[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"contrast-sensitivity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:contrast-sensitivity":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,57,88],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100609329","clinical-evaluation-of-low-contrast-visual-performance-and-low-light-phenomena-in-patients-with-various-intraocular-lens-implants-100609329",false,"NCT07213167","Clinical Evaluation of Low Contrast Visual Performance and Low Light Phenomena in Patients With Various Intraocular Lens Implants","Clinical Evaluation of Low Contrast Defocus Curves, Low Light Photic Phenomena, and Dysphotopsia Profiles in Pseudophakic Patients","Inclusion Criteria:\n\n* Minimum 22 years of age\n* Bilateral pseudophakia, at least 3 months postoperative from IOL implantation, with one of the study IOL models in at least one eye.\n* Availability, willingness, and sufficient cognitive awareness to comply with examination procedures\n* Signed informed consent and HIPAA authorization or equivalent documentation necessary to comply with applicable privacy laws pertaining to medical treatment in the governing countries\n* Ability to understand and respond to a questionnaire in English\n\nExclusion Criteria:\n\n* Any clinically significant pupil abnormalities (non-reactive, fixed pupils, or abnormally shaped pupils.\n* Inability to focus or fixate for prolonged periods of time (e.g., due to strabismus, nystagmus, etc.)\n* Uncorrected distance visual acuity worse than 20\u002F25 in either eye\n* Prior corneal refractive surgery (LASIK, LASEK, RK, PRK, etc.) or intraocular surgery. Note: Prophylactic peripheral iridotomies and peripheral laser retinal repairs that, in the opinion of the investigator will not confound study outcomes are acceptable.\n* Posterior capsular opacification with grading worse than 1+\n* Ocular findings that may, in the opinion of the investigator, affect vision and\u002For contrast sensitivity","ALL","22 Years",{"count":19,"type":20},120,"ESTIMATED","1 Day","OBSERVATIONAL","The goal of this clinical investigation is to evaluate visual acuity and contrast sensitivity in low lighting conditions using several different testing devices, and measure nighttime side effects of intraocular lens (IOL) implants after cataract surgery.\n\nResearchers will compare the results for three different types of IOLs to see how each lens contributes to overall visual function, patient experience and satisfaction.\n\nParticipants will:\n\n* Complete two different questionnaires about their current vision\n* Undergo visual testing using several different devices",[25,26,27,28,29],"Dysphotopsia","Posterior Capsule Opacification","Visual Acuity","Visual Function","Contrast Sensitivity",[25,26,31,32,33,34,35,36,37,38,39,40,41,42,43],"Halometry","Manifold Vision Meter","PRVSQ","AIOLIS","TECNIS Eyhance IOL","TECNIS Symfony Optiblue IOL","TECNIS Odyssey IOL","Low Contrast","Defocus Curves","Low Light Photic Phenomena","Dysphotopsia Profiles","Pseudophakia","TECNIS 1-Piece","RECRUITING","2026-03-31",{"date":47,"type":48},"2026-04-06","ACTUAL",{"date":50,"type":48},"2025-09-24",{"date":52,"type":20},"2026-08",{"name":54,"class":55},"Dr. Daniel H. Chang, MD","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":16,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":68,"conditions":69,"keywords":73,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":56},"100481492","the-effect-of-upper-blepharoplasty-on-vision-quality-in-the-early-postoperative-period-100481492","NCT05549713","The Effect of Upper Blepharoplasty on Vision Quality in the Early Postoperative Period","The Effect of Upper Blepharoplasty on Anatomical and Functional Aspects of Vision in the Early Postoperative Period","Inclusion Criteria:\n\n* Patients with functional dermatochalasis on the upper eyelid with subjective difficulties due to obstructing the upper part of visual field: swelling of the eyelids in the morning with difficulties in opening the eyes, use of the frontal musculature to be able to have at least a partial width of the field of vision in the upper part that is adequate for daily functioning, and headaches.\n\nExclusion Criteria:\n\n* History of corneal refractive surgery, pterygium, glaucoma, nuclear sclerosis \\> 4th degree, severe dry eye, age-related macular degeneration, neuro-ophthalmological diseases, use of hormone therapy, diabetic retinopathy or condition after panretinal photocoagulation. Corneal pathologies such as keratoconus and gross eyelid malposition conditions such as entropion, ectropion and marked laxity of the eyelids are also grounds for exclusion from the study.","45 Years","90 Years",{"count":67,"type":20},40,"Contrast sensitivity (CS) and tear film (TF) changes are noted in late postoperative period after upper blepharoplasty (UB), while the same was rarely investigated in the early postoperative period. The reason for aforementioned improvement of vision quality is unclear. Suggested explanations include changes in higher-order aberrations, elimination of the overlay effect created by excess skin on the upper eyelids and\u002For eyelashes directed toward the eyelid, or changes in corneal topography (CT) and keratometry.\n\nFurthermore, there is no consensus on the best technique for UB. Due not only to different surgical techniques, but also to different methods of measuring the tear film quality, it is very difficult to quantify the aforementioned studies.\n\nWhile changes in tear volume parameters and changes in tear film (TF) rupture have been investigated in detail, changes in the lipid layer have rarely been investigated.\n\nAccording to previous studies, there are different findings about changes in CT after UB.\n\nThe aim of the research is to determine whether there are anatomical (CT) and functional (TF and CS) changes in subjects with functional dermatochalasis before the procedure and in a month-long postoperative period.\n\nThe research is conducted on examinees diagnosed by clinical examination with functional dermatochalasis with the exclusion of examinees with ocular or systemic conditions affecting TF, best corrected visual acuity or CT.\n\nDetailed medical history and ophthalmologic examination will be performed with grading of the external appearance of the upper eyelids. All diseases and conditions that can lead to changes in CS, TF or corneal defects will be noted. Preoperatively all subjects will have CS recorded in photopic conditions, TF analysis and CT (Keratograph 5M, OCULUS Optikgeraete GmbH, Wetzlar, Germany). UB will be performed in the operating room at the UED. At first (seven days postoperatively) and second (one month postoperative) check-up a CS check will be performed at the UED and TF analysis and CT at Lens LTD.",[70,29,71,72],"Excess Skin of Both Eyelids","Tear Film Insufficiency of Both Eyes","Corneal Topography",[74,75,76,77,78],"Corneal topography","Contrast sensitivity","Eyelid disease","Meibomian gland dysfunction","Blepharoplasty","2024-12-30",{"date":81,"type":48},"2024-12-31",{"date":83,"type":48},"2022-09-08",{"date":85,"type":20},"2026-01-01",{"name":87,"class":55},"Osijek University Hospital",{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":16,"minAge":95,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":98,"conditions":99,"keywords":100,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":110,"locationsCount":56},"100554371","optimization-of-the-skin-test-procedure-with-iodinated-contrast-products-for-certain-patients-suspected-of-immediate-hypersensitivity-100554371","NCT06498219","Optimization of the Skin Test Procedure With Iodinated Contrast Products for Certain Patients Suspected of Immediate Hypersensitivity","OPT-TC-PCI","Inclusion Criteria:\n\n* Major subject (≥18 years old)\n* Subject treated in the allergology department in the period from June 1, 2020 to July 3, 2023 for suspected allergic hypersensitivity to ICPs and having had at least one undiluted intradermal reaction to one or more ICPs.\n* Absence of written opposition in the medical file of the subject (and\u002For their legal representative if applicable) to the reuse of their data for scientific research purposes.\n\nExclusion Criteria:\n\n* Presence of opposition from the subject (and\u002For their legal representative if applicable) to the reuse of their data for scientific research purposes.","18 Years",{"count":97,"type":20},100,"Hypersensitivity to iodinated contrast products (ICP) affects 1 to 3% of injected patients. These reactions require an allergological assessment with skin tests in order to distinguish allergic immunological mechanisms from other non-specific mechanisms. Current recommendations recommend carrying out prick tests followed by intradermal reactions up to a 10th dilution. However, undiluted IDRs are carried out by several teams under certain conditions, without this having been validated. Experience tends to show that these IDRs are relevant in certain patients to make the diagnosis without risk.",[29],[29,101,102,103],"Iodinated contrast products","Allergic immunological mechanisms","Allergy","2024-07-04",{"date":106,"type":48},"2024-07-12",{"date":108,"type":48},"2023-12-21",{"date":81,"type":20},{"name":111,"class":55},"University Hospital, Strasbourg, France"]