[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"conduction-block-atrioventricular\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:conduction-block-atrioventricular":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100622015","lll-vs-sdl-for-lbbp-a-non-inferiority-rct-100622015",false,"NCT07378124","LLL vs. SDL for LBBP: A Non-inferiority RCT","Efficacy and Safety Comparison of Lumenless Lead Versus Stylet-driven Lead in Intraoperative Application of Left Bundle Branch Pacing Guided by Continuous Pacing Monitoring With S-V Dissociation as the Primary Outcome: A Non-inferiority, Multicenter, Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Symptomatic sick sinus syndrome (SSS);\n* Complete or advanced atrioventricular block (AVB);\n* Patients with heart failure complicated by left bundle branch block (LBBB) and biventricular dyssynchrony;\n* Patients with atrial fibrillation (AF) complicated by refractory rapid ventricular rate who are scheduled for atrioventricular node ablation and permanent pacemaker implantation;\n* Other patients who meet the indications for dual-chamber pacemaker implantation as specified in current guidelines\n\nExclusion Criteria:\n\n* Patients who are ineligible for transvenous cardiac pacemaker implantation due to anatomical abnormalities, infections, or other factors;\n* Patients with existing implantable cardiac electronic devices (ICEDs);\n* Patients who opt for right-sided venous access for any reason;\n* Patients with an expected survival of less than 1 year;\n* Patients who have been enrolled in other clinical trials related to implantable cardiac electronic devices within 3 months prior to enrollment in this study.","ALL",{"count":18,"type":19},288,"ESTIMATED","INTERVENTIONAL",[22],"NA","Left Bundle Branch Pacing (LBBP) has emerged as one of the most commonly used physiological pacing modalities in clinical practice. However, the key determinants of procedural success lie in the accurate intraoperative identification of proper LBB lead positioning and the prevention of cardiac perforation. Our previous research has established a methodology for Lumenless Lead (LLL) implantation under the guidance of continuous pacing monitoring, and this methodology has been further adapted for Stylet-driven Lead (SDL) implantation. The present study is designed as a multicenter, randomized controlled trial, aiming to compare the differences in efficacy and safety between LLL and SDL during LBBP procedures guided by continuous pacing monitoring, with the presence of S-V dissociation serving as the criterion for confirming optimal LBB lead positioning.",[25,26],"Bradycardia","Conduction Block, Atrioventricular","NOT_YET_RECRUITING","2026-01-31",{"date":30,"type":31},"2026-02-03","ACTUAL",{"date":33,"type":19},"2026-01-24",{"date":35,"type":19},"2027-12-31",{"name":37,"class":38},"Ningbo No.2 Hospital","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":20,"phases":51,"briefSummary":52,"conditions":53,"keywords":57,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":39},"100509241","left-bundle-brancharea-pacing-to-avoid-pacing-induced-cardiomyopathy-100509241","NCT05910866","LEft Bundle branchArea Pacing to Avoid Pacing-induced CARdiomyopathy","LEft Bundle branchArea Pacing to Avoid Pacing-induced CARdiomyopathy: the LEAP-CAR Prospective, Randomized Trial","LEAP-CAR","Inclusion Criteria:\n\n* advanced AVB (frequent 2° degree or 3° degree AVB, atrial fibrillation - AF - with advanced AV block) and preserved or slightly reduced LVEF (\\>45%)\n\nExclusion Criteria:\n\n* LVEF ≤45%\n* signs or symptoms of heart failure at enrollment\n* unstable angina or acute coronary syndrome \\\u003C3 months\n* percutaneous coronary intervention or coronary-artery bypass surgery \\\u003C3 months\n* life expectancy \\\u003C6 months\n* previous hospitalization for heart failure\n* evidence of pulmonary artery hypertension of any origin\n* valvular disease greater than moderate\n* previous heart transplant pregnancy","18 Years",{"count":50,"type":19},130,[22],"LEAP-CAR will evaluate the benefit of left bundle branch area pacing (LBBAP), comparing to conventional right ventricular pacing (RVP), in preventing pacing-induced cardiomyopathy (PICM) in patients undergoing pacemaker implant for advanced (2° or 3° degree) atrioventricular block, with baseline left ventricular ejection fraction (LVEF) \\>45%.\n\nLEAP-CAR is a randomized, prospective, double blind clinical trial.",[25,54,55,26,56],"Heart Failure","Pacemaker-Induced Cardiomyopathy","Cardiac Remodeling, Ventricular",[58,59,60,61],"left bundle branch area pacing","conduction system pacing","physiologic pacing","pacing-induced cardiomyopathy","RECRUITING","2024-01-29",{"date":65,"type":31},"2024-01-30",{"date":67,"type":31},"2023-06-10",{"date":69,"type":19},"2026-06-10",{"name":71,"class":38},"Azienda Ospedaliero Universitaria Maggiore della Carita"]