[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"congestion-venous\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:congestion-venous":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,54,87,114,144],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100634598","training-medical-residents-in-the-use-of-the-venous-excess-ultrasound-vexus-score-for-bedside-volume-assessment-100634598",false,"NCT07541768","Training Medical Residents in the Use of the Venous Excess UltraSound (VExUS) Score for Bedside Volume Assessment.","Training Medical Residents in the Use of the Venous Excess UltraSound (VExUS) Score for Bedside Volume Assessment: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Medical residents in general internal medicine\n* Basic ultrasound skills (POCUS component 1 or ≥200 scans)\n* Working at study site during study period\n\nExclusion Criteria:\n\n* SGUM certification in abdominal ultrasound\n* Advanced duplex ultrasound experience\n* Prior vascular\u002Fduplex training",true,"ALL",{"count":19,"type":20},23,"ESTIMATED","INTERVENTIONAL",[23],"NA","This randomized controlled trial evaluates the effectiveness of two training approaches (in-person versus remote) for teaching medical residents to apply the Venous Excess Ultrasound (VExUS) score for bedside volume assessment in patients with acute heart failure. Resident performance will be compared to that of expert physicians certified in abdominal and duplex sonography.",[26,27,28,29],"Acute Heart Failure (AHF)","Fluid Over-load","Congestion","Congestion, Venous",[31,32,33,34,35,36,37,38,39,40],"Vexus","Venous Excess Ultrasound","Point-of-Care Ultrasound","POCUS","Ultrasound Training","Medical Education","Volume Assessment","Venous Congestion","Duplex Ultrasound","Bedside Ultrasound","RECRUITING","2026-04-16",{"date":44,"type":45},"2026-04-21","ACTUAL",{"date":47,"type":45},"2026-03-20",{"date":49,"type":20},"2026-12-31",{"name":51,"class":52},"Insel Gruppe AG, University Hospital Bern","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":63,"targetDuration":4,"studyType":21,"phases":65,"briefSummary":66,"conditions":67,"keywords":71,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":53},"100598921","natriuresis-guided-depletion-after-cardiac-surgery-100598921","NCT07077772","Natriuresis-guided Depletion After Cardiac Surgery","Evaluation of Natriuresis-guided Depletion After Cardiac Surgery: a Monocentric, Open-label, Randomized Controlled Trial","EASY-CS","Inclusion Criteria:\n\n* Adult patient (age \\> 18 years)\n* Scheduled for cardiac surgery, including mitral valve repair or replacement, aortic valve replacement, coronary artery bypass grafting (CABG), ascending aortic repair, or combined procedures\n* Undergoing surgery with cardiopulmonary bypass (CPB)\n* Eligible to receive intravenous furosemide for fluid overload within 48 hours following surgery, as prescribed by the referring physician\n* Written and oral informed consent obtained\n* Covered by the French national health insurance (Sécurité Sociale)\n\nExclusion Criteria:\n\n* Aortic arch repair requiring deep hypothermic circulatory arrest\n* Active endocarditis\n* Hemodynamic instability requiring vasopressor or inotropic support (norepinephrine, dobutamine, epinephrine, or vasopressin)\n* Failure to wean from CPB requiring mechanical circulatory support\n* Chronic kidney disease with an estimated glomerular filtration rate (eGFR) \\\u003C 60 mL\u002Fmin\n* Chronic use of loop diuretics\n* Known allergy to furosemide\n* Active postoperative bleeding and\u002For reoperation for bleeding\n* Participation in another interventional study that may affect the primary outcome measure\n* Patient deprived of liberty by administrative or judicial decision, or placed under legal protection (guardianship or curatorship)","18 Years",{"count":64,"type":20},102,[23],"Fluid overload (FO) is a common complication after cardiac surgery, associated with increased morbidity and mortality. Loop diuretics, especially furosemide, are routinely used to manage FO, but their use is often empirical. Recent data suggest that natriuresis-guided furosemide titration using point-of-care urinary sodium sensors (LAQUAtwin NA-11, Horiba) may improve the efficiency and safety of fluid removal, but no randomized trial has yet evaluated this approach in postoperative cardiac surgery patients\n\nOur goal is to assess the clinical impact, safety, and feasibility of a natriuresis-guided furosemide protocol after cardiac surgery requiring cardiopulmonary bypass.",[68,69,29,70,27],"Cardiac Surgery","Diuresis","Sodium Depletion",[72,73,74,75,76,77],"natriuresis","fluid overload","cardiac surgery","furosemide","venous congestion","loop diuretics","2026-01-19",{"date":80,"type":45},"2026-01-21",{"date":82,"type":45},"2025-06-25",{"date":84,"type":20},"2027-10",{"name":86,"class":52},"Centre Hospitalier Universitaire, Amiens",{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":94,"targetDuration":4,"studyType":21,"phases":96,"briefSummary":97,"conditions":98,"keywords":99,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":113},"100600622","simple-urine-composition-based-personalized-algorithm-for-effective-congestion-relief-in-decompensated-heart-failure-100600622","NCT07099885","Simple Urine Composition-based Personalized Algorithm for Effective Congestion Relief in Decompensated Heart Failure","SAFER-DHF","Inclusion Criteria:\n\n* Adult patients over 18 years of age who provide informed consent\n* Ability to enroll in the study within the first 24 hours of hospitalization\n* Primary reason for hospitalization is acute heart failure with signs of congestion (at least moderate lower extremity edema)\n* NT-proBNP \\> 1500 pg\u002Fml\n* Anticipated need for diuretic therapy for at least 48 hours from the time of study enrollment\n\nExclusion Criteria:\n\n* End-stage kidney disease requiring renal replacement therapy\n* Hemodynamic instability requiring inotropic support\n* Active infection requiring intravenous antibiotic therapy",{"count":95,"type":20},90,[23],"The aim of this study is to evaluate the effectiveness of loop diuretic adaptative algorithm that is based on machine learning, urine output prediction tool, in decongestion of acute heart failure patients.\n\nA total of 90 patients will be enrolled in the study. Of these, 45 will be assigned to the algorithm-based intervention group, while the remaining 45 will serve as the control group. In the control group, all decisions regarding diuretic therapy will be made solely by the attending physician, without the use of the algorithm.\n\nPatients will receive intravenous furosemide, with the initial dose determined by the attending physician. Two hours after administration of the diuretic, a spot urine sample will be collected to measure sodium and creatinine concentrations. Based on these values, the 6-hour urine output will be estimated using the machine learning, urine output prediction tool (http:\u002F\u002Fdiuresis.umw.edu.pl). This estimate will guide the diuretic therapy plan for the first 24 hours of hospitalization. On the second day, the procedure will be repeated using the same methodology.",[26,29],[100,101,102,103],"decongestion","diuretics","algorithm","acute heart failure","2025-08-06",{"date":106,"type":45},"2025-08-12",{"date":108,"type":45},"2025-08-01",{"date":110,"type":20},"2027-01-31",{"name":112,"class":52},"Wroclaw Medical University",2,{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":122,"targetDuration":124,"studyType":125,"phases":4,"briefSummary":126,"conditions":127,"keywords":130,"overallStatus":134,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":53},"100589776","evolution-of-tissue-perfusion-and-venous-congestion-markers-in-fluid-responsive-septic-shock-patients-100589776","NCT06958809","Evolution of Tissue Perfusion and Venous Congestion Markers in Fluid-Responsive Septic Shock Patients","Evolution of Tissue Perfusion and Venous Congestion Markers in Fluid-Responsive Septic Shock Patients: Evaluating the Benefit-Risk Balance of Fluid Resuscitation","FLUID-IMPACT","Inclusion Criteria:\n\n* Septic shock (sepsis-3 criteria)\n* Under mechanical ventilation\n* Central venous catheter in the superior vena cava territory and arterial catheter in place\n* Response to fluid resuscitation as per standard definition (i.e., an increase in cardiac output \\>10% assessed by subaortic velocity time integral \\[VTI\\] using echocardiography)\n\nExclusion Criteria:\n\n* Patient under 18 years of age\n* Lack of social security coverage \u002F adult under legal protection\n* Pregnant woman\n* Inability to obtain non-opposition consent",{"count":123,"type":20},200,"28 Days","OBSERVATIONAL","Septic shock remains a leading cause of mortality in intensive care, and while fluid resuscitation (FR) is a cornerstone of early management, its benefit-risk balance is highly variable. Excessive fluid administration can cause venous congestion and organ dysfunction, while insufficient resuscitation risks hypoperfusion. Current strategies often rely on fluid responsiveness (i.e., increased cardiac output after fluids), but this does not guarantee improved outcomes, particularly if congestion ensues.\n\nThis prospective, multicenter, observational study aims to assess the clinical impact of FR in septic shock patients who are fluid responsive. The primary objective is to evaluate changes in tissue perfusion and venous congestion markers following FR. Patients will be categorized into four response profiles based on the presence or absence of perfusion improvement and congestion worsening.\n\nSecondary objectives include exploring the prognostic implications of each profile (organ dysfunction, mortality), identifying pre-FR predictors of adverse responses, evaluating changes in congestion markers after passive leg raising (PLR), and performing phenotypic clustering and mediation analyses.\n\nEligible patients are adults with septic shock requiring vasopressors and mechanical ventilation, with confirmed fluid responsiveness via echocardiography. Each patient will undergo standardized pre- and post-FR assessments, including cardiac ultrasound, Doppler of hepatic\u002Fportal veins (VeXUS), CVP, perfusion markers, and blood gases.\n\nData on SOFA scores, organ support duration, and 28-day mortality will be collected. Approximately 170 patients will be enrolled across five ICUs experienced in advanced hemodynamic monitoring. Statistical analyses will include multivariate modeling, clustering, ROC curves, and mediation analyses.\n\nBy identifying phenotypes of fluid-responsive but fluid-intolerant patients, the study aims to refine fluid management strategies and improve outcomes through more personalized care in septic shock.",[128,129,29],"Septic Shock","Fluid Resuscitation",[131,132,76,133],"septic shock","fluid resuscitation","tissue perfusion","NOT_YET_RECRUITING","2025-04-25",{"date":137,"type":45},"2025-05-06",{"date":139,"type":20},"2026-02-01",{"date":141,"type":20},"2027-08-01",{"name":143,"class":52},"Hospital Ambroise Paré Paris",{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":150,"eligibilityCriteria":151,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":125,"phases":4,"briefSummary":154,"conditions":155,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":53},"100586358","hepatic-doppler-to-assess-venous-congestion-during-invasive-mechanical-ventilation-dohecov-100586358","NCT06914336","Hepatic Doppler to Assess Venous Congestion During Invasive Mechanical Ventilation (DOHECOV)","Hepatic Doppler to Assess Venous Congestion During Invasive Mechanical Ventilation","DOHECOV","Inclusion Criteria:\n\n* intubated for more than 24 hours\n\nExclusion Criteria:\n\n* Chronic end-stage renal disease on admission\n* Atrial Fibrillation\n* Cirrhosis\n* Portal thrombosis\n* Refusal to participate\n* non-opposition could not be obtained from themselves or their trusted support person in the event of incapacity\n* Under legal protection.",{"count":153,"type":20},100,"The purpose of the study is to investigate venous congestion using hepatic vein doppler for ICU patients with invasive mechanical ventilastion. The primary outcome is the systolic to diastolic hepatic vein velocity ratio S\u002FD . The objective is to find a significant association between S\u002FD and different congestion indicators.",[29],"2025-04-04",{"date":158,"type":45},"2025-04-06",{"date":160,"type":45},"2025-03-24",{"date":162,"type":20},"2028-10-31",{"name":164,"class":52},"University Hospital, Brest"]