[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"congenital-heart-defect\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:congenital-heart-defect":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,43,73,95,121,143,174],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100573047","cardiopediatric-home-monitoring-tool-100573047",false,"NCT06741189","Cardiopediatric Home Monitoring Tool","OSCAR","Inclusion Criteria:\n\n* Patients aged between 0 and 36 months inclusive\n* With a congenital heart defect\n* Underwent cardiac surgery at Nantes University Hospital\n* Affiliated to a social security scheme\n* Free, informed and written consent of the 2 holders of parental authority\n\nNon Inclusion Criteria:\n\n* Clinical or family situation contraindicating a return home\n* Physical inability to connect to the Exolis platform at home\n* Insufficient understanding on the part of those with parental authority\n* Extracardiac co-morbidities responsible for organ failure requiring repeated\n* Hospitalisation for non-cardiovascular reasons (e.g. severe renal failure, neurological neurological deficit, complex immune deficiency, etc).\n* Patient and\u002For parents under legal protection","ALL","0 Minutes","36 Months",{"count":20,"type":21},186,"ESTIMATED","INTERVENTIONAL",[24],"NA","We hypothesize that a home monitoring program combined with routine postoperative care significantly reduces morbidity and mortality after neonatal and pediatric cardiac surgery. This project differs from the previously published experiences by (a) providing an innovative telemedicine solution via the use of validated measurement sensors, (b) an alert system based on individualized standards, established for each care pathway, and (c) a protocolized response from medical teams in the management of alerts generated by the home monitoring tool.",[27],"Congenital Heart Defect",[29],"Congenital heart defects, cardiac surgery, care pathway, home monitoring, morbidity and mortality","RECRUITING","2026-06-23",{"date":33,"type":34},"2026-06-25","ACTUAL",{"date":36,"type":34},"2025-10-30",{"date":38,"type":21},"2028-07-30",{"name":40,"class":41},"Nantes University Hospital","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":54,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100228988","swiss-national-registry-of-adults-with-congenital-heart-disease-100228988","NCT02258724","Swiss National Registry of Adults With Congenital Heart Disease","Nationales Register Zur Erfassung Von Erwachsenen Mit Angeborenen Herzfehlern","SACHER","Inclusion Criteria:\n\nAdult (above 18 years of age) with congenital heart disease, treated in one of the Swiss centre with specialized organisation for GUCH patients.\n\nSigned informed consent. Patients with trisomy 21: the parents or legal guardian will have to give the consent.\n\nExclusion Criteria:\n\nNone","18 Years",{"count":53,"type":21},5000,"20 Years","OBSERVATIONAL","Due to successes in the last decades in pediatric heart surgery and cardiology, 90-95% of the children with congenital heart disease reach adult age.This results in an increasing number of adults or \"grown-ups\" with congenital heart disease (ACHD or GUCH patients) that require special health care organization and training programmes. Long term complications of these GUCH patients and optimum treatment strategies are still poorly known. The aim of this registry is to collect quantitative and qualitative data regarding GUCH patients treated in specialised centres in Switzerland.",[58,27],"Congenital Heart Disease",[60,61,62],"Adult","Registry","Grown-up congenital heart disease","2026-04-28",{"date":65,"type":34},"2026-05-04",{"date":67,"type":4},"2013-09",{"date":69,"type":21},"2033-12",{"name":71,"class":41},"University Hospital, Basel, Switzerland",6,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":51,"enrollmentInfo":79,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":42},"100585254","the-association-between-tau--gfap-and-postoperative-neurological-impairment-in-patients-undergoing-cardiac-surgery-100585254","NCT06899971","The Association Between Tau & GFAP and Postoperative Neurological Impairment in Patients Undergoing Cardiac Surgery","Inclusion Criteria:\n\n* less than 18 years old\n* undergoing cardiac surgery with cardiopulmonary bypass at Boston Children's Hospital\n\nExclusion Criteria:\n\n* undergoing an emergent procedure and do not have more than 1 hour ahead of time to review the consent\n* patient in a moribund condition American Society of Anesthesiology (ASA 5)\n* patient with a hematological and\u002For oncological disease\n* Jehovah witnesses\n* patient on preoperative mechanical ventilation",{"count":80,"type":21},100,"Patients born with heart defects often undergo surgical procedures on a heart lung machine. With improvements in medical and surgical management, their survival has significantly improved, but their brain insult has not been paid much attention. This study is to determine the relationship between specific proteins in the blood and brain injury in patients less than 18-year-old undergoing heart surgery.",[83,84,27],"Cardiac Surgery Requiring Cardiopulmonary Bypass","Brain Injury","NOT_YET_RECRUITING","2026-03-16",{"date":88,"type":34},"2026-03-17",{"date":90,"type":21},"2026-05-01",{"date":92,"type":21},"2027-12-31",{"name":94,"class":41},"Boston Children's Hospital",{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":16,"minAge":101,"maxAge":4,"enrollmentInfo":102,"targetDuration":4,"studyType":22,"phases":104,"briefSummary":105,"conditions":106,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":42},"100596198","aim-3-pilot-study-of-a-serious-game-to-promote-transition-readiness-skills-100596198","NCT07042334","Aim 3: Pilot Study of a Serious Game to Promote Transition Readiness Skills","Inclusion criteria:\n\n\\- Patient with congenital heart disease, their parent, and their clinician\n\nExclusion criteria:\n\n-Significant visual or cognitive impairment that would impede their ability to play the game and\u002For complete the study.","12 Years",{"count":103,"type":21},150,[24],"This study involves testing a new video game designed to support adolescents with congenital heart disease (CHD) in preparing to manage their health independently. The game aims to teach essential skills such as communicating with healthcare providers, understanding medical information, and managing appointments and medications. This small pilot study will evaluate the game's usability, acceptability, and its impact on participants' confidence and preparedness for managing their heart care. Feedback will be collected from adolescent participants, their parents, and healthcare providers, and the study will examine how the game influences communication during clinical visits.",[107,108,109,27,110,111],"Serious Games","Transition-age Youth","Transition to Adult Care","Congenital Heart Disease in Adolescence","Patient Centered Care","2026-02-20",{"date":114,"type":34},"2026-02-24",{"date":116,"type":34},"2026-01-22",{"date":118,"type":21},"2026-08",{"name":120,"class":41},"University of Utah",{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":4,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":129,"conditions":130,"keywords":132,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":42},"100561304","clinical-readiness-skin-punch-biopsy-sample-collections-100561304","NCT06588426","Clinical Readiness Skin Punch Biopsy Sample Collections","Clinical Readiness Skin Punch Biopsy Sample Collection","Inclusion Criteria:\n\n* Age 18 and older\n* Congenital heart disease\n* Likely to qualify for an active clinical trial under IND 28611 in the future\n\nExclusion Criteria:\n\n* Previous cardiac transplantation\n* Unable or unwilling to consent\n* HIV diagnosis\n* Hepatitis diagnosis",{"count":80,"type":21},"This is a clinical readiness skin punch biopsy sample collection study. This will allow to reduce manufacturing time when patients are identified as eligible to receive product under separate interventional treatment protocol.",[131,27],"Congenital Heart Disease (CHD)",[133,27],"CHD","2025-06-23",{"date":136,"type":34},"2025-06-25",{"date":138,"type":34},"2024-09-13",{"date":140,"type":21},"2027-07",{"name":142,"class":41},"HeartWorks, Inc.",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":11,"sex":16,"minAge":150,"maxAge":151,"enrollmentInfo":152,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":153,"conditions":154,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":42},"100370678","nirs-in-congenital-heart-defects---correlation-with-echocardiography-100370678","NCT04106479","NIRS in Congenital Heart Defects - Correlation With Echocardiography","Do Cerebral and Renal Saturations Measured With Near-infrared Spectroscopy Correlate With Echocardiographic Markers of Perfusion and Cardiac Performance in Congenital Heart Disease?","Inclusion Criteria:\n\nA prospective study will be conducted of all newborns with tetralogy of fallot, trucus arteriosus, D-transposition of great arteries, PS, AS, coarctation of the aorta, DILV, AVC, DORV, HLHS, TA and PAIVS consecutively admitted at our institution (Montreal Children's Hospital) neonatal intensive care unit (NICU) from January 2018 to January 2020. Patients with CHD will be compared to a control population of term infants admitted and monitored in the NICU with antenatal suspicion of coarctation, ruled-out postnatally.\n\nExclusion Criteria:\n\nPatients will be excluded if premature less than 34 weeks of estimated gestational age (GA) at birth or if parents do not consent. Parental consent can be withdrawn at any time during the study.","0 Days","7 Days",{"count":80,"type":21},"Neonatal patients with congenital heart defects (CHD) have changing physiology in the context of transitional period. Patients with CHD are at risk of low perfusion status or abnormal pulmonary blood flow. Near infrared spectroscopy has been used in neonatal intensive care units (NICU) to measure end-organ perfusion. The investigator plan on monitoring newborns with CHD admitted to the NICU with NIRS and echocardiography during the first week of life and correlate measures of perfusion from Dopplers to cerebral and renal NIRS.",[27,155,156,157,158,159,160,161,162,163,164],"Single-ventricle","Coarctation of Aorta","Atrioventricular Canal","Hypoplastic Left Heart","Transposition of Great Vessels","Interrupted Aortic Arch","Tricuspid Atresia","Pulmonary Atresia","Aortic Atresia","Tetralogy of Fallot","2025-06-12",{"date":167,"type":34},"2025-06-17",{"date":169,"type":34},"2019-10-11",{"date":171,"type":21},"2025-12-01",{"name":173,"class":41},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre",{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":4,"eligibilityCriteria":180,"healthyVolunteers":181,"sex":182,"minAge":51,"maxAge":4,"enrollmentInfo":183,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":185,"conditions":186,"keywords":188,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":5},"100492909","automated-fetal-cardiac-function-in-babies-affected-by-heart-diseases-100492909","NCT05698277","Automated Fetal Cardiac Function in Babies Affected by Heart Diseases","Automated Fetal Cardiac Function Parameters in Congenital Heart Disease","Inclusion Criteria:\n\n* Inclusion criteria for the CHD Group are as follows: singleton pregnancies; gestational age between 19+6 and 36+6 weeks gestation, determined by the last menstrual period and confirmed by first trimester ultrasound; isolated congenital cardiac anomaly diagnosed.\n* Inclusion criteria for the Control Group are as follows: singleton pregnancies; gestational age between 19+6 and 27+6 weeks gestation, determined by the last menstrual period and confirmed by first trimester ultrasound; no congenital cardiac anomaly diagnosed\n\nExclusion Criteria common to the 2 groups (Cases and Controls):\n\n* Fetuses whose mothers have comorbidities that have been proven to potentially affect cardiac function including:\n\n  * intrahepatic cholestasis\n  * pre-gestational and gestational diabetes\n  * preeclampsia\n  * growth restricted fetuses defined as estimated fetal weight or abdominal circumference \\\u003C3rd percentile for GA\n* Fetuses with other structural extracardiac anomalies at ultrasound examination\n* Fetuses affected by any diagnosed genetic abnormalities",true,"FEMALE",{"count":184,"type":21},495,"The goal of this international multicentre prospective observational cohort study with a nested case-control study is to test some automated fetal heart functional parameters in healthy babies compared to those affected by a congenital heart condition.\n\nThe main questions it aims to answer are:\n\n* If there is a significant difference between the two populations of infants\n* Whether these parameters could significantly improve the predictive value of actual cardiovascular profile score to predict hydrops Participants will be offered two automated cardiac function assessments between 27+6 and 29+6 gestational weeks and between 34+6 and 36+6 weeks of gestation. Functional parameters will be compared between the two study groups and evaluated over time.",[27,187],"Cardiac Function",[189,190],"Congenital Heart Diseases","Fetal Cardiac Function","2024-12-09",{"date":193,"type":34},"2024-12-10",{"date":195,"type":34},"2023-05-01",{"date":197,"type":21},"2028-02-01",{"name":199,"class":41},"Anna Erenbourg"]