[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"conduct-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:conduct-disorder":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,51,92,117,147,181,213,241],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100410940","developing-brain-impulsivity-and-compulsivity-100410940",false,"NCT04631042","Developing Brain, Impulsivity and Compulsivity","An Observational Study of the Developing Brain, Impulsivity and Compulsivity","* INCLUSION CRITERIA:\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n1. Stated willingness to comply with all study procedures and availability for the duration of the study.\n2. Must be between 6 and 80 years of age.\n3. Ability of participant to understand and the willingness to sign a written informed consent document.\n\nEXCLUSION CRITERIA:\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n1. Cognitively not capable of performing study procedures or lack of capacity to provide informed consent. Indications of a lack of cognitive capacity could include a known full-scale IQ under 70, or a history from the screening interview that implies global intellectual disabilities (e.g., placement in a school for children with intellectual disability etc.)\n2. Very premature birth (i.e., birth before 32 weeks of gestational age).\n3. Any known brain abnormalities (e.g., tumor, periventricular leukomalacia, microcephaly) or history of medical conditions known to affect cerebral anatomy (e.g., epilepsy, history of stroke, head injury with a loss of consciousness of one hour or more).\n4. Psychotic disorders (including schizophrenia, psychosis not otherwise specified).\n5. Dementia, or other conditions that, in the opinion of the investigators, would impede compliance or possibly hinder completion of the study.\n6. Pregnant women.\n7. Any other medical or psychiatric condition that in the opinion of the PI may confound study data\u002Fassessments.\n\nAdditional exclusion criteria for optional MRI procedure:\n\n1\\. Individuals who are not able to receive an MRI (e.g., metal bioimplants, claustrophobia, inability to lie flat on their backs, pregnant women, and any other contraindications for MRI scanning according to the NMR Center MRI safety guidelines).","ALL","6 Years","80 Years",{"count":20,"type":21},1100,"ESTIMATED","OBSERVATIONAL","Background:\n\nImpulsivity is acting 'without thinking.' Compulsivity is being overly inflexible. People vary in how impulsive or compulsive they are. Extreme versions of these behaviors play a role in mental disorders. Researchers want to study changes in the brain to learn more about these behaviors. Differences in genes may also play a role.\n\nObjective:\n\nTo learn about genetic \\& brain features that explain why levels of impulsivity and compulsivity vary across people.\n\nEligibility:\n\nPeople ages 6 - 80\n\nDesign:\n\nParticipants will be screened with a medical history and medical record review.\n\nParticipants will talk about their mental and behavioral development. They may discuss topics like drug use and sexual activity. They will complete surveys about their compulsivity and impulsivity. Parents of child participants may also complete these surveys.\n\nParticipants may take memory, attention, and thinking tests. They may give blood or saliva samples for gene studies and they may give blood to make induced pluripotent stem cells. Participants may have their face and irises photographs taken.\n\nParticipants may have a magnetic resonance imaging scan. It will take pictures of their brain. The scanner is shaped like a cylinder. Participants will lie on a table that slides in and out of the scanner. A coil will be placed over their head. They will lie still, watch a movie, and play a game.\n\nParticipants may ask family members to join the study. Researchers are particularly interested in recruiting twin pairs to the study.\n\nParticipants under age 25 may repeat these tests every 1-2 years until they turn 25 or until the study ends. For those over age 25, participation will last less than 1 month.",[25,26,27,28,29],"Typical Development","Obsessive Compulsive Disorder","Conduct Disorder","Attention Deficit Hyperactivity Disorder","Autism Spectrum Disorder",[31,32,33,34,35,36,37],"Neurodevelopmental disorder","Twin","Natural History","Heritability","Glutamate","developmental trajectory","Brain Connectivity","RECRUITING","2026-06-24",{"date":41,"type":42},"2026-06-25","ACTUAL",{"date":44,"type":42},"2022-09-30",{"date":46,"type":21},"2031-12-31",{"name":48,"class":49},"National Institute of Mental Health (NIMH)","NIH",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":73,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":5},"100599994","using-mentalization-based-therapy-to-support-children-and-adolescents-referred-to-specialist-mental-health-services-in-the-nhs-for-aggressive-andor-violent-behaviour-100599994","NCT07091721","Using Mentalization Based Therapy to Support Children and Adolescents Referred to Specialist Mental Health Services in the NHS for Aggressive and\u002For Violent Behaviour","The Mentalization Intervention for Children and Adolescents (MICA) Study: A Randomised Controlled Trial of Support for Aggressive and Violent Behaviour Via Forensic Child and Adolescent Mental Health Services (FCAMHS)","MICA","Inclusion Criteria:\n\n* Age 10-17 years at the time of referral;\n* Aggression and\u002For violence are indicated at referral or assessment;\n* Participation in the evaluation would not interfere with statutory orders;\n* Child and parent\u002Fcarer (for children 10-15 years) are able to consent and engage with the study materials;\n* Living in the community at time of referral and no imminent plans to move to hospital, residential, or secure settings.\n\nAdditional inclusion criteria for participants recruited from a clinician's existing caseload:\n\n* There has been no direct contact between child and FCAMHS clinicians, including assessments.\n* There has been no indirect therapeutic support provided by FCAMHS e.g. advising non-FCAMHS professionals on therapeutic support.\n* It is permissible for the clinician to have previously engaged in consultation activities where these did not involve contact with the child.\n\nExclusion Criteria:\n\n* Age under 10 or age 18 or older at the time of referral;\n* No evidence of aggression and\u002For violence indicated at referral or assessment;\n* FCAMHS are only offering a one-off consultation or assessment (e.g., the network around the child requires support to manage risk but additional input is not required);\n* Child's level of English is not sufficient to engage in the intervention;\n* Child and\u002For parents\u002Fcarers refuse to engage with FCAMHS;\n* No statutory service is involved in supporting the child;\n* No statutory service will agree to hold the child's case open for a minimum of six months.\n* Currently involved in another psychological intervention research study.","10 Years","17 Years",{"count":62,"type":21},632,"INTERVENTIONAL",[65],"NA","The MICA Study is a research project that has been designed to work out how helpful mentalisation based therapy is. This is a new type of support that helps young people make sense of their own behaviours and feelings, and those of others. It involves meeting regularly with a mental health practitioner and parents\u002Fcarers can be involved in some meetings too. It is hoped that this new type of support will help young people stop acting aggressively\u002Fviolently.\n\nThis project will be delivered in Forensic Child and Adolescent Mental Health Services (FCAMHS) in England. This service supports some of the most vulnerable young people in the country, who may also have involvement from other professionals including the Youth Justice System.\n\nThe aim of the research is to make the support better for young people who use these services. This research involves doing a randomised controlled trial. This means half the young people will get the usual support from FCAMHS, and half will get the usual support plus the new support. The results will be used to compare mentalisation based therapy to the support FCAMHS usually provides. This will show the best way to support young people with their aggressive\u002Fviolent behaviours.\n\nTo start with, young people will answer a questionnaire. Following this, young people will receive either usual support or usual support plus MBT for six months. After this, young people will answer a questionnaire again. Some young people will be asked to take part in an optional interview to share their thoughts on this research. All young people aged 10-17 years who have been referred to a FCAMHS in England will be asked to take part, as long as they can speak and understand English. Some young people might not want to take part in this research and that will not change the support they receive.",[27,68,69,70,71,72],"Mentalization Based Therapy","Violent Behavior","Aggressive Behaviour","Adolescent Behavior","Children Behavior",[74,75,76,77,78,79,80,81],"The Mentalization Intervention for Children and Adolescents (MICA) study.","Forensic Child and Adolescent Mental Health Services (FCAMHS).","Aggressive and violent behaviour.","Mentalization-Based Therapy.","Conduct disorder.","Mental Health.","Young people.","MBT-CD","2026-05-07",{"date":84,"type":42},"2026-05-08",{"date":86,"type":42},"2025-12-03",{"date":88,"type":21},"2027-06",{"name":90,"class":91},"Anna Freud","OTHER",{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":16,"minAge":99,"maxAge":60,"enrollmentInfo":100,"targetDuration":4,"studyType":63,"phases":102,"briefSummary":105,"conditions":106,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":50},"100579963","phase-1-pathways-2-success-100579963","NCT06831123","Pathways 2 Success","Pathways 2 Success: A Study of School-Based Prevention Programs Supporting Positive Adolescent Development","Inclusion Criteria:\n\n1. A 9th or 10th grade student in a partner school district\n2. Referral due to elevated social\u002Femotional risk indicated on a standardized screening tool or a referral from school support staff due to concerns about school-based conduct problems\n3. Adolescents and their parents must be fluent in English\n\nExclusion Criteria:\n\n1. Currently receiving special education services (i.e., an IEP) due to a behavioral or emotional disturbance\n2. Existing diagnoses of autism spectrum disorder, pervasive developmental disorders, developmental\u002Fintellectual disability, or serious psychiatric disorders requiring specialized mental health treatment (e.g., psychosis, bipolar, substance use disorder, etc.)","13 Years",{"count":101,"type":21},120,[103,104],"PHASE1","PHASE2","This study involves a 3-arm randomized controlled trial designed to investigate the feasibility and acceptability of three preventive interventions designed to reduce risk for escalations in adolescent conduct problems. High school students identified to be at risk for conduct problems will be randomly assigned to one of three intervention options, including a mindfulness-based program, a mindfulness-based program augmented by a new mobile app, and a life skills program. Assessments related to intervention outcomes will be completed by adolescents, parents\u002Fguardians, and teachers at baseline, 2 weeks post-intervention, and at a 3-month follow-up.",[27,107],"Oppositional Defiant Disorder","2026-04-09",{"date":110,"type":42},"2026-04-13",{"date":112,"type":42},"2025-03-12",{"date":114,"type":21},"2027-02-28",{"name":116,"class":91},"University of Minnesota",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":124,"enrollmentInfo":125,"targetDuration":4,"studyType":63,"phases":127,"briefSummary":128,"conditions":129,"keywords":133,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":50},"100544791","matching-assessment-and-treatment-for-children-with-disruptive-behaviour-and-their-parents-100544791","NCT06373484","Matching Assessment and Treatment for Children With Disruptive Behaviour and Their Parents","MATCH-DB","Inclusion Criteria:\n\n* Child is borderline\u002Fclinically at risk on the Child Behaviour Checklist (CBCL) or Teacher Report Form (TRF) (T-score greater than or equal to 60 on Externalizing Problems composite scale or a T-score greater than or equal to 65 on the Oppositional Defiant Disorder and\u002For Conduct Disorder scales)\n* Child has clinically severe impairment in the interpersonal relations (greater than 3), functioning in schoolwork (greater than 3), or total domains (greater than 15) on the Columbia Impairment scale.\n* Parent is able and willing to participate in a group treatment\n\nExclusion Criteria:\n\n* Child has an ongoing query or diagnosis of Pervasive Developmental Disorder or Autism or Asperger's Disorder\n* Evidence of cognitive delays or an intellectual disability (based on the Kauffman Brief Intelligence Test-2 (KBIT-2), verbal and\u002For IQ composite standard score below 80 or collateral information)\n* Child behaviour or emotional functioning that make group participation not possible\n* Child preference for individual treatment.\n* Parent behaviour or emotional functioning that make group participation not possible\n* Parent preference for individual treatment.","12 Years",{"count":126,"type":21},200,[65],"This study will develop and test whether personalized profiles of children with Disruptive Behaviour Disorder (DBD) and their parents based on important psychological, emotional, and neuropsychological indicators predict their response to child cognitive behavioral treatment and Behavioral Parent Training.",[130,131,132,28,27,107],"Disruptive Behavior Disorder","Emotional Disorder","Behavioural Disorder",[134,135,28,27,107,136,137],"Emotional and Behavioural Disorders","Disruptive Behaviour Disorder","Parenting Skills","Behavioural Parenting Training","2026-03-16",{"date":140,"type":42},"2026-03-17",{"date":142,"type":42},"2022-10-01",{"date":144,"type":21},"2027-09",{"name":146,"class":91},"Centre for Addiction and Mental Health",{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":16,"minAge":154,"maxAge":155,"enrollmentInfo":156,"targetDuration":158,"studyType":22,"phases":4,"briefSummary":159,"conditions":160,"keywords":166,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":50},"100613984","assessing-real-life-effectiveness-of-treatment-in-neurodevelopmental-disorders-100613984","NCT07273695","Assessing Real Life Effectiveness of Treatment in Neurodevelopmental Disorders","ALERT","Inclusion Criteria\n\n* Children and adolescents aged 8-15 years;\n* Diagnosis of externalizing disorder, ADHD, and\u002For emotional dysregulation (assessed with questionnaires, interviews, and\u002For clinical observation);\n* Intelligence quotient ≥ 75.\n\nExclusion Criteria\n\n* IQ \\\u003C 75;\n* Substance abuse and addictions;\n* Psychosis;\n* Acute disorders;\n* Organic brain disorders;\n* Presence of neurological diseases, epilepsy;\n* Genetic syndromes;\n* Co-diagnosis with other psychiatric or neurodevelopmental disorders (e.g., autism, anxiety, depression, etc.) and prior psychopharmacological therapy will not be considered exclusion criteria but will be recorded and declared.","8 Years","15 Years",{"count":157,"type":21},80,"9 Months","The goal of this observational study is to learn if and how pharmacological and psychotherapeutic group treatments can treat clinical symptoms of children and adolescent patients with ADHD.\n\nThe main questions it aims to answer are:\n\n* Are pharmacological and psychotherapeutic treatments effective on the clinical symptoms of patients with ADHD?\n* Are pharmacological and psychotherapeutic treatments effective on symptoms of emotion-behavioral dysregulation?\n* Is it possible to find associations between individual characteristics and treatment responses evaluating behavioral and neural correlates in children and adolescents with traits of emotion-behavioral dysregulation, externalizing disorders, and\u002For ADHD, using a panel of multimodal measures. May the data collected contribute to the definition of profiles useful for generating predictive hypotheses aimed at developing more personalized interventions?\n\nResearchers will compare the data collected from patients treated with pharmacological and psychotherapeutic group treatments with the data of subjects of comparable sex\u002Fgender, age, diagnoses, on the waiting list for treatment to see if pharmacological and psychotherapeutic treatments effects ADHD and emotional dysregulation symprtoms.\n\nParticipants, patients who are offered treatment by clinicians according to standard clinical practice, will be asked to participate in the study by undergoing experimental assessments before and after the treatment.\n\nThe multimodal panel of proposed assessments includes:\n\n* behavioral assessments, conducted through the completion of clinical and socio-demographic questionnaires;\n* neuropsychological assessments, conducted through standardized computerized neuropsychological tests;\n* neurophysiological assessments, conducted through the recording of NIRS (near infrared spectroscopy) and EEG (electroencephalogram) signals during an attentional task (Go-NoGo) and via a smartwatch.",[161,162,163,27,164,165],"Emotional Dysregulation","Externalizing Problems","Oppositional Defiant","Disruptive Behaviours","Attention Deficit Hyerpactivity Disorder",[167,168,169,170,171],"attention deficit hyperactivity disorder","child training","methylphenidate","emotional dysregulation","externalizing disorders\u002Fbehaviors","2025-11-28",{"date":174,"type":42},"2025-12-09",{"date":176,"type":42},"2025-09-19",{"date":178,"type":21},"2026-12",{"name":180,"class":91},"IRCCS Eugenio Medea",{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":4,"eligibilityCriteria":187,"healthyVolunteers":11,"sex":16,"minAge":154,"maxAge":155,"enrollmentInfo":188,"targetDuration":4,"studyType":63,"phases":190,"briefSummary":191,"conditions":192,"keywords":199,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":208,"leadSponsor":210,"locationsCount":212},"100488223","big-feelings-a-study-on-childrens-emotions-in-therapy-100488223","NCT05637320","Big Feelings: A Study on Children's Emotions in Therapy","Biobehavioural Regulation of Negative Emotion as a Transdiagnostic Mechanism of Children's Psychotherapy","Inclusion Criteria:\n\n* Child must be between the ages of 8 and 15 years old and have English proficiency\n* Parents must be over the age of 18 and have English proficiency\n* Must be seeking psychosocial treatment for concerns related to anxiety, depression, or disruptive behaviours\n\nExclusion Criteria:\n\n* Child has low cognitive functioning that would prevent active participation in research tasks\n* Child reports active suicidality that requiring acute care or hospital intervention\n* Child meets criteria for psychosis, schizophrenia spectrum disorders, eating disorders or autism spectrum disorders\n* Child does not assent to participate in the study",{"count":189,"type":21},202,[65],"The goal of this clinical trial is to learn about how psychotherapy works for children and adolescents aged 8 - 15 with anxiety, depression, trauma, or disruptive behaviour. The main question it aims to answer is:\n\n• Is the biobehavioural regulation of negative emotion a transdiagnostic mechanism of treatment response in psychotherapy for children with anxiety, depression, trauma and\u002For disruptive behaviour?\n\nChildren and their parents will be randomly assigned to an evidence-based, transdiagnostic treatment (the Modular Approach to Therapy for Children with Anxiety, Depression, Trauma, and Conduct Problems; MATCH-ADTC) or a waitlist control condition. Participants in both groups will complete a baseline assessment, weekly measures consisting of brief symptom scales and medication tracking, and quarterly assessments every 3 months. Following the intervention\u002Fwaitlist period, our team will conduct post-test assessments. All assessments, except for the weekly surveys, will consist of symptom scales, clinical interviews, experimental tasks and physiological measures.",[193,194,195,27,107,196,197,198],"Anxiety Disorders","Depressive Disorder","Mood Disorders","Regulation, Emotion","Child Behavior Disorders","Trauma and Stressor Related Disorders",[200,201,202,203],"Child psychotherapy","Emotion regulation","Physiology","Mechanism of change","2025-01-27",{"date":206,"type":42},"2025-01-29",{"date":142,"type":42},{"date":209,"type":21},"2027-12-31",{"name":211,"class":91},"University of Guelph",2,{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":11,"sex":16,"minAge":219,"maxAge":4,"enrollmentInfo":220,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":222,"conditions":223,"keywords":227,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":50},"100566611","a-study-on-the-preference-of-risperidone-dosage-forms-100566611","NCT06657430","A Study on the Preference of Risperidone Dosage Forms","Inclusion Criteria:\n\n* Patients with schizophrenia, bipolar disorder, autism spectrum disorder, mental retardation or their primary caregivers who voluntarily participate in the study.\n\nExclusion Criteria:\n\n* Have difficulty reading and understanding Chinese or refuse to participate in the study.","18 Years",{"count":221,"type":21},1000,"This study aimed to understand patients' needs and preferences for antipsychotic dosage forms.",[224,225,29,27,226],"Schizophrenia","Bipolar Affective Disorder","Mental Retardation",[228,229,230,231],"risperidone","patch","cross-sectional study","preference","2024-10-23",{"date":234,"type":42},"2024-10-24",{"date":236,"type":42},"2024-09-19",{"date":238,"type":21},"2025-02-28",{"name":240,"class":91},"Shanghai Mental Health Center",{"id":242,"slug":243,"hasResults":11,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":247,"eligibilityCriteria":248,"healthyVolunteers":11,"sex":249,"minAge":155,"maxAge":250,"enrollmentInfo":251,"targetDuration":4,"studyType":63,"phases":253,"briefSummary":254,"conditions":255,"keywords":257,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":212},"100500938","cft-focused-mental-health-intervention-with-exposure-training-for-youngsters-100500938","NCT05802758","CFT-focused Mental Health Intervention With Exposure Training for Youngsters","Compassion-focused Mental Health Intervention With Exposure Training in Virtual Reality for Youngsters Living in an Institution","CFT+VR","Inclusion Criteria:\n\n* Express conduct disorder psychopathology and psychopathic personality traits\n* Are placed to a prison or a state residential school for at least 9 months\n\nExclusion Criteria:\n\n* Females\n* Non-Finninsh-speaking\n* Remaining in the institution facility less than 9 months\n* Intellectual dissability\n* Presence of psychotic symptoms\n* Autism\n* History of epilepsy\n* Currently participating another psychotherapeutic intervention","MALE","20 Years",{"count":252,"type":21},144,[65],"The aim of this study is to explore if individual CFT-based intervention with exposure training in virtual reality decreases conduct disorder symptoms and callous-unemoitonal traits , as well as increases subjective emotional welbeing among 15-to-20 year-old male prisoners and boys placed to state's residential schools. We will also study factors that may predict adherence to the intervention. These factors include mental well-being, motivation, and working alliance. In addition, we will evaluate the costs of the program.",[27,256],"Psychopathic Personality Trait",[258],"psychotherapy, virtual reality, boys","2023-07-30",{"date":261,"type":42},"2023-08-01",{"date":263,"type":42},"2023-01-01",{"date":265,"type":21},"2029-12-31",{"name":267,"class":91},"Helsinki University Central Hospital"]