[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"conjunctival-diseases\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:conjunctival-diseases":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100313324","three-dimensional-analysis-of-emmprin-on-conjunctival-epithelial-cells-surface-in-severe-dry-eye-syndrome-altesse-100313324",false,"NCT03358979","Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE)","ALTESSE","Patients:\n\nInclusion criteria\n\n* 18 years and over\n* Severe eye dryness (grade 3 or 4) as defined by the International Dry Eye Work Shop (2007): Frequent symptoms, Impregnation of fluorescein at the conjunctival level, marked fluorescein staining at the corneal level, Tear Break Up Time ≤ 5 seconds (fluorescein test) Schirmer's test score without anesthesia ≤ 5mm at 5 minutes\n* Patients without eye treatment or patients undergoing long-term stable eye treatment for whom a new treatment is being introduced\n\nExclusion criteria - Known pregnancy or breastfeeding\n\nControl subjects:\n\nInclusion criteria\n\n\\- 18 years and over\n\nExclusion criteria\n\n* Wearer of contact lenses\n* Topical ocular treatment\n* Known pregnancy or breastfeeding","ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","OBSERVATIONAL","Modifications of cell surface markers (including EMMPRIN) were observed in conjunctival epithelial cells during dry eye syndrome ; this study aims to describe the modifications of the repartition of these cell surface markers before and after initiation of a treatment.",[24,25],"Conjunctival Diseases","Dry Eye Syndromes",[24,25,27,28],"Antigens","CD147","RECRUITING","2025-12-02",{"date":32,"type":33},"2025-12-08","ACTUAL",{"date":35,"type":33},"2017-12-14",{"date":37,"type":20},"2027-03",{"name":39,"class":40},"Fondation Ophtalmologique Adolphe de Rothschild","NETWORK"]