[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"continuous-positive-airway-pressure-cpap\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:continuous-positive-airway-pressure-cpap":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,79,107],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100600769","distribution-of-mood-and-personality-characteristics-and-their-influence-on-treatment-compliance-100600769",false,"NCT07101796","Distribution of Mood and Personality Characteristics and Their Influence on Treatment Compliance","Inclusion Criteria:\n\n* Age: 18\\~70 years old\n* Suspected OSA based on symptoms such as snoring, waking at night, daytime sleepiness, or requiring OSA screening due to related conditions; or confirmed OSA patients referred for sleep monitoring or CPAP pressure titration.\n* Subjects are conscious, utterly independent in behavioral and cognitive ability, and able to answer questions independently;\n* The patients gave informed consent to the study and cooperated with relevant treatment and evaluation.\n\nExclusion Criteria:\n\n* Age below 18 or above 70 years old\n* No symptoms suggestive of OSA and no need for OSA screening; or patients without confirmed OSA\n* lacking full independence in behavior and cognitive ability, unable to answer questions independently\n* Patients who did not give informed consent or were unwilling to cooperate with treatment and evaluation","ALL","18 Years","70 Years",{"count":19,"type":20},200,"ESTIMATED","OBSERVATIONAL","This study intends to investigate the personality and psychological characteristics of OSA patients using classical standard scales and obtain treatment information and adherence data through prospective follow-up to summarize the distribution characteristics of mood and personality characteristics of OSA patients and their influence on treatment adherence. A thorough understanding of OSA patient characteristics from the perspective of personality and psychological characteristics will be of great significance to the classification of OSA patients, precision treatment, and improving treatment compliance.",[24,25,26,27,28],"Personality","Patient Compliance","Anxiety","Depression","Continuous Positive Airway Pressure (CPAP)",[30,31,32,26,33,28],"Obstructive sleep apnea","personality","patient compliance","depression","RECRUITING","2025-07-28",{"date":37,"type":38},"2025-08-03","ACTUAL",{"date":40,"type":38},"2024-09-14",{"date":42,"type":20},"2025-08",{"name":44,"class":45},"Peking University First Hospital","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":46},"100593036","effect-of-cpap-versus-apap-in-patients-with-obesity-undergoing-bariatric-surgery-protocol-100593036","NCT07001215","Effect of CPAP Versus APAP in Patients With Obesity Undergoing Bariatric Surgery Protocol","ObesAOS","Inclusion Criteria:\n\n* Subjects aged 18 to 80 years who meet the criteria for bariatric surgery and are on the surgical waiting list after approval by the bariatric surgery committee (BMI ≥35, or BMI ≥30 with comorbidities).\n* Diagnosis of moderate or severe sleep apnea, defined by an Apnea-Hypopnea Index (AHI) \\>15, requiring treatment according to protocol (\"Patients with an AHI of 15 or higher will be treated with CPAP if they have hypertension, excessive daytime sleepiness, or sleep-related symptoms not explained by other causes\" \\[17\\]).\n* Patients must be able to read and understand the informed consent and provide signed consent.\n\nExclusion Criteria:\n\n* Patients with central sleep apnea or periodic breathing\n* Patients with any active neoplasm\n* Patients with severe uncontrolled psychiatric disorders, alcoholism, or active drug addiction\n* Patients with unacceptable surgical\u002Fanesthetic risk\n* Patients who have undergone previous surgery for OSA or who have been treated with positive airway pressure and did not tolerate it","80 Years",{"count":56,"type":20},104,"INTERVENTIONAL",[59],"NA","Introduction Obstructive sleep apnea (OSA) is a common disorder in obese patients, especially those undergoing bariatric surgery. OSA is characterized by upper airway obstruction during sleep, leading to intermittent hypoxia and sleep fragmentation. Obesity and OSA are closely related conditions that can exacerbate each other. Positive airway pressure therapy is essential for managing OSA, but adherence to therapy can be challenging, particularly in patients who experience rapid physiological changes after bariatric surgery.\n\nObjective This study aims to determine whether automatic positive airway pressure therapy (APAP) improves nightly usage hours compared to continuous positive airway pressure therapy (CPAP) in obese patients undergoing bariatric surgery. Secondary objectives include evaluating the percentage of nights with therapy use over 4 hours, reduction of the residual apnea-hypopnea index (AHI), changes in daytime sleepiness, pressure requirements, side effects, sleep-related quality of life, reduction in in-person visits, and optimization of healthcare resources.\n\nMethodology A randomized, parallel-group, open-label, controlled clinical trial will be conducted. Adult patients eligible for bariatric surgery with a diagnosis of moderate to severe OSA (AHI \\> 15) requiring positive pressure therapy will be included. Participants will be randomized to receive either APAP or CPAP. Follow-up will be conducted over 12 months after surgery, with assessments at 3, 6, and 12 months. Data will be collected on treatment adherence, residual AHI, OSA symptoms, daytime sleepiness, quality of life, and treatment costs.\n\nAPAP therapy is expected to improve nightly usage hours compared to CPAP. It is also expected that APAP will show better adaptation to changing pressure needs after bariatric surgery. Data will be analyzed to evaluate the effectiveness and cost-efficiency of both therapies.\n\nThis study will provide evidence on the efficacy of APAP compared to CPAP in obese patients undergoing bariatric surgery. The results will help optimize the treatment of OSA in this population and improve patients' quality of life. Additionally, the study is expected to contribute to the optimization of healthcare resources by reducing in-person visits and repeated sleep studies.",[62,63,64,65,28],"Sleep Apnea, Obstructive","Bariatric Surgery","Obesity","Treatment Adherence and Compliance",[67,28,68,63,64],"Obstructive Sleep Apnea (OSA)","Automatic Positive Airway Pressure (APAP)","NOT_YET_RECRUITING","2025-07-17",{"date":72,"type":38},"2025-07-23",{"date":74,"type":20},"2025-09-15",{"date":76,"type":20},"2028-09-15",{"name":78,"class":45},"Hospital Universitario Ramon y Cajal",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":57,"phases":89,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":106},"100576153","combining-light-therapy-and-cpap-in-depression-100576153","NCT06781593","Combining Light Therapy and CPAP in Depression","Effects of Light Therapy on Compliance With Continuous Positive Airway Pressure in a Population of Depressed Patients Newly Fitted With Devices for Obstructive Sleep Apnea","LUCIOPRESS","Inclusion Criteria:\n\n* Adults consulting at the MICHEL JOUVET unit, CH Le Vinatier, Bron\n* Adults with a diagnosis of major depressive episode (DSM-V) and with a MADRS score ≥ 15\n* Adults with a diagnosis of OSAS on ventilatory polygraphy or polysomnography (AASM 2017 criteria) requiring CPAP.\n\nExclusion Criteria:\n\n* Refusal to participate.\n* Pregnant and breast-feeding women\n* Under guardianship or curatorship.\n* Unstable psychiatric or physical pathology (e.g., hypomania, high suicidal risk) considered incompatible with the study by the investigators.\n* Other psychiatric, neurologic or somatic conditions\n* Contraindication to light therapy: retinopathy, retinitis pigmentosa, diabetic retinopathy, macular degeneration, glaucoma, recent eye surgery (less than 3 months).\n\npatient wishing to choose a provider other than the protocol provider.\n\n* Patient wishing to choose a device other than SEFAM's S-BOX or a mask other than the nasal mask at the time of introduction.\n* Nasal obstruction.\n* Refusal to use actimetry, refusal to use light therapy, refusal to use CPAP.",{"count":88,"type":20},130,[59],"In a double-blind, parallel-group controlled trial, we aim to measure the effect of two weeks of light therapy combined with the CPAP on compliance CPAP in patients with major depressive disorder.",[92,93,94,95,28,96],"Major Depression","Sleep Architecture","Obstructive Sleep Apnea","Compliance","Light Therapy","2025-04-24",{"date":99,"type":38},"2025-04-29",{"date":101,"type":38},"2025-01-17",{"date":103,"type":20},"2027-10-30",{"name":105,"class":45},"Hôpital le Vinatier",2,{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":57,"phases":116,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":46},"100577259","effects-of-face-mask-continuous-positive-airway-pressure-vs-noninvasive-ventilation-vs-high-flow-nasal-oxygen-on-intubation-free-survival-in-acute-hypoxemic-respiratory-failure-the-tripod-randomized-clinical-trial-100577259","NCT06795971","Effects of Face Mask Continuous Positive Airway Pressure Vs. Noninvasive Ventilation Vs. High-flow Nasal Oxygen on Intubation-free Survival in Acute Hypoxemic Respiratory Failure: the TRIPOD Randomized Clinical Trial","TRIPOD","Inclusion Criteria:\n\n1. Age≥18 yrs;\n2. A ratio of the partial pressure of arterial oxygen (PaO2) to the FiO2 of 300 mm Hg or less, or a ratio of pulse oximetry oxygen saturation (SpO2) to the FiO2 of 315 or less (SpO2≤97%) and the need for (1) noninvasive positive pressure ventilation with at least 5 cm H2O PEEP, or (2) high-flow nasal cannula at 30L\u002Fmin or higher, or (3) standard oxygen with oxygen flow rate of at least 10 L\u002Fmin;\n3. Sign informed consent.\n\nExclusion Criteria:\n\n1. Patients that have already received Continuous positive airway pressure, Noninvasive ventilation continuously for more than 24 hours before the screening visit.\n2. Previous bout of mechanical ventilation during index hospitalization.\n3. Exacerbation of chronic lung disease, including asthma or chronic obstructive pulmonary disease.\n4. Moderate to severe cardiac insufficiency (New York Heart Association class \\>II or left ventricular ejection fraction\\\u003C50%) or cardiogenic pulmonary edema.\n5. Hemodynamic dysfunction, defined as vasopressor dose \\> 0.3 µg\u002Fkg\u002Fmin of norepinephrine-equivalent to maintain systolic blood pressure \\> 90 mm Hg.\n6. Impaired consciousness with a Glasgow coma score ≤ 12.\n7. Patients with urgent need for intubation, including respiratory or cardiac arrest, respiratory pauses with loss of consciousness or gasping for air, severe hypoxemia defined as SpO2 lower than 90% despite maximal oxygen support.\n8. Patients with contraindication to NIV according to the French consensus conference, patient refusal, cardiorespiratory arrest, coma, non-drained pneumothorax, unresolved vomiting, upper airway obstruction, hematemesis or severe facial trauma, thoracic or abdominal surgery in the previous 7 days.\n9. A do-not-intubate order at time of inclusion.\n10. Pregnancy.",{"count":115,"type":20},1300,[59],"Acute hypoxemic respiratory failure (AHRF) is a common indication for admission to an intensive care unit (ICU), with mortality exceeding 50% in cases where invasive mechanical ventilation is needed. Therefore, assessment of the most adequate oxygen strategy to avoid intubation in patients with AHRF deserves consideration.Previous studies have indicated that non-invasive oxygenation strategies, including high-flow nasal oxygen (HFNO), helmet or face mask noninvasive ventilation (NIV), and continuous positive airway pressure (CPAP), are effective in preventing endotracheal intubation in adult patients with AHRF when compared to the standard oxygen therapy. However, the optimal non-invasive oxygenation strategies remain uncertain. This study aim to determine whether CPAP, compared with HFNC or NIV, increase the intubation-free survival during study period in patients with AHRF.",[119,120,121,28],"Acute Hypoxemic Respiratory Failure","High-Flow Nasal Oxygen Therapy","Noninvasive Ventilation","2025-02-24",{"date":124,"type":38},"2025-02-26",{"date":126,"type":38},"2025-01-23",{"date":128,"type":20},"2027-12-31",{"name":130,"class":45},"Southeast University, China"]