[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"connective-tissue-graft\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:connective-tissue-graft":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,46,68,108,141,168,190],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100641906","evaluation-of-multilayered-prf-in-comparison-with-connective-tissue-graft-by-sohn-ponchos-technique-on-peri-implant-mucosal-enhancement-in-the-esthetic-zone-100641906",false,"NCT07649239","Evaluation of Multilayered PRF in Comparison With Connective Tissue Graft by Sohn Poncho's Technique on Peri-implant Mucosal Enhancement in the Esthetic Zone","Evaluation of Multilayered PRF in Comparison With Connective Tissue Graft by Sohn Poncho's Technique on Peri-implant Mucosal Enhancement in the Esthetic Zone. A Randomized Clinical Trial","-Inclusion Criteria: Patients with single bounded missing tooth in the esthetic zone Patients in the age group of 21-65 years Patients having good oral hygiene (mean plaque score of \\\u003C 25%) and with stable periodontal status.\n\n-Exclusion Criteria: Smokers patients Patients with poor maintenance of oral hygiene, as determined by a mean plaque score of ≥ 25% despite efforts by the clinician to improve oral hygiene maintenance.\n\nPatients with medically compromised conditions like uncontrolled diabetes mellitus or any systemic diseases that may result in compromised hard and soft tissue healing.",true,"ALL","20 Years","70 Years",{"count":21,"type":22},26,"ESTIMATED","INTERVENTIONAL",[25],"NA","An effective biological seal is crucial for protecting and supporting dental implants, particularly in the anterior region for the desired esthetic outcome.PRF membrane and CTG has been utilized to improve peri-implant soft tissue thickness and increase the width of keratinized tissue around dental implants. The stability of the PRF membrane is maintained by securing it with the healing abutment of the implant. While a few longitudinal studies have assessed the benefits of using PRF membrane with Sohn's Poncho technique in the posterior region, its effectiveness in the anterior region of the mouth remains to be evaluated.",[28,29,30,31,32],"Soft Tissue","Peri-Implant Health","Soft Tissue Augmentation at Dental Implants","Connective Tissue Graft","PRF","RECRUITING","2026-06-12",{"date":36,"type":37},"2026-06-16","ACTUAL",{"date":39,"type":37},"2026-01-10",{"date":41,"type":22},"2027-02-01",{"name":43,"class":44},"Gulf Medical University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":16,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":45},"100541881","volumetric-dimensional-changes-after-surgical-pontic-site-development-procedures-with-connective-tissue-graft-or-collagen-matrix-100541881","NCT06335628","Volumetric Dimensional Changes After Surgical Pontic Site Development Procedures With Connective Tissue Graft or Collagen Matrix","Inclusion Criteria:\n\n* Informed Consent signed by the subject\n* Age ≥ 18 years\n* Willingness to sign informed consent and to participate in the study\n* Single tooth gap or extended edentulous space in the lower or posterior jaw including a pontic site with a soft tissue deficiency.\n* Tooth gap of ≥ 8 mm.\n* Presence of natural or artificial opposing dentition\n* Sufficient vertical interocclusal space of an implant restoration (7mm)\n* Bounded by natural and periodontally stable teeth\n* Treatment plan must include tooth replacement with an implant or tooth-supported fixed dental prosthesis.\n\nExclusion Criteria:\n\n* Any physical or mental disorder that would interfere with the ability to perform adequate oral hygiene or the capability of providing written informed consent and compliance with the protocol\n* Severe bruxism, clenching habits, or presence of oro-facial pain\n* Uncontrolled diabetes mellitus (HbA1c \\>7.0)\n* Clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc.)\n* Any active oral or systemic acute infections\n* Currently receiving chemo- or radiotherapy or a history of radiotherapy in the head and neck area\n* Severe hematologic disorders\n* Any other diseases or medications that may compromise normal wound healing\n* Pregnancy or nursing mother\n* Contraindications and limitations of the MD as described in the instructions for use: during pregnancy or lactation, children, presence of acute infection in the surgical area, patients with known sensitivity to porcine material or collagen allergies.\n* Vulnerable subjects\n* Known or suspected non-compliance\n* Drug or alcohol abuse\n* Inability to follow the procedures of the investigation, e.g. due to language problems, psychological disorders, dementia, etc.\n* Participation in another investigation with an investigational drug or another MD within the 30 days preceding and during the present investigation,\n* Enrolment of the PI, his\u002Fher family members, employees and other dependent persons","18 Years",{"count":54,"type":22},38,[25],"The aim of this research project is to compare two surgical procedures to improve soft tissue volume. Both procedures have already been validated, but despite their great clinical relevance, little data exists in the literature. With this study, the investigators aim to evaluate volumetric changes of connective tissue graft versus biomaterial (membrane). In addition, further clinical measurements will be taken and patient satisfaction will be assessed.",[31,58],"Volume Collagen Matrix Xenograft","2026-05-26",{"date":61,"type":37},"2026-05-27",{"date":63,"type":37},"2024-08-28",{"date":65,"type":22},"2030-04",{"name":67,"class":44},"University of Bern",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":16,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":23,"phases":78,"briefSummary":79,"conditions":80,"keywords":84,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":45},"100634082","pontic-site-development-with-or-without-fixed-partial-denture-100634082","NCT07535060","Pontic Site Development With or Without Fixed Partial Denture","Clinical and Volumetric Evaluation of Soft Tissue Augmentation Using Connective Tissue Graft (CTG) in Pontic Site Defects With and Without Fixed Partial Dentures. A Non-randomized Clinical Trial.","Pontic Site","Inclusion Criteria:\n\n* Patients will on missing tooth in the esthetic zone (2nd premolar to 2nd premolar), missing at least 3 months prior to recruitment, with or without FPD\n* Systemically free patient\n* ≥18 years of age\n* Intact gingival tissue with at least 2mm keratinized tissue in adjacent teeth\n* Patients accept to provide informed consent\n\nExclusion Criteria:\n\n* Smokers.\n* Pregnancy and lactation\n* Periodontitis\n* Severe gagging reflex\n* Handicapped and mentally challenged patients\n* Active soft tissue infection",{"count":77,"type":22},20,[25],"This study aims to evaluate the effectiveness of soft tissue augmentation using connective tissue graft (CTG) in pontic site defects. It compares clinical and volumetric outcomes between sites with an existing fixed partial denture (FDP) and sites without an FDP.\n\nFollowing tooth extraction, alveolar ridge resorption often leads to soft tissue defects that can compromise esthetics, function, and prosthetic outcomes. CTG is considered the gold standard for soft tissue augmentation due to its predictable improvement in tissue thickness and stability.\n\nIn this non-randomized clinical trial, patients with single edentulous sites in the esthetic zone will undergo CTG using a standardized surgical technique. The primary outcome is keratinized tissue thickness, while secondary outcomes include keratinized tissue width, volumetric soft tissue changes, esthetic evaluation (Pink Esthetic Score), plaque index, post-operative pain, and patient satisfaction.\n\nClinical and digital assessments will be conducted preoperatively and at follow-up intervals up to 6 months. The study aims to determine whether performing CTG around an existing bridge provides comparable or improved outcomes compared to sites without a bridge, potentially offering a less invasive alternative to prosthetic replacement.",[81,82,83,31],"Mucogingival Defects","Pontic Site Development","Keratinized Tissue Deficiency",[85,86,82,87,88,89,90,91,92,93,94,95,96,97,98],"Connective Tissue Graft (CTG)","Soft Tissue Augmentation","Alveolar Ridge Defects","Fixed Partial Denture (FDP)","Ridge Augmentation","Periodontal Plastic Surgery","Keratinized Tissue Thickness","Keratinized Tissue Width","Esthetic Outcome","Pink Esthetic Score (PES)","Volumetric Soft Tissue Analysis","Dental Prosthetics","Edentulous Ridge","Non-Randomized Clinical Trial","2026-04-27",{"date":101,"type":37},"2026-05-01",{"date":103,"type":37},"2025-10-06",{"date":105,"type":22},"2027-06-01",{"name":107,"class":44},"Cairo University",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":17,"minAge":116,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":23,"phases":119,"briefSummary":120,"conditions":121,"keywords":125,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":4},"100624888","immediate-implants-in-front-teeth-with-bone-loss-regeneration-and-temporary-crown-in-a-randomized-clinical-study-100624888","NCT07415486","Immediate Implants in Front Teeth With Bone Loss: Regeneration and Temporary Crown in a Randomized Clinical Study","Immediate Implant Placement in Buccal Dehiscence Aesthetic Sites With Simultaneous Regeneration and Immediate Provisionalization: a Controlled Randomized Clinical.","GBR \u002F RCT","Inclusion Criteria:\n\n* • Adult patients with ⩾ 25 years of age.\n\n  * Ability to understand all the study procedures and to comply with them along the entire study period. Ability and willingness to give written informed consent.\n  * Periodontal health in an intact or reduced periodontium (2017 World Workshop in Periodontal and Peri-implant Diseases and Conditions) (G. Caton et al., 2018).\n  * Good level of oral hygiene (Plaque Index \\\u003C 20%) (Löe, 1967).\n  * Failing tooth in the anterior area of the maxillary arch (incisors, canines and premolars).\n  * Bone availability for a prosthetically driven single-unit immediate implant.\n  * A peri-implant BBD with a minimum vertical dimension height (VDH) of 3mm, detected by means of a CT imaging.\n  * Presence of adjacent teeth.\n  * Presence of antagonist teeth.\n  * Keratinized mucosa of at least 2mm on the buccal aspect of the tooth to be extracted.\n\nExclusion Criteria:\n\n* Smokers ⩾ 10 cigarettes per day.\n\n  * Pregnant women or lactating females.\n  * Acute periapical infection.\n  * Presence of buccal\u002Fpalatal and\u002For interproximal gingival recession in the target tooth.\n  * Any systemic disease or medication that contraindicates implant treatment or could influence the outcome of the therapy (i.e., non-controlled diabetes mellitus, osteoporosis, radiotherapy, bisphosphonate medication, ...).\n  * Long-term non-steroidal anti-inflammatory drug therapy (⩾ 3 months).\n  * Lack of primary manual stability of the implant during installation.","25 Years",{"count":118,"type":22},24,[25],"This clinical trial investigates the biological and clinical outcomes of immediate implant placement in aesthetic areas presenting with buccal bone dehiscence. Traditionally, these defects are treated with a bone graft and covered using a collagen membrane; however, there is ongoing debate about whether the membrane is necessary for optimal regeneration. This study proposes the use of a connective tissue graft instead of a collagen membrane, aiming to improve soft tissue volume and aesthetics without compromising bone healing.\n\nThe objective of the study is to evaluate whether the use of an autogenous connective tissue graft in combination with a deproteinized bovine bone mineral with collagen (DBBM-C) achieves results that are not inferior to the conventional protocol that uses DBBM-C and a collagen membrane. The main outcome variable is the vertical buccal bone gain measured after twelve months of healing.\n\nThe study design is a randomized controlled clinical trial including twenty-four patients divided equally into two groups. Each participant will attend eight follow-up visits over twelve months. After atraumatic tooth extraction, immediate implants (BLC, Straumann) will be placed using a prosthetically guided protocol. Buccal dehiscence will be measured intraoperatively, and a partial-thickness tunnel flap will be prepared to allow soft tissue adaptation and graft placement.\n\nIn the control group, the defect will be filled with DBBM-C and covered with a collagen membrane stabilized with horizontal mattress sutures. In the test group, the defect will receive DBBM-C covered by a connective tissue graft harvested from the palate and fixed in a similar manner. When primary stability is equal to or greater than 35 N\u002Fcm, an immediate screw-retained provisional crown will be delivered; if stability is lower, a customized healing abutment or Maryland-type provisional will be used instead.\n\nAfter three months, digital impressions will be taken to fabricate the definitive zirconia restoration. All restorative steps will be performed by experienced clinicians using a standardized digital workflow. Patients will follow routine postoperative care instructions, including soft diet and restricted brushing in the surgical area for one week.\n\nThe main benefits of this study include advancing the understanding of regeneration strategies for buccal bone dehiscence and improving clinical decision-making in immediate implant protocols. Participants are also expected to benefit from implant-supported rehabilitation, functional restoration, and aesthetic improvement. The potential risks are minimal and limited to typical surgical complications such as discomfort, swelling, or minor infection, which will be managed following established clinical protocols.\n\nIf a patient declines participation, conventional implant treatment will be offered, or alternative prosthetic options such as fixed or removable restorations will be provided. Any intra- or postoperative complications during the study will be treated promptly and documented according to institutional standards.\n\nThe biomaterials used include BLC Straumann implants, Bio-Oss Collagen (DBBM-C), Bio-Gide collagen membranes, and appropriate suture materials. Procedures will employ standard periodontal and tunneling instruments, as well as a digital intraoral scanner for accurate prosthetic fabrication.\n\nStatistical analysis will involve descriptive and inferential methods. The Kolmogorov-Smirnov test will assess normality, and mixed ANOVA models will evaluate differences between groups and across time points. Covariate adjustment will be performed using ANCOVA when necessary, and intra- and inter-examiner reliability will be tested with the intraclass correlation coefficient. The level of statistical significance will be set at 0.05.\n\nThe expected outcome is that the use of an autogenous connective tissue graft will demonstrate bone regeneration results equivalent to those obtained with a collagen membrane, while potentially improving soft tissue thickness and aesthetic integration. This finding would support the clinical use of soft tissue grafts as an alternative to collagen membranes in immediate implant placement within aesthetic regions showing buccal dehiscence.\n\nAll study procedures follow the principles of the Declaration of Helsinki and ethical standards for human clinical research. Participants will receive detailed information about the study protocol and will sign informed consent before inclusion.\n\nIn summary, this study aims to determine whether a connective tissue graft can safely replace a collagen membrane in the management of buccal dehiscence during immediate implant placement, offering comparable regenerative outcomes with possible superior soft tissue aesthetics.",[122,31,123,124],"Immediate Dental Implant Placement","Connective Tissue Graft Harvesting","Soft Tissue Management in Subcrestal Dental Implants",[126,127,128,129,130],"Connective tissue graft","volumen changes in vestibular plate","immediate implant placement","emergence profile","immediate aesthetic crown","NOT_YET_RECRUITING","2026-02-12",{"date":134,"type":37},"2026-02-17",{"date":136,"type":22},"2026-04-01",{"date":138,"type":22},"2029-07-01",{"name":140,"class":44},"Universitat Internacional de Catalunya",{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":16,"sex":17,"minAge":148,"maxAge":149,"enrollmentInfo":150,"targetDuration":4,"studyType":23,"phases":152,"briefSummary":153,"conditions":154,"keywords":156,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":45},"100616266","flapless-immediate-implant-placement-with-socket-shield-technique-versus-connective-tissue-graft-in-anterior-maxilla-100616266","NCT07303374","Flapless Immediate Implant Placement With Socket Shield Technique Versus Connective Tissue Graft in Anterior Maxilla","Supra-Implant Complex Stability Following Flapless Immediate Implant Placement With Socket Shield Technique Versus Connective Tissue Graft in Anterior Maxilla 1-Year Randomized Clinical Trial","Inclusion Criteria:\n\n* Initial intact thick gingival biotype\n* 2 mm band of keratinized tissue,\n* Thin intact labial bone plate (\\\u003C 1mm)\n* Good apical bone for primary stability\n* Patients who had provided an informed consent.\n\nExclusion Criteria:\n\n* Immediate implants with bone grafts or guided bone regeneration procedures\n* Uncontrolled diabetes mellitus\n* Patients taking IV bisphosphonates for treatment of osteoporosis\n* Patients with active infection related at the site of implant\n* Patients with untreated active periodontal diseases.","21 Years","50 Years",{"count":151,"type":22},28,[25],"The present study aims to compare the dimensional stability of the supra-implant complex following flapless immediate implant placement using two socket management approaches: the connective tissue graft and the socket shield technique. Three-dimensional volumetric analysis and cone-beam computed tomography (CBCT) will be employed to assess and quantify changes in soft and hard tissue thickness and height surrounding the implant site.",[122,31,155],"Socket Shield Technique",[157,126],"Socket Shield","2025-12-18",{"date":160,"type":37},"2025-12-24",{"date":162,"type":22},"2026-02",{"date":164,"type":22},"2027-05",{"name":166,"class":167},"International Dental Contiuing Education","NETWORK",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":16,"sex":17,"minAge":52,"maxAge":174,"enrollmentInfo":175,"targetDuration":4,"studyType":23,"phases":176,"briefSummary":177,"conditions":178,"keywords":180,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":4},"100587289","clinical-and-volumetric-changes-following-single-pontic-site-development-using-multilayered-platelet-rich-fibrin-versus-connective-tissue-grafting-in-the-maxillary-esthetic-zone-100587289","NCT06926452","Clinical and Volumetric Changes Following Single Pontic Site Development Using Multilayered Platelet Rich Fibrin Versus Connective Tissue Grafting in the Maxillary Esthetic Zone","Inclusion Criteria:\n\n* Adults from the age of 18 - 40 years\n* Patients with missing maxillary teeth\u002Ftooth in the area from 2nd premolar to 2nd premolar with ridge defect according to Seibert classification (Class I, II and III).\n* Intact gingival tissue with at least 2mm keratinized tissue.\n* Periodontally healthy patients.\n* Patients accepts to provide informed consent.\n\nExclusion Criteria:\n\n* Smokers.\n* Pregnant females.\n* Handicapped and mentally challenged patients.\n* Systemic disease compromising wound healing.\n* Active soft tissue infection","80 Years",{"count":118,"type":22},[25],"In clinical practice most patients' first concern is esthetics, soft tissue grafting is becoming routine in clinical practice to make up for the deficiency in supra-crestal tissue dimension that typically follows tooth loss. The edentulous site experiences major qualitative and quantitative changes because of a number of sequential events that occur after tooth extraction. Ridge dimensional alterations of the underlying bone and the soft tissue architecture overlaying it are the consequence of the socket healing process. To maintain the remaining teeth, aesthetic jaw support and optimal food chewing, lost teeth must be replaced. The teeth adjacent to and opposing a missing tooth will eventually tip, shift, and migrate, disrupting normal function. One integral part of the new strategy for treating periodontal diseases is thought to be surgical periodontal operations. Soft tissue grafting has become more frequently utilized to improve the aesthetics of teeth and dental implant sites by treating mucogingival abnormalities, restoring an appropriate width of keratinized tissue, and enhancing tissue thickness. SCTG has its own limitations, such as lack of graft availability, need for a second surgical site, proximity to palatine neurovascular complex and unaesthetic tissue contour at the recipient site. Due to these limitations, investigations on more regenerative nature techniques have been explored such as PRF, Using PRF instead of SCTG has the added value of decreasing discomfort and postoperative pain after the surgical procedure due to having additional donor site, To the best of our knowledge testing multi-layer PRF against SCTG in pontic site augmentation was never done before.",[179,31],"Pontic Site Augmentation",[181],"Pontic site augmentation","2025-04-07",{"date":184,"type":37},"2025-04-13",{"date":186,"type":22},"2025-05",{"date":188,"type":22},"2026-09",{"name":107,"class":44},{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":194,"acronym":4,"eligibilityCriteria":195,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":149,"enrollmentInfo":196,"targetDuration":4,"studyType":23,"phases":197,"briefSummary":199,"conditions":200,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":45},"100561348","phase-2-xengenic-cortical-membranes-versus-connective-tissue-graft-with-coronally-advanced-flap-for-the-treatment-of-peri-implant-soft-tissue-dehiscences-a-randomized-controlled-clinical-trial-100561348","NCT06588998","Xengenic Cortical Membranes Versus Connective Tissue Graft With Coronally Advanced Flap for the Treatment of Peri-implant Soft Tissue Dehiscences: A Randomized, Controlled Clinical Trial","Inclusion Criteria:\n\n* Adults (20-50) years old. •peri-implant soft tissue dehiscence . •Thin gingival phenotype. •Optimal compliance as evidenced by no missing treatment appointments and positive attitude towards oral hygiene.\n\nExclusion Criteria:\n\n* •Medically compromised patients and systemic conditions precluding implant and periodontal surgery. •Smokers, diabetics, pregnant or lactating women. •History of chemotherapy, radiotherapy in head and\u002For neck region. •Bisphosphonate therapy.",{"count":77,"type":22},[198],"PHASE2","Peri-implant soft tissue dehiscences represent a common complication in implant dentistry, often leading to esthetic and functional challenges. Current treatment options, including Xengenic cortical membranes and connective tissue graft with coronally advanced flap, aim to promote soft tissue regeneration and improve clinical outcomes. However, there is a need for comparative studies to determine the optimal treatment modality for peri-implant soft tissue dehiscences.",[201,31],"Immediate Implant","2024-09-05",{"date":204,"type":37},"2024-09-19",{"date":206,"type":37},"2024-06-01",{"date":208,"type":22},"2024-12-30",{"name":210,"class":44},"Amr Anwar Mohamed Ellithy Yousef"]