[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"control-condition\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:control-condition":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,47,79,117,146,174,205,235,262,289,317,338,368,397],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100567638","using-ecological-momentary-data-to-inform-a-web-intervention-for-romantic-partners-concerned-about-their-loved-ones-drinking-100567638",false,"NCT06670794","Using Ecological Momentary Data to Inform a Web Intervention for Romantic Partners Concerned About Their Loved Ones' Drinking","CP Inclusion Criteria:\n\n* be at least 18 years old\n* be in a romantic relationship with their partner\n* be living with their partner,\n* have a computer, tablet, or mobile phone with Internet access\n* have no plans to separate from their partner in the next 60 days\n* indicate no concerns they would be physically hurt by their partner on the Intimate Partner Screen\n\nCP Exclusion Criteria:\n\n* drinking scores at or above the threshold for DP participation\n\nDP Inclusion Criteria:\n\n* be at least 18 years old\n* misuses alcohol as defined by their scores (4+ for women\u002Fnon-gender confirming, 5+ for men) on the consumption portion of the Alcohol Use Disorder Identification Test (AUDIT-C) (Dawson et al., 2005)\n* has a computer, tablet, or mobile phone with Internet access\n* indicates no concerns they would be physically hurt by their partner\n\nDP Exclusion Criteria:\n\n* current alcohol treatment\n* currently concerned about their partner's drinking",true,"ALL","18 Years",{"count":19,"type":20},160,"ESTIMATED","INTERVENTIONAL",[23],"NA","Aim 1. Couples (N=50 dyads) with a Concerned Partner (CP) and a Drinking Partner (DP) will independently complete baseline and follow-up surveys and a 21-day EMA with three daily reports on their communication and DP's drinking. Aim 2. Iteratively develop a four-session web based intervention and evaluate the WBI's feasibility and acceptability with 15 CPs. Aim 3. Perform a pilot randomized controlled trial (RCT) comparing WBI to psychoeducation control in 110 couples.",[26,27],"Experimental","Control Condition",[29,30,31,32,33,34],"alcohol","alcohol use disorder","community reinforcement and family training","concerned partners","concerned significant others","communication","NOT_YET_RECRUITING","2026-07-01",{"date":38,"type":39},"2026-07-02","ACTUAL",{"date":41,"type":20},"2026-09-29",{"date":43,"type":20},"2027-02-28",{"name":45,"class":46},"University of Florida","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100644047","acute-muscular-and-vascular-responses-to-a-single-session-of-exercise-with-bfr-in-copd-100644047","NCT07668921","Acute Muscular and Vascular Responses to a Single Session of Exercise With BFR in COPD","Blood Flow Restriction (BFR): a Novel Approach to Potentiate the Effects of Rehabilitative Exercise Training in COPD? Study of Acute - Muscular, and Vascular - Responses to a Single Session of Exercise With BFR","2BFREE_aigu","Inclusion Criteria:\n\n* Negative pregnancy test and use of an acceptable contraceptive method throughout the study duration for women of childbearing potential\n* Established COPD defined as obstructive ventilatory defect (FEV1\u002FFVC \\\u003C 0.70 or below the 5th percentile)\n* Resting lung hyperinflation defined as functional residual capacity \\> 2.5 z-scores according to the Global Lung Function Initiative (GLI)\n* Clinical stability of COPD for at least 3 months, with no recent exacerbation requiring treatment modification\n* Covered by a national health insurance system\n* Able and willing to provide written informed consent\n\nNon-inclusion Criteria:\n\n* Presence of a medical device incompatible with magnetic stimulation\n* Inability to perform an exercise test on a cycle ergometer\n* Any usual contraindication to exercise testing, including:\n\n  * Recent myocardial infarction (3-5 days)\n  * Unstable coronary insufficiency\n  * Severe stenotic valvular disease\n  * Uncontrolled arrhythmia with hemodynamic instability\n  * Recent unexplained syncope\n  * Uncontrolled heart failure\n  * Uncontrolled arterial hypertension (systolic blood pressure ≥200 mmHg and\u002For diastolic blood pressure ≥110 mmHg at rest)\n  * Acute thromboembolic disease and\u002For pulmonary edema\n* Conditions contraindicating the use of blood flow restriction (BFR), including:\n\n  * Coagulation disorder\n  * Peripheral neuropathy\n  * Uncontrolled hypertension (\\>160\u002F100 mmHg)\n  * Peripheral arterial disease\n  * History of venous thrombosis\n  * Intensive care unit stay within the last 3 months\n* Participation in another study during an exclusion period\n* Inability to be contacted in case of emergency\n* Individuals covered under Articles L1121-5 to L1121-8 of the French Public Health Code (protected populations, including pregnant or breastfeeding women, prisoners, minors, individuals under legal protection, psychiatric inpatients, etc.)\n* Staff members with a hierarchical relationship with the principal investigator","45 Years",{"count":57,"type":20},40,[23],"Exercise training is a cornerstone of pulmonary rehabilitation (PR) in patients with chronic obstructive pulmonary disease (COPD). However, some patients derive limited benefits from conventional exercise programs. Previous studies suggest that the magnitude of exercise-induced muscle fatigue is associated with training effectiveness, with patients unable to develop significant muscle fatigue (\"non-fatiguers\") showing smaller improvements in functional capacity and quality of life.\n\nBlood flow restriction (BFR) exercise consists in performing physical exercise while applying external pressure to the proximal part of the exercising limb, thereby reducing oxygen delivery to the muscles and limiting metabolite clearance. This approach has been shown to induce significant muscular adaptations despite the use of low exercise intensities. Because exercise intensity in COPD patients is often constrained by ventilatory limitations, BFR training may enhance muscle adaptations while reducing respiratory stress, potentially improving the effectiveness of PR.\n\nThe primary objective of this monocentric randomized crossover study is to compare lower-limb muscle fatigue induced by a single exercise session performed with BFR versus a standard exercise session in patients with COPD.",[27,61,62],"Pulmonary Disease (COPD), Chronic Obstructive","Blood Flow Restriction Training (BFRT)",[64,65,66,67,68],"Muscle Fatigue","COPD","Aerobic exercise","Resistance exercise","Blood Flow Restriction Training","2026-06-25",{"date":71,"type":39},"2026-06-30",{"date":73,"type":20},"2026-11",{"date":75,"type":20},"2028-12",{"name":77,"class":46},"University Hospital, Grenoble",1,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":21,"phases":90,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":4},"100643208","online-socio-emotional-dyad-training-for-healthcare-professionals-well-being-and-social-skills-phase-ii-100643208","NCT07637422","Online Socio-emotional Dyad Training for Healthcare Professionals' Well-being and Social Skills, Phase II.","The Edu:Social Health Care Project Phase II: Investigating the Effects of an Online Socio-emotional Dyad Intervention on Healthcare Professionals' Mental Health, Resilience, Social Competencies and Behaviors.","EduSocHealth2","Inclusion Criteria:\n\n1. Between 18- and 65-years old.\n2. Currently practicing a healthcare profession in Germany or Austria 2a. Belongs to one of the eligible state-regulated professions with legally defined independent responsibility for patient care, including diagnosis, treatment, psychotherapy, maternity care, or the overall nursing process (e.g., physician, psychotherapist, midwife, or registered nurse).\n\n2b. Regular direct contact with patients or clients as part of the professional role (3) Proficient in German. (4) Informed consent. (5) No diagnosis of a psychiatric disorder within the past two years. (6) Stable internet access and necessary technical equipment (mobile phone with internet access).\n\n(7) No regular contemplative practice (≤ 50 hours total within the past six months); healthy population, non-clinical population.\n\nExclusion Criteria:\n\n(8) Insufficient German proficiency. (9) Lack of stable internet access or required devices (mobile phone with internet access).\n\n(10) No informed consent. (11) Not currently practicing the profession, or working only in administrative, research, or teaching roles without patient contact.\n\n11a. Professions are excluded if their primary role is supportive, assistive, emergency transport, preventive, counseling-focused, or based on prescribed adjunct therapies rather than independent responsibility for patient care, along with non-human-related professions. This includes, for example, nursing assistants, health psychologists, physiotherapists, occupational therapists, speech therapists, dietitians, massage therapists, paramedics (Sanitäter), and other comparable support or adjunct roles.\n\n11b. No regular direct patient or client contact (12) Regular contemplative practice (\\> 50 hours in the past six months (e.g., dyad, mindfulness, compassion-based practices).\n\n(13) Current psychiatric diagnosis or therapy, or reaching screening cutoffs on:\n\n* Patient Health Questionnaire-9 (PHQ-9 ; Martin et al., 2006 ; Löwe et al., 2004 ; Cutoff ≥ 15 ; or endorsing suicidality on the item 9),\n* Generalized Anxiety Disorder-7 (GAD-7; Löwe et al., 2007; Spitzer et al., 2006; Cutoff ≥ 15)\n* Toronto Alexithymia Scale-20 (TAS-20; Bagby et al., 1994; Ritz \\& Kannapin, 2000; Cutoff ≥ 61)\n* Standardized Assessment of Personality - Abbreviated Scale (SAPAS; Moran et al., 2003; Söchtig et al., 2012, Cutoff ≥ 4).","68 Years",{"count":89,"type":20},666,[23],"Edu:Social Health Care Project Phase II is a non-randomized waitlist-controlled trial with sequential recruitment of the intervention and waitlist control groups (nrWLC), designed to evaluate the effects of a partner-based Dyad-based empathy-compassion mental training (EmCo) intervention on healthcare professionals with regard to following primary outcome domains: 1) mental health, 2) resilience, 3) social cohesion and support, 4) social skills, 5) coping and emotion regulation, and 6) social behaviors.\n\nOne main goal is to examine the effects of such adapted 8-week EmCo Dyad intervention within the health care context, with a particular focus on strengthening healthcare professionals' mental health, resilience, social skills and behaviors, and social cohesion as well as fostering interprofessional attitudes by pairing every week study partners across different healthcare disciplines with each other for practicing their daily Dyads (e.g., nurses will practice daily via app with medical doctors or midwives).\n\nA further aim is to validate the novel Dyad Voice Assessment (DYVA) task, which explores the use of app-based voice recordings as indicators of healthcare professionals' emotional states during their daily partner-based Dyad practice. By combining healthcare professionals' self-reported practice-related emotions with partner-based evaluations, this approach aims to generate new and innovate, more objective markers of training-induced changes in emotional processing and regulation over time in a real-live applied setting.\n\nThe final aim is to investigate the cognitive and affective mechanisms and factors underlying observed changes in healthcare professionals' mental health, resilience, social cohesion, social skills and social behaviors, that may explain observed training-related effects in primary outcome domains. Based on previous research, we expect the socio-emotional EmCo Dyad training to activate evolutionary old care- and affiliation-based motivational systems that foster positive affect and motivation, acceptance, trust social capacities and behavioral tendencies. These processes should go along with reduction in loneliness, stress and other mental vulnerabilities (anxiety, depression, burn-out etc.) and foster social skills such as empathy, compassion as well as social cohesion and resilience.",[93,27],"Intervention Condition",[95,96,97,98,99,100,101,102,103,104,105,106,107],"Mental Training","Dyad training","Compassionate Listening","Empathic Listening","Empathy","Compassion","Mental-Health","Online & App-based Training","Resilience","Social Cohesion","Social Skills","AI-based Voice Assessment","Healthcare professionals","2026-06-04",{"date":110,"type":39},"2026-06-09",{"date":112,"type":20},"2026-08-31",{"date":114,"type":20},"2027-04-03",{"name":116,"class":46},"Max Planck Social Neuroscience Lab",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":123,"eligibilityCriteria":124,"healthyVolunteers":15,"sex":16,"minAge":125,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":21,"phases":128,"briefSummary":129,"conditions":130,"keywords":132,"overallStatus":136,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":78},"100629622","exercise-and-protein-efficiency-in-t2d-100629622","NCT07477067","Exercise and Protein Efficiency in T2D","Exercise Impact on Dietary Protein Efficiency in Older Adults With Type 2 Diabetes","ADA","Inclusion Criteria:\n\n* At least 65 years old\n* Body mass index: 25-40 kg\u002Fm\\^2\n* Female: Waist to hip ratio \\>0.8\n* Male: Waist to hip ratio \\>1.0\n* Free from structured exercise during the prior 6 months (mo) weight stable for the prior 6 months\n\nT2D group:\n\n-Diagnosed by a physician with elevated glycosylated hemoglobin (HbA1c) \\>6.5%\n\nControl group:\n\n-Normoglycemic with HbA1c levels not exceeding 5.6% and fasting blood glucose levels below or equal to 99 mg\u002FdL (5.5mmol)\n\nExclusion Criteria:\n\n* Uncontrolled diabetes (evidence of HbA1c \\> 10%, prescription of insulin)\n* Diagnoses of diabetic neuropathy or failing diabetic neuropathy screening\n* Statins\n* Peripheral edema Consumption of ergogenic-levels of dietary supplements that may affect muscle mass (e.g., creatine, HMB), insulin-like substances, or anabolic\u002Fcatabolic pro-hormones (e.g., DHEA) within 6 weeks prior to participation.\n* Untreated hypothyroidism, epilepsy, medications that affect vasoactivity, possibility of pregnancy, and any neurological, cardiovascular, or musculoskeletal disease that precludes exercise testing.","65 Years",{"count":127,"type":20},30,[23],"In this randomized controlled trial, 30 older adults (aged\\> 65 years; 15 with T2D, 15 controls) will participate in a 12-week progressive exercise training program. They will undergo pre- and post-testing that includes body composition measures; oral glucose tolerance testing; cardiovascular fitness and muscle performance testing; dietary protein efficiency assessed using the indicator amino acid oxidation (IAAO) method; and a gut microbiota trial. The dietary protein efficiency trial will include repeated ingestion of crystallized amino acids (drink) containing stable isotopes, urine samples, and breath samples. The gut microbiome trial will consist of a single ingestion of a Mediterranean-based modeled meal enriched with 13C-phenylalanine (in the drink) and repeated blood draws. Participants will also be asked to give a fecal sample after the gut microbiome trial.",[131,27],"Type 2 Diabetes",[131,133,134,135],"Obesity","Exercise Intervention","Protein Metabolism","RECRUITING","2026-04-27",{"date":139,"type":39},"2026-04-29",{"date":141,"type":39},"2026-02-09",{"date":143,"type":20},"2028-07-01",{"name":145,"class":46},"University of Illinois at Urbana-Champaign",{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":154,"targetDuration":4,"studyType":21,"phases":156,"briefSummary":157,"conditions":158,"keywords":160,"overallStatus":136,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":172,"locationsCount":78},"100619885","hip-abduction-and-adduction-during-neurodynamic-stretching-100619885","NCT07350434","Hip Abduction and Adduction During Neurodynamic Stretching","The Acute Effects of Neurodynamic Stretching on the Shear Wave Velocity: the Effects of Hip Adduction and Abduction","HIPROT","Inclusion Criteria:\n\n* healthy\n* physical active\n* no injuries (lower limb or back pain) in the past 3 months\n\nExclusion Criteria:\n\n* Specific lower limb (hamstring) injuries in the past 2 years\n* Not restraining activity 24h before participation",{"count":155,"type":20},12,[23],"Neurodynamic mobilization techniques are widely applied in rehabilitation and physiotherapy to enhance the mobility and function of peripheral nerves. Two main approaches are distinguished : Nerve tensioning and nerve flossing. They both involve proximal and distal joint movements to induce greater neural sliding while avoiding excessive tensile stress. However, contradictory findings following neurodynamic stretching highlighted the current lack of consensus regarding the position that should be used. Moreover, neurodynamic techniques are of interest for patients, it appeared it could also be applied in healthy individuals and more particularly in athletes. Accordingly, the primary objective of the present study was to determine the immediate effect of two hip positions (adduction vs. abduction) during neurodynamic flossing techniques on the sciatic nerve and hamstring tissues using the shear wave elastography (SWE, a form of ultrasonography).",[159,27],"Stretching",[161,162,163,164,165,166],"stretching","stiffness","nerve","muscle","flexibility","hip",{"date":168,"type":39},"2026-04-28",{"date":170,"type":39},"2026-02-01",{"date":71,"type":20},{"name":173,"class":46},"University of Burgundy",{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":4,"eligibilityCriteria":180,"healthyVolunteers":15,"sex":16,"minAge":55,"maxAge":181,"enrollmentInfo":182,"targetDuration":4,"studyType":21,"phases":183,"briefSummary":184,"conditions":185,"keywords":189,"overallStatus":136,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":78},"100622525","foot-strengthening-to-improve-balance-and-gait-in-older-adults-100622525","NCT07384754","Foot Strengthening to Improve Balance and Gait in Older Adults","Evaluation of a Novel Foot Strengthening Device for Improving Fall Risk, Balance, and Gait With Age","Inclusion Criteria:\n\n* Healthy adults: age 45-85 years old\n* Able to walk without an assistive walking device or lower limb prosthesis\n* No history of foot or ankle surgery\n* No history of regular minimalist footwear use\n* No foot or ankle issues for which study activities may be contraindicated\n* BMI \\\u003C= 40\n\nExclusion Criteria:\n\n* Deemed unfit for physical activity by the Physical Activity Readiness Questionnaire (PAR-Q)\n* Current or history of an unresolved musculoskeletal, neurological, cardiovascular, pulmonary\u002Frespiratory, metabolic, renal condition, disease, or problem\n* Use of orthotics in daily (i.e., non-athletic) footwear\n* Pregnancy\n* Any other disease or problems that may affect movement or the ability to exercise even at a low intensity","85 Years",{"count":19,"type":20},[23],"The goal of this clinical trial is to learn whether different foot-strengthening strategies can improve foot strength, balance, walking ability, and fall-related outcomes in middle-aged and older adults (ages 45-85 years).\n\nThe main questions it aims to answer are:\n\n* Does foot strength change from baseline after an 8-week foot-strengthening intervention?\n* Do balance, gait, and physical function improve following different foot-strengthening approaches?\n\nResearchers will compare minimalist footwear use, a foot exercise program, a foot-strengthening device (ToePro), and no intervention to see if these interventions lead to greater improvements in foot strength, balance, gait, and fall-related outcomes than no intervention.\n\nParticipants will:\n\n* Complete baseline and post-intervention laboratory testing of foot strength, balance, physical function, and walking gait\n* Perform foot strengthening exercises or wear minimalist footwear (if applicable) five days\u002Fweek for eight weeks\n* Complete daily logs to record intervention compliance",[186,187,188,27],"Minimalist Footwear","Traditional Foot Exercise Program","Foot Strengthening Device (ToePro)",[190,191,192,193,194,195],"Balance","Gait","Intrinsic Foot Muscles","Minimalist footwear","Aging","Fall prevention","2026-01-26",{"date":198,"type":39},"2026-02-03",{"date":200,"type":39},"2026-01-01",{"date":202,"type":20},"2027-06-30",{"name":204,"class":46},"Indiana University",{"id":206,"slug":207,"hasResults":11,"nctId":208,"briefTitle":209,"officialTitle":209,"acronym":210,"eligibilityCriteria":211,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":212,"targetDuration":4,"studyType":214,"phases":4,"briefSummary":215,"conditions":216,"keywords":218,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":234},"100612543","vision-and-proprioception-evaluation-with-robotics-after-stroke-100612543","NCT07254949","Vision and Proprioception Evaluation With Robotics After Stroke","VIPERS","Inclusion criteria for stroke participants:\n\n* 18 years of age or older\n* First clinical diagnosis of stroke\n* No recent muscle skeletal injuries to the arms, neck, or back\n* No history of other neurological disease\u002Finjury (Ie. MS, Parkinson's, Brain Tumour, etc.)\n* Corrected vision 20\u002F50 or better\n* Able to follow multi-step commands.\n* Living independently prior to stroke\n* Can consent to participate in research\n\nInclusion criteria for control participants:\n\n* 18 years of age or older\n* No history stroke, or Trans Ischemic Attack (TIA)\n* No recent muscle skeletal injures to the arms, neck, or back\n* No history of other neurological disease\u002F injury (Ie. MS, Parkinson's, Brain Tumour, etc)\n* No pre-stroke history of eye movement disorders\n* Corrected vision 20\u002F50 or better\n* Able to follow multi-step commands\n* Can consent to participate in research\n\nExclusion Criteria:\n\n* Prior history of stroke\u002Fsignificant neurologic problem (e.g. Parkinson's)\n* Symptomatic medical conditions that would interfere with participation (e.g. uncontrolled angina)\n* Contraindications to Magnetic Resonance Imaging (MRI)\n* Pre-stroke history of visual field\u002Foculomotor abnormalities.",{"count":213,"type":20},425,"OBSERVATIONAL","Stroke is highly prevalent in Canada and can lead to profound upper limb impairments in motor and sensory function, as well and vision. Clinical assessments for these functions often lack sensitivity making detecting impairments and tracking their recovery after stroke difficult. It is known that sensory function and vision interact to inform motor behaviours, yet how each of these modalities might contribute to motor impairments and subsequent recovery after stroke is undetermined.\n\nUsing robotics to assess neurologic function after a stroke can be very beneficial, as they can measure on the scale of millimetres and milliseconds which can more easily detect subtle deficits in a persons function. Compared to current clinical tools, robotics offer greater objectivity and reliability, as they do not rely on the examiners clinical experience and\u002For impression. The use of robotics not only offers a more precise measurement, but robotics assessments can be completed in a relatively short amount of time, in comparison to some of the current clinical assessment tools, which can take along time to complete. In addition to robotics, collecting neuroimaging (MRI\u002FCT) will allow us to relate our robotic and eye-tracking measures to neuroanatomical information about the person's stroke. With this data, we will assess how the brain changes post-stroke in relation to the recovery of motor, sensory and visual functions.\n\nThis research will: 1) examine the relationship between visual and proprioceptive impairment on motor and eye movement behaviour over time after stroke, and 2) identify neuroanatomical correlates of visual, proprioceptive and sensory integrative dysfunction that impact motor recovery after stroke and examine the ability of regional damage and network disruption to predict recovery.\n\nObjectives:\n\n1. Determine the impact of visual field loss and visual neglect in stroke survivors with impaired movement over the first 6 months post-stroke.\n2. Identify the impact of Proprioceptive Impairment and Sensory Integration Impairment on recovery post-stroke using robotics and eye tracking.\n3. Understand the impact of damage to neuroanatomic structures involved in vision, proprioception and sensory integration on motor recovery using MRI after stroke.\n\nThe VIPERS study is recruiting both stroke and control participants. Stroke participants are recruited within the first 28 days post-stroke and are assessed longitudinally across the first 6-months post-stroke (four study timepoints). Control participants just complete a single session.",[217,27],"Stroke",[217,219,220,221,222,223,224],"Sensation","Movement","Vision","Robotics","Eye-Tracking","Imaging","2025-11-19",{"date":227,"type":39},"2025-11-28",{"date":229,"type":20},"2026-01",{"date":231,"type":20},"2031-06",{"name":233,"class":46},"Dr. Sean Dukelow",2,{"id":236,"slug":237,"hasResults":11,"nctId":238,"briefTitle":239,"officialTitle":240,"acronym":4,"eligibilityCriteria":241,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":242,"enrollmentInfo":243,"targetDuration":4,"studyType":21,"phases":245,"briefSummary":246,"conditions":247,"keywords":249,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":253,"lastUpdatePostDateStruct":254,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":260,"locationsCount":78},"100570724","inducing-self-dehumanization-to-examine-oxytocin-and-suicide-risk-100570724","NCT06710964","Inducing Self-Dehumanization to Examine Oxytocin and Suicide Risk","Inducing Self-Dehumanization to Examine the Effects on Oxytocin and Suicide Risk","Inclusion Criteria:\n\n* Between the ages of 18 and 40\n* Biological females will be screened to ensure that they have a regular menstrual cycle with a length of 26-30 days and will be scheduled according to their cycle (see Research Strategy for details).\n* At least a moderate level of self-dehumanization (i.e., a sum score of 12 or greater out of a possible score of 28) and lifetime suicidal ideation\n\nExclusion Criteria:\n\n* A phobia of needles (i.e., Trypanophobia)\n* Any medical conditions precluding them from engaging in a 10-hour fast (consumption of water is allowed and encouraged)\n* Life-threatening suicide risk which would result in taking appropriate steps to ensure safety of the individual (e.g., hospitalization)\n* A psychosis-related diagnosis","40 Years",{"count":244,"type":20},50,[23],"The goal of this experiment is to further determine if self-dehumanization is a novel risk factor for suicide. This study will induce self-dehumanization using a novel experimental self-dehumanized future condition (i.e., a futuristic paradigm that likens the individual to a machine) and compare this group to a control group to analyze the pathway between higher perceptions of self-dehumanization, suicidal ideation, and changes in oxytocin concentrations.\n\nIt is hypothesized that participants randomly assigned to the self-dehumanized mechanistic future condition will exhibit temporary increases in suicidal ideation (which will be thoroughly assessed, intervened upon following the induction) and decreases in oxytocin concentrations as compared to the control condition, which will not display significant changes. Further, we will explore if the magnitude of the oxytocin response will partially mediate the change in suicidal ideation.",[248,27],"Mechanistic Self-Dehumanization Condition",[250,251,252],"self-dehumanization","suicidal ideation","oxytocin","2025-10-10",{"date":255,"type":39},"2025-10-14",{"date":257,"type":20},"2026-04",{"date":259,"type":20},"2028-08",{"name":261,"class":46},"Florida State University",{"id":263,"slug":264,"hasResults":11,"nctId":265,"briefTitle":266,"officialTitle":267,"acronym":268,"eligibilityCriteria":269,"healthyVolunteers":15,"sex":16,"minAge":4,"maxAge":270,"enrollmentInfo":271,"targetDuration":4,"studyType":214,"phases":4,"briefSummary":273,"conditions":274,"keywords":275,"overallStatus":136,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":78},"100569451","determining-paediatric-usual-values-for-hormones-dosages-by-lc-msms-100569451","NCT06694415","Determining Paediatric Usual Values for Hormones Dosages by LC-MS\u002FMS","Determining Paediatric Usual Values for Hormones Dosages by Mass Spectrometry","DOSHOMASS","Inclusion Criteria:\n\n* Male or female patient ≤ 20 years old\n* undergoing a blood sample as part of their pathology routine follow-up\n\nExclusion Criteria:\n\n* Any identified or suspected endocrine pathology\n* Any acute infectious or inflammatory disorder","20 Years",{"count":272,"type":20},1500,"Liquid chromatography coupled with mass spectrometry (LC-MS\u002FMS) is now the method of choice for steroid hormone analysis, as it enables analyses to be carried out on small-volume samples on a wider range of hormones, with improved specificity compared with immunoassays. Hormone assays currently face a twofold problem: on the one hand, immunoassays are highly dependent on the synthesis of antibody kits manufactured by companies with immunotechnology expertise; on the other hand, these immunoassays may require the use of radioactive products for quantification, generating considerable risks for both staff and environment. There are international recommendations from expert societies (World Anti-Doping Agency, Endocrine society) to develop new, more reliable assay methods, such as LC-MS\u002FMS, and to phase out immuno- and radioassay techniques.\n\nHowever, changing measurement methods requires the development of reference values to maintain and optimize the management of patients.\n\nThe aim of this project is therefore to establish usual values in a paediatric population, through collaboration between the clinical departments of the APHP and the METOMICS laboratory, which has mastered the technology.",[27],[276,277,278,279],"LC-MS\u002FMS","Hormones","Children","Usual values","2025-08-25",{"date":282,"type":39},"2025-08-26",{"date":284,"type":39},"2025-01-02",{"date":286,"type":20},"2026-12",{"name":288,"class":46},"Assistance Publique - Hôpitaux de Paris",{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":293,"acronym":4,"eligibilityCriteria":294,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":295,"targetDuration":4,"studyType":21,"phases":297,"briefSummary":298,"conditions":299,"keywords":301,"overallStatus":136,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":315,"locationsCount":78},"100601679","adapting-an-evidence-based-intervention-to-improve-hiv-testing-and-prep-uptake-in-vietnam-100601679","NCT07113626","Adapting An Evidence-Based Intervention To Improve HIV Testing And PrEP Uptake In Vietnam","Inclusion Criteria:\n\n* Young men who have sex with men (YMSM):\n\nTheater testing. YMSM are eligible if they (1) are 18-24 years old Vietnamese male; (2) report having anal intercourse with another man in the last 6 months; (3) are HIV negative or of unknown HIV status; (4) own a smartphone; (5) currently live in Hanoi, (6) are able to read and understand Vietnamese without assistance, and (7) are willing to provide informed consent.\n\nBeta testing. Eligibility is similar to theater testing. Randomized controlled trial (RCT). YMSM are eligible if they (1) are 18-24 years old Vietnamese male; (2) report having anal intercourse with another man in the last 6 months; (3) are HIV negative or of unknown HIV status; (4) own a smartphone; (5) currently live in Hanoi, (6) are able to read and understand Vietnamese without assistance, and (7) are willing to provide informed consent and (8) are not being currently on pre-exposure prophylaxis (PrEP).\n\n* Other key stakeholders:\n\nEligibility criteria of this group are (1) having worked with MSM-related health issues at an HIV\u002FPrEP clinic or community-based organizations (CBO) for at least 6 months and (2) willingness to provide informed consent.\n\nExclusion Criteria:\n\n* Young men who have sex with men (YMSM):\n\nTheater testing. None Beta testing. Participants will be deemed ineligible if they are unwilling to provide contact information.\n\nRandomized controlled trial. Exclusion criteria include (1) unwilling to provide contact information; (2) currently enrolled in other HIV testing or PrEP program\u002Fintervention.\n\n* Other key stakeholders: None",{"count":296,"type":20},124,[23],"Young men who have sex with men are experiencing an ongoing HIV epidemic in Vietnam, with an HIV prevalence of 12%. However, HIV testing and pre-exposure prophylaxis (PrEP) use among young men who have sex with men remain low. To improve HIV testing and PrEP use, mobile health (mHealth) interventions hold great promise to reach young men who have sex with men in low- and middle-income countries. HealthMindr, an evidence-based mHealth intervention developed in the United States for men who have sex with men, is an ideal option for adaptation for young men who have sex with men in Vietnam. The specific aims are to (1) Adapt the HealthMindr app to improve HIV testing and PrEP uptake among young men who have sex with men in Vietnam; (2) Examine acceptability, feasibility and preliminary effectiveness of the adapted app among young men who have sex with men in Vietnam and (3) Explore barriers and facilitators of implementing the adapted app among young men who have sex with men in Vietnam. In Aim 1, theater testing will be conducted through focus group discussions with young men who have sex with men and key other stakeholders, including health officials, clinic staff and community-based organizations. Theater testing data will be used to refine the app for beta testing. During beta testing, a small group of young men who have sex with men will use the app for 30 days, then complete an online survey and an exit interview to rate the app's usability, provide their perspectives of the app and report any other areas for improvement. App analytics will also be collected to understand whether and how the app is used. In Aim 2, the adapted app with be tested among young men who have sex with men through a randomized controlled design. Young men who have sex with men will be randomized into the intervention or control arm (1:1 ratio). The intervention arm will have full access to the app for 3 months, while the control group will receive standard-of-care HIV services. Key app features include HIV test planning, risk and PrEP eligibility assessment, ordering of free condoms and HIV test kits, information about PrEP, and PrEP provider and HIV testing locations. HIV testing and PrEP use will be assessed at baseline and 3 months and compared between groups. A mixed methods approach will be used to evaluate app acceptability and feasibility. Quantitative data on acceptability and feasibility will be collected through the 3-month online survey, while qualitative data will be collected through in-depth interviews with a subset of young men who have sex with men in the intervention arm and other key stakeholders. In Aim 3, through the same qualitative study as Aim 2, factors that influence the implementation of the app will be explored. Determinants from seven domains will be identified: condition, technology, value proposition, adopter system, health organization, wider system and embedding\u002Fadaption over time. Only when mHealth interventions are both effective and adopted can they maximize their potential to reduce HIV incidence among target populations. This proposal will generate data for designing a full-scale hybrid type 1 effectiveness-implementation trial to test the adapted app and identify implementation strategies to address the barriers of app implementation in low and middle-income countries.",[300,27],"Intervention",[302,303,304,305,306,307],"young men who have sex with men","HIV\u002FAIDS","HIV testing","PrEP","mHealth","Vietnam","2025-08-17",{"date":310,"type":39},"2025-08-22",{"date":312,"type":39},"2025-01-15",{"date":314,"type":20},"2029-08-31",{"name":316,"class":46},"Hanoi Medical University",{"id":318,"slug":319,"hasResults":11,"nctId":320,"briefTitle":321,"officialTitle":322,"acronym":4,"eligibilityCriteria":323,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":324,"targetDuration":4,"studyType":214,"phases":4,"briefSummary":326,"conditions":327,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":330,"startDateStruct":332,"completionDateStruct":334,"leadSponsor":336,"locationsCount":78},"100601383","copper-to-zinc-ratio-in-end-stage-renal-disease-patients-outcome-100601383","NCT07109778","Copper to Zinc Ratio in End Stage Renal Disease Patients Outcome","Impact of Copper to Zinc Ratio on Outcome of End Stage Renal Disease Patients","Inclusion Criteria:\n\n* ESRD patients including those on maintenance HD\n\nExclusion Criteria:\n\n* Acute kidney injury or rapidly progressive glomerulonephritis, acute infections or active inflammatory conditions as sepsis and autoimmune diseases, liver cirrhosis (Child-Pugh Class B or C), gastrointestinal disorders as inflammatory bowel disease, malabsorption, history of organ transplantation excluding kidney transplantation who may be included in a separate analysis if sufficient numbers are recruited, receiving total parenteral nutrition, Cu or Zn metabolism disorders as Wilson's disease, vitamin complex supplementation or antioxidants within the past 6 months, recent hospitalization within the past 3 months, recent surgery within 3 months, recent blood transfusion \\\u003C 3 months, Pregnancy or lactation, Malignancy.",{"count":325,"type":20},150,"The goal of this observational clinical trial is to Study the impact of copper to zinc ratio on the outcome of ESRD patients",[328,27],"ESRD (End Stage Renal Disease)","2025-07-31",{"date":331,"type":39},"2025-08-07",{"date":333,"type":20},"2025-08-01",{"date":335,"type":20},"2026-04-01",{"name":337,"class":46},"Minia University",{"id":339,"slug":340,"hasResults":11,"nctId":341,"briefTitle":342,"officialTitle":343,"acronym":4,"eligibilityCriteria":344,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":345,"targetDuration":4,"studyType":21,"phases":347,"briefSummary":348,"conditions":349,"keywords":350,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":361,"startDateStruct":363,"completionDateStruct":364,"leadSponsor":366,"locationsCount":4},"100590286","effectiveness-of-ai-chatbots-in-improving-students-general-wellbeing-100590286","NCT06965439","Effectiveness of AI Chatbots in Improving Students' General Wellbeing","Evaluating the Effectiveness of AI Chatbots in Improving Students' General Wellbeing","Inclusion Criteria:\n\nCurrent undergraduate student at the National University of Singapore (NUS)\n\nAged 21 years and above\n\nProficient in English\n\nNot currently undergoing psychological treatment or taking psychiatric medication\n\nNo history of self-harm or suicide\n\nScores below 10 on both the GAD-7 and PHQ-9 (i.e., subclinical levels of anxiety and depression)\n\nExclusion Criteria:\n\nCurrently undergoing psychological treatment or counselling\n\nCurrently taking psychiatric medication\n\nHistory of self-harm or suicidal ideation\n\nScores ≥10 on the GAD-7 and\u002For PHQ-9, indicating moderate to severe anxiety or depression\n\nInability to provide informed consent or comply with study procedures",{"count":346,"type":20},172,[23],"The goal of this randomised controlled trial is to evaluate the effectiveness of an AI mental health chatbot in promoting emotional wellbeing and perceived empathy among university students in Singapore with mild or subclinical symptoms of anxiety and depression. The main questions it aims to answer are:\n\nCan the chatbot provide emotional validation and be perceived as empathic?\n\nDoes the chatbot reduce symptoms of anxiety and depression and improve wellbeing more than an inactive control condition?\n\nResearchers will compare students who engage in four sessions with the chatbot to students who complete four neutral writing tasks to assess differences in emotional wellbeing, empathy, and resilience.\n\nParticipants will:\n\nComplete baseline wellbeing assessments\n\nBe randomised to:\n\nFour 20-minute chatbot sessions providing personalised support using cognitive-behavioural and compassion-focused techniques (intervention group), or\n\nFour 20-minute neutral writing sessions unrelated to mental health (control group)\n\nComplete post-session and follow-up wellbeing questionnaires\n\nAll sessions are conducted virtually over Zoom. Participants are full-time students at the National University of Singapore, aged 21 and above. The study aims to inform future development of AI tools for emotional support in non-clinical settings.",[27,300],[351,352,353,354,355,356,357,358,359,103],"Writing task","Mental health chatbot","Digital mental health","Emotional wellbeing","Subclinical anxiety","Subclinical depression","University students","AI intervention","Cognitive behavioural therapy (CBT)","2025-05-01",{"date":362,"type":39},"2025-05-11",{"date":333,"type":20},{"date":365,"type":20},"2025-10-31",{"name":367,"class":46},"National University of Singapore",{"id":369,"slug":370,"hasResults":11,"nctId":371,"briefTitle":372,"officialTitle":373,"acronym":4,"eligibilityCriteria":374,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":375,"enrollmentInfo":376,"targetDuration":4,"studyType":21,"phases":378,"briefSummary":379,"conditions":380,"keywords":383,"overallStatus":136,"whyStopped":4,"lastUpdateSubmitDate":388,"lastUpdatePostDateStruct":389,"startDateStruct":391,"completionDateStruct":393,"leadSponsor":395,"locationsCount":78},"100583164","effect-of-exercise-and-heat-stress-on-acute-cardiometabolic-adaptations-in-healthy-young-adults-100583164","NCT06872762","Effect of Exercise and Heat Stress on Acute Cardiometabolic Adaptations in Healthy Young Adults","Does Heat Stress Improve the Acute Metabolic and Cardiovascular Adaptations to Exercise","Inclusion Criteria:\n\n-regularly physically active as determined via ParQ+\n\nExclusion Criteria:\n\n* smokers\n* bronchial asthma\n* chronic obstructive pulmonary disease\n* obese\n* alcoholism\n* requiring daily medications that may effect responses to exercise,\n* anti-arrhythmogenics\n* inhalers\n* history of cardiovascular, respiratory, neurological, skeletal muscle disease\n* irregular\u002Fabsent menstrual cycle (females)\n* unexpected responses to pre-experimental exercise tests\n* previous diagnosis of heat stroke","50 Years",{"count":377,"type":20},15,[23],"Life in space is completely void of physical and environmental stress. It is well known that living things need regular physical stress (e.g. exercise) to remain strong, functional and healthy. More and more research is showing that regular environmental stress, for example heat and hypoxia, can further improve physical health. Astronauts aboard the international space station (ISS) exercise for 1-2 hours every day to avoid physical deconditioning that would otherwise cause them to age rapidly in space. Although physical exercise is very effective in remedying this deconditioning, today's astronauts still have physiological changes that indicate accelerated aging. This is a cause for concern given NASA's priority to travel to mars within the next decade; a mission that will require at least double the duration in space for our astronauts. The investigators think that the complete absence of environmental stress, i.e., heat, may be contributing to the accelerated aging that occurs during spaceflight. Our study will assess the health effects of adding heat stress to exercise that could be performed in space by astronauts. The goal is to inform best practice for astronauts to avoid physical deconditioning during long-duration spaceflight. This information will also be relevant to life on earth as spaceflight is a model of inactivity here on earth. Therefore, the potential benefits of adding heat stress will likely translate to life in space and on earth.",[381,382,27],"Exercise","Heat Strain",[384,385,386,387],"exercise","heat strain","glucose tolerance test","arterial compliance","2025-03-06",{"date":390,"type":39},"2025-03-12",{"date":392,"type":39},"2025-03-01",{"date":394,"type":20},"2026-05-21",{"name":396,"class":46},"Northern Arizona University",{"id":398,"slug":399,"hasResults":11,"nctId":400,"briefTitle":401,"officialTitle":401,"acronym":4,"eligibilityCriteria":402,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":403,"targetDuration":4,"studyType":214,"phases":4,"briefSummary":405,"conditions":406,"keywords":410,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":415,"lastUpdatePostDateStruct":416,"startDateStruct":418,"completionDateStruct":420,"leadSponsor":422,"locationsCount":4},"100563970","integrated-phenotyping-of-the-gut-platelet-liver-axis-in-the-progression-of-chronic-liver-disease-igal-axis-100563970","NCT06623084","Integrated Phenotyping of the Gut-plAtelet-Liver AXIS in the Progression of Chronic Liver Disease (iGAL-AXIS)","Inclusion Criteria:\n\n* age\\>18;\n* NAFLD patients according to EASL Guidelines 2016.\n\nExclusion Criteria:\n\n* decompensated cirrhosis, other causes of chronic liver disease (infectious and immune-mediated); malabsorption syndromes (i.e., celiac disease, food allergy, small bowel bacterial overgrowth);\n* inflammatory bowel disease; previous GI surgery;\n* immunodeficiencies; neurological handicaps;\n* use of NSAIDs, antibiotics, probiotics, or anti-secretory drugs within the 2 months preceding enrollment;\n* abnormality of hemostasis and thrombosis; malignancies.",{"count":404,"type":20},132,"Objective of the study Our working hypothesis is that platelets activated by gut-derived metabolites dock in the liver of NAFLD patients and amplify the inflammatory state by releasing pro-inflammatory cytokines\u002Fchemokines, which in turn recruit and activate leukocytes in the liver sinusoids. Combined stimuli from leukocytes and platelets would then lead to metabolic reprogramming of hepatocytes, progression to NASH and eventually cirrhosis.\n\nTo test this hypothesis, the investigators propose 2 objectives. Primary objective: To identify platelet features that correlate with liver disease progression.\n\nSecondary objective: To study the mechanistic relationship between gut dysbiosis, metabolome composition, inflammation, and platelet activation in chronic liver disease.",[407,408,409,27],"Non-alcoholic Fatty Liver Disease (NAFLD)","NASH - Nonalcoholic Steatohepatitis","Cirrhosis",[411,412,413,414],"Platelets","Liver","Metabolomics","Microbiota","2024-10-02",{"date":417,"type":39},"2024-10-04",{"date":419,"type":20},"2024-09-30",{"date":421,"type":20},"2025-12-24",{"name":423,"class":46},"Stefania Basili"]