[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"connective-tissue-defect\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:connective-tissue-defect":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100626575","a-novel-volume-stable-matrix-for-gingival-recession-coverage-at-teeth-100626575",false,"NCT07437417","A Novel Volume Stable Matrix for Gingival Recession Coverage at Teeth","Assessment of Connective Tissue Graft vs. a New Collagen Matrix for Periodontal Tissue Thickening and Coverage of Single or Multiple Adjacent Gingival Recessions of Orthodontically Treated Patients. A Randomized Clinical Trial","FibroGide","Inclusion Criteria:\n\n* Written informed consent\n* Healthy patients referred to the clinic for recession coverage\n* Miller Class I, II or III facial gingival recession (GR) defect, \\>3 mm, located on the buccal of the maxillary or mandibular canine and incisor area.\n\nExclusion Criteria:\n\n* History of diseases with hypocoagulability, instable diabetes mellitus, post-irradiation in the head and neck area, infectious diseases or heart diseases that need prophylactic antibiosis before dental treatments or a medication with effect on the gingiva: Ciclosporin A, compounds of Phenytoin, calcium channel blockers, pregnant or breastfeeding patients",true,"ALL","18 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","Periodontal health and preservation of the dentition without tooth loss are important quality of life components and should be safeguarded in order to provide optimal function and esthetics. Optimal treatment of gingiva recessions is likely to allow for more efficient use of healthcare resources and reduced costs long-term. It is evident that the prevalence in gingival recession is high and its consequences on the aging population constitute an important healthcare issue that requires further attention. The standard therapy of gingival recession encompasses a coronally advanced flap or coronally advanced tunnel flap and a connective tissue graft from the palate. Harvesting of the palatal graft involves a second surgical site and increased morbidity for the patients.This project aims to compare the connective tissue graft against a novel volume stable collagen matrix.\n\nPatients will be treated according to standard protocols of the Department of Periodontology. In the test group patient will undergo tissue thickening with a collagen matrix and the modified coronally advanced tunnel technique. The control group will undergo the standard protocol using a connective tissue graft from the palate along with the modified coronally advanced tunnel technique. No study specific risks do exist.",[28,29],"Gingival Recession","Connective Tissue Defect",[31,32,33],"Connective tissue graft","Collagen Matrix","single and multiple gingival recessions","RECRUITING","2026-02-23",{"date":37,"type":38},"2026-02-27","ACTUAL",{"date":40,"type":38},"2025-09-01",{"date":42,"type":22},"2030-08-01",{"name":44,"class":45},"University of Bern","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":46},"100494209","aortic-stiffness-in-patients-with-genetic-aortopathies-100494209","NCT05715203","Aortic Stiffness in Patients With Genetic Aortopathies","Aortic Stiffness in Patients With Genetic Aortopathies: Intervention Analysis","PULSEWAVE","Inclusion Criteria:\n\n* Subjects with AAT, either syndromic or non syndromic;\n* Signed informed consent\n\nExclusion Criteria:\n\n* Patients with early menopause and\u002For osteoporosis, rheumatic heart disease and active malignant tumours;\n* Patients with acute and chronic inflammatory conditions such as: chronic liver disease, chronic renal insufficiency and diseases affecting the thyroid system;\n* Seropositivity to HIV, HCV, HBsAg and SARS-CoV-2;\n* Pregnancy",{"count":56,"type":22},250,"OBSERVATIONAL","The goal of this observational study is to study arterial stiffness in patients with thoracic ascending aortic aneurysms (TAA), either syndromic or non-syndromic. The main questions it aims to answer are:\n\n* Stratification of aortic risk based on arterial stiffness; Compare measurements with morphological and haemodynamic features of the ascending thoracic aorta.\n\nParticipants will be asked to undergo non-invasive evaluation of blood pressure and arterial stiffness.",[60,61,29],"Rare Diseases","Aortic Stiffness",[63,64,65],"arterial stiffness","Ascending aortic aneurysm","pulse wave velocity","2025-09-08",{"date":68,"type":38},"2025-09-10",{"date":70,"type":38},"2023-02-15",{"date":72,"type":22},"2025-12-31",{"name":74,"class":45},"IRCCS Policlinico S. Donato"]