[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"concussion-diagnosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:concussion-diagnosis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,48,83,105,137],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100644586","phase-2-bcaas-in-concussion-30-100644586",false,"NCT07670195","BCAAs in Concussion 3.0","HIT HEADS 3.0: Head Injury Treatment: A Randomized, Placebo-controlled, Double-blinded, Therapeutic Clinical Trial of Branched Chain Amino Acids (BCAAs) in the Treatment of Concussion","Inclusion Criteria:\n\n1. Males and females,11 - 23 years of age.\n2. Weigh at least 40kg.\n3. Meeting concussion criteria for the American Congress of Rehabilitative Medicine.\n\n   a. One or more clinical signs or two or more acute symptoms with at least one VVE abnormality.\n4. Present within 4 days of injury.\n5. Post-menarchal females must have a negative urine pregnancy test.\n6. Informed consent by the participant, or for participants \\\u003C18 years old both informed consent by a parent\u002Fguardian and child assent.\n\nExclusion Criteria:\n\n1. Evidence of moderate or severe TBI, including GCS \\\u003C13, TBI requiring hospital admission, or TBI requiring neurosurgical intervention.\n2. Prior concussion or TBI within 90 days.\n3. Known history of maple syrup urine disease or known family history of maple syrup urine disease.\n4. Any investigational drug use within 30 days prior to enrollment.\n5. Participants who are pregnant, planning on becoming pregnant during the study duration, or breastfeeding.\n6. Non-English speaking participants or parent\u002Fguardian.",true,"ALL","11 Years","23 Years",{"count":21,"type":22},150,"ESTIMATED","INTERVENTIONAL",[25],"PHASE2","This study is a randomized, placebo-controlled, double-blinded, therapeutic exploratory clinical trial of branched chain amino acids (BCAAs) in the treatment of concussion. The aim of the study is to determine whether administration of high-dose BCAAs compared to placebo promotes concussion recovery.",[28,29,30,31],"Concussion (Diagnosis)","MTBI - Mild Traumatic Brain Injury","Concussion, Brain","Concussion",[31,33,34,35],"mTBI","BCAAs","Branched Chain Amino Acids","NOT_YET_RECRUITING","2026-06-19",{"date":39,"type":40},"2026-06-26","ACTUAL",{"date":42,"type":22},"2026-07",{"date":44,"type":22},"2027-12",{"name":46,"class":47},"Akiva Cohen","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":62,"conditions":63,"keywords":68,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100599263","multidimensional-sleep-health-intervention-to-optimize-concussion-recovery-100599263","NCT07082218","Multidimensional Sleep Health Intervention to Optimize Concussion Recovery","Multidimensional Sleep Health Intervention to Optimize Concussion Recovery: A Randomized Clinical Trial","SCORE","Inclusion Criteria:\n\n* Participants will be symptomatic at the time of enrollment (Post-Concussion Symptom Inventory \\[PCSI\\] score ≥9)\n* Diagnosed with a concussion by a healthcare provider using the American Congress of Rehabilitation Medicine diagnostic criteria\n* 10-19 years of age (aligned with World Health Organization definition of 'adolescent')\n\nExclusion Criteria:\n\n* History of treatment for pre-concussion sleep-related disorders","10 Years","19 Years",{"count":59,"type":22},54,[61],"NA","Following adolescent concussion, poor sleep health is common and relates to the development of persisting post-concussion symptoms, and uninjured adolescents (independent of concussion) also commonly experience sleep insufficiency. Given the sparse guidance that exists for clinicians to provide evidence-based sleep health recommendations for adolescents with a concussion, the primary objectives of this prospective randomized clinical trial of adolescents with a recent concussion are to discover if a multidimensional and prescriptive sleep health intervention leads to: 1) faster symptom resolution time, better sleep quality, or longer sleep duration; and 2) improved sleep habits, mental health, or academic engagement, relative to standard-of-care post-concussion sleep health guidance. Findings from this research will provide the basis for more precise sleep health recommendations for adolescents who experience a concussion.",[28,64,65,66,67],"Concussion, Mild Traumatic Brain Injury","Treatment","Sleep Health","Depression, Anxiety",[69,70,71],"intervention","mild traumatic brain injury","sleep quality","RECRUITING","2026-06-17",{"date":75,"type":40},"2026-06-18",{"date":77,"type":40},"2025-09-10",{"date":79,"type":22},"2027-06-15",{"name":81,"class":47},"University of Colorado, Denver",1,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":93,"briefSummary":94,"conditions":95,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":82},"100642880","nature-as-medicine-for-the-healing-brain-utilization-of-a-nature-based-exposure-intervention-for-decreasing-concussion-recovery-timeline-and-symptom-load-100642880","NCT07642739","Nature as Medicine for the Healing Brain: Utilization of a Nature-based Exposure Intervention for Decreasing Concussion Recovery Timeline and Symptom Load","Inclusion Criteria:\n\n1. Require that any participant is 14-35 years old\n2. Required that any participant under 18 years old can be accompanied by a parent or legal guardian for the duration of the study\n3. Required that participants be English speakers\n4. Required that persons be able to provide consent for themselves\n5. Required that the participant must have suffered a clinically diagnoses concussion 5 days or less prior to the first study visit\n6. Concussion must have been diagnosed by a licensed clinical medicine professional.\n7. No additional professional treatment modalities outside of normal clinical concussion recovery recommendations may have been received prior to study participation. These include participation in a separate concussion rehabilitation study, cognitive behavioral therapies, vestibule-ocular therapies (balance), in-patient physical therapy, consumption of stimulant medication, and chiropractic manipulation.\n8. Injury must have been diagnosed as a concussion or mild-traumatic brain injury. Participant must not have been diagnosed with of severe traumatic brain injury, hematoma, fractured skull or facial bones, or comatose.\n\nExclusion Criteria:\n\n1. Exclude persons under 14 years old or over 35 years old\n2. Exclude persons taking anti-inflammatory drugs (both prescription and OTC), or those who will have taken them within 24 hours prior to Visit 1\n3. Exclude smokers and former smokers, as defined by CDC. (Anyone who smokes daily or who has smoked at least 100 cigarettes in their lifetime)\n4. Those with presence of an active infection (including a dental infection)\n5. Exclude persons who have migraines\n6. Exclude persons taking mood stabilizer medications\n7. Exclude persons who have consumed alcohol within 48 hours prior to study participation, participants will be asked this by one of the study members through the exclusion criteria screening form when they first contact the study\n8. Exclude persons who are pregnant.","14 Years","35 Years",{"count":92,"type":22},24,[61],"The overall goal of this research is to provide pilot data that informs and drives a larger scale research project, incorporating multiple contemporary measurement modalities, to understand the utility and pathological mechanisms by which exposure to nature-based settings may aid in recovery time and symptom relief of individuals suffering from concussion, and decrease their risk of developing Persistent Post-Concussion Syndrome (PPCS).\n\nWe hypothesize that successful adherence to a nature-based exposure therapy intervention program will decrease recovery time and severity of symptom trajectory of concussion, as measured through multimodal assessments of brain structural and functional integrity.",[28],"2026-06-09",{"date":98,"type":40},"2026-06-11",{"date":100,"type":22},"2026-07-01",{"date":102,"type":22},"2027-08-01",{"name":104,"class":47},"Penn State University",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":112,"minAge":113,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":23,"phases":117,"briefSummary":118,"conditions":119,"keywords":122,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":82},"100616309","female-concussion-head-cooling-100616309","NCT07303933","Female Concussion Head Cooling","The Association Between Head Cooling and Cognition, Neuroinflammatory Cytokines, Menstrual Cycle, Sleep Patterns, Mental Health and Concussions","Inclusion Criteria:\n\n1. Require that any participant is 18-27 years old\n2. Require that participants be English speakers\n3. Require that participants are females\n4. Require that persons be able to provide consent for themselves\n\nExclusion Criteria:\n\n1. Exclude persons under 18 years old or over 27 years old\n2. Exclude persons taking anti-inflammatory drugs (both prescription and OTC), or those who will have taken them within 24 hours prior to Visit 1\n3. Exclude smokers and former smokers, as defined by CDC. (Anyone who smokes daily or who has smoked at least 100 cigarettes in their lifetime)\n4. Those with scalp infections, sun burns, skin cancers, and\u002For prior surgical scars should not participate\n5. Those with presence of an active infection (including a dental infection)\n6. Exclude persons who have migraines\n7. Exclude persons taking mood stabilizer medications\n8. Exclude persons who have consumed alcohol within 48 hours prior to study participation.\n9. Exclude persons who are males","FEMALE","18 Years","27 Years",{"count":116,"type":22},32,[61],"This research is being done to examine the benefits of a 28 day head cooling intervention on cognition, inflammation of the brain, sleep quality, menstrual symptom interaction, and mood in acutely concussed females. Brain cooling has been shown to cause temporary symptom relief after traumatic brain injury, but its implications for decreasing timeline of full concussion recovery, particularly in females during periods of confounding neuropsychological menstrual symptoms, remains unexplored.",[28,120,121],"Concussion Post Syndrome","Concussion, Mild",[123,31,124,125,126,127,128],"Brain cooling","Neuroinflammation","Mental Health","Cognition","Menstrual cycle","Female","2025-12-23",{"date":131,"type":40},"2025-12-26",{"date":133,"type":22},"2026-01-15",{"date":135,"type":22},"2027-01-01",{"name":104,"class":47},{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":16,"sex":17,"minAge":113,"maxAge":144,"enrollmentInfo":145,"targetDuration":4,"studyType":23,"phases":147,"briefSummary":148,"conditions":149,"keywords":153,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":164},"100584721","dizziness-due-to-visual-stimuli-in-patients-with-concussion-and-other-causes-of-dizziness-examination-of-balance-behaviour-100584721","NCT06893029","Dizziness Due to Visual Stimuli in Patients With Concussion and Other Causes of Dizziness: Examination of Balance Behaviour","Visually Induced Dizziness in Concussed and Non-Concussed Dizzy Patients: Identifying the Pathophysiology of Postural Control Upon Optokinetic Stimuli","Inclusion Criteria:\n\n* Age between 18 and 60 years\n* Binocular vision\n* Recent concussion\u002FmTBI within 4 weeks to 18 months post-injury for concussed patients\n* Diagnosis related to dizziness or VID within 4 weeks to 18 months for non-concussed dizzy patients (including vestibular migraine)\n* Signed ICF for included participants or signed general consent for retrospectively included patients if an ICF cannot be obtained.\n\nExclusion Criteria:\n\n* BMI greater than 30\n* Acute vestibular syndrome lasting at least 24 hours\n* Severe non-correctable visual impairment\n* Balance issues not dizziness-related, including:\n\n  1. Neurological conditions (e.g., migraine)\n  2. Orthopaedic conditions (e.g., lower extremity injury)\n  3. Infectious diseases\n  4. Other medical contexts\n* Dizziness attributed to prescribed drugs, substance abuse, or mental disorders\n* Cognitive impairments compromising task comprehension\n* Preceding history of traumatic brain injury in the last 12 months\n* History of severe traumatic brain injury with persisting impairments\n* Other potentially confounding problems (e.g., psychiatric disease)\n* Frequent episodes of rotatory vertigo","60 Years",{"count":146,"type":22},240,[61],"This research project aims to measure how balance is affected by special visual stimulation. Dizziness caused by complex moving visual patterns, known as optokinetic stimulation, is usually called visually induced dizziness (VID).\n\nThe study includes patients with persistent symptoms after a concussion and those with non-traumatic dizziness. Healthy participants serve as a control group for the comparison of balance and symptom responses.\n\nThe optokinetic stimulation is done using either a physical rotating disk or a virtual reality (VR) headset. The visual effects are created by bright moving dots. During the stimulation, these patterns move in a specific manner and directions while the subject's balance is recorded. Symptoms such as dizziness, headache, and nausea are also documented.\n\nThe goal of this project is to improve objective diagnosis of VID. By comparing patients and healthy subjects, the study aim to assess the severity of the disorder. It is also assumed that using different visual stimuli during the balance assessment will offer more sensitive and accurate results.\n\nIn the long term, this innovative assessment method shall support clinicians to establish the diagnosis of VID, and improve the treatment and management of patients with VID.",[150,28,151,152],"Dizziness","Traumatic Brain Injury","Balance Assessment",[154],"Visually induced dizziness","2025-09-15",{"date":157,"type":40},"2025-09-19",{"date":159,"type":40},"2025-05-14",{"date":161,"type":22},"2027-10-31",{"name":163,"class":47},"Dominik Straumann",2]