[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"conduction-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:conduction-disorder":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100608423","biomarkers-of-inflammation-and-fibrosis-in-conduction-disorders-after-tavi-100608423",false,"NCT07201363","Biomarkers of Inflammation and Fibrosis in Conduction Disorders After TAVI","The Role of Inflammation and Fibrosis in the Development of Conduction Disorders After Transcatheter Aortic Valve Implantation","Inclusion Criteria:\n\n* Written consent to participate in the trial\n* Diagnosis of severe AS according to current European Society of Cardiology (ESC) guidelines for valvular heart disease\n\nExclusion Criteria:\n\n* Acute infectious disease\n* Chronic inflammatory or autoimmune disease\n* Corticosteroid or other immunosuppressive therapy\n* Active malignant disease\n* Liver disease accompanied by dysfunction\n* Permanent pacemaker implanted previously\n* An acute myocardial infarction within three months before the procedure\n* A surgical procedure within three months before the procedure\n* Previous surgical or transcatheter aortic valve replacement\u002Fimplantation\n* End-stage chronic kidney disease (eGFR \\\u003C15 ml\u002Fmin)",true,"ALL","18 Years",{"count":20,"type":21},102,"ESTIMATED","OBSERVATIONAL","Prediction of conduction disorders (CDs) in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) is an important and complex process with a significant impact on patient outcomes. The goal of this observational prospective trial is to investigate the role of pre-procedural values of systemic biomarkers of inflammation and fibrosis in the prediction of new-onset CDs and permanent pacemaker implantation (PPI) in patients undergoing the TAVI procedure.",[25,26,27,28],"TAVI(Transcatheter Aortic Valve Implantation)","Conduction Disorder","Aortic Stenosis","Permanent Pacemaker Implantation",[27,30,26,31,32,33],"Biomarkers","Fibrosis","Inflammation","Transcatheter Aortic Valve Implantation","RECRUITING","2025-09-30",{"date":37,"type":38},"2025-10-06","ACTUAL",{"date":40,"type":38},"2024-12-12",{"date":42,"type":21},"2026-08",{"name":44,"class":45},"Clinical Hospital Center Rijeka","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":57,"studyType":22,"phases":4,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":46},"100422116","biobank-for-arrhythmia-and-conduction-disorders-toward-pathophysiology-based-treatment-100422116","NCT04776642","Biobank for \"Arrhythmia and Conduction Disorders: TowArd Pathophysiology Based Treatment\"","\"Arrhythmia and Conduction Disorders: TowArd Pathophysiology Based Treatment\" ADAPT Biobank","ADAPT","Inclusion criteria:\n\n* Patients visiting the AMC outpatient clinic\n* Patients included in an ongoing clinical trial linked to this biobank. Studies are listed under point \"Groups and interventions\" and include:\n\n  * MARK AF\n  * INDICO AF\n  * PREDICT AF\n  * WEIGHTLOSS AF\n  * MAD AF\n* Patients included in future clinical trial linked to this biobank. Studies may be linked to this biobank that investigates prevalent or incident cardiac arrhythmias.\n* Cardiac arrhtymias are defined as\n\n  * Supraventricular tachycardia, among which the most common are:\n\n    * Atrial Fibrillation (AF)\n    * Atrial Tachycardia (AT)\n    * Atrial Flutter (AFL)\n    * Atrioventricular Nodal Reentrant Tachycardia (AVNRT)\n    * Atrioventricular Reentrant Tachycardia (AVRT)\n  * Ventricular tachycardia, among which the most common are:\n\n    * Ventricular Tachycardia (VT)\n    * Ventricular Flutter (VFL)\n    * Ventricular Fibrillation (VF)\n  * Bradycardia:\n\n    * Sinus Node Dysfunction\n    * AV Node Dysfunction\n    * Interventricular Conduction Disorder\n  * Arrhythmogenic cardiomyopathies, among which the most common are:\n\n    * Dilated Cardiomyopathy\n    * Restrictive Cardiomyopathy\n    * Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)\n\nExclusion criteria (shared for all studies):\n\n* Age \\\u003C 18\n* Unable or unwilling to comply with study procedures\n* Pregnancy or of childbearing potential without adequate contraception\n* NYHA class IV heart failure symptoms or left ventricular ejection fraction \\\u003C35%.",{"count":56,"type":21},1000,"5 Years","The 'ADAPT' Biobank is a collection of body material and data from patients with or at risk of cardiac arrhythmias who underwent or will undergo (non-) invasive treatment for this disease. Its main objective is to obtain a comprehensive collection of patient information and material to facilitate research and gain better insight into the complex pathophysiology of the different arrhythmias, the multifactorial process, the heterogeneity in clinical presentation, and prognosis.\n\nBodily material is used for biochemical marker assessments, histological and molecular analyses for research in cardiac arrhythmias.",[60,26,61],"Arrythmia","Pathophysiology","2024-01-24",{"date":64,"type":38},"2024-01-25",{"date":66,"type":38},"2014-12-18",{"date":68,"type":21},"2030-01",{"name":70,"class":45},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)"]