[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"consciousness-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:consciousness-disorders":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,46,82,106,135,154,185,209],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100587617","paired-vagus-nerve-stimulation-in-mobilization-of-patients-with-prolonged-disorders-of-consciousness-100587617",false,"NCT06930716","Paired Vagus Nerve Stimulation in Mobilization of Patients With Prolonged Disorders of Consciousness","Use of Paired Vagus Nerve Stimulation in Mobilization of Patients With Prolonged Disorders of Consciousness: A Pilot Feasibility Study","Inclusion Criteria:\n\n* Patients with a diagnosis of pDOC (includes coma, VS\u002FUWS, MCS, MCS +, MCS-) as defined as disorder of consciousness (DOC) greater than 6 weeks post onset\n* Patients deemed medically safe to participate in physical therapy (PT) as evaluated by the study physicians.\n\nExclusion Criteria:\n\n* Patients who have emerged from MCS (CRS-R score 6 on Motor Function scale and\u002For 2 on Communication Scale).\n* Patients medically unsafe for participation in PT as indicated by one of the study physicians (including but not limited to those receiving intravenous sedation, those with integumentary breakdown or known pressure injuries, those with cardiovascular or cerebrovascular conditions precluding initiation of physical therapy \\[ie uncontrolled intracranial pressure, severe symptomatic orthostatic hypotension, etc.).\n* Patients with DOC less than 6 weeks post onset will also be excluded.\n* Patients who do not meet technical requirements of the RTTM device will be excluded\n\n  * weighing greater than 135 kg\n  * length of legs below 75 cm or above 100 cm,\n  * fixed contractures of lower extremity including hip, knee, ankle, or foot).\n* Does not have an identified care partner or legally authorized representative to consent to participation","ALL","22 Years",{"count":19,"type":20},15,"ESTIMATED","INTERVENTIONAL",[23],"NA","Prolonged disorders of consciousness (pDOC) are defined as DOC lasting \\>1 year post injury for patients with Traumatic Brain Injury (TBI) and \\>3 months post injury for patients with non-TBI and at present there are limited treatments that reliably lead to enhanced prognosis. The rehabilitation process throughout the continuum of care for patients with pDOC necessitates restorative strategies to facilitate arousal and functional recovery and coordinated medical management. Rehabilitation interventions for patients with DOC and pDOC have evolved in the past decade, with an emerging body of evidence highlighting the benefits of rehabilitation intervention even in the acute. While there is data to support the individual utility of these modalities, no work to date has investigated the benefits of pairing transauricular vagus nerve stimulation (taVNS) and robotic tilt table mobilization (RTTM) to maximize functional recovery in patients with pDOC. This study will report on the safety, feasibility, and preliminary short- and long-term outcomes of RTTM with simultaneously paired Transcutaneous auricular vagus nerve stimulation (taVNS) for Severe Acquired Brain Injury (SABI) patients with pDOC . Fifteen (15) participants will be recruited and complete a 12-week rehabilitation protocol using paired taVNS and RTTM. Once participants have been screened and enrolled in the study, they will complete three study phases: T1: a baseline observation of standard of care T2, intervention, and T3 longitudinal follow up.",[26,27,28],"Consciousness Disorders","Brain Injury","Altered Level of Consciousness",[30,31,32],"Therapy","Rehabilitation","Neuromodulation","RECRUITING","2026-06-16",{"date":36,"type":37},"2026-06-18","ACTUAL",{"date":39,"type":37},"2025-08-12",{"date":41,"type":20},"2027-12-30",{"name":43,"class":44},"Icahn School of Medicine at Mount Sinai","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100614262","promoting-recovery-after-brain-injury-using-focused-ultrasound-100614262","NCT07277309","Promoting Recovery After Brain Injury Using Focused Ultrasound","ReBOUND","Inclusion Criteria:\n\n* Brain injury resulting in DoC diagnosis, following international guidelines\n* At least 18 years of age\n* Legally authorized representative (surrogate) available to consent\n\nExclusion Criteria:\n\n* History of neurological disorder other than the brain injury\n* Metal implant or other condition precluding MRI\n* Manifest continuous spontaneous movement (which would prevent safe\u002Fsuccessful MRI)\n* Participation in concurrent therapeutic study\n* Pregnancy","18 Years","79 Years",{"count":56,"type":20},36,[23],"The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this project aims to (1) determine neurobehavioral responses to low-intensity focused ultrasound (LIFUP) in patients with disorders of consciousness (DoC) following brain injury, (2) determine neurophysiologic (EEG) responses to LIFUP in patients with DoC and (3) identify and evaluate ethical perspectives of patient representatives (family members and surrogate decision-makers) surrounding investigation of therapeutic neuromodulation technologies such as LIFUP in patients with DoC.",[26,60],"Disorders of Consciousness Due to Severe Brain Injury",[62,63,64,65,66,67,68,69,70,71],"Disorder of Consciousness","Vegetative State","Minimally Conscious State","Minimally Conscious State Plus","Minimally Conscious State Minus","Traumatic Brain Injury","CVA (Cerebrovascular Accident)","Anoxia, Brain","Thalamic Infarction","Coma; Prolonged","2026-06-12",{"date":74,"type":37},"2026-06-15",{"date":76,"type":37},"2026-05-26",{"date":78,"type":20},"2029-07",{"name":80,"class":44},"Massachusetts General Hospital",2,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":90,"targetDuration":4,"studyType":21,"phases":92,"briefSummary":93,"conditions":94,"keywords":95,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":105},"100588280","ultrasound-stimulation-for-patients-in-a-disorder-of-consciousness-100588280","NCT06939348","Ultrasound Stimulation for Patients in a Disorder of Consciousness","Safety and Efficacy of Thalamic Focused Ultrasound Stimulation (tFUS) for Promoting Recovery After Severe Traumatic Brain Injury","tFUS","Inclusion Criteria:\n\n1. Diagnosis of DoC, following international guidelines, as assessed with the CRS-R.\n2. Prolonged status (\\>28days post-injury)\n3. If on a psychotropic medication regimen, that regimen will be stable for at least 4 weeks prior to entry to the study and the patient will be willing to remain on a stable regimen during the protocol.\n4. legally authorized representative available to consent for the patient to participate in the study\n\nExclusion Criteria:\n\n1. History of neurological disorder (other than the brain injury).\n2. Metal implant or other condition precluding safe entry in the MR-environment.\n3. Manifest continuous spontaneous movement (which would prevent safe\u002Fsuccessful imaging).\n4. Participation in another concurrent clinical trial.\n5. Need for mechanical ventilation.\n6. Craniotomy (no bone flap).\n7. Cranioplasty spanning the left temporal bone window.",{"count":91,"type":20},60,[23],"The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this multicenter project aims to (1) establish short-term efficacy of tFUS as a therapeutic to promote recovery in patients with prolonged DoC as compared to sham treatment, (2) establish dose-related safety and efficacy of tFUS as a therapeutic intervention in prolonged DoC patients and (3) explore preliminary predictors and biomarkers of susceptibility and response to thalamic sonication.",[26,60],[62,63,64,65,66,67,68,69,70,71],"2026-05-18",{"date":98,"type":37},"2026-05-22",{"date":100,"type":37},"2025-04-26",{"date":102,"type":20},"2028-09-29",{"name":104,"class":44},"University of California, Los Angeles",4,{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":113,"sex":16,"minAge":53,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":117,"phases":4,"briefSummary":118,"conditions":119,"keywords":120,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":45},"100547318","micro-movements-in-patients-with-prolonged-disorders-of-consciousness-100547318","NCT06406413","Micro-movements in Patients With Prolonged Disorders of Consciousness","Study of Micro-movements in Patients With Prolonged Disorders of Consciousness","Inclusion Criteria:\n\n1. Patients with consciousness disorders for more than 28 days following severe brain injury, assessed by the CRS-R scale to meet the criteria for VS or MCS;\n2. Aged between 18 and 80 years;\n3. Stable vital signs;\n4. Voluntary participation of family members with signed informed consent;\n5. Good cooperation, minimal facial and spontaneous activities, no use of antiepileptic or sedative drugs.\n\nExclusion Criteria:\n\n1. Locked-in syndrome;\n2. Contraindications for EEG examination;\n3. Contraindications for MRI scanning, such as the presence of internal metallic implants;\n4. Diseases and factors that may affect brain function assessment, such as metabolic disorders, poisoning, shock, etc.",true,"80 Years",{"count":116,"type":20},179,"OBSERVATIONAL","The goal of this observational study is to learn about the micro-movements in patients with prolonged disorders of consciousness. The main questions it aims to answer are:\n\nUse the neuropsychological paradigm model to monitor micro-movements, assess the patient's remaining level of consciousness and accurately classify it; screen out patients with cognitive-motor dissociation to improve the prognosis of cognitive function; explore the remaining brain function of patients with chronic disorders of consciousness and promote relevant study of neural mechanisms.\n\nParticipants will be subjected to consciousness assessment by CRS-r scale, and their micro-movement changes in response to various emotional stimuli will be captured, along with the collection of EEG and MRI data. Follow-up evaluations will be conducted using the CRS-R scale and GOS scale, with a follow-up period of 6 months.",[26],[121,122,123,124,125],"disorders of consciousness","consciousness disorders","micro-movement","consciousness","Multidimensional paradigm stimulation","2026-01-13",{"date":128,"type":37},"2026-01-14",{"date":130,"type":37},"2024-05-01",{"date":132,"type":20},"2026-12",{"name":134,"class":44},"First Affiliated Hospital of Zhejiang University",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":113,"sex":16,"minAge":53,"maxAge":114,"enrollmentInfo":141,"targetDuration":143,"studyType":117,"phases":4,"briefSummary":144,"conditions":145,"keywords":146,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":149,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":153,"locationsCount":45},"100522900","micro-expressions-in-patients-with-prolonged-disorders-of-consciousness-100522900","NCT06088628","Micro-expressions in Patients With Prolonged Disorders of Consciousness","Study of Micro-expressions in Patients With Prolonged Disorders of Consciousness",{"count":142,"type":20},200,"6 Months","The goal of this observational study is to learn about the microexpressions in patients with prolonged disorders of consciousness. The main questions it aims to answer are:\n\n* Inducing micro-expression changes in patients with prolonged disorders of consciousness through various emotional stimuli, and further to achieve precise classification of their levels of consciousness.\n* Detecting micro-expressions in patients with prolonged disorders of consciousness to assist clinical diagnosis of levels of consciousness, e.g., complement the disgnosis of clinical scales such as CRS-r scale.\n* By monitoring micro-expression changes in patients with prolonged disorders of consciousness, researchers can explore their residual brain function, thereby advancing research into relevant neural mechanisms.\n\nParticipants will be subjected to consciousness assessment by CRS-r scale, and their micro-expression changes in response to various emotional stimuli will be captured, along with the collection of EEG and MRI data. Follow-up evaluations will be conducted using the CRS-R scale and GOS scale, with a follow-up period of 6 months.",[26],[121,122,147,148,124],"microexpressions","emotional stimuli",{"date":128,"type":37},{"date":151,"type":37},"2022-09-27",{"date":132,"type":20},{"name":134,"class":44},{"id":155,"slug":156,"hasResults":11,"nctId":157,"briefTitle":158,"officialTitle":159,"acronym":160,"eligibilityCriteria":161,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":4,"enrollmentInfo":162,"targetDuration":4,"studyType":21,"phases":164,"briefSummary":165,"conditions":166,"keywords":167,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":81},"100559776","measuring-brain-complexity-to-detect-and-predict-recovery-of-consciousness-in-the-icu-100559776","NCT06568536","Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICU","Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICU (COMPASS)","COMPASS","Inclusion Criteria:\n\n1. Age greater than or equal to 18\n2. Functionally independent at baseline\n3. Acquired brain injury within the last 28 days\n4. Disorder of consciousness, as defined by no instance of following commands (i.e., Glasgow Coma Scale motor score = 6) on two or more consecutive assessments\n5. Continuous intravenous sedation able to be discontinued for at least 10 minutes\n6. ICU clinicians approve safe placement of 64-electrode EEG cap on the scalp\n\nAdditional inclusion criteria are present in the study protocol.\n\nExclusion Criteria:\n\n1. Status epilepticus or uncontrolled seizure disorder\n2. No head CT scan from current hospital admission AND contraindications for MRI: conductive, ferromagnetic, or other magnetic-sensitive metals implanted in the head (e.g., cochlear implants, implanted electrodes\u002Fstimulators, aneurysm clips or coils, stents, bullet fragments)\n3. Medical instability, restlessness, or other factors identified by the PI that would either prevent safe participation or compromise data acquisition\n4. Hemicraniectomy\n\nIf a subject meets a contraindication for MR imaging, the subject may participate in all other aspects of the study except MRI.",{"count":163,"type":20},120,[23],"Disorders of consciousness (DoC) caused by severe brain injury affect millions of people worldwide each year. A patient's level of consciousness in the intensive care unit (ICU) significantly impacts the recovery from disability and is a primary determinant of family decisions about withdrawal of life-sustaining therapy (WLST). However, reliable assessment of consciousness in the ICU remains elusive. Transcranial magnetic stimulation-electroencephalography (TMS-EEG) is a tool that has shown the best performance in detecting signs of consciousness in patients with chronic DoC. The goals of this prospective, observational study are to demonstrate the diagnostic performance and prognostic utility of TMS-EEG in the ICU setting.",[26],[168,169,170,171,172,173,174,175,176],"unresponsive wakefulness syndrome","vegetative state","minimally conscious state","transcranial magnetic stimulation","electroencephalography","traumatic brain injury","coma recovery scale - revised","functional electroencephalogram","functional imaging","2025-05-12",{"date":179,"type":37},"2025-05-15",{"date":181,"type":37},"2024-11-08",{"date":183,"type":20},"2029-08-01",{"name":80,"class":44},{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":4,"eligibilityCriteria":191,"healthyVolunteers":11,"sex":16,"minAge":192,"maxAge":193,"enrollmentInfo":194,"targetDuration":4,"studyType":21,"phases":196,"briefSummary":197,"conditions":198,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":45},"100546008","effect-of-esketamine-on-conscious-state-in-patients-with-pdoc-100546008","NCT06389344","Effect of Esketamine on Conscious State in Patients With pDoC","Effect of Esketamine on Conscious State in Patients With Prolonged Disorders of Consciousness#a Prospective, Randomized, Exploratory Study","Inclusion Criteria:\n\n1.16-65 years old 2.Native Chinese language 3.pDoC after acquired brain injury 4.Scheduled to undergo surgery 5.Signed informed consent\n\nExclusion Criteria:\n\n1. Continuous sedation treatment was carried out within 72 hours before the study\n2. Airway stenosis and severe ventilation or ventilation dysfunction caused by various reasons\n3. Known or suspected to have serious cardiac, pulmonary and renal dysfunction 1)Severe cardiac dysfunction: a. unstable coronary syndrome b. Congestive heart failure: left ventricular ejection fraction less than 50%, elevated BNP c.Severe arrhythmia d. History of severe valvular disease 2)Severe pulmonary dysfunction: a. history of pulmonary heart disease b. History of chronic obstructive pulmonary disease 3)Severe renal dysfunction: a. Endogenous creatinine clearance (Ccr) less than 30ml\u002Fmin b. The glomerular filtration rate (GFR) was less than 30ml\u002Fmin•1.73m2\n4. Allergic history of sedative drugs\n5. Combined with other mental or nervous system diseases\n6. Other reasons are not suitable for this study.","16 Years","65 Years",{"count":195,"type":20},116,[23],"The goal of this clinical trial is to learn about the effect of intraoperative infusion of subanesthetic dose of esketamine on conscious status in patients with prolonged disorders of consciousness under sevoflurane anesthesia.\n\nParticipants will be patients with prolonged disorders of consciousness undergoing surgery with general anesthesia at Beijing Tiantan Hospital. 0.3mg\u002Fkg esketamine or saline will be infused will be infused intravenously at a constant speed within 30 min after tracheal intubation\u002Fpneumatectomy fixation. Coma recovery scale-revised, Glasgow coma scale, Full Outline of UnResponsiveness scores, SedLine multi-channel electroencephalogram and perioperative adverse events after surgery will be investigated.",[199,26],"Esketamine","2024-07-29",{"date":202,"type":37},"2024-07-30",{"date":204,"type":37},"2024-05-20",{"date":206,"type":20},"2026-06-30",{"name":208,"class":44},"Beijing Tiantan Hospital",{"id":210,"slug":211,"hasResults":11,"nctId":212,"briefTitle":213,"officialTitle":214,"acronym":215,"eligibilityCriteria":216,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":4,"enrollmentInfo":217,"targetDuration":4,"studyType":21,"phases":219,"briefSummary":220,"conditions":221,"keywords":224,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":235,"locationsCount":45},"100548870","connectivity-and-neural-signatures-of-consciousness-in-unresponsive-states-100548870","NCT06426615","Connectivity and Neural Signatures of Consciousness in Unresponsive States","Connectivity and Neural Signatures of Consciousness In Unresponsive States (CONSCIUS) - a Study of Brain Activity in Disorders of Consciousness","CONSCIUS","Inclusion Criteria:\n\n* 18 years old or older\n* Brain injury of any kind, with impaired consciousness or suspected seizures\n\nExclusion Criteria:\n\n* \\\u003C 18 years old\n* Known pregnancy\n* Any condition that, in the judgement of the investigator, makes participation in the study unsafe or unfeasible (e.g., irreversible coagulopathy, large intracranial tumors, surgical technical problems…)",{"count":218,"type":20},20,[23],"The CONSCIUS study is a prospective, interventional study including patients with acute brain injury and impaired consciousness implanted with intracranial electrodes. The aim of the study is to investigate seizures and thalamocortical neural dynamics underlying behavioral unresponsiveness.",[222,67,26,223],"Acute Brain Injury","Seizures",[225,223,226,227],"Consciousness","Neural dynamics","Intracranial recordings and stimulation","2024-05-17",{"date":230,"type":37},"2024-05-23",{"date":232,"type":37},"2024-01-01",{"date":234,"type":20},"2027-12-31",{"name":236,"class":44},"Universitaire Ziekenhuizen KU Leuven"]