[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"concussion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:concussion":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,50,82,112,137,183],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100054323","rehabilitation-education-and-self-management-for-adolescents-after-mild-traumatic-brain-injury-100054323",false,"NCT07698015","Rehabilitation, Education, and SElf-management for Adolescents After Mild Traumatic Brain Injury","A Decentralized, Investigator Blinded, Randomized, Parallel-group Study to Determine the Feasibility of an 8-week Smart-phone App Delivered Mindfulness- Based Intervention Versus a Health Education Program for Adolescents With Persisting Symptoms After Concussion\u002FmTBI","RESET","Inclusion Criteria:\n\n1. Age 12-18\n2. Structured interview confirming a concussion\u002FmTBI or suspected concussion\u002FmTBI diagnosis according to the American Congress of Rehabilitation Medicine definition\n3. Concussion\u002FmTBI occurred 1-12 months prior to randomization\n4. Persisting symptoms after concussion as demonstrated by a score \\>75th percentile on the Health and Behaviour Inventory compared to orthopedic injury normative group\n5. English proficiency\n\nExclusion Criteria:\n\n1. Parent- or self-reported psychiatric hospitalization in past year or prior diagnosis of a psychiatric disorders or psychiatric symptoms that may be contraindicated for mindfulness-based interventions (e.g., psychosis)\n2. Participation in a clinical trial using the Dawn intervention app in acute concussion (e.g., \\\u003C2 weeks post-injury).","ALL","12 Years","18 Years",{"count":21,"type":22},72,"ESTIMATED","INTERVENTIONAL",[25],"NA","Concussion or mild traumatic brain injury (mTBI) is a major public health concern. Most adolescents will recover from mTBI without complication; however, a sizeable minority experience symptoms that last more than one most post-injury (i.e., persisting symptoms after concussion). Few evidence-based treatments exist for adolescents with persisting symptoms after concussion. Mindfulness-based interventions (MBIs) are effective for treating a wide range of mental and physical health conditions that overlap with post-concussion symptoms. Participants will participate in an 8-week smartphone app-based MBI or a health education program as a control. The study will determine the practicality of doing a larger study to evaluate the effectiveness of the MBI by assessing participants' level of interest, view of intervention helpfulness, and their completion of all the components of the study.",[28,29,30],"Brain Concussion","Mild Traumatic Brain Injury","Concussion",[32,33,34,35,36],"concussion","mild traumatic brain injury","mindfulness-based intervention","digital health","persisting symptoms after concussion","NOT_YET_RECRUITING","2026-07-06",{"date":40,"type":41},"2026-07-13","ACTUAL",{"date":43,"type":22},"2026-09-01",{"date":45,"type":22},"2028-05-31",{"name":47,"class":48},"Molly Cairncross","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":17,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":62,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":4},"100644586","phase-2-bcaas-in-concussion-30-100644586","NCT07670195","BCAAs in Concussion 3.0","HIT HEADS 3.0: Head Injury Treatment: A Randomized, Placebo-controlled, Double-blinded, Therapeutic Clinical Trial of Branched Chain Amino Acids (BCAAs) in the Treatment of Concussion","Inclusion Criteria:\n\n1. Males and females,11 - 23 years of age.\n2. Weigh at least 40kg.\n3. Meeting concussion criteria for the American Congress of Rehabilitative Medicine.\n\n   a. One or more clinical signs or two or more acute symptoms with at least one VVE abnormality.\n4. Present within 4 days of injury.\n5. Post-menarchal females must have a negative urine pregnancy test.\n6. Informed consent by the participant, or for participants \\\u003C18 years old both informed consent by a parent\u002Fguardian and child assent.\n\nExclusion Criteria:\n\n1. Evidence of moderate or severe TBI, including GCS \\\u003C13, TBI requiring hospital admission, or TBI requiring neurosurgical intervention.\n2. Prior concussion or TBI within 90 days.\n3. Known history of maple syrup urine disease or known family history of maple syrup urine disease.\n4. Any investigational drug use within 30 days prior to enrollment.\n5. Participants who are pregnant, planning on becoming pregnant during the study duration, or breastfeeding.\n6. Non-English speaking participants or parent\u002Fguardian.",true,"11 Years","23 Years",{"count":61,"type":22},150,[63],"PHASE2","This study is a randomized, placebo-controlled, double-blinded, therapeutic exploratory clinical trial of branched chain amino acids (BCAAs) in the treatment of concussion. The aim of the study is to determine whether administration of high-dose BCAAs compared to placebo promotes concussion recovery.",[66,67,68,30],"Concussion (Diagnosis)","MTBI - Mild Traumatic Brain Injury","Concussion, Brain",[30,70,71,72],"mTBI","BCAAs","Branched Chain Amino Acids","2026-06-19",{"date":75,"type":41},"2026-06-26",{"date":77,"type":22},"2026-07",{"date":79,"type":22},"2027-12",{"name":81,"class":48},"Akiva Cohen",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":93,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":111},"100472060","rtms-for-military-tbi-related-depression-100472060","NCT05426967","rTMS for Military TBI-related Depression","ADEPT: Adaptive Trial for the Treatment of Depressive Symptoms Associated With Concussion Using Repetitive Transcranial Magnetic Stimulation Protocols","ADEPT","Inclusion Criteria:\n\n* Age 18-55 at the time of consent. Older individuals will not be enrolled in this initial trial for reasons of safety and expected reduced efficacy.\n* Current or former US military service member eligible for care at a Military Treatment Facility (MTF) or Veterans Administration Medical Center (VAMC.)\n* Able to provide written, informed consent in English .\n* Self-reported or medically diagnosed history of concussion (synonymous with \"mild TBI.\") \\>6 months, but \\\u003C26 years prior to consent, defined based on the DoD\u002FVA definition:\n\n  1. Positive Loss of Consciousness of \\\u003C30 minutes as confirmed by the TBI Screener and\u002For medical records and\u002For;\n  2. Positive Alteration of Consciousness of \\\u003C24 hours as confirmed by the TBI Screener and\u002For medical records and\u002For;\n  3. Positive Post-traumatic Amnesia of 0 to 1 day as confirmed by the TBI Screener and\u002For medical records.\n\n     * Note: Neuroimaging data or documentation from medical records is not required.\n* Baseline MADRS \\>13 at the time of screening indicating at least mild-moderate depressive symptoms.\n* Maintained a steady psychotropic medication regimen for six weeks and a steady behavioral therapy regimen for twelve weeks prior to enrollment in the study.\n* Female participants with child-bearing potential must agree to use an effective method of birth control during the course of the study.\n* Under the care of a primary care and\u002For behavioral health provider.\n\nExclusion Criteria:\n\n* Elevated risk of seizures at the time of rTMS including any of the following:\n\n  1. History of unprovoked seizures.\n  2. History of seizure within 24 hours of sustaining a concussion(s) or other head injury regardless of whether it was determined to have been related to concussion.\n  3. Family history of two or more unprovoked seizures in a first degree relative (parent, sibling, or child).\n  4. History of Moderate, Severe, or Penetrating TBI based on TBI Screener and\u002For medical records.\n  5. Intracranial lesion (such as intracranial tumor or intraparenchymal hemorrhage) that, in the opinion of the investigators, would increase seizure risk.\n  6. Currently taking medication or other substances (such as tricyclic antidepressants or neuroleptics) that, in the opinion of the investigator, lowers the seizure threshold.\n* Contraindications to awake 3T MRI without contrast at the time of the Baseline MRI according to site radiology department criteria.\n* Severe claustrophobia interfering with medication\u002Fsedation-free 3T closed-bore MRI.\n* Intracranial lesion that would produce an artifact that would compromise the integrity of rsfMRI data.\n* History of severe or recent uncontrolled heart disease.\n* Presence of a cardiac pacemaker or intracardiac lines.\n* Any implant, prosthesis or other permanent alteration of the body (such as implanted neurostimulators and medication pumps) that, in the opinion of the investigator, would be unsafe with MRI or TMS or that would produce an artifact that would compromise the integrity of data.\n* Presence of rapidly progressive illnesses such as late-stage cancer, neurodegenerative conditions, major organ failure, etc.\n* History of Bipolar Disorder or Schizophrenia Spectrum Disorders.\n* Current evidence of substance-induced mood disorder, active psychosis, or depression secondary to general medical illness other than TBI.\n* Severe or uncontrolled substance use.\n* Concomitant or lifetime history of receiving open-label TMS, due to issues preserving blinding.\n* Concomitant or recent history (within 12 weeks prior to enrollment) of receiving other neurostimulatory treatment, including but not limited to transcranial direct current (tDCS), transcranial alternating current (tACS), alpha stim, or electroconvulsive therapy.\n* Suicide attempt within six months prior to enrollment.\n* Right upper extremity amputation or other condition precluding left motor threshold calibration.\n* Unable to complete timeline of study (e.g., planned hospitalization partway through the study period.)\n* Prisoner, or other legally restricted freedom of movement and participation.\n* Any other considerations that, in the opinion of the investigators, may adversely affect participant safety, participation, or the scientific validity of the data being collected (e.g., erratic or unreliable responses, inconsistent communication, inability to remain on a steady neurotropic medication and\u002For behavioral therapy regimen over the course of the Randomization phase of the study.)","55 Years",{"count":92,"type":22},198,[25],"The purpose of this study is to investigate the efficacy, safety, and tolerability of two dorsolateral prefrontal cortex (DLPFC) repetitive transcranial magnetic stimulation (rTMS) protocols to alleviate symptoms of depression in United States (U.S.) military service members and veterans with a history of concussion\u002Fmild traumatic brain injury (TBI).",[96,29,30],"Depressive Symptoms",[98,96,30,99,100],"Transcranial Magnetic Stimulation (TMS)","Mild Traumatic Brain Injury (TBI)","Functional Magnetic Resonance Imaging (fMRI)","RECRUITING","2026-04-24",{"date":104,"type":41},"2026-04-29",{"date":106,"type":41},"2024-12-16",{"date":108,"type":22},"2026-12-31",{"name":110,"class":48},"Henry M. Jackson Foundation for the Advancement of Military Medicine",3,{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":119,"minAge":19,"maxAge":120,"enrollmentInfo":121,"targetDuration":4,"studyType":23,"phases":123,"briefSummary":125,"conditions":126,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":49},"100631940","phase-2-optimized-neuroplasticity-enhanced-depression-one-d-transcranial-magnetic-stimulation-tms-treatment-for-female-athletes-with-co-morbid-depression-and-concussion-100631940","NCT07507214","Optimized, Neuroplasticity-Enhanced-Depression (ONE-D) Transcranial Magnetic Stimulation (TMS) Treatment for Female Athletes With Co-morbid Depression and Concussion","Optimized, Neuroplasticity Enhanced-Depression (ONE-D) Transcranial Magnetic Stimulation (TMS) Treatment for Female Athletes With Co-morbid Depression and Concussion","Inclusion Criteria:\n\n* Female athletes, both recreational and professional\n* ages 18-65 years old\n* Concussion as determined by clinical history (at least 72 hours post-diagnosis) and Post-Concussion Symptom Scale (PCSS) score above 7 OR more than 4 total symptoms present\n* Depression as determined by Patient Health Questionnaire - (PHQ-9) score of 10 or greater indicating moderate depression or greater\n* Treatment-resistant depression as determined by previously taken or currently taking an oral antidepressant for at least 6 weeks\n\nExclusion Criteria:\n\n* Pregnant or breast-feeding individuals\n* History of seizures or epilepsy\n* Implanted devices (such as cochlear implants, brain stimulators, aneurysm clips or stents)\n* Participants undergoing treatment with ototoxic medications (aminoglycosides, cisplatin)\n* History of bipolar disorder\n* Pacemakers or implanted defibrillators\n* Allergy or other contraindications to d-cycloserine\n* Other contraindications as determined by PI\n* Unable to provide informed consent due to language or other barriers\n* Incarceration\n* Biological male gender","FEMALE","65 Years",{"count":122,"type":22},35,[63,124],"PHASE3","Concussion and depression have long been recognized to be intertwined pathologies.1-3 Although female athletes are more likely to suffer from mental health symptoms than males athletes following a concussion,2 research in this area has been largely biased toward males.4 Recently functional MRI (fMRI) studies5 in concussed athletes have established that there are patterns of local alterations in neural connectivity in the frontal cortex that demonstrate anatomic congruency with transcranial magnetic stimulation (TMS) studies that mapped alternations in neural connectivity to functional and somatic symptoms.6 Thus, there is potential that TMS treatment could decrease both symptom profiles, revolutionizing comorbid treatment options. Possible Benefits:\n\nPrevious studies have showed a 70% remission rate for depression symptoms. It is possible that participants could have improvement in depressive or concussive symptoms after the ONE-D TMS treatment.",[30,127],"Depression","2026-03-27",{"date":130,"type":41},"2026-04-02",{"date":132,"type":22},"2026-06-01",{"date":134,"type":22},"2028-06-01",{"name":136,"class":48},"University of Florida",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":57,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":146,"phases":4,"briefSummary":147,"conditions":148,"keywords":163,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":181,"locationsCount":49},"100303705","retinal-imaging-in-neurodegenerative-disease-100303705","NCT03233646","Retinal Imaging in Neurodegenerative Disease","Evaluating the Retinal and Choroidal Microvasculature and Structure Using Multimodal Retinal and Choroidal Imaging in Neurodegenerative Disease: iMIND Research Study","Inclusion Criteria:\n\n* Adults with neurodegenerative disease ((MCI, PD, AD, FTD, DLB, ALS, MS, HD, TBI, concussion, PTSD and other neurodegenerations as well as Down Syndrome)\n* Adults without neurodegenerative disease\n\nExclusion Criteria:\n\n* Inability to cooperate with or complete testing or other neurologic or age- related ocular conditions that would impact image acquisition.\n* Eyes that have had intraocular surgery, other than cataract surgery.\n\nIf two eyes satisfy the inclusion criteria, both eyes will be included in the study. If one eye satisfies the inclusion criteria, the eye that qualifies will be included in the study.",{"count":145,"type":22},2000,"OBSERVATIONAL","This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD), or other neurodegenerative disease, diseases as outlined.",[149,150,151,152,153,154,155,156,157,158,30,159,160,161,162],"Alzheimer's Disease","Mild Cognitive Impairment","Parkinson's Disease","Multiple Sclerosis","Huntington Disease","Lewy Body Dementia","Frontotemporal Dementia","Amyotrophic Lateral Sclerosis (ALS)","APOE-4 Positive","Traumatic Brain Injury","Post-Traumatic Stress Disorder","Down Syndrome","Neuro-Degenerative Disease","Normal Cognition",[164,165,166,167,168,169,170,171,172,173,174],"OCT angiography (OCTA)","Optical Coherence Tomography (OCT)","Vessel Density","Superficial Capillary Plexus","Retinal microvasculature","Scanning Laser Ophthalmoscopy","Ultra-widefield (UWF) Imaging","Perfusion Density","Retinal Nerve Fiber Layer","Ganglion Cell Inner Plexiform Layer","Choroidal Vascularity Index","2026-02-02",{"date":177,"type":41},"2026-02-04",{"date":179,"type":41},"2017-07-20",{"date":108,"type":22},{"name":182,"class":48},"Duke University",{"id":184,"slug":185,"hasResults":11,"nctId":186,"briefTitle":187,"officialTitle":188,"acronym":189,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":191,"enrollmentInfo":192,"targetDuration":4,"studyType":23,"phases":194,"briefSummary":195,"conditions":196,"keywords":198,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":49},"100600573","cervico-vestibular-home-exercise-program-feasibility-100600573","NCT07099248","Cervico-vestibular Home Exercise Program Feasibility","Feasibility and Acceptability of a Cervico-vestibular Home Exercise Program Following Concussion in Children","Concussion HEP","Inclusion Criteria:\n\n1. Patients \\\u003C18 years old\n2. Presenting to clinic ≤1 month after injury\n3. Diagnosed with a concussion at their clinic visit\n4. Have a total symptom score of 3 or more on the PCSI\n5. Visual acuity\u002Fhearing adequate for testing\n6. Parent\u002Fpatient must be fluent in English\n7. Ability to provide assent, Legally Appointed Representative available to provide informed consent\n\nExclusion Criteria:\n\n1. Patients ≥18 years old\n2. Moderate and severe TBI\n3. History of seizures\n4. History of \\>3 prior concussions\n5. History of chronic headaches\u002Fmigraines\n6. Presenting to clinic \\>1 month after injury","17 Years",{"count":193,"type":22},30,[25],"The purpose of this pilot study is to:\n\n1. Determine the feasibility of adherence to completing the home cervico-vestibular exercise program following concussion.\n2. Investigate the acceptability of the cervico-vestibular home exercise program.\n3. Investigate the impact of the cervico-vestibular home exercise program on symptom reduction, return to play, and return to learn\n4. Analyze the timing at which a home exercise program is typically prescribed.\n\nParticipants will be asked to do and keep track of exercises made to help in their concussion recovery over a two-week period. Participants will come back to see their doctor and complete surveys about how easy the exercises were to do and if they liked them.",[30,197],"Sports Injuries in Children",[30,199],"Home Exercise Program","2025-07-25",{"date":202,"type":41},"2025-08-01",{"date":204,"type":22},"2025-09",{"date":206,"type":22},"2026-08",{"name":208,"class":48},"Texas Scottish Rite Hospital for Children"]