[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"conservative-management\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:conservative-management":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,66],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100590463","epidemiological-factors-and-optimization-of-conservative-approaches-to-precancerous-lesions-of-female-reproductive-organs-100590463",false,"NCT06967740","Epidemiological Factors and Optimization of Conservative Approaches to Precancerous Lesions of Female Reproductive Organs","Inclusion Criteria:\n\n* Informed Consent\n* cervical biopsy - HG lesion\n* Age: 18-46 years\n* colposcopicaly visible transformation zone\n* HPV: Unvaccinated\n* cytology all except AIS, adenocarcinoma, squamous cell carcinoma, AGC NEO\n\nExclusion Criteria:\n\n* cytology AIS, AGC NEO, adenocarcinoma, squamous cell carcinoma\n* immunosuppression\n* active autoimmune disease\n* history of cervical cryodestruction\n* HPV vaccinated prior to start of the study","FEMALE","18 Years","46 Years",{"count":19,"type":20},200,"ESTIMATED","OBSERVATIONAL","The primary aim of this study is to develop a recommended clinical practice guideline for managing women with HPV HR (high-risk human papillomavirus) positivity and cervical lesions. Additionally, in collaboration with the Bioptic Laboratory, the study will analyze the integration of HPV HR testing into screening programs for women aged 35, 45, and 55, with a focus on optimizing management strategies for HPV HR-positive women.\n\nResearch Objectives:\n\n* Evaluate spontaneous regression\u002Fprogression over two years based on HPV HR genotyping (three groups - according to Alinity: high, intermediate, and low risk).\n* Assess spontaneous regression\u002Fprogression over two years based on HPV HR genotyping and viral load in HPV-vaccinated vs. non-vaccinated patients.\n* Evaluate spontaneous regression\u002Fprogression over two years based on methylation results.\n* Assess spontaneous regression\u002Fprogression over two years based on CinTec plus results.",[24,25,26,27],"Cervical Cancer","Cervical Intraepithelial Neoplasia (CIN)","Risk Factors","Conservative Management",[25,29,30],"Conservative management","Precancerous cervical lesions","RECRUITING","2025-07-29",{"date":34,"type":35},"2025-07-31","ACTUAL",{"date":37,"type":35},"2024-11-01",{"date":39,"type":20},"2029-12",{"name":41,"class":42},"Nikola Janovska","OTHER_GOV",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":43},"100582344","a-prospective-study-evaluating-the-impact-of-conservative-management-on-retained-products-of-conception-and-emv-100582344","NCT06862089","A Prospective Study Evaluating the Impact of Conservative Management on Retained Products of Conception and EMV","Inclusion Criteria:\n\n* Recent history of miscarriage or delivery (within the past 8 weeks)\n* Strong willingness to undergo conservative management\n* Hemodynamically stable\n* Signed informed consent form\n\nExclusion Criteria:\n\n* Heavy vaginal bleeding (requiring immediate surgical intervention)\n* Active pelvic or systemic infection (e.g., fever \\>38°C, elevated CRP\u002FWBC)\n* Severe dysfunction of vital organs (heart, liver, or kidney)\n* Known drug allergies or contraindications to proposed medications (e.g., misoprostol intolerance)\n* Suspected ectopic pregnancy or gestational trophoblastic disease (confirmed by ultrasound or β-hCG levels)\n* Placenta accreta spectrum disorders diagnosed during current pregnancy\n* History of uterine artery embolization",{"count":51,"type":20},120,"The goal of this observational study is to learn about the therapeutic effects of the conservative treatment approach on pepole with retained products of conception (RPOC) and Enhanced myometrial vascularity (EMV).\n\nThe main question it aims to answer is: Is it possible to achieve the natural resolution of RPOC by combining it with EMV through conservative treatment？ Participants will receive conservative treatment (such as mifepristone, GnRH-a, or expectant management) following the initial diagnosis of RPOC and EMV, and the therapeutic efficacy of the conservative approach will be assessed after the completion of two menstrual cycles.",[54,55,27],"Retained Products of Conception","Miscarriage","2025-06-12",{"date":58,"type":35},"2025-06-15",{"date":60,"type":35},"2024-10-23",{"date":62,"type":20},"2026-12-30",{"name":64,"class":65},"Fu Xing Hospital, Capital Medical University","OTHER",{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":79,"studyType":21,"phases":4,"briefSummary":80,"conditions":81,"keywords":82,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":43},"100579796","risk-factors-of-failure-of-conservative-treatment-in-acute-non-complicated-appendicitis-100579796","NCT06828952","Risk Factors of Failure of Conservative Treatment in Acute Non Complicated Appendicitis","appendicitis","Inclusion Criteria:\n\n* Male or female patients é diagnosis of acute appendicitis .\n* Patients with ages: from 16 to 60 years old.\n\nExclusion Criteria:\n\n* complicated AA (appendicolith, perforation, peri appendicular abscess or suspicion of a tumor).\n* inflammatory bowel disease.\n* inability to co-operate and give informed consent.\n* diffuse peritonitis.\n* antibiotic documented allergy \\& allergy to contrast media .\n* Patients with serious comorbid conditions DM \\& renal insufficiency, serum creatinine \\> 150 μmol\u002Fl .\n* Pregnant \\& lactating patient.\n* Patients with bleeding diathesis and those on anticoagulants.\n* Patients with advanced malignancies \\& patient on immunosuppressive drugs .\n* Patients with previous appendectomy.\n* Extreme of age.",true,"ALL","16 Years","60 Years",{"count":78,"type":20},100,"2 Days","From this study, it can be concluded that patients who meet the following criteria are more likely to fail expectant management and thus should not be considered for the NOM of uncomplicated acute appendicitis. These include the duration of symptoms before presenting to a surgical emergency , the presence of fever within 24 hours of presenting to a surgical emergency, TLC cells\u002FdL, CRP mg\u002FL, appendix diameter mm, modified Alvarado score , and adult appendicitis score .",[27],[83],"Appendicitis","NOT_YET_RECRUITING","2025-02-13",{"date":87,"type":35},"2025-02-17",{"date":89,"type":20},"2025-06-22",{"date":91,"type":20},"2025-12-02",{"name":93,"class":65},"Ahmed Mohammed Hussein Sayed"]