[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"congenital-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:congenital-disorders":23},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,69,93],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":16,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":26,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100491005","international-study-of-cerebral-oxygenation-and-electrical-activity-during-major-neonatal-surgery-100491005",false,"NCT05673499","International Study of Cerebral Oxygenation and Electrical Activity During Major Neonatal Surgery","Inclusion Criteria:\n\n1. Infants ≤ 60 weeks post-menstrual age on day of surgery.\n2. Neonatal surgery for congenital abdominal\u002Fgastrointestinal malformations (diaphragmatic hernia, gastroschisis, omphalocele, intestinal atresia, Hirschsprung's disease, imperforate anus, necrotizing enterocolitis), congenital cystic adenomatoid\u002Fpulmonary airway malformation (CCAM\u002FCPAM), esophageal\u002Ftracheoesophageal fistula (EF\u002FTEF), and spinal malformations (myelomeningocele, sacrococcygeal teratoma).\n3. The same patient may be enrolled multiple times for repeat or different procedures that meet the above criteria. These subjects will be counted more than once towards the enrollment goal.\n4. Parental\u002Fguardian permission.\n\nExclusion Criteria:\n\n1\\) Patients with hydrocephalus limiting frontal-parietal brain volume, interventricular hemorrhage (grades 3 or 4), malformation or cerebral infarction of frontal-parietal brain.","ALL","60 Weeks",{"count":18,"type":19},900,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to determine the incidence of perioperative cerebral desaturation in neonates undergoing surgery for congenital malformations. The main questions it aims to answer are:\n\n1. The perioperative factors associated with occurrence of cerebral desaturation\n2. The association between perioperative cerebral desaturation, perioperative\u002Fhospital outcomes, and physiological conditions.\n\nParticipants will undergo Near-infrared spectroscopy (NIRS) and electroencephalogram (EEG) monitoring for one hour before surgery, during surgery, and up to 24 hours after surgery.",[23,24,25],"Congenital Disorders","Cerebral Desaturation","Neonatal Surgery",[27,28],"Electroencephalography","Near-infrared spectroscopy","RECRUITING","2026-04-20",{"date":32,"type":33},"2026-04-23","ACTUAL",{"date":35,"type":33},"2022-08-12",{"date":37,"type":19},"2027-12-31",{"name":39,"class":40},"Children's Hospital of Philadelphia","OTHER",15,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":51,"minAge":4,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":68},"100393642","measuring-adverse-pregnancy-and-newborn-congenital-outcomes-100393642","NCT04405700","Measuring Adverse Pregnancy and Newborn Congenital Outcomes","Measuring Adverse Pregnancy and Newborn Congenital Outcomes: An IeDEA Collaboration Study","MANGO","C1. Prospective recruitment of HIV+ and HIV- pregnant women enrolling in ANC at the site:\n\nInclusion criteria for women\n\n1. Pregnant and enrolled in ANC at the study site;\n2. Understands English or Swahili.\n\nExclusion criteria for women a. Any physical or mental disability that prevents the woman from providing informed consent\n\nInclusion criteria for infants\n\na. All infants at any gestational age who are born to enrolled women will be included Exclusion criteria for infants (none)\n\nC2. Data collection for all deliveries at the site:\n\nInclusion criteria for women a. Woman delivers at the site and the delivery is registered at the site\n\nExclusion criteria for women (none)\n\nInclusion criteria for live\u002Fstillborn infants\n\na. Infant is delivered at the site and results in the infant\u002Fstillbirth being registered at the site\n\nExclusion criteria for infants (none)\n\nC3. Photos\u002Fvideos of infants with CAs:\n\nInclusion criteria for infants\n\n1. The infant is live or stillborn at ≥ 24 weeks estimated gestational age\n2. The infant has a suspected CA on surface exam\n\nExclusion criteria for infants (none)",true,"FEMALE",{"count":53,"type":19},2800,"The purpose of this study is to develop a pharmacovigilance (PV) surveillance program to monitor adverse pregnancy and infant outcomes, including the presence of congenital abnormalities, among HIV-positive and HIV-negative women and their infants at clinical sites affiliated with the International Epidemiology Databases to Evaluate consortium (IeDEA).",[56,57,23,58],"HIV\u002FAIDS","Pregnancy Related","Newborn Morbidity","2025-08-15",{"date":61,"type":33},"2025-08-19",{"date":63,"type":33},"2020-09-29",{"date":65,"type":19},"2026-05-31",{"name":67,"class":40},"Indiana University",1,{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":50,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":78,"conditions":79,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":68},"100496836","vaccinations-and-people-with-disabilities-100496836","NCT05749419","Vaccinations and People With Disabilities","Questionnaires and Focus Groups Based Quantitative & Qualitative Study of Vaccine Hesitancy and Confidence Among At-risk and Marginalized Populations: Persons With Special Needs, Intellectual Disabilities and Congenital Anomalies","Inclusion Criteria:\n\n• Diagnosed children with disabilities, chronic diseases or congenital anomalies\n\nExclusion Criteria:\n\n* Undiagnosed children\n* Inadequate filled out questionnaires",{"count":77,"type":19},1000,"The goal of this observational study is to learn about vaccinations hesitancy, delay or avoidance in children with chronic diseases, congenital anomalies or disabilities. The main questions it aims to answer are:\n\n• Attitudes of caregivers towards vaccinating their children, obstacles that postpone vaccinations, and the status of vaccinations of these children.\n\nParticipants will fill out questionnaires and some will be included in focused groups for the qualitative part of the study.\n\nResearchers will compare the vaccinations status of the research group to their siblings' status as well as the published national records of vaccination compliance.",[80,81,82,23,83],"Vaccine Refusal","Compliance, Patient","Disability, Intellectual","Pediatric Disorder","2025-04-01",{"date":86,"type":33},"2025-04-03",{"date":88,"type":33},"2023-07-01",{"date":90,"type":19},"2026-01",{"name":92,"class":40},"Hadassah Medical Organization",{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":15,"minAge":99,"maxAge":4,"enrollmentInfo":100,"targetDuration":102,"studyType":20,"phases":4,"briefSummary":103,"conditions":104,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":68},"100413244","study-of-late-foetal-human-organ-development-100413244","NCT04661059","Study of Late-foetal Human Organ Development","Inclusion Criteria:\n\n* ≥18 years old pregnant women who attend the Fetal Medicine Unit for concerns about a fetal abnormality where they decide to proceed to termination of pregnancy\n\nExclusion Criteria:\n\n* Screening labs positive for maternal HIV, Hepatitis B and Hepatitis C, Chlamydia and Herpes.\n* Subject unable to make an informed decision about termination of pregnancy.","18 Years",{"count":101,"type":19},2000,"20 Years","Knowledge about abnormal organ development is important to understand pathology and to develop novel treatment approaches for individuals with congenital and acquired disease. Most of our current understanding is based on examination of tissues from the embryo and early fetus, collected from women undergoing termination of pregnancy in the first trimester (third) of pregnancy. There is very little known about normal and abnormal organ development from a developmental perspective during the crucial last two-thirds of pregnancy when much remodelling of fetal tissues occurs. We aim to collect tissue from a variety of developing fetal organs in the last two-thirds of pregnancy from women who decide to undergo a termination of pregnancy and who wish to undergo a clinical fetal postmortem (PM) examination.",[23],"2023-12-04",{"date":107,"type":33},"2023-12-05",{"date":109,"type":33},"2022-02-03",{"date":111,"type":19},"2040-12-31",{"name":113,"class":40},"University College London Hospitals"]