[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"congenital-pulmonary-airway-malformation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:congenital-pulmonary-airway-malformation":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100539372","atomized-inhalation-icg-for-treatment-of-congenital-lung-malformations-100539372",false,"NCT06302985","Atomized Inhalation ICG for Treatment of Congenital Lung Malformations","Application of Atomized Inhalation ICG in Thoracoscopic Surgery for Pulmonary Sequestration in Children: a Multicentre Prospective Study","Inclusion Criteria:\n\n* children with congenital lung malformations diagnosed by CT or MRI scan\n\nExclusion Criteria:\n\n* 1\\. ages \\\u003C3 months and \\>14 years 2. complicated other life-threatening disease; 3. complicated severely pulmonary infection","ALL","3 Months","14 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","To investigate the safety and effectiveness of preoperative aerosol inhalation ICG solution for thoracoscopic accurate resection of congenital lung malformations in children.",[27,28,29,30,31],"Pulmonary Sequestration","Congenital Pulmonary Airway Malformation","Indocyanine Green","Thoracoscopic Surgery","Children","RECRUITING","2024-10-13",{"date":35,"type":36},"2024-10-16","ACTUAL",{"date":38,"type":36},"2024-03-01",{"date":40,"type":21},"2050-12-31",{"name":42,"class":43},"Jiexiong Feng","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":5},"100493158","the-collaborative-neonatal-network-for-the-first-cpam-trial-100493158","NCT05701514","The COllaborative Neonatal Network for the First CPAM Trial","The COllaborative Neonatal Network for the First Congenital Pulmonary Airway Malformation (CPAM) Trial","CONNECT","Inclusion Criteria:\n\n* Lesion detected during routine prenatal ultrasound screening\n* Delivery at term: gestational age ≥37 weeks\n* Birthweight \\> -2SD or \\>P10\n* Asymptomatic at birth defined as no prolonged respiratory distress or oxygen support (\\\u003C 24 hours)\n* Asymptomatic up to the moment of inclusion\n* Confirmation of CPAM on postnatal chest CT-scan at 3-9 months of age, according to structured report form (34)\n* Unilateral lesion occupying no more than one lung lobe as assessed on chest CT-scan at 3-9 months of age\n\nExclusion Criteria:\n\n* Bilateral lesion\n* Development of symptoms before randomization, considered by treating physician as caused by CPAM with reasonable certainty\n* Complicated pregnancy defined as (pre-)eclampsia, pregnancy diabetes in mother, foetal hydrops or severe polyhydramnios on prenatal ultrasound\n* Syndrome associated anomalies on genetic analysis confirmed by genetic expert\n* Major associated malformations. Anomalies include cardiac malformations requiring surgical correction or follow-up by a paediatric cardiologist, congenital malformations requiring major surgical intervention, and anomalies that affect normal lung growth and development.\n* Suspicion of malignancy on chest CT scan evaluation at the age of 3-9 months\n* Participation in another randomised controlled trial","1 Month","1 Year",{"count":56,"type":21},176,[24],"The goal of this clinical trial is to compare conservative wait-and-see management to elective surgical intervention, in asymptomatic Congenital Pulmonary Airway Malformation (CPAM) children.\n\nChildren assigned to the intervention group will undergo surgical resection of the CPAM between 6 and 9 months of age. Children assigned to the control group will be monitored conservatively. The follow-up scheme will be uniform for both treatment groups and last for 5 years.\n\nThe primary outcome is the difference in maximal endurance at five years of age between the surgical and conservative group. Secondary outcome measures are molecular genetic diagnostics, validated questionnaires - on parental anxiety, quality of life and health care consumption -, repeated imaging, and pulmonary morbidity during follow-up, as well as surgical complications and histopathology.",[28],[61,62,63,64],"Asymptomatic CPAM","Optimal management","Conservative vs surgical","Randomized",{"date":66,"type":36},"2024-03-04",{"date":68,"type":36},"2023-01-01",{"date":70,"type":21},"2030-12-31",{"name":72,"class":43},"Erasmus Medical Center"]