[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"conduction-system-pacing\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:conduction-system-pacing":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,46,81,106,136,160,186,229,251,272],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100534655","csp-versus-bivp-for-heart-failure-patients-with-rvp-upgraded-to-cardiac-resynchronization-therapy-100534655",false,"NCT06241651","CSP Versus BiVP for Heart Failure Patients With RVP Upgraded to Cardiac Resynchronization Therapy","Conduction System Pacing Versus Biventricular Pacing for Heart Failure Patients With Right Ventricular Pacing Upgraded to Cardiac Resynchronization Therapy: a Prospective Multicenter Non-inferiority Randomized Controlled Study","CSP-UPGRADE","Inclusion Criteria:\n\n1. Patients with symptomatic heart failure (LVEF \\\u003C50%) after right ventricular pacing for at least 3 months;\n2. NYHA class II-IV;\n3. NT-proBNP \\>125pg\u002FmL in patients with sinus rhythm, NT-proBNP \\>250pg\u002FmL in patients with atrial fibrillation;\n4. Right ventricular pacing percentage \\>40%;\n5. Adult patients aged 18-80;\n6. With informed consent signed.\n\nExclusion Criteria:\n\n1. History of acute myocardial infarction within 3 months before enrollment;\n2. Frequent premature ventricular contraction (\\>15%) or malignant ventricular arrhythmia which is difficult to control;\n3. History of valvular heart disease intervention within 3 months before enrollment;\n4. After mechanical tricuspid valve replacement;\n5. Ventricular septal hypertrophy (≥15mm during diastole);\n6. Complex congenital heart disease;\n7. History of heart transplantation;\n8. Enrollment in any other study;\n9. Pregnant or with child-bearing plan;\n10. A life expectancy of less than 12 months.","ALL","18 Years","80 Years",{"count":21,"type":22},66,"ESTIMATED","INTERVENTIONAL",[25],"NA","The present study is a prospective, multicenter, non-inferiority, randomized controlled trail. It aims to investigate whether the efficacy of conduction system pacing (CSP) is non-inferior to biventricular pacing (BiVP) in patients with heart failure and right ventricular pacing (RVP) requiring upgrading to cardiac resynchronization therapy (CRT).",[28,29,30,31,32],"Conduction System Pacing","Biventricular Pacing","Cardiac Resynchronization Therapy","Right Ventricular Pacing","Heart Failure","RECRUITING","2026-05-11",{"date":36,"type":37},"2026-05-14","ACTUAL",{"date":39,"type":37},"2024-01-01",{"date":41,"type":22},"2027-03",{"name":43,"class":44},"The First Affiliated Hospital with Nanjing Medical University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":62,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":80},"100609654","left-bundle-branch-area-pacing-lbbap-pmcf-study-100609654","NCT07217392","Left Bundle Branch Area Pacing (LBBAP) PMCF Study","LBBAP PMCF","Inclusion Criteria:\n\n1. Meets current clinical practice guidelines for implantation of Tendril STS 2088TC or UltiPace LPA1231 lead in the Left Bundle Branch Area\n2. Are ≥ 18 years of age or age of legal consent, whichever age is greater.\n3. Subject is willing to comply with clinical investigation procedures and agrees to return to clinic for all required follow-up visits, tests, and exams.\n4. Subject has been informed of the nature of the clinical investigation, agrees to its provisions and has provided a signed written informed consent, approved by the IRB\u002FEC.\n\nExclusion Criteria:\n\n1. Patient meets a standard contraindication for lead implant including:\n\n   1. the presence of tricuspid atresia\n   2. patients with mechanical tricuspid valves\n   3. patients who are expected to be hypersensitive to a single dose of one milligram of dexamethasone sodium phosphate\n2. Patient is currently implanted with a pacemaker, ICD, or CRT-D\u002FP device\n3. Patient has had a previous unsuccessful attempt to place a lead in the LBB area\n4. Patient has planned cardiac surgical procedures or interventional measures within 3 months after implant\n5. Patient is expected to receive a heart transplant within 6 months\n6. Patient life expectancy less than 6 months\n7. Patient has the presence of another life-threatening, underlying illness separate from their cardiac disorder\n8. Patient is enrolled or planning to enroll in another clinical trial that might confound the results of the present study\n9. Pregnant or nursing subjects and those who plan pregnancy during the clinical investigation follow-up period.\n10. Presence of other anatomic or comorbid conditions, or other medical, social, or psychological conditions that, in the investigator's opinion, could limit the subject's ability to participate in the clinical investigation or to comply with follow-up requirements of the clinical investigation.",{"count":54,"type":22},200,[25],"The objective of this study is to evaluate the safety and effectiveness of LBBA pacing\u002Fsensing in patients implanted with the Tendril STS 2088TC or UltiPace LPA1231 lead through 6 months post-implant.",[58,31,32,59,60,61,28],"Bradycardia","Atrial Fibrillation (AF)","Cardiac Disease","Left Bundle Branch Area Pacing",[63,64,65,66,67,68,69],"Right ventricular pacing","cardiac disease","heart failure","atrial fibrillation","bradycardia","left bundle branch area pacing","conduction system pacing","2026-04-22",{"date":72,"type":37},"2026-04-24",{"date":74,"type":37},"2025-07-24",{"date":76,"type":22},"2027-04-30",{"name":78,"class":79},"Abbott Medical Devices","INDUSTRY",13,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":91,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":45},"100455730","physiological-pacing-for-av-block-to-prevent-pacemaker-induced-cardiomyopathy-100455730","NCT05214365","Physiological Pacing for AV Block to Prevent Pacemaker-induced Cardiomyopathy","Physiological Pacing vs.Conventional Pacing in the Prevention of Pacemaker-induced Cardiomyopathy: A Randomized Study","PHYSPAVB","Inclusion Criteria:\n\n* The patient must be ≥ 18 years of age.\n* The patient must indicate their acceptance to participate in the study by signing an informed consent document.\n* Patients with EF\\> 50% and indication for pacemaker implantation due to atrial-ventricular block according to current clinical guidelines.\n\nExclusion Criteria:\n\n* Inability to understand and sign the informed consent.\n* Patients with severe comorbidities and life expectancy \\\u003C1 year.\n* Patients with severe cognitive impairment or other comorbidities resulting in dependence for basic activities of daily life.\n* Patients who cannot come to our center to carry out the follow-up of the study.","100 Years",{"count":54,"type":22},[25],"The implantation of a pacemaker and conventional cardiac pacing from the right ventricle (apex or septum) is an effective and safe therapy for the treatment of patients with atrioventricular block and bradycardia.",[28,94],"Conventional Ventricular Pacing",[96],"Pacemaker-induced cardiomyopathy","2026-03-30",{"date":99,"type":37},"2026-03-31",{"date":101,"type":37},"2022-02-01",{"date":103,"type":22},"2026-09-01",{"name":105,"class":44},"Hospital Clinic of Barcelona",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":23,"phases":117,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":135},"100630846","conduction-system-pacing-vs-biventricular-pacing-for-cardiac-resynchronization-therapy-100630846","NCT07492979","Conduction System Pacing vs. Biventricular Pacing for Cardiac Resynchronization Therapy","Nordic-CSP - a Randomized Nordic Study - Is Conduction System Pacing Superior Compared to Conventional BIV-CRT in Reducing the Death or Heart Failure-related Hospitalization in Patients With Heart Failure and Bundle Branch Block?","Nordic-CSP","Inclusion Criteria:\n\n* ≥18 years of age,\n* LVEF ≤ 35%,\n* NYHA Class II-IV (IV only outpatients),\n* optimized in medical treatment (OMT)\n\nAND one of the following:\n\n. LBBB according to AHA\u002FACC\u002FHRS Scientific Statement from 2009 and ≥130ms or\n\n* LBBB-like intraventricular conduction delay (IVCD) \\> 150ms or RV paced QRS and indication for upgrade to CRT (\\> 40% RV pacing) OR\n* ≥18 years of age,\n* LVEF ≤ 40 %\n* pacing indicated by AV-block and, thus, expected large percentage of ventricular pacing.\n\nExclusion Criteria:\n\n* recent acute myocardial infarction (AMI)\n* coronary artery bypass graft (CABG) (\\\u003C3 months)\n* life expectancy \\\u003C2 years, patients in hemodialysis\n* treatment with a cardiac implantable electronic device (CIED) is contraindicated.\n* Patients are excluded with regards to the MRI sub study if eGFR \\> 35 ml\u002Fmin, in case or contrast allergy or certain metal implants.","99 Years",{"count":116,"type":22},1100,[25],"The NORDIC-CSP trial is an investigator-initiated, blinded, nordic RCT aimed at evaluating whether using direct pacing of the HIS bundle (HIS)-pacing or left bundle branch (LBB) pacing is superior to conventional biventricular pacing in reducing the incidence of the composite endpoint of death and non-planned HF hospitalization. The study will be conducted in the 4 CRT-centres in Denmark and 6-8 centres from countries Sweden, Norway and Finland.",[120,32,28],"Cardiac Resynchronisation Therapy (CRT)",[112,69,122,123,124,30],"His-pacing","LBB-pacing","Biventricular pacing","NOT_YET_RECRUITING","2026-03-20",{"date":128,"type":37},"2026-03-25",{"date":130,"type":22},"2026-03-01",{"date":132,"type":22},"2031-07-01",{"name":134,"class":44},"Rigshospitalet, Denmark",4,{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":17,"minAge":144,"maxAge":4,"enrollmentInfo":145,"targetDuration":4,"studyType":23,"phases":146,"briefSummary":147,"conditions":148,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":135},"100628622","left-bundle-branch-area-pacing-versus-right-ventricular-pacing-in-atrioventricular-block-with-preserved-ejection-fraction-100628622","NCT07464041","Left Bundle Branch Area Pacing Versus Right Ventricular Pacing in Atrioventricular Block With Preserved Ejection Fraction","Left Bundle Branch Area Pacing With a Stylet-Driven Lead Versus Right Ventricular Pacing in Patients With Atrioventricular Block and Preserved Ejection Fraction: A Multicenter Randomized Trial","NOVEL II","Inclusion Criteria:\n\nPatients requiring permanent pacemaker implantation for the following indications:\n\n* Third-degree AV block\n* First- or second-degree AV block with an expected ventricular pacing burden ≥40%\n* Atrial fibrillation with slow ventricular response with an expected ventricular pacing burden ≥40%\n\nExclusion Criteria:\n\n* Prior implantation of a cardiac pacemaker or implantable cardioverter-defibrillator\n* Left ventricular ejection fraction ≤50%\n* Indication for cardiac resynchronization therapy\n* Life expectancy ≤1 year (e.g., patients not eligible for heart transplantation due to end-stage heart failure, patients with DNR orders, those receiving hospice care after refusal of life-sustaining treatment, or patients with terminal cancer not eligible for chemotherapy or radiotherapy)","19 Years",{"count":54,"type":22},[25],"Conventional right ventricular pacing (RVP) has been associated with ventricular dyssynchrony and an increased risk of pacing-induced cardiomyopathy, which may lead to worse clinical outcomes. These adverse effects are more pronounced in patients with pre-existing left ventricular dysfunction. To overcome these limitations, left bundle branch area pacing (LBBAP), which directly engages the cardiac conduction system to preserve physiological ventricular activation, has been increasingly adopted in clinical practice.\n\nHowever, in patients with atrioventricular block and preserved left ventricular ejection fraction (LVEF ≥50%), evidence demonstrating the long-term clinical superiority of LBBAP over conventional RVP remains limited. As a result, both pacing strategies continue to be used in current practice. This multicenter randomized trial aims to compare the efficacy, safety, and lead stability of LBBAP using a stylet-driven extendable screw-in lead versus conventional RVP in patients with atrioventricular block and preserved ejection fraction.",[149,150,28],"Atrioventricular Block","Left Bunde Branch Area Pacing","2026-03-06",{"date":153,"type":37},"2026-03-11",{"date":155,"type":37},"2024-04-29",{"date":157,"type":22},"2027-06-30",{"name":159,"class":44},"Samsung Medical Center",{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":166,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":168,"targetDuration":4,"studyType":23,"phases":170,"briefSummary":171,"conditions":172,"keywords":174,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":185},"100614199","central-haemodynamics-and-pacing-for-av-block-100614199","NCT07276490","Central Haemodynamics and Pacing for AV Block","The Pacing in Atrioventricular Block: a Comparative Evaluation of Central Haemodynamics, Cardiac Function, and Quality of Life","PACE-CCQ","Inclusion Criteria:\n\n* Age 18-80 years\n* Diagnosis of atrioventricular block\n* Expected survival \\>1 year\n\nExclusion Criteria:\n\n* Reduced left ventricular ejection fraction (EF \\\u003C45%)\n* Expected ventricular pacing burden \\\u003C20%\n* Inter-arm systolic blood pressure difference \\>15 mmHg\n* Percutaneous coronary intervention or coronary artery bypass surgery within the last 30 days\n* Secondary hypertension\n* Orthostatic hypotension\n* Clinically significant valvular heart disease\n* Congenital heart disease\n* Pulse wave analysis or pulse wave velocity measurement cannot be reliably performed\n* Pregnancy or breastfeeding\n* Withdrawal of consent by the subject\n* Loss of contact during the study",{"count":169,"type":22},124,[25],"A randomized, single-blind study comparing two pacing strategies in patients with atrioventricular block requiring permanent pacemaker implantation. This trial evaluates the impact of conduction system pacing (left bundle branch area pacing) versus standard right ventricular pacing on central hemodynamics, cardiac function, and patient quality of life over 12 months. The study will enroll 124 patients from two Estonian tertiary hospitals and measure central systolic arterial pressure as the primary outcome, with secondary assessments of arterial stiffness, echocardiographic parameters, electrical activation patterns, and quality of life scores.",[149,173,31,28],"Pacing Therapy",[69,175,176],"atrioventricular block","right ventricular pacing",{"date":178,"type":37},"2026-03-09",{"date":180,"type":37},"2025-11-28",{"date":182,"type":22},"2027-12-31",{"name":184,"class":44},"University of Tartu",2,{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":192,"eligibilityCriteria":193,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":194,"targetDuration":196,"studyType":197,"phases":4,"briefSummary":198,"conditions":199,"keywords":203,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":220,"lastUpdatePostDateStruct":221,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":45},"100616406","study-of-ahre-burden-in-patients-undergoing-bachmann-bundle-area-pacing-and-left-bundle-branch-pacing-100616406","NCT07305194","Study of AHRE Burden in Patients Undergoing Bachmann Bundle Area Pacing and Left Bundle Branch Pacing.","Study of Atrial High-Rate Episode Burden in Patients Undergoing Concurrent Bachmann Bundle Area Pacing and Left Bundle Branch Pacing , Compared With Either Left Bundle Branch Pacing or Conventional Right Ventricular Pacing.","AHRE-BLAST","Inclusion Criteria:\n\n* Adult patients (≥ 18 years) with a clear indication for permanent pacing, according to ESC guidelines \\[15\\] for the management of conduction disturbances (e.g. symptomatic bradycardia, complete atrioventricular block, sinus node dysfunction).\n* Sinus rhythm at the time of implantation, with no documented episodes of atrial fibrillation prior to implantation, either in the medical history or in previous recordings (ECG, Holter, telemetry).\n* Ability to be followed up for at least 24 months after implantation.\n* Provision of written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* History of atrial fibrillation prior to implantation, either permanent or paroxysmal, documented on ECG, Holter, or telemetry.\n* Prior pharmacological or interventional treatment for AF (e.g. antiarrhythmic drugs, catheter ablation).\n* Inability to comply with long-term follow-up or non-adherence to follow-up visits.\n* Contraindications to pacemaker lead placement at the selected sites.\n* Participation in another study that could influence the results.\n* Previous device implantation.",{"count":195,"type":22},460,"24 Months","OBSERVATIONAL","This prospective observational study evaluates the burden of Atrial High-Rate Episodes (AHRE) in patients without a prior history of atrial fibrillation who undergo concurrent Bachmann Bundle Area Pacing (BBAP) and Left Bundle Branch Pacing (LBBP). Physiological pacing at these sites aims to improve interatrial conduction and reduce the risk of atrial arrhythmias.\n\nThe study includes a comparative assessment across three patient groups:\n\n1. BBAP + LBBP (physiological pacing group)\n2. Right Atrial Appendage (RAA) pacing + LBBP\n3. Conventional pacing - RAA and Right Ventricular (RV) pacing AHRE burden will be quantified via device diagnostics and remote monitoring at 3, 12 and 24 months post-implantation. Episodes will be classified by duration (0-6 min, 6-24 h, \\>24 h), differentiating subclinical AHRE from clinically documented AF.\n\nSecondary analyses include electrocardiographic changes (P-wave indices), the need for antiarrhythmic therapy, and comprehensive echocardiographic evaluation of atrial function (e.g., LA strain, conduction delays, LAVI).\n\nThe study aims to determine whether physiological pacing (BBAP + LBBP) provides superior protection against AHRE development compared with RAA + LBBP and conventional pacing strategies.",[200,59,201,202,28],"Atrial Arrhythmia","Pacemaker Implantation","Left Bundle Branch Pacing",[204,205,206,207,208,209,210,211,212,213,214,215,216,217,218,219],"Atrial High-Rate Episodes (AHRE)","Subclinical Atrial Fibrillation","Bachmann Bundle Area Pacing (BBAP)","Left Bundle Branch Pacing (LBBP)","Physiological Pacing","Interatrial Conduction","Atrial Synchrony","P-wave Duration","Atrial Electromechanical Remodeling","Atrial Strain","Left Atrial Reservoir Strain","Inter-atrial Conduction Delay (IACD)","Speckle Tracking Echocardiography","Left Atrial Volume Index (LAVI)","Atrial Arrhythmias","Device-Detected AF","2025-12-11",{"date":222,"type":37},"2025-12-26",{"date":224,"type":22},"2026-01-01",{"date":226,"type":22},"2028-04-14",{"name":228,"class":44},"University Hospital of Patras",{"id":230,"slug":231,"hasResults":11,"nctId":232,"briefTitle":233,"officialTitle":233,"acronym":4,"eligibilityCriteria":234,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":89,"enrollmentInfo":235,"targetDuration":4,"studyType":197,"phases":4,"briefSummary":237,"conditions":238,"keywords":240,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":246,"completionDateStruct":247,"leadSponsor":249,"locationsCount":4},"100600186","fluoroless-conduction-system-implant-100600186","NCT07094217","Fluoroless Conduction System Implant","Inclusion Criteria:\n\n1. Patients with a ventricular pacing indication: high grade atrioventricular block and symptomatic trifasicular, bifasicular block or left bundle branch block LBBB for cardiac resynchronisation therapy\n2. Adults willing to take part (ages 18 - 100 years old)\n3. Able to give consent.\n\nExclusion Criteria:\n\n1. Unable to give consent\n2. Children age \\\u003C 18 years and adults \\> 100 years old\n3. Pregnant patients • As per standard of care, female patients of child-bearing age will have a urine pregnancy test prior to their procedure.",{"count":236,"type":22},75,"Conduction system pacing is a new way of stimulating the heart using pacemaker wires. Traditional pacemakers stimulate the heart muscle which causes disordered heart beats: the walls of the heart move at different times. This wears down the heart over time.\n\nConduction system pacemakers stimulate the heart's electrical system directly producing natural heart beats that are much less disordered. These pacemakers can be challenging to insert with different heart shapes, sizes and scars. This can increase procedure times and time exposed to xray as pacemakers are inserted using x-rays to guide where the lead is implanted.\n\nThis study aims to allow conduction system pacemakers to be implanted without the use of normal xray (fluoroscopy).\n\nThe investigators will create an anatomical shell of the heart using special plastic (mapping) catheters that is inserted within the heart from the groin. The investigators will use a special heart scanning (echo) catheter to see how the pacemaker wire is inserted into the heart muscle. The investigators will use MRI to confirm that the information we collect is accurate. Using this information the investigators will create a protocol to implant a lead that does not require xray, using only the mapping catheter.",[239,28],"Pacemaker",[241,69,242],"fluoroless","left bundle area pacing","2025-07-28",{"date":245,"type":37},"2025-07-30",{"date":245,"type":22},{"date":248,"type":22},"2026-07-30",{"name":250,"class":44},"Imperial College London",{"id":252,"slug":253,"hasResults":11,"nctId":254,"briefTitle":255,"officialTitle":255,"acronym":256,"eligibilityCriteria":257,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":89,"enrollmentInfo":258,"targetDuration":4,"studyType":197,"phases":4,"briefSummary":260,"conditions":261,"keywords":262,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":271,"locationsCount":45},"100593699","solutions-to-the-challenges-of-conduction-system-pacing-100593699","NCT07009834","Solutions to the Challenges of Conduction System Pacing","CSA","Inclusion Criteria:\n\n1. Patients with a ventricular pacing indication: high grade atrioventricular block and symptomatic trifasicular, bifasicular block or left bundle branch block LBBB for cardiac resynchronisation therapy\n2. Adults willing to take part (ages 18 - 100 years old)\n3. Able to give consent.\n\nExclusion Criteria:\n\n1. Unable to give consent\n2. Children age \\\u003C 18 years and adults \\> 100 years old\n3. Pregnant patients As per standard of care, female patients of child-bearing age will have a urine pregnancy test prior to their procedure.",{"count":259,"type":22},300,"Conduction system pacing is a new way of stimulating the heart using pacemaker wires. Traditional pacemakers stimulate the heart muscle which causes disordered heart beats: the walls of the heart move at different times. This wears down the heart over time.\n\nConduction system pacemakers stimulate the heart's electrical system directly producing natural heart beats that are much less disordered. Unfortunately, these pacemakers can only be implanted by a small group of experts at specialised centres with specialist equipment. This study aims to allow conduction system pacemakers to be offered to any patient at any hospital by simplifying the process of inserting the pacemaker wires and the improving the pacemaker's ability to interpret electrical traces.\n\nFirstly, the best locations in the heart for conduction system pacemaker wires using specialised electrical traces, MRI and ultrasound scans will be identified. Features that can be seen on X-ray to guide doctors to these locations will then be identified. Secondly, the investigators will collect electrical information from the pacemaker wires and additional electrical traces to develop an algorithm that can make the interpretation the electrical traces more accurate.",[28,173],[263,256],"Challenges of conduction system pacing","2025-07-09",{"date":266,"type":37},"2025-07-14",{"date":268,"type":37},"2023-11-06",{"date":270,"type":22},"2026-11-06",{"name":250,"class":44},{"id":273,"slug":274,"hasResults":11,"nctId":275,"briefTitle":276,"officialTitle":276,"acronym":277,"eligibilityCriteria":278,"healthyVolunteers":279,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":280,"targetDuration":282,"studyType":197,"phases":4,"briefSummary":283,"conditions":284,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":5},"100522923","long-term-outcomes-of-conduction-system-pacing-a-national-multicenter-observational-study---normandhis--stimuhis-100522923","NCT06088927","Long-term Outcomes of Conduction System Pacing: a National Multicenter Observational Study - NORMAND'HIS \u002F STIMU'HIS","STIMU'HIS","Inclusion Criteria:\n\n* Patient who had undergone conduction system pacing attempt\n* Age \\> 18 yo\n* Capacity to understand the nature of the study, legal ability and willingness to give informed consent\n\nExclusion Criteria:\n\n* Patient under guardianship, trusteeship, or legal protection.\n* Pregnant woman (positive urine pregnancy test) or breastfeeding or lack of proven effective contraception (according to the WHO definition) or menopausal without confirmed diagnosis (non-medically induced amenorrhea for at least 12 months before the inclusion visit).",true,{"count":281,"type":22},2500,"2 Years","This prospective multicenter registry will evaluate the long-term electrical, echocardiographic, and clinical outcomes of conduction system pacing (CSP). There is currently limited data in the literature regarding the long-term results and benefits of CSP. The long-term maintenance of conduction system (His bundle or Left Bundle Branch) capture and physiological ventricular activation is an essential prerequisite for the expected benefits of this technique.\n\nThere is currently no prospective study evaluating the preservation of CSP during long-term follow-up. The design of the present study will allow reliable evaluation of CSP maintenance at 2 years follow-up. The prospective collection of electrical data (pacing thresholds, impedance, R wave sensing) during pacemaker follow-up visits will confirm thresholds stability over the long term. The incidence of atrial fibrillation episodes will also be precisely evaluated and will provide new information. Although pathophysiological studies have demonstrated less impairment of left atrial function with conduction system pacing, there is currently no data on the incidence of atrial fibrillation in patients implanted with a CSP pacemaker.\n\nEchocardiographic data will be prospectively collected in order to analyse the evolution of left ventricular ejection fraction (LVEF) after CSP. This systematic follow-up is rarely found in CSP studies, often retrospective, with significant missing echocardiographic data. The hypothesis is that patients benefiting from CSP will not develop the deleterious effects demonstrated with conventional right ventricular pacing, such as left ventricular dilation and LVEF impairment. Inter- and intraventricular asynchrony criteria will also be systematically evaluated during follow-up echocardiography.Finally, this prospective cohort will also systematically collect clinical follow-up data (hospitalizations for heart failure and NYHA stage).",[28],"2023-10-12",{"date":287,"type":37},"2023-10-18",{"date":289,"type":37},"2023-03-01",{"date":291,"type":22},"2028-03-31",{"name":293,"class":44},"University Hospital, Rouen"]