,30],"Colorectal Cancer","Surgical Site Infection","Chlorhexidine","Complications","RECRUITING","2026-03-29",{"date":34,"type":35},"2026-03-31","ACTUAL",{"date":37,"type":35},"2024-07-02",{"date":39,"type":21},"2026-12-31",{"name":41,"class":42},"Nanchong Central Hospital","OTHER_GOV",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":59,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":43},"100582617","efficacy-and-safety-of-colorectal-anastomotic-leak-testing-100582617","NCT06865638","Efficacy and Safety of Colorectal Anastomotic Leak Testing","A Comparative Study of Clinical Outcomes Between Leak Testing and No Leak Testing for Anastomosis in Colorectal Cancer Surgery: a Multicenter, Stratified Randomized Controlled Trial.","Inclusion Criteria:\n\n1. Patients diagnosed with colorectal cancer by pathology and scheduled for surgical treatment who meet the surgical indications.\n2. Aged between 18 and 85 years.\n3. American Society of Anesthesiologists (ASA) physical status classification is I - III.\n4. The patient or his\u002Fher legal representative can understand and sign the informed consent form and is willing to cooperate throughout the study process.\n\nExclusion Criteria:\n\n1. Patients with preoperatively diagnosed anastomotic leak or other severe abdominal infections.\n2. Patients with severe cardiovascular and cerebrovascular diseases (such as recent myocardial infarction, unstable angina pectoris, severe heart failure, acute cerebral infarction, etc.) who cannot tolerate surgery and related tests.\n3. Patients with severely impaired liver and kidney function (liver function Child - Pugh classification C or above, creatinine clearance rate \\\u003C 30 ml\u002Fmin).\n4. Patients with coagulation disorders (such as platelet count \\\u003C 50×10⁹\u002FL, international normalized ratio (INR) \\> 1.5, etc.) that cannot be corrected or are receiving anticoagulant therapy that cannot be adjusted.\n5. Patients with a history of abdominal radiotherapy or multiple abdominal surgeries and severe abdominal adhesions that may affect the operation and detection procedures.\n6. Patients with other malignant tumors who are receiving active anti-tumor treatment such as radiotherapy and chemotherapy.\n7. Patients with mental illness or cognitive impairment who cannot cooperate with the study process and follow-up.",{"count":52,"type":21},264,[24],"To evaluate the effectiveness of the gastroscopy, air, and methylene blue (GAM) leak testing in reducing the incidence of postoperative anastomotic complications, especially anastomotic leakage, in patients with colorectal cancer. The primary outcomes included is the incidence of anastomotic complications (mainly anastomotic leak) within 30 days after surgery",[27,56,57,30,58],"Leakage Testing","Colorectal Surgery","Anastomotic Leakage",{"date":34,"type":35},{"date":61,"type":35},"2024-12-22",{"date":63,"type":21},"2029-04-01",{"name":41,"class":42},{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":72,"targetDuration":4,"studyType":22,"phases":74,"briefSummary":75,"conditions":76,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":43},"100608994","pre-emptive-endoscopic-vacuum-therapy-reduces-the-incidence-of-anastomotic-leakage-after-colorectal-cancer-surgery-100608994","NCT07208786","Pre-emptive Endoscopic Vacuum Therapy Reduces the Incidence of Anastomotic Leakage After Colorectal Cancer Surgery","Randomized Clinical Trial on Pre-emptive Endoscopic Vacuum Therapy Versus Conventional Management for the Prevention of Anastomotic Leakage After Colorectal Cancer Surgery","Inclusion Criteria:\n\n1. Pathologically diagnosed with colorectal cancer, planned for radical surgery (right hemicolectomy, left hemicolectomy, or anterior resection of the rectum, etc.).\n2. Age 18-85 years, American Society of Anesthesiologists (ASA) classification I-III.\n3. Anastomosis to be performed in a single stage (meeting anastomotic criteria).\n4. Patient or legal guardian is able to understand and sign the informed consent form and comply with follow-up.\n\nExclusion Criteria:\n\n1. Preexisting anastomotic leakage or severe intra-abdominal infection before surgery.\n2. Complicated by severe cardiovascular or cerebrovascular diseases (e.g., acute myocardial infarction, acute phase of cerebral infarction).\n3. Severe liver or kidney dysfunction (liver function Child-Pugh class C, creatinine clearance \\\u003C30 ml\u002Fmin).\n4. Coagulation disorders (platelets \\\u003C50×10⁹\u002FL, INR \\>1.5) or receiving anticoagulant therapy that cannot be adjusted.\n5. History of abdominal radiotherapy or multiple abdominal surgeries leading to severe intra-abdominal adhesions.\n6. Complicated by other malignant tumors and currently undergoing radiotherapy or chemotherapy.\n7. Psychiatric illness or cognitive impairment preventing compliance with the study.",{"count":73,"type":21},110,[24],"Evaluate the safety and efficacy of postoperative Pre-emptive EVT (PEVT) in reducing the incidence of anastomotic leaks within 30 days after surgery in patients with colorectal cancer. Compare the differences between the PEVT group and the control group in terms of operation time, length of hospital stay, and total medical costs. Analyze the incidence of other postoperative complications in the two groups, such as wound infection, abdominal abscess, and intestinal obstruction. Assess the impact of PEVT on postoperative recovery indicators, including time to first flatus, time to first defecation, and time to ambulation. Observe the occurrence of PEVT-related adverse events, such as device displacement, bleeding, and infection.",[27,57,30,58,77],"Endoscopic Vacuum Therapy","2026-03-28",{"date":80,"type":35},"2026-04-02",{"date":82,"type":35},"2025-09-22",{"date":84,"type":21},"2026-12-30",{"name":41,"class":42},{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":94,"targetDuration":96,"studyType":97,"phases":4,"briefSummary":98,"conditions":99,"keywords":103,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":43},"100625464","perioperative-outcomes-after-neoadjuvant-therapy-in-colorectal-cancer-100625464","NCT07422974","Perioperative Outcomes After Neoadjuvant Therapy in Colorectal Cancer","The Impact of Neoadjuvant Therapy on Perioperative Complications and Treatment Outcomes in Patients Undergoing Colorectal Cancer Resection","Neocolon","Inclusion Criteria:\n\n* Adults aged ≥18 years with histologically confirmed colorectal cancer\n* Planned surgical treatment for colorectal cancer (either laparoscopic LPSC or open laparotomy)\n* Ability to understand the study protocol and provide written informed consent.\n* Both sexes\n* ASA classification II or III\n* Patients who received neoadjuvant therapy is investigational group and patients who did not receive neoadjuvant therapy is control group\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Patients who are not conscious, not oriented, or unable to provide informed consent\n* Patients unable to understand the study protocol\n* Emergency surgical cases\n* Patients on chronic corticosteroid therapy",{"count":95,"type":21},68,"2 Months","OBSERVATIONAL","This prospective study investigates the effects of neoadjuvant therapy on endothelial function, microvascular tissue density, and tissue fibrosis in patients with colorectal cancer and their association with perioperative complications. The primary objective is to assess differences in microvascular tissue density between patients who received neoadjuvant therapy and those who did not, biomarkers, and demographic factors between patients who received neoadjuvant therapy and those who underwent surgery as initial treatment, and to compare clinical outcomes. The study will include 34 patients treated with neoadjuvant therapy and 34 patients for whom surgery is the first-line treatment. Patients will be followed until discharge from the hospital, and complications after discharge will be monitored through medical records one month after surgery.",[100,30,101,102],"Colorectal Carcinoma (CRC)","Neoadjuvant Therapy","Endothelial Dysfunction",[104,101,105,106,107,108],"Colorectal Carcinoma","Microvascular Density","Treatment Outcome","Wound Healing","Critical care","2026-02-13",{"date":111,"type":35},"2026-02-20",{"date":113,"type":35},"2026-01-09",{"date":115,"type":21},"2027-05-01",{"name":117,"class":118},"Osijek University Hospital","OTHER",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":126,"enrollmentInfo":127,"targetDuration":4,"studyType":22,"phases":129,"briefSummary":131,"conditions":132,"keywords":135,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":149},"100595193","phase-3-feasibility-of-enhanced-recovery-after-surgery-without-prophylactic-abdominal-drainage-tubes-after-laparoscopic-distal-gastrectomy-for-gastric-cancer-100595193","NCT07029269","Feasibility of Enhanced Recovery After Surgery Without Prophylactic Abdominal Drainage Tubes After Laparoscopic Distal Gastrectomy For Gastric Cancer","Feasibility of Enhanced Recovery After Surgery Without Prophylactic Abdominal Drainage Tubes After Laparoscopic Distal Gastrectomy For Gastric Cancer: A Prospective, Multicenter, Non-inferiority, Randomized, Open-label, Controlled Trial","Inclusion Criteria:\n\n1. Patients' age from 18 to 80 years old;\n2. Histopathologically confirmed gastric adenocarcinoma;\n3. Clinical tumor stage of cT1-4N0-3M0;\n4. Laparoscopic distal gastrectomy approach;\n5. ECOG score of 0-1;\n6. Written informed consent\n\nExclusion Criteria:\n\n1. Patients with severe concurrent illness or comorbid diseases;\n2. Patients with severe pyloric obstruction, recurrent or remnant gastric cancer; 3. Patients with perforation, or undergoing emergency surgery;\n\n4\\. Patients with a history of radiotherapy; 5. Patients undergoing complex abdominal surgeries other than laparoscopic cholecystectomy or appendectomy; 6. Patients with peritoneal, hepatic or ovarian metastasis, or simultaneous tumors in other parts of the body preoperatively and intraoperatively; 7. Patients with diabetes and poor recent glycemic control; 8. Patients with autoimmune diseases who have received corticosteroid treatment; 9. Patients with a BMI ≥30 kg\u002Fm2 or \\\u003C18 kg\u002Fm2; 10. Patients with gastrointestinal hemorrhage and hemoglobin levels below 90 g\u002FL; 11. Patients with hypoproteinemia and albumin levels below 30 g\u002FL; 12. Patients with portal hypertension; 13. Patients with severe edema or dense fibrosis intraoperatively after neoadjuvant therapy; 14. Patients with intraoperative findings of duodenal invasion; 15. Patients with combined organ resection; 16. Reconstruction different from BillrothⅡand Braun anastomosis; 17. Patients with preoperative pathological examination inconsistent with postoperative result; 18. Declined to participate; 19. Patients with poor compliance and withdrew from the study halfway","80 Years",{"count":128,"type":21},454,[130],"PHASE3","This study aims to compare the effects of using prophylactic abdominal drainage tubes during Enhanced Recovery After Surgery (ERAS) in patients undergoing Laparoscopic Distal Gastrectomy (LDG) for gastric cancer through a multicenter non-inferiority randomized trial. The study is divided into two groups: 1. ERAS-tubeless group: The ERAS protocol without nasogastric decompression, nasojejunal feeding or prophylactic abdominal drainage tubes. 2. ERAS-tube group: the ERAS protocol with prophylactic abdominal drainage tubes, along with no nasogastric decompression or nasojejunal feeding tubes. Patients will be randomly assigned to the two groups in a 1:1 ratio, with the primary analysis based on the modified intention-to-treat population (mITT) and secondary analysis on the per-protocol (PP) population. Perioperative management will adhere to ERAS guidelines, and postoperative quality of life will be assessed using the EORTC QLQ-C30 questionnaire and QoR-15 scores. Preliminary training on the standard ERAS protocol is administered to all members in the team before the initiation of the study, ensuring in-group members to fully master the requirements and other related contents in the study. Data collectors, analysts, and outcome evaluators will remain blinded to group allocation. The findings of this study are expected to provide high-quality evidence on the feasibility of omitting prophylactic abdominal drainage in the context of ERAS, thereby contributing to the optimization of postoperative management strategies for gastric cancer surgery.",[133,134,30],"Gastric Adenocarcinoma","Laparoscopic Gastrectomy",[136,137,138,139],"Enhanced Recovery After Surgery","tubeless","gastric adenocarcinoma","laparoscopic distal gastrectomy","2025-12-16",{"date":142,"type":35},"2025-12-17",{"date":144,"type":35},"2025-06-16",{"date":146,"type":21},"2028-09-10",{"name":148,"class":118},"Zuoyi Jiao",6,{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":154,"acronym":4,"eligibilityCriteria":155,"healthyVolunteers":11,"sex":16,"minAge":156,"maxAge":4,"enrollmentInfo":157,"targetDuration":4,"studyType":97,"phases":4,"briefSummary":159,"conditions":160,"keywords":164,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":43},"100584998","urinary-infection-and-colonization-in-bone-procedures-100584998","NCT06896643","Urinary Infection and Colonization in Bone Procedures","Inclusion Criteria:\n\n* Age over 65 years, including\n* Elective or acute trauma\u002Forthopedic bone surgery\n* Urine examination as part of pre-anesthetic examination, urine + sediment, in case of suspicion - bacteriological examination\n* Signed informed consent for research as part of pre-anesthetic examination (I or II), respecting informed consent as an expression of the patient's \"free will\"\n\nExclusion Criteria:\n\n* Negative finding in urine: chemical examination + sediment preoperatively\n* Respondent under the influence of premedication, alcohol, or drugs\n* Sensory impairment (blindness)\n* Delirious preoperative state\n* Severe mental disorder\n* Sopor\n* coma\n* Septic state\n* Acute respiratory failure\n* Disagreement with participation in the study","65 Years",{"count":158,"type":21},80,"For seniors aged 65 and over (inclusive) undergoing surgical procedures (bone surgery, traumatology, orthopedics) in an acute or elective setting, the relationship between preoperative urinary tract infection\u002Fcolonization (within 30 days before the procedure) and the occurrence of predefined postoperative complications (monitoring during the patients' hospitalization) will be observed",[161,30,162,163],"Urinary Tract Infection","Urinary Tract Infection (Diagnosis)","Frailty",[165,166,167,168,169],"urinary","tract","infection","colonization","postoperative complications","2025-07-06",{"date":172,"type":35},"2025-07-08",{"date":174,"type":35},"2025-06-01",{"date":176,"type":21},"2026-06-01",{"name":178,"class":118},"Tomas Bata Hospital, Czech Republic",{"id":180,"slug":181,"hasResults":11,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":156,"enrollmentInfo":186,"targetDuration":4,"studyType":22,"phases":188,"briefSummary":189,"conditions":190,"keywords":192,"overallStatus":197,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":4},"100568021","the-effect-of-catheter-protector-on-catheter-dwell-time-and-complications-100568021","NCT06675786","The Effect of Catheter Protector on Catheter Dwell Time and Complications","The Effect of Catheter Protector on Catheter Dwell Time and Complications in Patients with Peripheral Venous Catheter in the Oncology Clinic","Inclusion Criteria:\n\n* Inclusion Criteria\n* Hospitalized in the oncology clinic\n* The one with the PVK attached,\n* Volunteered to participate in the research,\n* Treated in the same clinic during the study period,\n* No verbal, perceptual and visual communication problems,\n* 22-24 G (Blue) size catheter used,\n* Between the ages of 18 and 65,\n* Literate,\n* Patients without scar tissue, infection, hematoma, edema at the sites to be used for PVK placement were included in the study.\n\nExclusion Criteria:\n\n* \\- With a clotting disorder,\n* Patients with problems with skin integrity or limb movement such as scar tissue, infection, hematoma, edema at the PVK site,\n* Blood or blood products given through a catheter,\n* Patients who wanted to leave, were referred to a different clinic or discharged during the study were excluded from the study.",{"count":187,"type":21},70,[24],"Objective: This study aimed to determine the effect of applying the IV House Ultradressing catheter protector on the frequency of peripheral venous catheter (PVC) replacements and complications in patients with peripheral venous catheterization in an oncology clinic.\n\nMaterials and Methods: The research was planned as a randomized controlled experimental study. The population of the study consisted of patients hospitalized in the oncology clinic. The sample of the study was calculated based on the data from the study by Büyükyılmaz et al. (2019), which found a significant difference in the average duration of catheter-related phlebitis in the intervention group (2.10 ± 1.55 days) compared to the control group (1.27 ± 0.45 days), with an effect size of d=0.72. As a result of the sample size calculation, 32 patients were predicted for each group. Considering that 10% of patients might drop out during the study, a total of 70 patients, with 35 in each group, were decided to be included. After the catheter is inserted, patients in the intervention group will have their catheter area protected with IV House Ultradressing, while no protective measures will be applied to the control group. Both groups will be evaluated in terms of catheter duration and PVC complications. It is planned to use t-tests and chi-square tests for data analysis.",[191,30],"Peripheral Catheterization",[193,194,195,196],"Peripheral Venous Catheterization","IV House","Complication","Phlebitis","NOT_YET_RECRUITING","2024-11-04",{"date":200,"type":35},"2024-11-05",{"date":202,"type":21},"2024-11-01",{"date":204,"type":21},"2025-05-30",{"name":206,"class":118},"Karamanoğlu Mehmetbey University",{"id":208,"slug":209,"hasResults":11,"nctId":210,"briefTitle":211,"officialTitle":211,"acronym":4,"eligibilityCriteria":212,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":213,"targetDuration":4,"studyType":97,"phases":4,"briefSummary":215,"conditions":216,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":223,"lastUpdatePostDateStruct":224,"startDateStruct":226,"completionDateStruct":228,"leadSponsor":230,"locationsCount":43},"100400137","carbon-monoxide-intoxication-in-korea-prospective-cohort-care-co-cohort-100400137","NCT04490317","CARbon monoxidE intoxiCatiOn in Korea: Prospective Cohort (CARE CO Cohort)","Inclusion Criteria:\n\n* Acute CO poisoning\n\nExclusion Criteria:\n\n* Declined to enrollment in the study",{"count":214,"type":21},1500,"This prospective cohort study enrolls subjects who experience carbon monoxide (CO) poisoning. The purpose of the study is to evaluate therapeutic effects of various treatments and short and long-term outcomes in CO poisoned patients. In addition, complications of brain and heart susceptible to CO are investigated through various ways and the association between complications and the patient's prognosis is also investigated. All subjects will be regularly monitored by physicians participating in this study.",[217,218,219,220,221,222,30],"Carbon Monoxide Poisoning","Myocardial Injury","Neurologic Deficits","Image, Body","Therapy","Prognostic Factors","2024-07-22",{"date":225,"type":35},"2024-07-23",{"date":227,"type":35},"2020-07-29",{"date":229,"type":21},"2035-12",{"name":231,"class":118},"Wonju Severance Christian Hospital"]