[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"continuous-positive-airway-pressure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:continuous-positive-airway-pressure":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,53,79,96,123,147],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":34,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100627110","start-cpap-therapy-in-obstructive-sleep-apnea-patients-after-atrial-fibrillation-ablation-100627110",false,"NCT07444372","Start CPAP Therapy in Obstructive Sleep Apnea Patients After Atrial Fibrillation Ablation","Start CPAP Therapy in Obstructive Sleep Apnea Patients After Atrial Fibrillation Ablation: A Multicenter, Open-label, Randomized Clinical Trial","STOP-AFib","Inclusion Criteria:\n\nPatients must meet all of the following conditions to be eligible for the study:\n\n* Age 18-75 years.\n* Patients with persistent AF scheduled for first-time catheter ablation.\n* Diagnosed with OSA.\n* Able to tolerate CPAP therapy.\n* Capable of understanding and complying with the study protocol.\n* Willing to sign the informed consent form.\n\nExclusion Criteria:\n\nPatients meeting any of the following criteria will be excluded from the study:\n\n* Secondary AF.\n* Left atrial anteroposterior diameter 60mm (measured via parasternal long-axis view).\n* Left ventricular ejection fraction \\\u003C 30%.\n* Comorbid moderate-to-severe mitral stenosis or history of prosthetic valve replacement (mechanical or bioprosthetic).\n* Pregnant or breastfeeding women.\n* History of myocardial infarction, percutaneous coronary intervention, or cardiac surgery within 3 months prior to screening.\n* History of stroke or transient ischemic attack within 6 months prior to screening.\n* Perioperative complications related to the ablation procedure occurring prior to randomization.\n* Inability to discontinue antiarrhythmic drugs (AADs) post-procedure due to other reasons.\n* Life expectancy \\\u003C 1 year.\n* Central sleep apnea.\n* Conditions requiring ventilatory support, including obesity hypoventilation syndrome (defined as BMI \\> 30kg\u002Fm² and awake PaCO₂ \\> 45mmHg), amyotrophic lateral sclerosis, or chronic obstructive pulmonary disease with \\> 1 episode of respiratory failure or hypercapnia.\n* Treatment-emergent central sleep apnea during CPAP tolerance assessment that cannot be corrected prior to randomization.\n* Receipt of instrumental or surgical treatment for OSA within 3 months prior to screening, including CPAP, oral appliances, ENT surgery, or bariatric surgery.\n* Use of glucagon-like peptide-1 receptor agonists, glucose-dependent insulinotropic peptide receptor agonists, or glucagon receptor agonists for weight loss within 3 months prior to screening, or plans to initiate such medications within the next year.\n* Current participation in other drug or device trials.","ALL","18 Years","75 Years",{"count":21,"type":22},658,"ESTIMATED","INTERVENTIONAL",[25],"NA","Atrial fibrillation (AF) is one of the most common clinical arrhythmias. Catheter ablation is an effective therapeutic strategy; however, recurrence rates remain substantial, ranging from 20% to 45%. Previous studies have established a strong association between obstructive sleep apnea (OSA) and the risk of AF recurrence following ablation. While continuous positive airway pressure (CPAP) is the standard intervention for OSA, and some observational studies suggest it may reduce post-ablation recurrence in patients with comorbid OSA, small randomized controlled trials have failed to confirm a clear benefit, potentially due to poor adherence.\n\nThis study aims to evaluate the clinical benefit of post-ablation CPAP therapy in AF patients with comorbid OSA.\n\nParticipants will:\n\n* Be randomly assigned to either the CPAP group or the usual care group.\n* If in the CPAP group, use a CPAP device for 12 months.\n* Wear an ambulatory ECG recorder for a 7-day period at 3, 6, 9, and 12 months post-operation.\n* Complete follow-up checkups either at the clinic or over the phone at 1, 3, 6, and 12 months after their procedure.",[28,29,30,31,32,33],"Obstructive Sleep Apnea","Sleep Disorder (Disorder)","Atrial Fibrillation (AF)","Sleep Disordered Breathing (SDB)","Arrhythmia","Continuous Positive Airway Pressure",[28,33,35,36,37,38,39],"Atrial Fibrillation","Ablation of atrial fibrillation","Sleep Disordered Breathing","Clinical Trial","Catheter Ablation","RECRUITING","2026-06-14",{"date":43,"type":44},"2026-06-16","ACTUAL",{"date":46,"type":44},"2026-05-12",{"date":48,"type":22},"2029-01-31",{"name":50,"class":51},"Beijing Anzhen Hospital","OTHER",27,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100559937","addressing-unintentional-leakage-when-using-nasal-cpap---study-b-100559937","NCT06570629","Addressing Unintentional Leakage When Using Nasal CPAP - Study B","Mechanisms of Weight Gain During CPAP Treatment in Patients With Obstructive Sleep Apnea","Inclusion Criteria:\n\n* Diagnosis of moderate and severe obstructive sleep apnea;\n* Use of CPAP with a nasal mask;\n* 95th percentile of unintentional leak from the last 7 days above 24 l\u002Fmin, or at least 4 sudden drops of leak over one night of nasal CPAP\n* Persistence of excessive leak at the end of Study A.\n\nExclusion Criteria:\n\n* Patients who experience unintentional leakage from the mask\u002Faccessories.\n* Diagnostic polysomnography examination with a predominance of central apnea;\n* Patients with unstable heart disease, bedridden, neurodegenerative diseases, severe psychiatric disorders and COPD;\n* Previous surgery for obstructive sleep apnea;\n* Severe nasal obstruction (NOSE questionnaire score equal or greater then 55 points).",true,{"count":62,"type":22},50,[25],"Oral unintentional leak is a common side effect of continuous positive airway pressure (CPAP) for obstructive sleep apnea (OSA) treatment. Management of oral unintentional leakage has not been standardized and the effectiveness of potential approaches have not been studied in controlled studies. Higher levels of CPAP are associated with higher leak. In the present study, a sequential approach to control excessive unintentional leak will be tested. In study A, the reduction of therapeutic CPAP level will be tested. In study B, oronasal CPAP will be compared to nasal CPAP with a chinstrap.",[33,66,28],"Adverse Effect",[68,69,28],"CPAP","Excessive leak","2025-04-27",{"date":72,"type":44},"2025-04-30",{"date":72,"type":22},{"date":75,"type":22},"2028-12-31",{"name":77,"class":51},"University of Sao Paulo General Hospital",1,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":60,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":64,"conditions":89,"keywords":90,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":91,"startDateStruct":92,"completionDateStruct":93,"leadSponsor":94,"locationsCount":95},"100559936","addressing-unintentional-leakage-when-using-nasal-cpap---study-a-100559936","NCT06570616","Addressing Unintentional Leakage When Using Nasal CPAP - Study A","Strategies for Controlling Unintentional Leakage in the Treatment of Obstructive Sleep Apnea With Continuous Positive Airway Pressure","Inclusion Criteria:\n\n* Diagnosis of moderate and severe obstructive sleep apnea;\n* Use of CPAP with a nasal mask;\n* 95th percentile of unintentional leak from the last 7 days above 24 l\u002Fmin or at least 4 sudden leak line drop events\n\nExclusion Criteria:\n\n* Patients who experience unintentional leakage from the mask\u002Faccessories.\n* Diagnostic polysomnography examination with a predominance of central apnea;\n* Patients with unstable heart disease, bedridden, neurodegenerative diseases, severe psychiatric disorders and COPD;\n* Previous surgery for obstructive sleep apnea;\n* Severe nasal obstruction (NOSE questionnaire score equal or greater then 55 points).",{"count":87,"type":22},100,[25],[33,66,28],[68,69,28],{"date":72,"type":44},{"date":72,"type":22},{"date":75,"type":22},{"name":77,"class":51},2,{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":104,"targetDuration":4,"studyType":23,"phases":106,"briefSummary":107,"conditions":108,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":78},"100563081","positive-pressure-therapy-to-optimize-lung-function-after-heart-surgery-100563081","NCT06611527","Positive Pressure Therapy to Optimize LUNG Function After Heart Surgery","Comparison Between Two Methods of Positive Pressure Therapy in the Prevention of Pulmonary Complications in the Immediate Postoperative Period of Cardiac Surgery: a Prospective, Randomized Clinical Trial","PRO-LUNGHS","Inclusion Criteria:\n\n* Immediate postoperative period of myocardial revascularization and\u002For valve replacement or plastic surgery;\n* Patients in the preoperative period at risk of developing pulmonary complications, characterized by the presence of at least 2 of the following risk factors: age ≥ 70 years, productive cough, diabetes, history of smoking, chronic obstructive pulmonary disease (COPD) defined by forced expiratory volume in 1 second (FEV1) lower than 75% of predicted, body mass index (BMI) ≥ 27 kg\u002Fm2, or only FEV1 lower than 80% and FEV1\u002Fforced vital capacity (FVC) ratio lower than 70% of predicted; OR patients in the postoperative period (up to 12 hours after extubation) with mild to moderate complications characterized by a pulmonary complication score lower than 3.\n\nExclusion Criteria:\n\n* Hemodynamic instability characterized by mean arterial pressure (MAP) lower than 60mmHg and\u002For acute arrhythmia of any etiology;\n* Need for intra-aortic balloon;\n* Duration of invasive mechanical ventilation exceeding 24 hours after surgery;\n* Pulmonary complication score ≥ grade 3;\n* Presence of signs of acute respiratory failure, such as respiratory rate (f) ≥ 25 breaths\u002Fmin and use of accessory muscles;\n* Chest tube with air leak;\n* Use of a pacemaker or implantable or external cardioverter-defibrillator.",{"count":105,"type":22},156,[25],"The most common cardiac surgeries are myocardial revascularization and valve replacement or plastic surgery. In the postoperative period of cardiac surgeries, the incidence of pulmonary complications ranges from 30% to 50% and is associated with increased length of hospital stay and morbidity and mortality. To reduce or minimize the occurrence of these complications, respiratory physiotherapy employs positive pressure reexpansion therapies, such as continuous positive airway pressure (CPAP) and positive pressure support with positive end-expiratory pressure (PS+PEEP).\n\nThe goal of this clinical trial is to compare the effects of two positive pressure therapies, CPAP versus PS+PEEP, on the incidence of pulmonary complications in patients in the postoperative period of myocardial revascularization and valve replacement or plastic surgery, with mild to moderate pulmonary dysfunction.\n\nThe main question it aims to answer is: Do patients in the immediate postoperative period of myocardial revascularization or valve replacement\u002Fplastic surgery, exhibiting mild to moderate pulmonary dysfunction, experience a comparable reversal of pulmonary conditions when treated with PS+PEEP versus CPAP?\n\nParticipants will undergo the following assessments: spirometry, respiratory muscle strength testing, handgrip strength testing, and electrical impedance tomography.\n\nIn the immediate postoperative period, participants will be randomized into two treatment groups: • Control Group PS+PEEP - application of 4 sets of 20 repetitions with PS to provide a tidal volume equal to 10ml\u002Fkg of predicted body weight, PEEP equal to 10 cmH2O, and inspired oxygen fraction (FiO2) to achieve peripheral oxygen saturation (SpO2) between 92-94%; • Experimental Group CPAP - application of CPAP at 10 cmH2O with FiO2 to achieve SpO2 between 92-94% for 30 minutes.",[109,110,33,111,112,113],"Postoperative Period","Physical Therapy Modalities","Respiratory Function Tests","Pulmonary Atelectasis","Heart Surgery","2025-04-08",{"date":116,"type":44},"2025-04-10",{"date":118,"type":44},"2025-01-08",{"date":120,"type":22},"2027-12",{"name":122,"class":51},"Federal University of São Paulo",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":130,"targetDuration":132,"studyType":133,"phases":4,"briefSummary":134,"conditions":135,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":78},"100557757","clinical-study-on-the-effect-of-cpap-on-af-recurrence-after-catheter-ablation-in-patients-with-af-and-osa-100557757","NCT06542263","Clinical Study on the Effect of CPAP on AF Recurrence After Catheter Ablation in Patients with AF and OSA","Clinical Study on the Effect of Continuous Positive Airway Pressure Ventilation on Atrial Fibrillation Recurrence After Catheter Ablation in Patients with Atrial Fibrillation and Obstructive Sleep Apnea","Inclusion Criteria:\n\n1. Clinical diagnosis of AF combined with moderate to severe OSA (OSA diagnostic criteria: apnea hypopnea index (AHI) greater than 15\u002Fhour, and at least 80% of all events are respiratory sleep obstructive events; AF includes persistent atrial fibrillation and paroxysmal atrial fibrillation)\n2. Age ≥ 18 years old\n3. The patient voluntarily participates in the project and signs informed consent\n4. All patients undergo overnight sleep pressure titration at the sleep center to determine the minimum pressure value for continuous positive airway pressure ventilation at home. All patients are required to undergo CPAP treatment at home at least 5 days a week, with each session lasting at least 4 hours\n\nExclusion Criteria:\n\n1. Patients with neuromuscular disorders, pulmonary hypopnea, and severe lung diseases\n2. Preoperative confirmation of thrombus in the left atrium\n3. The patient has no desire for conversion\n4. Secondary atrial fibrillation (hyperthyroidism, tumors, etc.)\n5. Individuals with contraindications to anticoagulants\n6. Left atrial diameter (LAD) exceeding 60mm (2D echocardiography long axis section data)\n7. Pregnant women\n8. History of myocardial infarction, percutaneous coronary intervention, and cardiac surgery in the past three months\n9. Stroke or transient ischemic attack in the past six months\n10. After artificial valve implantation surgery\n11. Severe renal insufficiency (creatinine Cr\\>2.5mg\u002Fdl or\\>221umol\u002FL, or glomerular filtration rate eGFR\\\u003C30ml\u002Fmin\u002F1.73m2)\n12. Acute diseases or active infections that occur before surgery, recorded as pain, fever, positive blood culture, and\u002For leukocytosis, or have been treated with antibiotics.\n13. Expected survival period\\\u003C1 year",{"count":131,"type":22},224,"1 Year","OBSERVATIONAL","Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice, significantly increasing the risks of death, stroke, heart failure, cognitive impairment, and dementia, thus severely impacting patients' quality of life. However, for AF patients with concomitant cardiovascular risk factors, particularly those with obstructive sleep apnea (OSA), the success rate of catheter ablation is significantly reduced. Continuous positive airway pressure (CPAP) is currently an effective treatment for OSA, effectively correcting nocturnal intermittent hypoxia and fragmented sleep caused by OSA. However, the effect of CPAP therapy on AF recurrence in patients with OSA undergoing catheter ablation remains controversial. Faced with conflicting research findings, our team recently conducted a meta-analysis (registration number CRD42023398588) to assess the impact of CPAP on AF recurrence post catheter ablation in patients with AF and OSA, suggesting that CPAP significantly reduces AF recurrence post catheter ablation (RR = 0.58, P \\\u003C 0.01). However, considering the limited number of included studies, potential bias risks, and confounding factors, our meta-analysis results await further confirmation through real-world studies by our team. Therefore, our team plans to conduct further research on the impact of CPAP on AF recurrence post catheter ablation in patients with moderate to severe OSA, aiming to provide clinical guidance for the treatment of AF in patients with moderate to severe OSA.",[35,33,28,136,137],"Recurrence","Observational Study","2025-01-20",{"date":140,"type":44},"2025-01-23",{"date":142,"type":44},"2024-08-09",{"date":144,"type":22},"2026-08-01",{"name":146,"class":51},"Second Affiliated Hospital of Soochow University",{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":4,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":17,"minAge":154,"maxAge":132,"enrollmentInfo":155,"targetDuration":4,"studyType":133,"phases":4,"briefSummary":157,"conditions":158,"keywords":159,"overallStatus":161,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":78},"100558960","nasal-problems-in-neonates-and-infants-subjected-to-cpap-100558960","NCT06557915","Nasal Problems in Neonates and Infants Subjected to CPAP","Evaluation of Nasal Problems in Neonates and Infants Subjected to CPAP in Sohag University Hospitals","Inclusion Criteria:\n\n* Neonates and infants subjected to CPAP and presented to ENT department for assessment of nasal condition\n\nExclusion Criteria:\n\n* Failure to obtain consent.\n* Children above 1 year\n* Adults","1 Day",{"count":156,"type":22},30,"The goal of this study is to Detect and Screen different nasal complications of using CPAP in neonates and infants and reach a consensus about minimizing nasal problems of CPAP in neonates and infants",[33],[160,68],"neonates","NOT_YET_RECRUITING","2024-08-14",{"date":164,"type":44},"2024-08-16",{"date":166,"type":22},"2024-10",{"date":168,"type":22},"2025-12",{"name":170,"class":51},"Sohag University"]